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Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying Xia Ming Sun Hai Huang Wei-lin jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

Overexpression of Kdm6b induces testicular differentiation in a temperature-dependent sex determination system

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ZOOLOGICAL RESEARCH 2024年第5期45卷 1108-1115页

作者： Chen, Qiran Sun, Wei jin, lin Zhou, Yingjie Li, Fang Ge, Chutian Zhejiang Wanli Univ Coll Biol & Environm Sci Ningbo 315100 Zhejiang Peoples R China Zhejiang Wanli Univ Inst Anim Sex & Dev Ningbo 315100 Zhejiang Peoples R China

In reptiles, such as the red-eared slider turtle ( Trachemys scripta elegans), ), gonadal sex determination is highly dependent on the environmental temperature during embryonic stages. This complex process, which leads to differentiation into either testes or ovaries, is governed by the finely tuned expression of upstream genes, notably the testis-promoting gene Dmrt1 and the ovary-promoting gene Foxl2. . Recent studies have identified epigenetic regulation as a crucial factor in testis development, with the H3K27me3 demethylase KDM6B being essential for Dmrt1 expression in T. s. elegans. However, whether KDM6B alone can induce testicular differentiation remains unclear. In this study, we found that overexpression of Kdm6b in T. s. elegans embryos induced the male development pathway, accompanied by a rapid increase in the gonadal expression of Dmrt1 at 31 degrees C, a temperature typically resulting in female development. Notably, this sex reversal could be entirely rescued by Dmrt1 knockdown. These findings demonstrate that Kdm6b is sufficient for commitment to the male pathway, underscoring its role as a critical epigenetic regulator in the sex determination of the red-eared slider turtle.

关键词： Temperature-dependent sex determination Sex reversal Kdm6b Dmrt1 T. s. elegans EARED SLIDER TURTLE EPIGENETIC REGULATION GENE DMRT1 SRY

Heterogeneous engineering of MnSe@NC@ReS_(2) core-shell nanowires for advanced sodium-/potassium-ion batteries

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Rare Metals 2024年第8期43卷 3713-3723页

作者： Sheng-Jun Lu jin-Yi lin Cai-Hong Wang Yu-Fei Zhang Yi Zhang Hao-Sen Fan College of Materials Science and Metallurgy Engineering Guizhou University Guiyang 550025China School of Energy Science and Engineering Nanjing Tech UniversityNanjing 211816China School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China

Sodium-ion batteries(SIBs) and potassium-ion batteries(PIBs) have been attracting great attentions and widely been exploited due to the abundant sodium/potassium ***,the preparation of high-powered anode materials for SIBs/PIBs plays a decisive role for the commercial applications of SIBs/PIBs in the *** selenides are a class of potential anode materials for SIBs/PIBs because of their small band gap and high electrical *** this work,MnSe and ReS_(2) core-shell nanowires connecting by polydopamine derived carbon nanotube(MnSe@NC@ReS_(2)) have been successfully synthesized from growing ReS_(2) nanosheets array on the surface of MnSe@NC nano wires,which present excellent Na^(+)/K^(+) storage *** applied as SIBs anode,the specific capacity of 300 mAh·g^(-1) was maintwined after 400 cycles at the current density of 1.0 A·g^(-1).Besides,it could also keep 120 mAh·g^(-1) specific capacity after 900 cycles at 1.0 A·g^(-1) for the anode of *** heterogeneous engineering and one-dimensional-two-dimensional(1D-2D) hybrid strategies could provide an ideal strategy for the synthesis of new hetero-structured anode materials with outstanding battery performance for SIBs and PIBs.

