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A peroxidase-like single-atom Fe-N_(5)active site for effective killing human lung adenocarcinoma cells

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Nano Research 2023年第4期16卷 5216-5225页

作者： liye Zhu Hong Zhong Dan Du Tao li Hoai Nguyen Scott PBeckman Wentao Xu jin-cheng li Nan cheng Yuehe lin Beijing Laboratory for Food Quality and Safety College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China School of Mechanical and Materials Engineering Washington State UniversityPullmanWA 99164USA Faculty of Chemical Engineering Yunnan Provincial Key Laboratory of Energy Saving in Phosphorus Chemical Engineering and New Phosphorus MaterialsKunming University of Science and TechnologyKunming 650500China Department of Chemistry and Biochemistry Northern Illinois University1425 W.Lincoln Hwy.DeKalbIL 60115USA X-ray Science Division Argonne National Laboratory9700 S.Cass AveLemontIL 60439USA Material Science Division Argonne National Laboratory9700 S.Cass AveLemontIL 60439USA

Single-atom catalyst(SAC)is one of the newest catalysts,and attracts people’s wide attention in cancer therapy based on their characteristics of maximum specific catalytic activity and high *** designed and synthesized a Fe-N decorated graphene nanosheet(Fe-N5/GN SAC)with the coordination number of *** enzymology and theoretical calculations,the Fe-N5/GN SAC has outstanding intrinsic peroxidase-like catalytic activity due to single-atom Fe site with five-N-coordination *** explored its potential on lung cancer therapy,and found that it could kill human lung adenocarcinoma cells(A549)by decomposing hydrogen peroxide(H_(2)O_(2))into toxic reactive oxygen species(ROS)under acidic microenvironment in threedimensional(3D)lung cancer cell *** study demonstrates a promising application of SAC with highly efficient single-atom catalytic sites for cancer treatment.

关键词： single-atom catalyst three-dimensional(3D) cancer cell model peroxidase-like catalytic activity cancer therapy

Synthesis of a novel tri-antennary galactoside with high hepatocyte targeting

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Chinese Chemical Letters 2007年第5期18卷 513-515页

作者： Lei Tang Yong Wu Jiao Lu Zhi Rong Zhang jin cheng Yang li Hai Key Laboratory of Drug Targeting Education Ministry West China School of Pharmacy Sichuan University Chengdu 610041 PR China

A novel bifunctional compound carrying duster thiogalactoside as the cell targeting ligands was synthesized for gene delivery to hepatocytes. Tetra-antennary dendr-OMs4 5 was used as a scaffold for the attachment of three galactosides, while the other mesylate end was linked with cholesterol through poly（ethylene glycol） chain. This design provided an effective entry for the synthesis of the bifunctional compound.

关键词： Cluster Cholesterylated galactoside Targeting ligand Hepatocyte-specific delivery Gene delivery

Single-Atom Ce-N_(4)-C-(OH)_(2)Nanozyme-Catalyzed Cascade Reaction to Alleviate Hyperglycemia

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Research 2023年第4期2023卷 463-473页

作者： Guangchun Song Jia Xu Hong Zhong Qi Zhang Xin Wang Yitong lin Scott PBeckman Yunbo Luo Xiaoyun He jin-cheng li Kunlun Huang Nan cheng Beijing Laboratory for Food Quality and Safety College of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China School of Mechanical and Materials Engineering Washington State UniversityPullmanWA 99164USA Faculty of Chemical Engineering Yunnan Provincial Key Laboratory of Energy Saving in PhosphorusChemical Engineering and New Phosphorus MaterialsKunming University of Science and TechnologyKunming 650000China Key Laboratory of Safety Assessment of Genetically Modified Organism(Food Safety) Ministry of AgricultureBeijing 100083China

The enzyme-mimicking catalytic activity of single-atom nanozymes has been widely used in tumor ***,research on alleviating metabolic diseases,such as hyperglycemia,has not been ***,we found that the single-atom Ce-N_(4)-C-(OH)_(2)(SACe-N_(4)-C-(OH)_(2))nanozyme promoted glucose absorption in lysosomes,resulting in increased reactive oxygen species production in HepG2 ***,the SACe-N_(4)-C-(OH)_(2)nanozyme initiated a cascade reaction involving superoxide dismutase-,oxidase-,catalase-,and peroxidase-like activity to overcome the limitations associated with the substrate and produce•OH,thus improving glucose intolerance and insulin resistance by increasing the phosphorylation of protein kinase B and glycogen synthase kinase 3β,and the expression of glycogen synthase,promoting glycogen synthesis to improve glucose intolerance and insulin resistance in high-fat diet-induced hyperglycemic ***,these results demonstrated that the novel nanozyme SACeN_(4)-C-(OH)_(2)alleviated the effects of hyperglycemia without evident toxicity,demonstrating its excellent clinical application potential.

