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Journal of Clinical and Nursing Research 2024年第5期8卷 283-292页

作者： Chengwen Shi Feifan Zhao Yingshuo Wang Chengxuan Liu aiyu Mao Siqi jin Peking University People’s Hospital Beijing 100000China

Objective:To explore the effects of progressive muscle relaxation training on anxiety,depression,and quality of life in patients with cerebral small vessel disease(CSVD).Methods:Sixty-one patients with CSVD in the Department of Neurology of a tertiary hospital were divided into an observation group(28 patients)and a control group(33 patients)by lottery *** control group received conventional nursing care,while the observation group received progressive muscle relaxation training interventions in addition to the conventional *** Hamilton Anxiety Scale(HAMA),the Hamilton Depression Scale(HAMD),and the Stroke-Specific Quality of Life Scale(SS-QOL)were used to compare the effects before the intervention,7 days after the intervention,and 30 days after the ***:Over time,at different time points after the intervention,the anxiety and depression scores of patients with CSVD in the observation group were significantly lower than those in the control group(P<0.05).The quality of life scores were significantly higher in the observation group compared to the control group(P<0.05),and these differences were statistically ***:Progressive muscle relaxation training can improve anxiety and depression in patients with cerebral small vessel disease and can effectively enhance their quality of life.

关键词： Progressive muscle relaxation training Cerebral small vessel disease(CSVD) Anxiety Depression Quality of life

Correlation Risk Modelling of Maternal Serum Alpha-Fetoprotein Variants(AFP-L2 and AFP-L3) in the Detection of Fetal Open Neural Tube Defects and Abdominal Wall Defects

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Correlation Risk Modelling of Maternal Serum Alpha-Fetoprote...

Correlation Risk Modelling of Maternal Serum Alpha-Fetoprotein Variants(AFP-L2 and AFP-L3) in the Detection of Fetal Open Neural Tube Defects and Abdominal Wall Defects

2019浙江省妇产科医师大会及妇产科学学术年会

作者： Yiming Chen Sha Lu Liu,Rimin Wen Zhang Chen,Lei Yixuan Yin Zhang,Lidan Jiejing Lian jin aiyu Wensheng Hu Department of Prenatal diagnosis and screening center Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital) Department of Cell Biology and Medical Genetics School of MedicineZhejiang University Department of Cell Biology and Medical Genetics School of MedicineZhejiang University866Yuhangtang Road

Objective:To evaluate correlation risk model screening efficiency of the maternal serum alphafetoprotein variants L2 and L3(AFP-L2 and AFP-L3) in the detection of fetal open neural tube defects(ONTD) and abdominal wall defects(AWD).Methods:We divided Subjects into the ONTD group(21 cases),the AWD group(16 cases) and the control group(38 cases) depending on the presence or absence of fetal ONTD or *** levels of AFP-L2 and AFP-L3 using the multiple of the median(MoM) were detected by Enzyme linked immunosorbent assay(ELISA).Comparative analysis was performed on AFP-L2 and AFP-L3 levels using a model created by multiple indicators to determine the efficiency of ONTD or AWD *** operating characteristic(ROC) curves were used to determine the optimal cut-off value,area under the curve(AUC) and to evaluate the screening performance of AFP-L2 and ***:AFP-L2 levels in the ONTD group and the AWD group were 1.77(0.76-2.89) MoM and 1.79(0.77-4.41) MoM,*** were both significantly higher than those in the control group [1.01(0.15-1.53) MoM,P<0.001)].AFP-L3 levels in the ONTD group and the AWD group were 2.85(0.74-5.85) MoM and 3.57(0.86-6.81) MoM,*** were also both significantly higher than those in the control group [1.16(0.13-1.92) MoM,P<0.001)].The AUC for screening ONTD or AWD using AFP-L2 was 0.830 [95% confidence interval(CI):0.734-0.926,P<0.001],while using AFP-L3 was 0.886 [95% confidence interval(CI):0.809-0.963,P<0.001].ROC curves indicated that the optimal threshold values for ONTD or AWD by AFP-L2 and AFP-L3 were 1.467 MoM and 1.944 MOM,*** corresponding sensitivity,specificity and Youden index for AFP-L2 and AFP-L3 were 0.703,0.947,0.650 and 0.730,0.974,0.703,*** correlation risk model established using AFP-L2 and AFP-L3 showed better screening efficiency than the original AFP MOM as a single-value ***:Mid-pregnancy maternal serum levels of AFP-L2 and AFP-L3 are good bi

