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Current Medical Science 2019年第5期39卷 748-753页

作者： Wen WANG Gan ZHA jin-jing zou Xun WANG Chun-nian LI Xiao-jun WU Department of Respiratory and Critical Care Medicine Rentnin Hospital of Wuhan UniversityWuhan 430060China

Although several studies confirmed that berberine may attenuate airway inflammation in mice with chronic obstructive pulmonary disease(COPD),its underlying mechanisms were not clear until *** aimed to establish an experiment mouse model for COPD and to investigate the effects of berberine on airway inflammation and its possible mechanism in COPD model mice induced by cigarette smoke extract(CSE).Twenty SPF C57BL/6 mice were randomly divided into PBS control group,COPD model group,low-dose berberine group and high-dose berberine group,5 mice in each *** neutrophils and macrophages were examined by Wright's *** levels of inflammatory cytokines TNF-α and IL-6 in bronchoalveolar lavage fluid(BALF)were detennined by enzyme-linked immunosorbent *** expression levels of TGF-β1,Smad2 and Smad3 mRNA and proteins in lung tissues were respectively detected by quantitative real-time polymerase chain reaction and Western *** was found that CSE increased the number of inflammation cells in BALF,elevated lung inflammation scores,and enhanced the TGF-β1/Smads signaling activity in ***-dose berberine restrained the alterations in the COPD mice induced by *** was concluded that high-dose berberine ameliorated CSE-induced airway inflammation in COPD ***-β1/Smads signaling pathway might be involved in the *** findings suggested a therapeutic potential of high-dose berberine on the CSE-induced airway inflammation.

关键词： berberine cigarette smoke extract chronic obstructive pulmonary disease TGF-β1/Smads signaling pathway

Characterization of Interfacial Bonding Mechanism for Graphene-Modified Powder Metallurgy Nickle-Based Superalloy

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Acta Metallurgica Sinica(English Letters) 2018年第7期31卷 753-760页

作者： jin-Wen zou Xiao-Feng Wang Jie Yang Chuan-Bo Ji Xu-Qing Wang Xian-Qiang Fan Zhi-Peng Guo AECC Beijing Institute of Aeronautical Materials Beijing 100089China Science and Technology on Advanced High Temperature Structural Materials Laboratory Beijing Institute of Aeronautical MaterialsBeijing 100089China School of Materials Science and Engineering Tsinghua UniversityBeijing 100089China

A modified FGH96 superalloy using 0.1 wt% graphene was successfully prepared using the wet mixing method. The interracial bonding mechanism between the graphene and the superalloy matrix was characterized using optical micro- scope, scanning electronic microscope, transmission electronic microscope and X-ray tomography. The results revealed that the graphene could be dispersed uniformly inside the matrix of the superalloy, and the bonding interface between graphene and the superalloy showed a rather diffusion instead of abrupt distinction, suggesting that the interface was formed via chemical fusion rather than a mechanical combination. The uniform dispersity of the graphene inside the superalloy matrix could improve the tensile properties significantly, including tensile strength, plasticity and yield strength. The existence of the graphene at the fracture surface further verified that the graphene could increase the effective bearing force of the material during the tensile test.

关键词： Powder metallurgical(PM)superalloy Graphene Interfacial binding mechanism Mechanical propertiesCharacterization

Synthesis and Herbicidal Activities of N'-(substituted pyrimidin-2-yl)-N-Substituted Phenoxyacetyl Thiourea Derivatives

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Chinese Chemical Letters 2000年第1期11卷 19-20页

作者： Si Jia XUE jin Shan zou Hai Jian YANG (Department of Chemistry, Central China Normal University, Wuhan 430079) Cent China Normal Univ Dept Chem Wuhan 430079 Peoples R China

Fifteen N'-(substituted pyrimidin-2-y1)-N-substituted phenoxyacetyl thioureas were synthesized and tested for biological activities. All of them are new compounds and their structures were confirmed by IR. IHNMR. MS and elemental analysis. Some of the target compounds showed excellent inhibitory activities against root and stalk of dicotyledon plant (such as radish). and selective on monoctyledon plant (such as rice).