关键词： diseases overcome initiated

Bulk preparation of free-standing single-iron-atom catalysts directly as the air electrodes for high-performance zinc-air batteries

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Carbon Energy 2023年第5期5卷 57-66页

作者： Hong-Bo Zhang Yu Meng Hong Zhong lili Zhang Shichao Ding lingzhe Fang Tao li Yi Mei Peng-Xiang Hou Chang liu Scott P.Beckman Yuehe lin Hui-Ming cheng jin-cheng li Yunnan Provincial Key Laboratory of Energy Saving in Phosphorus Chemical Engineering and New Phosphorus Materials Faculty of Chemical EngineeringKunming University of Science and TechnologyKunmingChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyangChina School of Mechanical and Materials Engineering Washington State UniversityPullmanWashingtonUSA Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIllinoisUSA Argonne National Laboratory X-Ray Science DivisionLemontIllinoisUSA

The keen interest in fuel cells and metal-air batteries stimulates a great deal of research on the development of a cost-efficient and high-performance catalyst as an alternative to traditional Pt to boost the sluggish oxygen reduction reaction(ORR)at the ***,we report a facile and scalable strategy for the large-scale preparation of a free-standing and flexible porous atomically dispersed Fe-N-doped carbon microtube(FeSAC/PCMT)*** from its unique structure that greatly facilitates the catalytic kinetics,mass transport,and electron transfer,our FeSAC/PCMT electrode exhibits excellent performance with an ORR potential of 0.942 V at^(-3) mA cm^(-2).When the FeSAC/PCMT sponge was directly used as an oxygen electrode for liquid-state and flexible solid-state zinc-air batteries,high peak power densities of 183.1 and 58.0 mW cm^(-2) were respectively achieved,better than its powdery counterpart and commercial Pt/C *** and theoretical investigation results demonstrate that such ultrahigh ORR performance can be attributed to atomically dispersed Fe-N_(5) species in FeSAC/*** study presents a cost-effective and scalable strategy for the fabrication of highly efficient and flexible oxygen electrodes,provides a significant new insight into the catalytic mechanisms,and helps to realize significant advances in energy devices.

关键词： atomic Fe-N_(5)species free-standing electrode large-scale preparation oxygen reduction reaction zinc-air battery

Research Progress of Nanomaterials-Based Sensors for Food Safety

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Journal of Analysis and Testing 2022年第4期6卷 431-440页

作者： Yuan-Xin li Hai-Yang Qin Can Hu Meng-Meng Sun Pei-Yi li Huan liu jin-cheng li Zhi-Bo li li-Dong Wu Jun Zhu College of Food Science and Engineering Dalian Ocean UniversityDalian116023China Chinese Academy of Fishery Sciences Beijing100141China College of Food Science and Technology Shanghai Ocean UniversityShanghai201306China Central Theater Centers for Disease Control and Prevention Beijing100042China

With the improvement of people’s requirements for food quality,food safety has become the focus of *** and more researchers continue to develop specific and convenient biochemical sensors for the detection of certain components in food,which also imposes higher requirements for the structure and performance of *** sensors based on carbon nanotubes,metal nanowires,nanofibers,metal-organic framework(MOF)compounds and other functional composite materials have the advantages of high sensitivity,great detection speed and reliable results,and have been continuously developed and widely used in medical,environmental and food safety *** paper reviews the progress of research on the application of the sensors based on the above functional nanomaterials in food detection in recent years,demonstrates the advantages brought by the functional composite materials,and discusses the challenges faced by the functional nanomaterials in the field of food safety testing,to provide an effective reference for developing functional composite material sensors for food safety testing.

关键词： Carbon nanotubes Metal nanowires Nanofibers MOFs Sensors Food safety

A new iridoid from Incarvillea delavayi

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Chinese Chemical Letters 2007年第12期18卷 1512-1514页

作者： Tao Lu Wei Dong Zhang Yue Hu Pei Chuan Zhang jin cheng li YunHeng Shen Department of Phytochemistry School of Pharmacy Second Military Medical University Shanghai 200433 China School of Pharmacy Shanghai Jiao tong University Shanghai 200030 China Shenyang Pharmaceutical University Liaoning Province Shenyang 110016 China

A new iridoid was isolated from the 80% ethanol extract of the whole plant of Incarvillea delavayi. Its structure was defined, and named incarvillic acid, on the basis of spectral evidences.

关键词： Incarvillea delavayi Bignoniaceae Iridoid Incarvillic acid

Three-dimensional interconnected graphene network-based high-performance air electrode for rechargeable zinc‒air batteries

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SusMat 2024年第3期4卷 192-203页

作者： Jia-Xing An Yu Meng Hong-Bo Zhang Yuanzhi Zhu Xiaohua Yu Ju Rong Peng-Xiang Hou Chang liu Hui-Ming cheng jin-cheng li Faculty of Chemical Engineering Yunnan Provincial Key Laboratory of Energy Saving in Phosphorus Chemical Engineering and New Phosphorus MaterialsKunming University of Science and TechnologyKunmingChina Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyangChina Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunmingChina

