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Occupational hand injuries:a current review of the prevalence and proposed prevention strategies for physical therapists and similar healthcare professionals

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Journal of Integrative Medicine 2018年第2期16卷 84-89页

作者： Giles Gyer jimmy Michael James Inklebarger The London College of Osteopathic Medicine 8-10 Boston PlaceLondon NWI 6QHUnited Kingdom

Hand injury is the second most common work-related musculoskeletal injury among physical therapists （PTs） and other manual therapy professionals such as osteopaths, physiotherapists, chiropractors, acupuncturists and massage therapists. However, the nature and extent of this problem have not been fully explored yet. Therefore, the objective of this study was to review the existing literature published on the prevalence, risk factors, consequences, and prevention of hand injuries among PTs and similar healthcare professionals. The lifetime prevalence of hand injuries was about 15%-46%, and the annual prevalence was reported as 5%-30%. Thumb injuries were found to be the most prevalent of all injuries, accounting more than 50% of all hand-related problems. The most significant risk factors for job-related hand injuries were performing manual therapy techniques, repetitive workloads, treating many patients per day, continued work while injured or hurt, weakness of the thumb muscles, thumb hypermobility, and instability at the thumb joints. Frs reported modifying treatment technique, taking time off on sick leave, seeking intervention, shifting the specialty area, and decreasing patient contact hours as the major consequences of these injuries. The authors recommend that PTs should develop specific preventive strategies and put more emphasis on the use of aids and equipment to reduce the risk of an unnecessary injury.

关键词： Occupational injuries Public health Physical therapists Occupational therapists Complementary therapies

Review: Physical Coloration-Nanoscopic Science and Macroscopic Impact

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Journal of Harbin Institute of Technology(New Series) 2021年第1期28卷 1-11页

作者： jimmy Xu School of Engineering and Department of Physics Brown UniversityProvidenceRhode Island 02912USA

Physical coloration stimulated the development of a new era of science and technology some hundred years *** is now again presenting us new opportunities and challenges on multiple *** article focuses on a selectively few of them that are more directional in nature:scalable nanomanufacturing of physical coloration,physical amplification of colorimetric sensing,and provision of biophilic lighting with real-time full-spectrum physical *** coloration is a rather large multi-dimensional field that is open and awaiting for creative minds and *** impact has been broad and profound to the well-being of *** article attempts to complement the reviews of broad scopes available in literature by one with a narrower focus on the more recent advances on the three fronts.

关键词： physical coloration plasmonics biophilic lighting spectral shaping nano-optics

Redox flow batteries based on insoluble redox-active materials.A review

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Nano Materials Science 2021年第1期3卷 17-24页

作者： Xiao Wang Jingchao Chai Jianbing“jimmy”Jiang Department of Chemistry University of CincinnatiP.O.Box 210172CincinnatiOH45221-0172United States

The ever-increasing demand for energy has stimulated the development of economical non-fossil *** representative of clean energy,solar and wind have been identified as the most promising energy sources due to their abundance,cost efficiency,and environmental *** intrinsic intermittent of the clean energy leads to the urgent requirements large-scale energy storage *** flow batteries(RFBs)are attractive technology due to their independent control over energy and *** redox-active flow battery is a new type of electrochemical energy storage technology that disperses redox-active particles in the *** with traditional flow batteries,insoluble flow batteries have advantages of large energy density and are very promising in the development of large-scale energy storage *** present,three types of insoluble flow batteries have been explored:slurry-based flow batteries,metal/slurry hybrid,and redox-mediator-assisted flow *** Review summarizes the research progress of insoluble flow batteries,and analyzes the key challenges from the fundamental research and practical application perspectives.

