检索结果-南通市图书馆

A　NOVEL　IN－SITU　SPECTROELECTROCHEMICAL　TECHNIQUE　WITH　PROBE　BEAM　DEFLECTION：FOR　STUDY　OF　THE　ION　EXCHANGE　BETWEEN　FILMS　ON　ELECTRODE　SURFACE　AND　SOLUTIONS

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1995年第11期6卷 983-986页

作者： Li, JH Cheng, GJ Liu, CW jin, jg Dong, SJ Chinese Acad Sci Changchun Inst Appl Chem Electroanalyt Chem Lab Changchun 130022 Peoples R China

A novel in-situ spectroelectrochemical technique, the combination of probe beam deflection (PBD) with cyclic voltammetry (CV),was used to study the ion cxchange process of prussian blue(PB) modified film electrode in contact with various electrolyte solutions. The ion exchange mechanism was veritied as following: where on reduction PB film in contact with an acidic KCl electrolyte, it was confirmed that protons enter into the PB film before K+ cations.

关键词： DEFLECTION PROBE WITH TECHNIQUE BEAM AND

Drug repurposing for cancer therapy

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying Xia Ming Sun Hai Huang Wei-Lin jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

超疏水耐酸碱改性纸张的制备与性能

高等学校化学学报 2024年第8期45卷 148-155页

作者：韩金娥王聃轲钮腾飞江南大学生命科学与健康工程学院无锡214122 江南大学化学与材料工程学院无锡214122

采用可见光促进的原子转移自由基聚合(ATRP)法,实现了叠氮基单体与含氟单体共聚,得到全氟辛酯叠氮苯酯共聚物,并将其应用于纸张表面改性,制成了超疏水耐酸碱改性纸张.研究了聚合物中各单体种类、比例及聚合物分子量对超疏水耐酸碱性能... 详细信息

采用可见光促进的原子转移自由基聚合(ATRP)法,实现了叠氮基单体与含氟单体共聚,得到全氟辛酯叠氮苯酯共聚物,并将其应用于纸张表面改性,制成了超疏水耐酸碱改性纸张.研究了聚合物中各单体种类、比例及聚合物分子量对超疏水耐酸碱性能的影响.此外,还表征了改性纸张的表面微观结构,研究了聚合物与纸张的连接方式,解释了改性纸张的超疏水耐酸碱性能原理.结果表明,当甲基丙烯酸-4-叠氮苯酯与甲基丙烯酸全氟辛酯的摩尔比为1∶4时,全氟辛酯叠氮苯酯共聚物-80改性后的纸张表现出极强的疏水性,水接触角达到165°,并在强酸(pH=1)或强碱(pH=13)环境下维持72 h无明显变化.制备的共聚材料在防水、耐酸碱应用中具有良好的应用前景.

关键词：叠氮单体含氟单体超疏水性耐酸碱改性纸张

维普期刊数据库博看期刊

Fractal scaling of effective diffusion coefficient of solute in porous media

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2001年第2期13卷 170-172页

作者： Liu, jg Nie, YF Tsinghua Univ Dept Environm Sci & Engn Beijing 100084 Peoples R China

Fractal approach is used to derive a power law relation between effective diffusion coefficient of solute in porous media and the geometry parameter characterizing the media. The results are consistent with the empirical equations analogous to Archie`s law and are expected to be applied to prediction of effective diffusion coefficient. Key words: diffusion; effective diffusion coefficient; fractal; porous media.

关键词： diffusion effective diffusion coefficient fractal porous media

How we have learned about the complexity of physiology,pathobiology and pharmacology of bile acids and biliary secretion

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第37期14卷 5617-5619页

作者： Jose jg Marin Laboratory of Experimental Hepatology and Drug Targeting CIBERehd University of SalamancaSalamanca 37007 Spain

During the last decades the concept of bile secretion as merely a way to add detergent components to the intestinal mixture to facilitate fat digestion/absorption and to eliminate side products of heine metabolism has evolved considerably. In the series of mini-reviews that the World Journal of Gastroenterology is to publish in its section of ＂Highlight Topics＇; we will intend to give a brief but updated overview of our knowledge in this field. This introductory letter is intended to thank all scientists who have contributed to the development of this area of knowledge in gastroenterology.

关键词： Bile flow Cholestasis Hepatocyte Liver Transport

Current updates on laboratory techniques for the diagnosis of male reproductive failure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2016年第3期18卷 392-401,I0008页

作者： Suresh C Sikka Wayne jg Hellstrom Department of Urology Tulane University School of Medicine New Orleans Louisiana USA.