Although zinc-air batteries(ZABs)are regarded as one of the most prospective energy storage devices,their practical application has been restricted by poor air electrode ***,we developed a free-standing air electrode that is fabricated on the basis of a multifunctional three-dimensional interconnected graphene ***,a three-dimensional interconnected graphene network with fast mass and electron transport ability,prepared by catalyzing growth of graphene foam on nickel foam and then filling reduced graphene oxide into the pores of graphene foam,is used to anchor iron phthalocyanine molecules with atomic Fe-N_(4)sites for boosting the oxygen reduction during discharging and nanosized FeNi hydroxides for accelerating the oxygen evolution during *** a result,the obtained air electrode exhibited an ultra-small electrocatalytic overpotential of 0.603 V for oxygen reactions,a high peak power density of 220.2mWcm^(-2),and a small and stable charge-discharge voltage gap of 0.70 V at 10mA cm^(-2)after 1136 ***,in situ Raman spectroscopy together with theoretical calculations confirmed that phase transformation of FeNi hydroxides takes place fromα-Ni(OH)_(x)toβ-Ni(OH)_(x)toγ-Ni^((3+δ)+)OOH for the oxygen evolution reaction and Ni is the active center while Fe enhances the activity of Ni active sites.

关键词： in situ Raman interconnected graphene network iron phthalocyanine NiFe hydroxide zinc‒air battery

Optimizing groundwater recharge plan in North China Plain to repair shallow groundwater depression zone, China

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Journal of Groundwater Science and Engineering 2023年第2期11卷 133-145页

作者： Rui-fang Meng Hui-feng Yang Xi-lin Bao Bu-yun Xu Hua Bai jin-cheng li Ze-xin liang Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China National Field Scientific Observation and Research Station on Groundwater and Ground Subsidence in the Plain Area of Cangzhou 050061 HebeiChina Shuifa Planning and Design Co. Ltd.Jinan 250100China Hebei Hydraulic Research Institute Shijiazhuang 050057China

The North China Plain is one of the main grain producing areas in China. However, overexploitation has long been unsustainable since the water supply is mainly from groundwater. Since 2014,the South-to-North Water Diversion Project's central route has been charted to the integrated management of water supply and over-exploitation, which has alleviated the problem to a certain extent. Although the Ministry of Water Resources has made many efforts on groundwater recharge since 2018 most of which have been successful, the recharge has not yet been sufficiently focused on the repair of shallow groundwater depression zones. It still needs further optimization. This paper discusses this particular issue,proposes optimized recharge plan and provides the following recommendations:(1) Seven priority target areas are selected for groundwater recharge in alluvial and proluvial fans in the piedmont plain, and the storage capacity is estimated to be 181.00×10~8 m~3;(2) A recharge of 31.18×10~8 m~3/a is required by 2035 to achieve the repair target;(3) It is proposed to increase the recharge of Hutuo River, Dasha River and Tanghe River to 19.00×10~8 m~3/a and to rehabilitate Gaoliqing-Ningbailong Depression Zone;increase the recharge of Fuyang River, Zhanghe River and Anyang River to 7.05×10~8 m~3/a and rehabilitate Handan Feixiang-Guangping Depression Zone;increase the recharge of Luanhe River by 0.56×10~8 m~3/a and restore Tanghai Depression Zone and Luanan-Leting Depression Zone;moderately reduce the amount of water recharged to North Canal and Yongding River to prevent excessive rebound of groundwater;(4) Recharge through well is implemented on a pilot basis in areas of severe urban ground subsidence and coastal saltwater intrusion;(5) An early warning mechanism for groundwater quality risks in recharge areas is established to ensure the safety. The numerical groundwater flow model also proves reasonable groundwater level restoration in the depression zones by 2035.

关键词： North China Plain Groundwater recharge Groundwater depression zone Recharge target areas Storage capacity Recharge source Recharge effectiveness

4A沸石吸附模拟核素Sr,Cs后的组分变化和结构表征

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矿物岩石 2005年第2期25卷 35-39页

作者：易发成金承黎李玉香西南科技大学四川绵阳621010

　通过4A沸石吸附模拟核素Sr,Cs前后的化学成分分析、X衍射分析和红外光谱分析等手段方法,分析探讨了模拟核素Sr,Cs在4A沸石的赋存状态,结果表明:4A沸石与模拟核素Sr,Cs之间主要以离子交换的方式发生作用,Sr2+,Cs+取代4A沸石中的可交换... 详细信息

　通过4A沸石吸附模拟核素Sr,Cs前后的化学成分分析、X衍射分析和红外光谱分析等手段方法,分析探讨了模拟核素Sr,Cs在4A沸石的赋存状态,结果表明:4A沸石与模拟核素Sr,Cs之间主要以离子交换的方式发生作用,Sr2+,Cs+取代4A沸石中的可交换离子Na+,占据4A沸石α笼中的6元环和8元环,导致4A沸石的晶胞参数增大,晶格发生畸变。

关键词： 4A沸石 Sr,Cs 离子交换晶格畸变