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A folic acid-decorated nanoparticles loaded JQ1 for oral squamous cell carcinoma therapy

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Chinese Chemical Letters 2024年第3期35卷 332-336页

作者： Dequan Zeng Zhongkai Ma Xin Zan Ting Luo xiang wang xiang Gao xianghui Fu School of Health Management Xihua UniversityChengdu 610039China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China College of StomatologySichuan UniversityChengdu 610041China Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengdu 610041China Breast Disease Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China

Oral squamous cell carcinoma(OSCC)is known as one of the most malignant tumors with high recurrence and fatality *** poor tumor-targeting ability of traditional chemotherapeutic drugs has been a grand challenge for anti-OSCC *** that,a large quantity of tumor associated macrophages in OSCC tissues further diminish the anti-tumor effects of these ***,we produced a therapeutic nano drug delivery system(FA-PEG-PLA-JQ1)through encapsulating JQ1[a small-molecule inhibitor of bromodomain containing protein 4(BRD4)]into the folic acid(FA)-modified nanoparticle(PEG-PLA),which could prolong the half-life of JQ1 and target the tumor *** then,JQ1 released from this nanoparticle could prevent OSCC growth inducing tumor cell apoptosis,inhibiting tumor angiogenesis and the polarization of M2 type *** conclusion,our date demonstrated the therapeutic benefits of FA-PEG-PLA-JQ1 against OSCC in vivo or in vitro,which could be a novel treatment strategy for OSCC in coming days.

关键词： Folic acid Nanoparticles JQ1 Oral squamous cell carcinoma Macrophages

Deciphering the Shared and Specific Drug Resistance Mechanisms of Anaplastic Lymphoma Kinase via Binding Free Energy Computation

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Research 2024年第1期2023卷 663-674页

作者： Yang Yu Zhe wang Lingling wang Qinghua wang Rongfan Tang Sutong xiang Qirui Deng Tingjun Hou Huiyong Sun Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 210009JiangsuP.R.China Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058ZhejiangP.R.China

Anaplastic lymphoma kinase(ALK),a tyrosine receptor kinase,has been proven to be associated with the occurrence of numerous *** there have been already at least 3 generations of ALK inhibitors approved by FDA or in clinical trials,the occurrence of various mutations seriously attenuates the effectiveness of the ***,most of the drug resistance mechanisms still remain ***,it is necessary to reveal the bottom reasons of the drug resistance mechanisms caused by the *** this work,on the basis of verifying the accuracy of 2 main kinds of binding free energy calculation methodologies[end-point method of Molecular Mechanics with Poisson-Boltzmann/Generalized Born and Surface Area(MM/PB(GB)SA)and alchemical method of Thermodynamic Integration(TI)],we performed a systematic analysis on the ALK systems to explore the underlying shared and specific drug resistance mechanisms,covering the one-drug-multiple-mutation and multiple-drug-onemutation cases.

关键词： drugs Anaplastic clinical

An ultra-porous g-C_(3)N_(4) micro-tube coupled with MXene(Ti_(3)C_(2)TX)nanosheets for efficient degradation of organics under natural sunlight

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Journal of Environmental Sciences 2024年第3期137卷 258-270页

作者： Zongyang Ya Qiyou wang jingjin Cai Peng wang Xinyu Jiang Zhiyin Cai Shanglin xiang Tingwei wang Dongyu Cai College of Materials Science&Engineering Nanjing Tech University30 South PuZhu RoadNanjing 211816China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University30 South PuZhu RoadNanjing 211816China

It remains as a challenge for realizing efficient photo-responsive catalysts towards largescale degradation of organic pollutants under natural *** work reports a new pore engineering strategy for creating ultra-porous g-C_(3)N_(4) micro-tubes with an unprecedentedly high specific surface area of 152.96 m^(2)/*** is mainly associated with releasing internal vapor pressure in the autoclave where the hydrothermal treatment of the urea/melamine mixture is *** by microscopic observation,porosity measurement and spectroscopic characterization,it is found that releasing the pressure at halfway of hydrothermal process is vital for forming exfoliated rod-like precursors and the de-aggregation of these rods presents substantial benefits on the production of mesopores on g-C_(3)N_(4) microtubes during the calcination of *** offers a large number of reactive sites required by photocatalytic *** these micro-tubes with Ti_(3)C_(2)T_(X) nanosheets via electrostatic interaction yields a 1D/2D heterojunction with a close interfacial *** addition of metallically conductive Ti_(3)C_(2)T_(X) nanosheets accelerates the separation between electrons and holes,and also enhances the light *** these merits of structural design lead to forming a group of highly efficient catalysts demonstrating an excellent photocatalytic degradation rate of k=0.0560 min^(-1)for RhB dyes under 100 mW/cm~2 visible light radiation that micks sunlight *** laboratory valuation is further supported by an outdoor test that shows a fast degradation rate of 0.0744 min^(-1)under natural sunlight.