The incidence of male reproductive failure leading to infertility, whether due to delayed parenthood, environmental issues, genetic factors, drugs, etc., is increasing throughout the world. The diagnosis and prognosis of male subfertility have become a challenge. While the basic semen assessment has been performed for many years, a number of studies question the value of the traditional semen characteristics. This is partly due to inadequate methods and standardization, limited knowledge of technical requirements for quality assurance, and an incomplete understanding of what clinical information a semen assessment can provide. Laboratories currently performing semen and endocrine assessment show great variability. The World Health Organization （WHO） manual for the evaluation of semen has been the core of andrology and fertility evaluation that has helped in further development of this field over many years. These include the physical appearance of the ejaculate, assessments of sperm count, motility, vitality, morphology, and functional aspects of the sperm and semen sample. These tests also include male endocrine profile, biochemical evaluation of the semen, detection of antisperm antibodies in serum, the use of computer-aided sperm analysis （CASA）, sperm DNA integrity, and its damage due to oxidative stress. Assisted reproductive techniques （e.g., IVF, ICSI） have shown great success but are too expensive. Further development in this field with newer techniques and extensive training/instructions can improve accuracy and reduce variability, thus maintaining the quality and standards of such an evaluation. There is an urgent need to have standardized training centers and increased awareness in this area of men＇s health for reproductive success.

关键词： male infertility quality control management reproductive failure semen evaluation World Health Organization manual

Sub-high Rate Directional Solidification

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 1998年第1期14卷 9-14页

作者： Fu, HZ Geng, XG Li, jg Zhang, J Northwestern Polytech Univ State Key Lab Solidificat Proc Xian 710072 Peoples R China

The main features of morphology evolution of crystal growth during near rapid directional solidification were reviewed and the concept of effective constitutional supercooling was proposed. On the basis of interface stability theory combined with experiments, the behaviour of transition from dendrites to fine cells was quantitatively described, and the transition from cells to plane front of absolute stability was also examined.

关键词： Rapid solidification

在线全文

学校读者我要写书评

暂无评论

基于深度流形学习的人脸年龄识别

无线电通信技术 2024年第4期50卷 799-806页

作者：张会影圣文顺金鑫南京工业大学浦江学院江苏南京211200 蚌埠学院艺术设计学院安徽蚌埠233030

现有的人脸年龄识别方法大多利用深度学习框架提取人脸特征来识别年龄,但深度学习方法提取的高维人脸特征往往包含大量的冗余信息,不利于人脸年龄的识别。为了提高人脸年龄识别算法的精度和鲁棒性,提出了一种基于深度流形学习(Deep Mani... 详细信息

现有的人脸年龄识别方法大多利用深度学习框架提取人脸特征来识别年龄,但深度学习方法提取的高维人脸特征往往包含大量的冗余信息,不利于人脸年龄的识别。为了提高人脸年龄识别算法的精度和鲁棒性,提出了一种基于深度流形学习(Deep Manifold Learning, DML)的算法,采用深度学习提取人脸特征,通过流形学习选择具有判别性的人脸特征,将深度学习提取的高维人脸特征嵌入到低维的判别子空间上识别年龄。在公开的人脸数据库MORPH和FG-NET上对DML算法进行了实验,结果表明DML方案平均绝对误差(Mean Absolute Error, MAE)大幅度降低,不同误差值下识别累积评分(Cumulative Score, CS)明显提高,显著优于当前流行的人脸年龄识别方法。

关键词：年龄识别流形学习深度学习卷积神经网络特征提取平均绝对误差

基于绿色化学的烯烃Meerwein水合反应创新综合实验设计

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

化学教育（中英文） 2024年第18期45卷 61-68页

作者：韩金娥钮腾飞江南大学生命科学与健康工程学院江苏无锡214122 江南大学化学与材料工程学院江苏无锡214122

聚焦前沿热点,实施科教融合,基于绿色化学理念,设计了烯烃Meerwein水合反应综合实验。该实验引入光催化合成技术,采用自制、可循环利用的催化剂,以水作为溶剂,在清洁可再生的太阳光照射下进行烯烃Meerwein水合反应,并探究合成了一系列1... 详细信息

聚焦前沿热点,实施科教融合,基于绿色化学理念,设计了烯烃Meerwein水合反应综合实验。该实验引入光催化合成技术,采用自制、可循环利用的催化剂,以水作为溶剂,在清洁可再生的太阳光照射下进行烯烃Meerwein水合反应,并探究合成了一系列1,2-二苯乙醇衍生物。本实验包含催化剂的制备与表征,产物的合成与表征,合成反应条件探索,催化剂循环利用实验,以及底物的适应性考察等,内容丰富有层次,涉及多学科知识交叉与融合,不仅提升学生的综合知识运用能力,还激发学生的科学探究兴趣和创新精神。

关键词：绿色化学 Meerwein水合反应光催化可循环催化剂