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Food Quality and Safety 2023年第2期7卷 317-329页

作者： Yake He Yanyun Zhu jimin lvi Ye Gu Ting Wang Jianchu Chen College of Biosystems Engineering and Food Science National-Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agro-Food ProcessingZhejiang Engineering Laboratory of Food Technology and EquipmentZhejiang UniversityHangzhouChina School of Automation Hangzhou Dianzi UniversityHangzhouChina

Using lactic acid bacteria(LAB)to ferment Huyou peel and pomace could provide a reference for making full use of Huyou resources and provide valuable suggestions for the industrial production of functional *** effects of LAB fermentation on the bioactive composition,volatile compounds and antioxidant activity of Huyou peel and pomace were *** showed that both Huyou peel and pomace were good substrates for LAB *** had remarkable influence on bioconversion of organic acids,among which ascorbic acid content was increased *** addition,LAB could produce flavonoids with enhanced bioactivity and *** particular,the contents of rhoifolin,quercitrin and quercetin were increased by over 100%.Besides,the volatile compounds contents and aroma complexity were ***,the antioxidant activity was ***,our study provides high-value applications of Huyou,and fermented products with improved nutritional value and flavor are potentially beneficial to human health.

关键词： Lactic acid bacteria,Huyou peel Huyou pomace bioactive composition volatile compounds

Impact of preoperative chemoradiotherapy on survival in patients with resectable pancreatic cancer

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World Journal of Gastroenterology 2007年第21期13卷 2945-2951页

作者： Plvi Vento Harri Mustonen Timo Joensuu Pivi Krkkinen Eero Kivilaakso Tuula Kiviluoto Departments of Surgery Helsinki University Central HospitalHelsinkiFinland Departments of Oncology Helsinki University Central HospitalHelsinkiFinland Departments of Pathology Helsinki University Central HospitalHelsinkiFinland

AIM:To explore whether preoperative chemoradiation therapy improves survival of patients with pancreatic cancer undergoing resectional surgery. METHODS:Forty-seven patients with a malignant pancreatic tumor localized in the head or uncinate process of the pancreas underwent radical pancreaticoduodenectomy. Twenty-two received chemoradiation therapy (gemcitabine and radiation dose 50.4 Gy) before surgery (CRR) and 25 patients underwent surgery only (RO). The study was non-randomised. Patients were identified from a prospective database. RESULTS:The median survival time was 30.2 mo in the CRR group and 35.9 mo in the RO group. No statistically significant differences were found in subclasses according to lymph node involvement,TNM stages,tumor size,or perineural invasion. The one,three and five year survival rates were 81%,33% and 33%,respectively,in the CRR group and 72%,47% and 23%,respectively,in the RO group. In ductal adenocarcinoma,the median survival time was 27 mo in the CRR group and 20 mo in the RO group. No statistically significant differences were found in the above subclasses. The one,three and five year survival rates were 79%,21% and 21%,respectively,in the CRR group and 64%,50% and 14%,respectively,in the RO group. The overall hospital mortality rate was 2%. The morbidity rate was 45% in the CRR group and 32% (NS) in the RO group. CONCLUSION:Major multicenter randomized studies are needed to conclusively assess the impact of neoadjuvant treatment in the management of pancreatic cancer.

关键词： Pancreatic cancer Neoadjuvant Chemoradiation Gemcitabine

Informed Design for Sustainable Growth

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创意与设计 2017年第3期 71-80页

作者： Mirja Kalviainen Noora Nylander Antti Heinonen Design Institute Lahti University of Applied Sciences

Lahti Growth model in the Lahti University of Applied Sciences is joining together the regional hub for design competence and the committed development of circular economy solutions. On the strategic level the circular solutions try to prevent waste from occurring in any part of the production and consumption process. This demands also design for user consumer behavior change. New emphasis for design education is required with guiding students in solving this behavior change challenge instead of designing concrete products. The user research for green behavior change reveals practical everyday, social life and interest related hindrances explaining the typical attitude – behavior gap with green actions. From the the user perspective the need is for service thinking based solutions, where the information communication, findability and availability of the offering amongst the everyday activities and interests is essential. This paper presents three into the design education integrated cases that present possibilities of the circular economy design and fulfill some important aspets of the user needs. The information design case for renewable energy production in the countryside developed both static posters and storytelling based animations about the horse manure based energy possibilities. The renewable energy research results data wrangling was integrated with information design ideas and visualisation production. The information design project produced results for clear, positive, context related and systemic information delivery. It also produced communication messaging about the normality, savings and history related sensibility achieved through recycling and producing renewable energy in the countryside. The second design case was about preowned product recycling possibilities through applying user information and service design process. The cross-disciplinary students' efforts produced finable, positive and without a car available service process, house cleaning