关键词： Carbon nitride MXene Heterojunction Photocatalysis

Microstructural evolution and deformation behavior of friction stir welded twin-induced plasticity steel

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Journal of Materials Science & Technology 2024年第2期169卷 68-81页

作者： Ke Qiao Kuaishe wang Jia wang Zhengyang Hao Yating xiang Peng Han Jun Cai Qi Yang Wen wang School of Metallurgical Engineering National and Local Joint Engineering Research Center for Functional Materials ProcessingXi’an University of Architecture and TechnologyXi’an 710055China Shanghai Research Institute of Materials Shanghai 200437China

The weldability of twin-induced plasticity(TWIP)steel with ultra-high strength via friction stir welding(FSW)technique was investigated,and microstructural evolution and deformation behavior of whole and micro-zones of FSW TWIP joint were studied for the first *** results showed that the content of recrystallized grains in the stir zone(SZ)increased from 10.5%of basal material(BM)to 14.2%,and that of heat affected zone(HAZ)increased to 78.6%.The percentage of annealing twins decreased from 26.8%in BM to 11%in SZ,while increased to 35%in *** with the BM,the ultimate tensile strength and yield strength of the FSW joint increased to 1036 and 550 MPa,respectively,reaching 106.7%and 110.9%of BM,*** elongation of the entire joint was 50.5%,which was lower than that of BM due to the nonuniform deformation during the tensile *** engineering strain was mainly concentrated in BM and SZ and transferred to each other during the tensile test,while the engineering strain in HAZ was always the ***,the tensile fracture occurred in the *** order of ultimate tensile strength of micro-zones in the FSW joint was as follows:HAZ>BM≈*** order of yield strength was as follows:HAZ>BM>SZ.

关键词： Twin-induced plasticity steel Friction stir welding Microstructure Mechanical property Deformation behavior

Design and validation of a variable camber wing structure

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Chinese Journal of Aeronautics 2024年第2期37卷 1-11页

作者： Xiasheng SUN jingfeng XUE jin ZHOU Zhigang wang Wenjuan wang Mengjie ZHANG Chinese Aeronautical Establishment Beijing 100012China School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Aircraft Strength Research Institute of China Xi’an 710065China Graduate School of Chinese Aeronautical Establishment Yangzhou 225002China

Variable camber wing technology is one of the important development trends of green aviation at *** smooth,seamless,continuous and adaptive change of wing camber,the aerodynamic performance is improved in achieving increase in lift and reduction in resistance and *** on the aerodynamic validation model CAE-AVM,Chinese Aeronautical Establishment(CAE)has carried out the design and validation of a variable camber wing,proposed an aerodynamic deformation matrix for the leading and trailing edges of aircraft wings in takeoff,landing and cruise *** structures and driving schemes are compared,and several key technology problems of leading and trailing edge deformation are solved.A full-size leading edge wind tunnel test piece with a span of 2.7 m and a trailing edge ground function test piece are *** deformation and shape maintenance capabilities of the leading edge is verified under real wind load conditions,and the load bearing and deformation capabilities of the trailing edge is verified under simulated follow-on *** results indicate that the leading and trailing edges of the variable camber wing can achieve the required deformation angle and have a certain load-bearing *** study can provide some insights into the application of variable camber wing technology for civil aircraft.

关键词： Variable camber wing Leading edge Trailing edge Structure Measurement and control Test

Exploration on electrical resistance tomography in characterizing the slurry spatial distribution in cemented granular materials

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 365-379页

作者： Bohao wang Wei wang Feng jin Handong TAN Ning LIU Duruo HUANG State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing 100084China Institute of Science and Technology China Three Gorges CorporationBeijing 100038China School of Geophysics and Information Technology China University of GeosciencesBeijing 100083China

This study investigated the application of electrical resistance tomography(ERT)in characterizing the slurry spatial distribution in cemented granular materials(CGMs).For CGM formed by self-flow grouting,the voids in the accumulation are only partially filled and the bond strength is often limited,which results in difficulty in obtaining in situ samples for quality ***,it is usually infeasible to evaluate the grouting effect or monitor the slurry spatial distribution by a mechanical *** this research,the process of grouting cement paste into high alumina ceramic beads(HACB)accumulation is reliably monitored with *** shows that ERT results can be used to calculate the cement paste volume in the HACB accumulation,based on calibrating the saturation exponent n in Archie’s *** results support the feasibility of ERT as an imaging tool in CGM characterization and may provide guidance for engineering applications in the future.