关键词： Heterogeneous engineering Core-shell nanowires MnSe@NC@ReS_(2)nanowires Na^(+)batteries K^(+)batteries

Characteristics of Elderly-Onset Rheumatoid Arthritis Patients With COVID-19

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Infectious Microbes & Diseases 2024年第1期6卷 36-42页

作者： Lanlan Xiao Xinlei Ma jinzhi Wu Junyu Liang Weiqian Chen jin lin Department of Rheumatology the First Affiliated HospitalZhejiang University School of MedicineHangzhouChina

This study aimed to investigate the clinical characteristics of elderly-onset rheumatoid arthritis(EORA)patients with *** ret-rospectively enrolled EORA patients diagnosed with COVID-19 from December 2022 through February 2023 and followed them *** characteristics of the patients and clinical data on COVID-19 were collected,and EORA-related data at the onset of rheu-matoid arthritis and during COVID-19 episodes were evaluated.A total of 102 EORA outpatients were enrolled and stratified into the COVID-19 group(n=60)and the non–COVID-19 group(n=42).In the COVID-19 group,56(93.3%)had symptoms,8(13.3%)had viral pneumonia,and 4(6.7%)developed severe *** logistic regression analysis showed that lack of COVID-19 vac-cination(P=0.016 and P=0.030,respectively)and having interstitial lung disease(P=0.013 and P=0.001,respectively)were inde-pendent risk factors for viral pneumonia and severe *** with the general population,EORA patients did not show significantly higher susceptibility to COVID-19 or a higher risk of severe ***,EORA patients with interstitial lung disease require special consideration during COVID-19 episodes.

关键词： COVID-19 elderly-onset rheumatoid arthritis COVID-19 vaccine interstitial lung disease

Design and application of copper/lithium composite anodes for advanced lithium metal batteries

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Rare Metals 2024年第3期43卷 942-970页

作者： Bin Zhang Ji-Ping Ma Yang Zhao Tong Li jin-lin Yang Zhan-ling Zhang Shi-Zhong Wei Guang-Min Zhou School of Materials Science and Engineering Henan University of Science and TechnologyLuoyang 471003China Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Shenzhen Geim Graphene Center Tsinghua-Berkeley Shenzhen InstituteTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

Lithium(Li)is a promising candidate for nextgeneration battery anode due to its high theoretical specific capacity and low reduction ***,safety issues derived from the uncontrolled growth of Li dendrite and huge volume change of Li hinder its practical application.C onstructing dendrite-free composite Li anodes can significantly alleviate the above ***(Cu)-based materials have bee n widely used as substrates of the composite electrodes due to their chemical stability,excellent conductivity,and good mechanical ***/lithium(Cu/Li)composite anodes significantly regulate the local current density and decrease Li nucleation overp otential,realizing the uniform and dendrite-free Li *** this review,Cu/Li composite methods including electrodeposition,melting infusion,and mechanical rolling are systematically summarized and ***,design strategies of Cu-based current collectors for high performance Cu/Li composite anodes are *** challenges and future development for Cu/Li composite anodes are presented and *** hope that this review can provide a comprehensive understanding of Cu/Li composite methods of the latest development of Li metal anode and stimulate more research in the future.

关键词： Lithium metal batteries Cu/Li composite anode Electrodeposition Thermal melting infusion Mechanical rolling

Feasibility of Scaling up the Cost-Competitive and Clean Electrolytic Hydrogen Supply in China

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Engineering 2024年第8期39卷 154-165页

作者： Guangsheng Pan Wei Gu Zhongfan Gu jin lin Suyang Zhou Zhi Wu Shuai Lu School of Electrical Engineering Southeast UniversityNanjing 210096China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China

Scaling up clean hydrogen supply in the near future is critical to achieving China’s hydrogen development *** study established an electrolytic hydrogen development mechanism considering the generation mix and operation optimization of power systems with access to *** on the incremental cost principle,we quantified the provincial and national clean hydrogen production cost performance levels in *** results indicated that this mechanism could effectively reduce the production cost of clean hydrogen in most provinces,with a national average value of less than 2 USD·kg^(-1) at the 40-megaton hydrogen supply *** cooperation via power transmission lines could further reduce the production cost to 1.72 USD·kg^(-1).However,performance is affected by the potential distribution of hydrogen *** the supply side,competitiveness of the mechanism is limited to clean hydrogen production,while from the demand side,it could help electrolytic hydrogen fulfil a more significant *** study could provide a solution for the ambitious development of renewables and the hydrogen economy in China.