关键词：产品设计创意技术创新品牌

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腹腔镜下子宫颈根治术

世界核心医学期刊文摘（妇产科学分册） 2005年第10期1卷 39-40页

作者： Cibula D Ungálpálfálvi L 张旸 Dept. of Obstetrics and Gynecology General Faculty Hospital 1st Med. Fac. of Charles University Apolinarska 18 Prague 2 Czech Republic

Background. Radical trachelectomy is a fertility preserving alternative for young women with early stages of cervical cancer. Currently, a technique of abdominal radical approach is used in a few centres. With growing availability of laparoscopy, a novel technique of laparoscopic radical trachelectomy might be an alternative. Case. Presented is one case of laparoscopic pelvic lymphadenectomy with radical trachelectomy in young woman with IB cervical cancer. No intraoperative or postoperative complications occurred. Operation time reached 250 min, estimated blood loss was 250 ml. Limited follow- up of 9 months was uneventful and patient indicates normal menstrual pattern and satisfactory sexual intercourse. Conclusion. Laparoscopic abdominal radical trachelectomy with pelvic lymphadenectomy might be an alternative technique in the treatment of early stages cervical cancer in patients who desire future pregnancy. The procedure is in principle identical to the standard abdominal radical hysterectomy. Centres practising laparoscopic radical hystertectomy can adopt the technique without any special surgical training.

关键词：腔镜根治术早期宫颈癌腹根估计失血量手术时间操作原则

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二氟乙酸乙酯的合成研究

有机氟工业 2017年第1期 26-29页

作者：刘波吕太勇罗源军庹洪张鸣李斌中昊晨光化工研究院有限公司四川富顺643201

二氟乙酸乙酯是一类用途极广的含氟精细化学品,市场前景广阔,具有较高的开发价值。虽然合成该化合物的方法较多,但都有各自的不足,为了解决上述问题,开展了温和条件下合成二氟乙酸乙酯的研究工作。以四氟乙烯为原料进行试验,以85.3%的... 详细信息

二氟乙酸乙酯是一类用途极广的含氟精细化学品,市场前景广阔,具有较高的开发价值。虽然合成该化合物的方法较多,但都有各自的不足,为了解决上述问题,开展了温和条件下合成二氟乙酸乙酯的研究工作。以四氟乙烯为原料进行试验,以85.3%的收率成功得到1,1,2,2-四氟乙基乙基醚,该中间体在酸性条件下与二氧化硅反应以91.7%的收率成功得到了目标产物二氟乙酸乙酯。结果表明:该合成方法具有反应条件温和、收率高、反应步骤少等特点,适用于工业化生产。

关键词：二氟乙酸乙酯四氟乙烯氢氟醚含氟精细化学品

肿瘤大体形态与上尿路尿路上皮癌患者预后的相关性分析

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中华泌尿外科杂志 2020年第5期41卷 334-340页

作者：袁易初张楠黄吉炜张进陈勇辉黄翼然杜传军陈继民薛蔚浙江大学医学院附属第二医院泌尿外科浙江310009 上海交通大学医学院附属仁济医院泌尿科上海200127

目的探讨肿瘤大体形态对上尿路尿路上皮癌(UTUC)患者根治手术后预后的影响。方法回顾性分析1998年1月至2019年6月浙江大学医学院附属第二医院(156例)和上海仁济医院(802例)收治的958例行根治手术的UTUC患者的临床和预后资料,男630例,女... 详细信息