关键词： pregnant women mid-pregnancy prenatal screening fetoprotein variant AFP-L2/AFP-L3 open neural tube abnormalities case-controlled study

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2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： Yiming Chen Sha Lu Liu Rimin Wen Zhang Chen Lei Yixuan Yin Zhang Lidan Jiejing Lian jin aiyu Wensheng Hu Department of Prenatal diagnosis and screening center Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital) Department of Cell Biology and Medical Genetics School of Medicine Zhejiang University

Objective: To evaluate correlation risk model screening efficiency of the maternal serum alphafetoprotein variants L2 and L3(AFP-L2 and AFP-L3) in the detection of fetal open neural tube defects(ONTD) and abdominal wall defects(AWD).Methods: We divided Subjects into the ONTD group(21 cases), the AWD group(16 cases) and the control group(38 cases) depending on the presence or absence of fetal ONTD or AWD. Serum levels of AFP-L2 and AFP-L3 using the multiple of the median(MoM) were detected by Enzyme linked immunosorbent assay(ELISA). Comparative analysis was performed on AFP-L2 and AFP-L3 levels using a model created by multiple indicators to determine the efficiency of ONTD or AWD screening. Receiver operating characteristic(ROC) curves were used to determine the optimal cut-off value, area under the curve(AUC) and to evaluate the screening performance of AFP-L2 and AFP-L3. Results: AFP-L2 levels in the ONTD group and the AWD group were 1.77(0.76-2.89) MoM and 1.79(0.77-4.41) MoM, respectively. They were both significantly higher than those in the control group [1.01(0.15-1.53) MoM, P<0.001)]. AFP-L3 levels in the ONTD group and the AWD group were 2.85(0.74-5.85) MoM and 3.57(0.86-6.81) MoM, respectively. They were also both significantly higher than those in the control group [1.16(0.13-1.92) MoM, P<0.001)]. The AUC for screening ONTD or AWD using AFP-L2 was 0.830 [95% confidence interval(CI): 0.734-0.926, P<0.001], while using AFP-L3 was 0.886 [95% confidence interval(CI): 0.809-0.963, P<0.001]. ROC curves indicated that the optimal threshold values for ONTD or AWD by AFP-L2 and AFP-L3 were 1.467 MoM and 1.944 MOM, respectively. The corresponding sensitivity, specificity and Youden index for AFP-L2 and AFP-L3 were 0.703, 0.947, 0.650 and 0.730, 0.974, 0.703, respectively. The correlation risk model established using AFP-L2 and AFP-L3 showed better screening efficiency than the original AFP MOM as a single-value model. Conclusion: Mid-pregnancy maternal serum level

关键词： pregnant women mid-pregnancy prenatal screening fetoprotein variant AFP-L2/AFP-L3 open neural tube abnormalities case-controlled study

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综合护理干预对尿路结石保守治疗的影响

中国现代医生 2013年第29期51卷 103-105页

作者：金爱玉朱勤杭州市第一人民医院急诊科浙江杭州310003 浙江省新华医院泌尿外科浙江杭州310005

目的探讨综合护理干预对尿路结石保守治疗的疗效影响。方法选取2011年1月～2012年6月就诊我院泌尿科行尿路结石保守治疗的患者184例，随机分为两组，均行体外冲击波碎石配合白拟排石汤治疗，其中一般护理组92例行常规护理，综合护理干预... 详细信息

