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Worldwide 1-month case fatality of ischaemic stroke and the temporal trend

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Stroke & Vascular Neurology 2020年第4期5卷 353-360页

作者： Runhua Zhang Yu Wang jiming fang Miaoxin Yu Yongjun Wang Gaifen Liu Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina ICES TorontoOntarioCanada

background The 1-month case fatality of ischaemic stroke is an essential epidemiological metric.Whereas the case fatality after ischaemic stroke and the temporal trend is uncertain.We aimed to estimate the 1-month case fatality of ischaemic stroke and its temporal trend,as well as its regional variation.Methods We searched PubMed and Embase to identify the studies for 1-month case fatality of ischaemic stroke.The population-based studies were included.Two investigators extracted the data and assessed the quality independently.One-month case fatality of ischaemic stroke was estimated using a random effects model.The temporal trend was evaluated using a mixed-effect meta-regression model.results A total of 59 articles with 77 time periods were included.The worldwide 1-month case fatality of ischaemic stroke was 13.5%(95%CI 12.3%to 14.7%).The case fatality was 10.8%(95%CI 8.3%to 13.5%)in Asia,14.2%(95%CI 12.6%to 15.9%)in Europe,14.0%(95%CI 11.2%to 17.1%)in South America and Caribbean,14.0%(95%CI 9.5%to 19.1%)in North America and 12.5%(95%CI 11.1%to 13.9%)in Australia and New Zealand.Overall,there was a non-significant decrease of 0.1%per year in case fatality.It decreased significantly in Europe(−0.2%annually,95%CI−0.4%to−0.01%)and North America(−0.2%annually,95%CI−0.4%to−0.04%),increased significantly in Australia and New Zealand(0.2%annually,95%CI 0.1%to 0.4%),while no evidence of change in other regions.Conclusion The 1-month case fatality of ischaemic stroke and its temporal trend were divergent across regions.Further studies are needed to address the reason of the regional difference,which will be helpful to guide the effort of reducing stroke burden.

关键词： trend annually assessed

An endophytic fungus interacts with the defensinlike protein OsCAL1 to regulate cadmium allocation in rice

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Molecular Plant 2024年第2期17卷 312-324页

作者： Tianyu Gu Ziai Qi Yating Wang Siying Chen Jing Yan Huapeng Qiu Yanxuan Yu Zjun fang Junmin Wang jiming Gong National Key Laboratory of Plant Molecular Genetics Shanghai Center for Plant Stress BiologyCAS Center for Excellence in Molecular Plant SciencesChinese AcademyofSciencesShanghai200032China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China University of the Chinese Academy of Sciences Beijing 100049China Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization College of Life ScienceHunan University of Science and TechnologyXiangtan411201China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China Institute of Crops and Nuclear Technology Utilization Zhejiang Academy of Agricultural SciencesHangzhou 310021China

Defensin-like proteins are conserved in multicellular organisms and contribute to innate immune re-sponses against fungal pathogens.In rice,defensins play a novel role in regulating cadmium(Cd)efflux from the cytosol.However,whether the antifungal activity of defensins correlates with Cd-efflux function remains unknown.In this study,we isolated an endophytic Fusarium,designed Fo1o,by a comparative mi-crobiome analysis of rice plants grown in a paddy contaminated with Cd.Fo10 is tolerant to high levels of Cd,but is sensitive to the defensin-like protein OsCAL1,which mediates Cd efflux to the apoplast.We found that Fo10 symbiosis in rice is regulated by OsCAL1 dynamics,and Fo10 coordinates multiple plant pro-cesses,including Cd uptake,vacuolar sequestration,efflux to the environment,and formation of Fe pla-ques in the rhizosphere.These processes are dependent on the salicylic acid signaling pathway to keep Cd levels low in the cytosol of rice cells and to decrease Cd levels in rice grains without any yield penalty.Fo10 also plays a role in Cd tolerance in the poaceous crop maize and wheat,but has no observed effects in the eudicot plants Arabidopsis and tomato.Taken together,these findings provide insights into the mech-anistic basis underlying how afungal endophyte and host plant interact to control Cd accumulation in host plants by adapting defense responses to promotethe establishment ofa symbiosis that permits adaptation to high-Cd environments.

关键词： defensin-like protein Fusarium oxysporum endophyte cadmium allocation

Effect of chronic intermittent hypoxia on expression of hepatic cytochrome P450 family members in rat liver

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Effect of chronic intermittent hypoxia on expression of hepa...

Behavioral Characteristics of Captive Giant Panda（Ailuropoda melanoleuca）During Mating Season and Detection of the Females’Rut

中华医学会呼吸病学年会——2013（第十四次全国呼吸病...