关键词： Membrane Redox flow battery Redox mediator Slurry

FACEts of mechanical regulation in the morphogenesis of craniofacial structures

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International Journal of Oral Science 2021年第1期13卷 1-16页

作者： Wei Du Arshia Bhojwani jimmy K.Hu State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina School of Dentistry University of California Los AngelesLos AngelesCAUSA Molecular Biology Institute University of California Los AngelesLos AngelesCAUSA

During embryonic development,organs undergo distinct and programmed morphological changes as they develop into their functional *** genetics and biochemical signals are well recognized regulators of morphogenesis,mechanical forces and the physical properties of tissues are now emerging as integral parts of this process as *** physical factors drive coordinated cell movements and reorganizations,shape and size changes,proliferation and differentiation,as well as gene expression changes,and ultimately sculpt any developing structure by guiding correct cellular architectures and *** this review we focus on several craniofacial structures,including the tooth,the mandible,the palate,and the *** discuss the spatiotemporal regulation of different mechanical cues at both the cellular and tissue scales during craniofacial development and examine how tissue mechanics control various aspects of cell biology and signaling to shape a developing craniofacial organ.

关键词： architectures organs morphogenesis

Pharmacologic RNA splicing modulation: a novel mechanism to enhance neoantigen-directed anti-tumor immunity and immunotherapy response

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Signal Transduction and Targeted Therapy 2021年第11期6卷 3167-3168页

作者： Kerryn Elliott Jonas Nilsson jimmy Van den Eynden Department of Medical Biochemistry and Cell Biology Institute of BiomedicineSahlgrenska Academy at University of GothenburgGothenburgSweden Sahlgrenska Cancer Center Department of SurgeryInstitute of Clinical SciencesUniversity of Gothenburg and Sahlgrenska University HospitalGothenburgSweden Harry Perkins Institute of Medical Research University of Western AustraliaPerthWAAustralia Department of Human Structure and Repair Anatomy and Embryology UnitGhent UniversityGhentBelgium

A recent study by Lu et al.1 suggests a novel approach to increasing responsiveness to immune checkpoint blockade (ICB) therapy. ICB is a promising form of cancer immunotherapy that aims to boost the anti-tumoral immune response. This response is primarily driven by the presentation of different types of antigens at the cancer cell membrane via the type I major histocompatibility complex (MHC I). Neoantigens are tumor-specific antigens that are small (mostly 9-mers) mutated peptides that generally result from somatic mutations. High tumor mutational burden, which results in the formation of many neoantigens, is currently one of the main biomarkers for ICB response prediction. Because ICB is only effective in a minority of patients, new therapeutic strategies are required to augment this response.

关键词： immunity immunotherapy mostly

Signaling Kinetics of DNA and Aptamer Biosensors Revealing Graphene Oxide Surface Heterogeneity

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Journal of Analysis and Testing 2022年第1期6卷 11-18页

作者： Po-Jung jimmy Huang Juewen Liu Department of Chemistry Waterloo Institute for NanotechnologyUniversity of WaterlooWaterlooON N2L 3G1Canada

Adsorption of fluorescently labeled DNA and aptamer probes to graphene oxide(GO)has been one of the most popular methods for developing *** the presence of target analytes,the quenched fluorescence would *** this work,we followed the kinetics of the reactions and found that the fluorescence would eventually drop after an initial increase,and this was attributed to the re-adsorption of the desorbed probe DNA *** a DNA probe and an aptamer for adenosine were *** re-adsorption was attributed to the surface heterogeneity of GO,and the DNA probes desorbed from relatively weaker binding sites were re-adsorbed on the stronger binding *** re-adsorption can be avoided by extensive washing the samples,and also by blocking the GO surface or by *** fundamental understanding is important for achieving a stable signal of such biosensors.