目的探讨综合护理干预对尿路结石保守治疗的疗效影响。方法选取2011年1月～2012年6月就诊我院泌尿科行尿路结石保守治疗的患者184例，随机分为两组，均行体外冲击波碎石配合白拟排石汤治疗，其中一般护理组92例行常规护理，综合护理干预组92例在一般护理组基础上进行综合护理干预，观察比较两组患者临床疗效和护理满意率。结果综合护理干预组治疗总有效率88．0％明显高于一般护理组的75．O％：综合护理干预组疼痛消失时间（25．1±7．3）h明显短于一般护理组的（68．7±8．7）h、血尿消失时间（23．8±4．4）h明显短于一般护理组的（48．6±7．2）h、排石时间（112．5±8．7）h明显短于一般护理组的（187．2±7．6）h；综合护理干预组护理满意率100％明显高于一般护理组的88％，差异均有统计学意义（P〈0．01）。结论对尿路结石保守治疗的患者给予正确积极的综合护理干预，可以有效提高临床疗效，快速缓解患者痛苦，构建和谐的护患关系，提高护理满意率。

关键词：尿路结石保守治疗护理

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急诊护理人员职业危害及其防护措施

中国现代医生 2013年第19期51卷 112-114页

作者：金爱玉张月平杭州市第一人民医院急诊科浙江杭州310003 浙江省新华医院感染科浙江杭州310005

目的分析急诊护理人员的职业危害原因以及防护对策。方法选取2011年3月～2013年2月我院急诊内科护理人员38名作为观察组,并随机抽取我院外科、内科、妇产科以及儿科护理38名作为对照组,对比分析两组职业损伤情况。结果急诊护理人员的职... 详细信息

目的分析急诊护理人员的职业危害原因以及防护对策。方法选取2011年3月～2013年2月我院急诊内科护理人员38名作为观察组,并随机抽取我院外科、内科、妇产科以及儿科护理38名作为对照组,对比分析两组职业损伤情况。结果急诊护理人员的职业危害因素主要为物理损伤、化学损伤、生物损伤以及护理人员自身心理因素,多种原因相互作用,引发护理人员职业损伤。结论急诊科护理人员的职业损伤是客观存在的,实施科学有效的防护措施可有效避免发生职业危害事件,从而确保护理人员的安全。

关键词：危险因素职业损伤急诊科护理人员防护措施

二维斑点追踪成像技术结合心肌做功评价蒽环类药物对乳腺癌患者左心室功能的影响

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中国癌症杂志 2020年第10期30卷 806-811页

作者：苗爱雨智文祥周瑾刘雅静王宇常才复旦大学附属肿瘤医院超声诊断科复旦大学上海医学院肿瘤学系上海200032

背景与目的:应用二维斑点追踪成像(two-dimensional speckle tracking imaging,2D-STI)结合心肌做功评价蒽环类药物对乳腺癌患者左心室功能的影响。方法:前瞻性选择2019年9月—2020年3月在复旦大学附属肿瘤医院行蒽环类药物治疗的35例... 详细信息

背景与目的:应用二维斑点追踪成像(two-dimensional speckle tracking imaging,2D-STI)结合心肌做功评价蒽环类药物对乳腺癌患者左心室功能的影响。方法:前瞻性选择2019年9月—2020年3月在复旦大学附属肿瘤医院行蒽环类药物治疗的35例乳腺癌患者,分别于化疗前、化疗2个周期后、4个周期后行常规超声心动图检查并获取动态二维图像,同时使用肱动脉袖带血压计测量患者收缩期及舒张期血压值,测量左房内径(left atrial diameter,LAD)、左心室舒张末期内径(left ventricular end-diastolic diameter,LVEDD)、左心室收缩末期内径(left ventricular end-systolic diameter,LVESD)、舒张末期室间隔厚度(diastolic interventricular septal depth,IVSD)、左心室舒张末期容积(left ventricular enddiastolic volume,LVEDV)、左心室收缩末期容积(left ventricular end-systolic volume,LVESV)、左心室射血分数(left ventricular ejection fraction,LVEF)、二尖瓣口舒张早期峰值流速(early diastolic peak velocity,E峰)、舒张晚期峰值流速(late diastolic tissue velocity,A峰)、二尖瓣环间隔处舒张早期峰值速度(early diastolic tissue velocity,e’),并计算E/A、E/e’;应用EchoPac软件脱机分析,获取左心室整体纵向应变(global longitudinal strain,GLS)、左心室分层纵向应变(GLSendo、GLSmid、GLSepi),以及左心室心肌整体做功指数(global myocardial work index,GWI)、整体有用功(global constructive work,GCW)、整体无用功(global wasted work,GWW)、整体做功效率(global myocardial work efficiency,GWE);并行统计学分析。结果:与化疗前比较,化疗2个周期乳腺癌患者GLSeondo、GLS有所减低,但差异无统计学意义(P>0.05);GWW增加,GWE降低(P0.05)。结论:2D-STI能早期检测乳腺癌患者在蒽环类药物化疗中左心室功能的早期改变,GWW及GWE较其他参数更敏感。