作者： xiaoyang chen yiming zeng xiaoping lin jiming fang yixiang zhang Department of Pulmonary Medicine Second Affiliated Hospital of Fujian Medical University

Objective Chronic intermittent hypoxia(CIH) has been associated with abnormalities in liver.This study aimed to investigate the effect of CIH on expression of hepatic cytochrome P450(CYP) family members in rat liver. Methods Eight Sprague Dawley rats were exposed to CIH for 12 weeks.Eight Sprague Dawley rats were exposed to intermittent room air as a control group.Total liver protein was extracted,and CYP1A2,CYP2C9, CYP3A4 and CYP2D6 were analyzed by western blot.

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Behavioral Characteristics of Captive Giant Panda（Ailuropod...

THRIVE评分预测中国国家卒中登记缺血性卒中患者不良预后和死亡的外部验证研究

野生动物生态与管理学术讨论会

作者： Ruyong SUN Dingzhen LIU jiming fang Rongping WEI Guiquan ZHANG Hemin ZHANG Ministry of Education Key Laboratory for Biodiversity Science and Eclogical Engineering ＆ Institute of Ecology Ministry of Education Key Laboratory for Biodiversity Science and Eclogical Engineering ＆ Institute of Ecology Ministry of Education Key Laboratory for Biodiversity Science and Eclogical Engineering ＆ Institute of Ecology China Conservation and Research Center for Giant Panda at Wologn China Conservation and Research Center for Giant Panda at Wologn China Conservation and Research Center for Giant Panda at Wologn

＜正＞It has been for 18 years since gian panda was bred successfully in captivity,however,there aremany problems remain unsolved.The most important is by What and how to detect the femnale‘s estruspeak properly and to pair it with the stud in time,Whether there are any simple behavioral methed for usto detect the female‘s rut.To solve questions above,a behaviotal observation on 23 giant pandas wasconducted at China Conservation and Research Cener for the Gian Panda,Wolong Nature Reserve

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THRIVE评分预测中国国家卒中登记缺血性卒中患者不良预后和死亡的...

中华医学峰会暨中华医学会神经病学分会第八届全国中青年神...

作者：陈玮琪刘改芬 jiming fang 王伊龙宋彦丽潘岳松李昊刘丽萍王春雪赵性泉王拥军首都医科大学附属北京天坛医院

目的Totaled Health Risks in Vascular Events(THRIVE)评分是预测缺血性卒中患者90天不良预后和死亡风险的评分工具。本研究目的是在中国卒中患者中验证THRIVE评分的预测效能,并将评分扩展到预测6、12个月患者的功能预后。方法在中国...

目的Totaled Health Risks in Vascular Events(THRIVE)评分是预测缺血性卒中患者90天不良预后和死亡风险的评分工具。本研究目的是在中国卒中患者中验证THRIVE评分的预测效能,并将评分扩展到预测6、12个月患者的功能预后。方法在中国国家卒中登记(CNSR)11064名缺血性卒中患者中验证THRIVE评分。不良预后定义为mRS评分为3-6分。应用ROC曲线下面积AUC值对于模型进行辨别能力检验。采用Pearson

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啮齿动物的空间分布格局

生态学杂志 1994年第1期13卷 39-44,68页

作者：房继明北京师范大学生物学系

啮齿动物的空间分布格局房继明（北京师范大学生物学系，１００８７５）ＳｐａｔｉａｌＤｉｓｔｒｉｂｕｔｉｏｎＰａｔｔｅｒｎｓｏｆＲｏｄｅｎｔｓ．￥ＦａｎｇＪｉｍｉｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＢｉｏｌｏｇｙ，Ｂｅｉｊｉｎ... 详细信息

啮齿动物的空间分布格局房继明（北京师范大学生物学系，１００８７５）ＳｐａｔｉａｌＤｉｓｔｒｉｂｕｔｉｏｎＰａｔｔｅｒｎｓｏｆＲｏｄｅｎｔｓ．￥ＦａｎｇＪｉｍｉｎｇ（ＤｅｐａｒｔｍｅｎｔｏｆＢｉｏｌｏｇｙ，ＢｅｉｊｉｎｇＮｏｒ－ｍａｌＵｎｉｖｅｒｓｉｔ...

关键词： spatial pattern rodents aggregated istribution.