关键词： 4-Nitrophenoxyacetyl thiourea 2,4-dichlorophenoxyacetyl thiourea synthesis 2-chlorophenoxyacetyl thiourea 2-amino pyrimidine herbicidal activity

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CCD摄像机技术的发展及应用

半导体光电 2005年第B03期26卷 176-177页

作者：邹锦解放军理大学工程兵工程学院，南京210007

介绍了CCD技术的发展和未来CCD市场的需求。讨论了CCD传感器需改进的几个问题和CCD摄像机技术性能的优化指标。阐述了CCD应用及其发展趋势。

关键词： CCD传感器 CCD摄像机 PC摄像机

Wafer-scale arrayed p-n junctions based on few-layer epitaxial GaTe

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Nano Research 2015年第10期8卷 3332-3341页

作者： Xiang Yuan Lei Tang Peng Wang Zhigang Chen Yichao zou Xiaofeng Su Cheng Zhang Yanwen Liu Weiyi Wang Cong Liu Fansheng Chen jin zou Peng Zhou Weida Hu Faxian Xiu StateKeyLaboratoryofSurfacePhysicsandDepartmentofPhysics andCollaborativeInnovationCenterofAdvancedMicrostructuresFudanUniversityShanghai200433China NationalLaboratoryforInflaredPhysics ShanghaiInstituteofTechnicalPhysicsChineseAcademyofSciencesShanghai200083China MaterialsEngineering TheUniversityofQueenslandBrisbaneQLD4072Australia SatelliteRemoteSensingLaboratory ShanghaiInstituteofTechnicalPhysicsChineseAcademyofSciencesShanghai200083China CentreforMicroscopyandMicroanalysis TheUniversityofQueenslandBrisbaneQLD4072Australia StateKeyLaboratoryofASICandSystem DepartmentofMicroelectronicsFudanUniversityShanghai200433China

Two-dimensional （2D） materials have attracted substantial attention in electronic and optoelectronic applications with the superior advantages of being flexible, transparent, and highly tunable. Gapless graphene exhibits ultra-broadband and fast photoresponse while the 2D semiconducting MoS2 and GaTe exhibit high sensitivity and tunable responsivity to visible light. However, the device yield and repeatability call for further improvement to achieve large-scale uniformity. Here, we report a layer-by-layer growth of wafer-scale GaTe with a high hole mobility of 28.4 cm^2/（V.s） by molecular beam epitaxy. The arrayed p-n ）unctions were developed by growing few-layer GaTe directly on fhree-inch Si wafers. The resultant diodes reveal good rectifying characteristics and a high photovoltaic external quantum efficiency up to 62% at 4.8 μW under zero bias. The photocurrent reaches saturation fast enough to capture a time constant of 22 μs and shows no sign of device degradation after 1.37 million cycles of operation. Most strikingly, such high performance has been achieved across the entire wafer, making the volume production of devices accessible. Finally, several photoimages were acquired by the GaTe/Si photodiodes with reasonable contrast and spatial resolution, demonstrating the potential of integrating the 2D materials with silicon technology for novel optoelectronic devices.

关键词： GaTe wafer-scaletwo-dimensional materials p-n junction imaging photodiode photosensor

A novel energy functional minimization model for speckle noise removal

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Optoelectronics Letters 2019年第5期15卷 386-390页

作者： CHEN Bo zou jin-bin CHEN Wen-sheng ZHANG Meng-yun Shenzhen Key Laboratory of Advanced Machine Learning and Applications College of Mathematics and Statistics Guangdong Key Laboratory of Intelligent Information Processing Shenzhen University

In this paper, a novel energy functional minimization model is proposed for ultrasound images denoising. A controllable regularized term and the variational method are employed in the process of speckle noise. This model not only improves the plasticity of the model, but also improves the effect and efficiency of noise removal. The new model has different diffusion performance in different regions. At the same time, the diffusion performance is related to the parameters introduced by the proposed model. Numerical simulation results show that different parameters have different denoising effects, and the proposed model for speckle noise removal is superior to traditional models.

关键词： functional minimization model speckle noise removal ultrasound images denoising

Weighted Norm Inequalities for Multipliers and Littlewood-Paley Functions on Local Fields

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Chinese Quarterly Journal of Mathematics 1991年第4期6卷 96-97页

作者： zou jin(Dept. of Math., Leshan Teachers’College) 乐山师范高等专科学校四川乐山

Let K be a local field, w（x） be a A-weight on K （1≤p≤∞）. We say that the measurable function m（x） is a multiplier on L（K,w）, if （m）∈L（K,w） for all f∈L（K,w） and there is a constant c>0,independent of... 详细信息

关键词： Weighted Norm Inequalities for Multipliers and Littlewood-Paley Functions on Local Fields

Study on the Intermediate in the o-Phenylenediamine Oxidative Reaction Using Hemoglobin as A Mimetic Peroxidase in Aqueous-Organic Two Phase

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Wuhan University Journal of Natural Sciences 2002年第1期7卷 117-121页