关键词： Low-carbon energy system Electrolytic hydrogen Renewables Cost optimization and analysis

Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside

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Journal of Pharmaceutical Analysis 2024年第6期14卷 926-929页

作者： Shiyu Chen Yuxuan Li Yingrui Zhang Hongren Yao Tong Xu Yi Zhang jin-Ming lin Xian-Li Meng State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu611137China Beijing Key Laboratory of Microanalytical Methods and Instrumentation Department of ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing100084China School of Ethnic Medicine Chengdu University of Traditional Chinese MedicineChengdu611137China

Microneurovascular units(mNVUs),comprising neurons,micro-glia,and blood-brain barrier(BBB)endothelial cells,are pivotal to the central nervous system and are associated with cerebral hypoxia and brain *** hypoxia triggers microglial overactivity,causing inflammation,neuronal injury,and disruption of the BBB[1].Salidroside(Sal),a key compound in Tibetan medicine Rhodiola crenulata,mitigates hypoxia-induced metabolic disorders and neuronal damage by preserving mitochondrial function[2].

关键词： injuries preserving Tibetan

Turbulent Image Restoration in Atmosphere with Cyclopean Processing via Binocular Fusion

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Chinese Physics Letters 2024年第8期41卷 33-38页

作者： Han Yao jin-Yan lin Li-Bang Chen Yi-Kun Liu Jian-Ying Zhou State Key Laboratory of Optoelectronic Materials and Technologies School of PhysicsSun Yat-Sen UniversityGuangzhou 510275China Guangdong Provincial Key Laboratory of Quantum Metrology and Sensing School of Physics and AstronomySun Yat-Sen University(Zhuhai Campus)Zhuhai 519082China

The outstanding issue to overcoming atmospheric turbulence on distant imaging is a fundamental interest and technological *** propose a novel scenario and technique to restore the optical image in turbulent environmental by referring to Cyclopean image with binocular *** human visual intelligence,image distortion resulting from the turbulence is shown to be substantially *** simulation results taking into account of the atmospheric turbulence,optical image system,image sensors,display and binocular vision perception are presented to demonstrate the robustness of the image restoration,which is compared with a single channel planar optical imaging and *** involving binocular telescope,image recording and the stereo-image display is conducted and good agreement is obtained between the simulation with perceptive experience.A natural extension of the scenario is to enhance the capability of anti-vibration or anti-shaking for general optical imaging with Cyclopean image.

关键词： image turbulence shaking

Surface plasmon-coupled radiative heat transfer between graphene-covered magnetic Weyl semimetals

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Science China Technological Sciences 2024年

作者： SONG jinlin YAO XinJie jin lin CHEN Lei ZHAO HaiLong CHENG Qiang School of Electrical and Information Engineering Wuhan Institute of Technology State Key Laboratory of Coal Combustion School of Energy and Power Engineering Huazhong University of Science and Technology

Weyl semimetals(WSMs) have recently attracted considerable research attention because of their remarkable optical and electrical properties. In this study, we investigate the near-field radiative heat transfer(NFRHT) between graphene-covered Weyl slabs, particularly focusing on the supported coupled surface plasmon polaritons(SPPs). Unlike bare Weyl slabs where the epsilon-near-zero(ENZ) effect contributes the most to the NFRHT, adding a monolayer graphene sheet yields coupled SPPs, i.e.,the coupling of graphene SPPs(GSPPs) and Weyl SPPs(WSPPs), which dominates the NFRHT. The graphene sheet greatly suppresses the ENZ effect by compressing the parallel wavevector, thereby enabling the heat transfer coefficient(HTC) to be significantly changed. Further, for the graphene-covered magnetic Weyl slab configuration, an increase in the number of Weyl nodes suppresses the SPP coupling and ENZ effect, thereby weakening the NFRHT with a regulation ratio of 4.4 whereas an increase in the Fermi level slightly influences the NFRHT. Several typical heterostructures are also proposed for comparison, and results show that a mono-cell structure has the largest total HTC. Our findings will facilitate the understanding of surface plasmon-coupled radiative heat transfer and enable opportunities in energy harvesting and thermal management at the nanoscale based on WSM-based systems.

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