根田鼠的熟悉性及其自然动情下的配偶选择(英文)

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兽类学报 1999年第4期19卷 287-297页

作者：赵亚军房继明孙儒泳北京师范大学生物系 100875

报道了在室内雌鼠自然动情条件下根田鼠两性个体配偶选择的 3种熟悉性效应的 5组实验结果 ,包括雌性对熟悉和陌生雄鼠、配偶和陌生雄鼠、配偶和熟悉雄鼠的择偶行为实验 ,雄性对熟悉和陌生雌鼠、配偶和陌生雌鼠的择偶行为实验。在实验前 ... 详细信息

报道了在室内雌鼠自然动情条件下根田鼠两性个体配偶选择的 3种熟悉性效应的 5组实验结果 ,包括雌性对熟悉和陌生雄鼠、配偶和陌生雄鼠、配偶和熟悉雄鼠的择偶行为实验 ,雄性对熟悉和陌生雌鼠、配偶和陌生雌鼠的择偶行为实验。在实验前 ,将 1对性成熟的雌雄鼠 (非亲缘关系 )每天关养8h共 8d建立熟悉性 ;配对雌雄鼠至少生育 1胎则为配偶关系。在Y形迷宫内的 30min实验中 ,两个被选择鼠分别以项链拴在横跨选择箱顶端中央的一根铁丝上 ,限制它们在各自箱内活动 ;而允许异性选择鼠从中立箱自由进入两个选择箱。记录选择鼠对异性被选择鼠的访问、社会探究、攻击、交配和友好行为的频次和时间。经Wilcoxon关联样本T检验发现 ,除交配行为不显著外 ,雌性根田鼠均选择熟悉性较高的雄鼠 ;而雄鼠不具这种选择性。该结果提示雌雄根田鼠的不同择偶行为也许就是反映该种婚配制度特征的直接行为过程。因此 ,在择偶行为中 ,雌性根田鼠表现的单配性倾向和雄鼠的多配性倾向 ,只能以其婚配制度为一雄多雌制的假设来解释。我们的实验还说明在多配制田鼠中 ,一雄多雌制与混交制在雌鼠择偶行为上是不同的 ,而与单配制的相似或相近 ,故简单地比较多配制与单配制则不能反映田鼠亚科动物婚配制度的多样性。

关键词：根田鼠配偶选择熟悉性婚配制度

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布氏田鼠种群生态及行为生态学研究进展

生态学杂志 1998年第1期17卷 65-69页

作者：尹峰房继明北京师范大学生物学系

布氏田鼠种群生态及行为生态学研究进展尹峰房继明（北京师范大学生物学系，１００８７５）ＲｅｓｅａｒｃｈＡｄｖａｎｃｅｓｉｎＰｏｐｕｌａｔｉｏｎＥｃｏｌｏｇｙａｎｄＢｅｈａｖｉｏｒａｌＥｃｏｌｏｇｙｏｆＢｒａｎｄｔ’ｓＶ... 详细信息

布氏田鼠种群生态及行为生态学研究进展尹峰房继明（北京师范大学生物学系，１００８７５）ＲｅｓｅａｒｃｈＡｄｖａｎｃｅｓｉｎＰｏｐｕｌａｔｉｏｎＥｃｏｌｏｇｙａｎｄＢｅｈａｖｉｏｒａｌＥｃｏｌｏｇｙｏｆＢｒａｎｄｔ’ｓＶｏｌｅｓ（Ｍｉｃｒｏｔｕｓｂｒａｎ...

关键词：田鼠布氏田鼠种群生态学行为生态学

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食品理化检验质量控制分析探讨

中国卫生产业 2021年第11期18卷 176-178,182页

作者：方吉明四川省峨眉山市疾病预防控制中心四川峨眉山614200

目的对食品理化检验质量控制进行分析探讨,以保证食品理化检验数据的准确、可靠。方法该文以食盐中碘测定为例,以GB标准方法—氧化还原滴定法为实验分析方法,探索在不同条件下对食品理化检验实验分析结果的影响因素。结果在不同条件下,... 详细信息

目的对食品理化检验质量控制进行分析探讨,以保证食品理化检验数据的准确、可靠。方法该文以食盐中碘测定为例,以GB标准方法—氧化还原滴定法为实验分析方法,探索在不同条件下对食品理化检验实验分析结果的影响因素。结果在不同条件下,相同的分析方法测定结果是不同的,不同方法和不同实验室测定结果也是不同的。结论在实际分析测定样品过程中,必须统一测定方法,严格执行方法要求和操作程序,并认真开展实验室室内质量控制和实验室之间的质量控制。即质量控制需贯穿于食品理化检验分析操作的始终,数据才具备科学性、准确性、可靠性。

关键词：食品理化检验质量控制