作者： Li Hai-cheng Li De-jia Huang Bo jin De-long zou Guo-lin College of Life Sciences Wuhan University Wuhan 430072 Hubei China

Hemoglobin was used as a mimetic enzyme for peroxidase to catalyze the oxidative reaction of o-phenylenediamine with H2O2 which functioned as an oxidant. The relationship between physicochemical properties of the intermediate and enzymatic activity of hemoglobin was studied. Since the solubility of the intermediate in the reaction is higher in butanol phase than in water phase, the intermediate itself diffused from the aqueous phase to the butanol phase. The experimental results showed that the rate of product and the stability of intermediate were associated with the temperature and the pH value of the buffer. The formation rate of intermediate and half-life period reveal the maximal in pH7, nevertheless, the whole rate of the catalytic reaction is the greatest in pH5, which the ratio of the initial rate in final product formation compared to that intermediate formation is the greatest.

关键词： hemoglobin mimetic enzyme intermediate two phase reaction mechanism

Time-sequential changes of differentially expressed miRNAs during the process of anterior lumbar interbody fusion using equine bone protein extract, rhBMP-2 and autograft

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Frontiers of Materials Science 2014年第1期8卷 72-86页

作者： Da-Fu CHEN Zhi-Yu ZHOU Xue-Jun DAI Man-Man GAO Bao-Ding HUANG Tang-Zhao LIANG Rui SHI Li-jin zou Hai-Sheng LI Cody BUNGER Wei TIAN Xue-Nong zou Laboratory of Bone Tissue Engineering Beijing Research Institute of Traumatology and Orthopaedics Beijing Jishuitan Hospital Beijing 100035 China Department of Spine Surgery/Orthopaedic Research Institute The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 China Department of Surgery the First Affiliated Hospital of Nanchang University Nanchang 330006 China Orthopaedic Research Laboratory/The Institute of Clinical Medicine Aarhus University Hospital DK-8000 Aarhus Denmark Medicine School Shenzhen University Shenzhen 518060 China

The precise mechanism of bone regeneration in different bone graft substitutes has been well studied in recent researches. However, miRNAs regulation of the bone formation has been always mysterious. We developed the anterior lumbar interbody fusion （ALIF） model in pigs using equine bone protein extract （BPE）, recombinant human bone morphogenetic protein-2 （rhBMP-2） on an absorbable collagen sponge （ACS）, and autograft as bone graft substitute, respectively. The miRNA and gene expression profiles of different bone graft materials were examined using microarray technology and data analysis, including self-organizing maps, KEGG pathway and Biological process GO analyses. We then jointly analyzed miRNA and mRNA profiles of the bone fusion tissue at different time points respectively. Results showed that miRNAs, including let-7, miR-129, m iR-21, miR-133, miR-140, miR-146, miR-184, and miR-224, were involved in the regulation of the immune and inflammation response, which provided suitable inflammatory microenvironment for bone formation. At late stage, several miRNAs directly regulate SMAD4, Estrogen receptor 1 and 5-hydroxytryptamine （serotonin） receptor 2C for bone formation. It can be concluded that miRNAs play important roles in balancing the inflammation and bone formation.

关键词： miRNA bone protein extract (BPE) recombinant human bone morphoge-netic protein-2 (rhBMP-2) autograft

Dependability Analysis for Fault-Tolerant Computer Systems Using Dynamic Fault Graphs

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China Communications 2014年第9期11卷 16-30页

作者： ZHAO Feng jin Hai zou Deqing QIN Pan Services Computing Technology and System Lab & Cluster and Grid Computing Lab School of Computer Scienceand Technology Huazhong University of Science and Technology Wuhan 430074 Hubei Province P. R. China

Dependability analysis is an important step in designing and analyzing safety computer systems and protection *** multi-processor and virtual machine increases the system faults' complexity,diversity and dynamic,in particular for software-induced failures,with an impact on the overall ***,it is very different for safety system to operate successfully at any active phase,since there is a huge difference in failure rate between hardware-induced and softwareinduced *** handle these difficulties and achieve accurate dependability evaluation,consistently reflecting the construct it measures,a new formalism derived from dynamic fault graphs(DFG) is developed in this *** exploits the concept of system event as fault state sequences to represent dynamic behaviors,which allows us to execute probabilistic measures at each timestamp when change *** approach automatically combines the reliability analysis with the system *** this paper,we describe how to use the proposed methodology drives to the overall system dependability analysis through the phases of modeling,structural discovery and probability analysis,which is also discussed using an example of a virtual computing system.

关键词： fault-tolerant system depend-ability analysis dynamic fault-graph structural link probability forecast