关键词：超声心动描记二维斑点追踪成像心室功能心肌做功,左乳腺癌蒽环类药物

钛夹联合尼龙绳牵引辅助技术在内镜黏膜下剥离术治疗早期胃角癌中的临床研究

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中华消化内镜杂志 2020年第5期37卷 321-325页

作者：马文聪张筱凤楼奇峰余爱玉沈绚丽金杭斌陆磊浙江大学医学院附属杭州市第一人民医院消化内科 310006

目的评估钛夹联合尼龙绳牵引辅助下内镜黏膜下剥离术(ESD)治疗早期胃角癌及癌前病变的应用价值及安全性。方法以2018年1—12月在杭州市第一人民医院行ESD治疗的59例早期胃角癌及癌前病变患者为研究对象,采用随机数字表法随机分入常规ESD... 详细信息

目的评估钛夹联合尼龙绳牵引辅助下内镜黏膜下剥离术(ESD)治疗早期胃角癌及癌前病变的应用价值及安全性。方法以2018年1—12月在杭州市第一人民医院行ESD治疗的59例早期胃角癌及癌前病变患者为研究对象,采用随机数字表法随机分入常规ESD组(对照组,n=28)和钛夹联合尼龙绳牵引组(试验组,n=31)。比较两组患者的黏膜下补充注射次数、ESD手术时间、病灶面积、黏膜剥离时间、单位时间切除率、病灶完整切除率以及手术并发症等情况。结果试验组黏膜下补充注射次数少于对照组[(2.3±1.1)次比(3.7±1.4)次,t=4.557,P<0.001];试验组的病灶面积和对照组相比差异无统计学意义[(12.7±2.6)cm2比(11.7±2.7)cm2,t=1.485,P=0.143];试验组ESD手术时间[(72.4±24.7)min比(93.6±28.9)min,t=3.043,P=0.004]和黏膜剥离时间[(67.7±23.3)min比(88.2±28.3)min,t=3.054,P=0.003]短于对照组,单位时间切除率高于对照组[(20.2±3.2)mm2/min比(14.3±3.4)mm2/min,t=6.879,P<0.001]。两组患者的一次性完整切除率均为100.0%。两组患者均未出现穿孔及术后出血等,试验组术中出血率低于对照组[19.4%(6/31)比35.7%(10/28),χ^2=1.992,P=0.158]。结论使用钛夹联合尼龙绳牵引辅助技术可降低胃角ESD的技术难度、缩短操作时间、降低术中出血可能,具有较好的应用价值。

关键词：胃肿瘤胃角内镜黏膜下剥离术尼龙绳钛夹牵引

Drosophila FMRP regulates microtubule network formation and axonal transport of mitochondria

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Drosophila FMRP regulates microtubule network formation and ...

脑血氧饱和度的无创伤测量和脑思维功能的研究

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： aiyu YAO~1,Shan jin~(1,2),Xin-Hai LI~1,Zhi-Hua LIU~1,Xue-Hua MA~1,jing TANG~1,Yong Q.ZHANG~(1,*) 1 Key Laboratory of Molecular and Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China 2 College of Life Sciences,Hubei University,Wuhan 430062,China