关键词： Kinetics DNA Aptamer Biosensors Graphene

Basel III FRTB:data pooling innovation to lower capital charges

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Financial Innovation 2021年第1期7卷 764-776页

作者： jimmy Yicheng Huang McGill University MontrealCanada

Background:Anticipated to overhaul the structure of market risk teams,IT teams,and trading desks within banks by 2023,Basel III’s Fundamental Review of the Trading Book requirements will also increase capital charges banks will incur *** case study focuses on describing what is needed with regards to the risk factor eligibility test(RFET)as well as for implementing a data pool to lower capital *** establishing a consortium of banks per region to implement a data pooling solution,participants can prove a wider breadth of modellable risk factors per asset class and use the Internal Models Approach(IMA)of valuing risk to lower capital charge requirements *** description:First,a description on the historical context surrounding the Fundamental Review of the Trading Book rules and the business requirements needed to comply with the risk factor eligibility test is *** an examination is conducted on the innovative data pooling initiative implemented by CanDeal,TickSmith Corp.,and the 6 largest Canadian banks to lower capital charge requirements under the Fundamental Review of the Trading *** and evaluation:A description is made on what types of data,expertise,and technology is needed to calculate for risk factor *** is up to each firm to decide if the benefits to using the Internal Models Approach to lower capital charges outweighs implementation and running costs of the underlying data *** a data pool for each region comes with challenges that include anti-competition law that may block the initiative,varied benefits to each competitive participant,and data security ***:It is evident that the data pool innovation provides benefits to lowering capital charges as the Canadian banks have seen an increase of modellability by several factors using the sample bond asset *** each firm must still determine internally if the benefits outweighs the technological costs they will i

关键词： charges benefits establishing

A charge-density-based general cation insertion algorithm for generating new Li-ion cathode materials

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npj Computational Materials 2020年第1期6卷 336-342页

作者： jimmy-Xuan Shen Matthew Horton Kristin A.Persson Department of Materials Science and Engineering University of CaliforniaBerkeleyBerkeleyCA 94720USA Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeley 94720USA

Future lithium(Li)energy storage technologies,in particular solid-state configurations with a Li metal anode,opens up the possibility of using cathode materials that do not necessarily contain Li in its as-made *** accelerate the discovery and design of such materials,we develop a general,chemically,and structurally agnostic methodology for identifying the optimal Li sites in any crystalline *** a given crystal structure,we attempt multiple Li insertions at symmetrically in-equivalent positions by analyzing the electronic charge density obtained from first-principles density functional *** this report,we demonstrate the effectiveness of this procedure in successfully identifying the positions of the Li ion in well-known cathode materials using only the empty host(charged)material as ***,applying the algorithm to over 2000 candidate cathode empty host materials we obtain statistics of Li site preferences to guide future developments of novel Li-ion cathode materials,particularly for solid-state applications.

关键词： charge insertion algorithm

Effects of biomechanical parameters of spinal manipulation: A critical literature review

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Journal of Integrative Medicine 2022年第1期20卷 4-12页

作者： Giles Gyer jimmy Michael James Inklebarger Imtiaz Ibne Alam Department of Clinical Skills the London College of Osteopathic MedicineBoston PlaceLondon NW1United Kingdom Department of Pharmacy Stamford University BangladeshDhaka 1217Bangladesh

Spinal manipulation is a manual treatment technique that delivers a thrust,using specific biomechanical parameters to exert its therapeutic *** parameters have been shown to have a unique dose-response relationship with the physiological responses of the *** far,however,there has not been a unified approach to standardize these biomechanical *** fact,it is still undetermined how they affect the observed clinical outcomes of spinal *** study,therefore,reviewed the current body of literature to explore these dosage parameters and evaluate their significance,with respect to physiological and clinical *** the experimental studies reviewed herein,it is evident that the modulation of manipulation’s biomechanical parameters elicits transient physiological responses,including changes in neuronal activity,electromyographic responses,spinal stiffness,muscle spindle responses,paraspinal muscle activity,vertebral displacement,and segmental and intersegmental acceleration ***,to date,there have been few clinical trials that tested the therapeutic relevance of these *** addition,there were some inherent limitations in both human and animal models due to the use of mechanical devices to apply the *** studies evaluating the effects of varying biomechanical parameters of spinal manipulation should include clinicians to deliver the therapy in order to explore the true clinical significance of the dose-response relationship.

关键词： Spinal manipulation Biomechanical characteristics Biomechanical parameters Dosage Force-time profile