目的探讨肿瘤大体形态对上尿路尿路上皮癌(UTUC)患者根治手术后预后的影响。方法回顾性分析1998年1月至2019年6月浙江大学医学院附属第二医院(156例)和上海仁济医院(802例)收治的958例行根治手术的UTUC患者的临床和预后资料,男630例,女328例。中位年龄67(30~89)岁。合并糖尿病120例,高血压病370例。252例有吸烟史。499例术前伴肾积水。119例有非肌层浸润性膀胱癌(NMIBC)病史或合并NMIBC。肿瘤位于肾盂489例,输尿管394例,同时位于肾盂和输尿管75例。543例行腹腔镜手术,415例行开放手术。分析肿瘤大体形态与各临床病理因素的关系,运用Kaplan-Meier法及log-rank检验进行生存分析,采用Cox比例风险模型进行单因素和多因素分析,分析肿瘤大体形态和临床病理因素对预后的影响。结果本研究958例病理检查结果显示,516例(53.9%)肿瘤呈乳头状(A组),442例(46.1%)呈平坦状(B组);肿瘤直径≤3 cm 543例,>3cm 415例;病理分级低级别275例,高级别683例;病理分期Ta^1期441例,T2期180例,T3期308例,T4期29例;227例行淋巴结清扫,其中62例病理检查证实淋巴结转移;48例伴有鳞状或腺样分化;150例存在淋巴血管侵犯(lvi);134例为多灶性生长;43例切缘阳性。中位随访39(2~206)个月,304例死亡,其中236例因UTUC死亡。A组5年总生存率(OS)和肿瘤特异性生存率(CSS)分别为76.6%和81.8%,均明显高于B组的54.4%和60.5%(P均lvi[24.4%(108/442)与8.1%(42/516),P3 cm(HR=1.407,95%CI 1.076~1.841,P=0.013)和lvi(HR=1.388,95%CI 1

关键词：泌尿系肿瘤上尿路尿路上皮癌肿瘤形态根治性肾输尿管切除术预后

诊断性输尿管镜检查对上尿路尿路上皮癌术后膀胱内复发的影响:双中心958例回顾性研究

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临床泌尿外科杂志 2021年第1期36卷 18-23页

作者：袁易初陈继民杜传军张进陈勇辉薛蔚黄翼然黄吉炜张楠浙江大学医学院附属第二医院泌尿外科杭州310009 上海交通大学医学院附属仁济医院泌尿外科

目的:探讨诊断性输尿管镜检查(URS)对上尿路尿路上皮癌(UTUC)患者根治手术后膀胱内复发(IVR)的影响。方法:回顾性分析1998年1月—2019年6月于浙江大学医学院附属第二医院(156例)和上海仁济医院(802例)就诊的958例UTUC患者的临床及随访... 详细信息

目的:探讨诊断性输尿管镜检查(URS)对上尿路尿路上皮癌(UTUC)患者根治手术后膀胱内复发(IVR)的影响。方法:回顾性分析1998年1月—2019年6月于浙江大学医学院附属第二医院(156例)和上海仁济医院(802例)就诊的958例UTUC患者的临床及随访资料。男630例,女328例,中位年龄67(30~89)岁。518例行诊断性URS(URS组),440例未行诊断性URS(非URS组)。伴有术前肾积水499例,糖尿病史138例,有吸烟史252例,非肌层浸润型膀胱癌(NMIBC)病史或合并NMIBC119例;肿瘤位于肾盂489例,位于输尿管394例,同时位于肾盂及输尿管75例。543例采取了腹腔镜手术,415例采取了开放手术。196例术后进行辅助化疗。病理检查结果显示,肿瘤直径≤3 cm 543例,>3 cm 415例;病理分级为低级别275例,高级别683例;病理分期为Ta~1期441例,T2期180例,T3期308例,T4期29例;227例进行淋巴结清扫,其中62例病理检查证实淋巴结转移;516例肿瘤呈乳头状,442例呈平坦状;48例伴有鳞状或腺样分化;150例存在淋巴血管侵犯(lvi);134例为多灶性生长。两组年龄(P=0.660)、性别(P=0.618)、糖尿病史(P=0.418)、吸烟史(P=0.173)、术前肾盂积水(P=0.777)、WHO分级(P=0.105)和肿瘤形态(P=0.051)比较差异均无统计学意义。而相较于非URS组,URS组有着更低的开放手术(P=0.032)、伴有NMIBC病史或合并NMIBC(P3 cm肿瘤(Plvi阳性(P=0.031)及多灶性生长(P=0.032)的比例。比较两组术后1年和5年膀胱内无复发生存率(IRFS)。Kaplan-Meier法绘制生存曲线,采用Cox比例风险模分析影响IRFS的因素。结果:本研究中位随访39(2~206)个月,192例(20.0%)发生IVR,其中URS组121例,非URS组71例。URS组1年和5年IRFS分别为87.1%和71.6%,低于非URS组的90.6%和80.9%(P=0.014)。Cox多因素回归分析结果显示URS(P3 cm(P=0.005)是IVR的独立危险因素。结论:20.0%的UTUC患者行根治手术后会出现IVR,URS是IVR的独立危险因素之一。

关键词：上尿路尿路上皮癌输尿管镜根治性肾输尿管切除术复发