＜正＞Fragile X syndrome,the most common form of inherited mental retardation,is caused by the absence of the fragile X mental retardation protein *** RNA-binding FMRP represses translation of the microtubule-associated protein IB（MAPIB） during synaptogenesis in the brain of the neonatal ***,the effect of FMRP on microtubules remains *** evidence shows that the structure and function of FMRP are well conserved across species from Drosophila to *** a genetic screen,we identified spastin as a dominant suppressor of rough eye caused by dfmrl over-expression,spastin encodes a microtubule-severing protein and its mutations cause neurodegenerative hereditary spastic *** and biochemical analysis revealed that dfmrl acts at upstream of or in parallel with spastin in multiple processes,including synapse development,locomotive behaviour and microtubule network *** showed that both loss- and gain-of-function mutations of dfmrl result in an apparently altered microtubule *** analysis revealed that the levels of a-tubulin and acetylated microtubules remained normal in dfmrl mutants but increased significantly when dfmrl was over-expressed. To examine the consequence of the aberrant microtubules in dfmrl mutants,we analyzed the microtubule-dependent mitochondrial transport and found that the number of mitochondria and the flux of mitochondrial transport were negatively regulated by *** results demonstrate that dFMRP has a crucial role in controlling microtubule formation and mitochondrial ***,defective microtubules and abnormal mitochondrial transport might account for,at least partially,the pathogenesis of fragile X mental retardation.

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生物医学工程学杂志 2001年第2期18卷 260-264页

作者：姚鹏李胜利张爱玉刘煜徐敏金泰义中国科学技术大学精密机械与精密仪器系合肥230026

利用近红外光谱法 (NIRS) ,根据广义郎伯特—比尔定律 (L am bert- Beer)可以实现活体脑血氧浓度的无创伤测量。在本论文中 ,通过将脑血氧饱和度和脑功能相结合的实验 ,讨论研究高级脑功能的可能性。利用事件相关实验可以检测脑的思维... 详细信息

利用近红外光谱法 (NIRS) ,根据广义郎伯特—比尔定律 (L am bert- Beer)可以实现活体脑血氧浓度的无创伤测量。在本论文中 ,通过将脑血氧饱和度和脑功能相结合的实验 ,讨论研究高级脑功能的可能性。利用事件相关实验可以检测脑的思维功能。实验结果的时域曲线差别不大。然而 ,利用 DFT,五个被实验者的实验数据表明2 0 Hz或 40 Hz频率的信号与困难的智力工作有关。

关键词：近红外光谱法脑血氧饱和度脑思维功能事件相关性实验 DFT

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小肝癌超声造影特征与病理组织学分析研究

临床超声医学杂志 2012年第2期14卷 100-103页

作者：廖继安王爱玉张化诚金夏祥解放军第一一三医院特诊科浙江省宁波市315040 宁波市第一人民医院超声科解放军第一一三医院病理科浙江省宁波市315040

目的探讨小肝癌(直径≤3cm)超声造影特征与肿瘤分化程度及病理组织学类型间的关系。方法采用超声造影技术观察87例小肝癌患者,109个病灶的超声增强时间及增强模式;分析肿瘤分化程度及病理组织学类型的超声造影影像学特点。结果 109个小... 详细信息

目的探讨小肝癌(直径≤3cm)超声造影特征与肿瘤分化程度及病理组织学类型间的关系。方法采用超声造影技术观察87例小肝癌患者,109个病灶的超声增强时间及增强模式;分析肿瘤分化程度及病理组织学类型的超声造影影像学特点。结果 109个小肝癌病灶,高分化52个,中分化38个,低分化19个。低分化肿瘤回声增强时间(12.2±2.14),显著少于高分化肿瘤(14.54±3.65),P<0.01,消退时间(46.57±9.15)早于中分化肿瘤(79.38±28.79),P<0.01;中分化肿瘤的消退时间显著早于高分化肿瘤(102.46±33.23),P<0.05。低分化肿瘤门静脉相和延迟相低增强比例(84.21%)显著高于高分化肿瘤(51.92%),P<0.01。与梁索型和假腺管型比较,实体型肿瘤的回声消退时间较短,门静脉相及延迟相低增强比例较高;纤维硬化型者动脉相高增强比例较低,门静脉相及延迟相高增强比例较高(P<0.05)。结论综合分析超声造影的影像学特征,对判断小肝癌的分化程度和与病理组织学类型具有重要的参考价值。

关键词：小肝癌超声检查造影剂病理学