关键词： electrical resistance tomography cemented granular material grouting spatial distribution Archie’s law

Impact of climate change on the global circulation of West Nile virus and adaptation responses: a scoping review

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贫困所致传染病(英文) 2024年第3期13卷 1-17页

作者： wang Hao-Ran Liu Tao Gao xiang wang Hong-Bin Xiao Jian-Hua Department of Veterinary Surgery Northeast Agricultural University Harbin Heilongjiang People’s Republic of China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine College of Veterinary Medicine Northeast Agricultural University Harbin Heilongjiang People’s Republic of China

Background West Nile virus (WNV), the most widely distributed flavivirus causing encephalitis globally, is a vector-borne pathogen of global importance. The changing climate is poised to reshape the landscape of various infectious diseases, particularly vector-borne ones like WNV. Understanding the anticipated geographical and range shifts in disease transmission due to climate change, alongside effective adaptation strategies, is critical for mitigating future public health impacts. This scoping review aims to consolidate evidence on the impact of climate change on WNV and to identify a spectrum of applicable adaptation *** body We systematically analyzed research articles from PubMed, Web of Science, Scopus, and EBSCOhost. Our criteria included English-language research articles published between 2007 and 2023, focusing on the impacts of climate change on WNV and related adaptation strategies. We extracted data concerning study objectives, populations, geographical focus, and specific findings. Literature was categorized into two primary themes: 1) climate-WNV associations, and 2) climate change impacts on WNV transmission, providing a clear understanding. Out of 2168 articles reviewed, 120 met our criteria. Most evidence originated from North America (59.2%) and Europe (28.3%), with a primary focus on human cases (31.7%). Studies on climate-WNV correlations (n = 83) highlighted temperature (67.5%) as a pivotal climate factor. In the analysis of climate change impacts on WNV (n = 37), most evidence suggested that climate change may affect the transmission and distribution of WNV, with the extent of the impact depending on local and regional conditions. Although few studies directly addressed the implementation of adaptation strategies for climate-induced disease transmission, the proposed strategies (n = 49) fell into six categories: 1) surveillance and monitoring (38.8%), 2) predictive modeling (18.4%), 3) cross-disciplinary collaboration (16.3%), 4)

关键词： West Nile virus Climate change Adaptation Vector-borne pathogens

Graphene oxide/Al_(2)O_(3)-based diffusive memristor cells:enabling robust crossbar arrays for multidisciplinary applications

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Rare Metals 2024年第8期43卷 3997-4005页

作者： Chen Liu Jun-Cheng jin Yi-Ke Xiao Xin-Xin wang Ping-Yuan Yan Yan-Qiang Cao Li-Yong Jiang Chuan-xiang Sheng Ye-Feng Yu School of Microelectronics Nanjing University of Science and TechnologyNanjing 210094China School of Science Nanjing University of Science and TechnologyNanjing210094China School of Information Science and Technology Fudan UniversityShanghai 200433China

A memristor crossbar array (MCA) has emerged as a cutting-edge platform for advanced memory and neuromorphic computing hardware,offering unrivaled bit-level storage density.A diffusive memristor cell (DMC) is particularly well-suited for MCA integration due to its inherent threshold switching characteristics as a selector,effectively addressing current sneak path *** DMC's potential is acknowledged,it necessitates furtherexploration of their practical applicability.

关键词： crossbar arrays offering

Effect of slow shot speed on externally solidified crystal,porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy

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China Foundry 2024年第1期21卷 11-19页

作者： Wen-ning Liu Wei Zhang Peng-yue wang Yi-xian Liu xiang-yi Jiao Ao-xiang Wan Cheng-gang wang Guo-dong Tong Shou-mei Xiong School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Tsinghua UniversityBeijing 100084Beijing China FAW Group Co. Ltd.Changchun 130013China China FAW Foundry Co. Ltd.Changchun 130013China

The effect of slow shot speed on externally solidified crystal(ESC),porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy was investigated by optical microscopy(OM),scanning electron microscopy(SEM)and laboratory computed tomography(CT).Results showed that the newly developed AlSi9MnMoV alloy exhibited improved mechanical properties when compared to the AlSi10MnMg *** AlSi9MnMoV alloy,which was designed with trace multicomponent additions,displays a notable grain refining effect in comparison to the AlSi10MnMg *** elements Ti,Zr,V,Nb,B promote heterogeneous nucleation and reduce the grain size of primaryα-*** a lower slow shot speed,the large ESCs are easier to form and gather,developing into the dendrite net and *** an increase in slow shot speed,the size and number of ESCs and porosities significantly *** addition,the distribution of ESCs is more dispersed and the net-shrinkage *** tensile property is greatly improved by adopting a higher slow shot *** ultimate tensile strength is enhanced from 260.31 MPa to 290.31 MPa(increased by 11.52%),and the elongation is enhanced from 3.72%to 6.34%(increased by 70.52%).

关键词： hypoeutectic Al-Si alloy high pressure die casting porosity externally solidified crystal tensile property