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Diagnosis and Treatment of Digestive Emergencies in Two Hospitals in Douala (Cameroon)

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Surgical Science 2021年第6期12卷 174-186页

作者： Jean Paul Engbang Basile Essola thomas jim-Kevin Moukoury Christian Beugheum Chasim Gertrude Massom Toumaleu Mathieu Motah Marcelin Ngowe Ngowe Faculty of Medicine and Pharmaceutical Sciences The University of Douala Douala Cameroon Douala Laquintinie Hospital Douala Cameroon Douala General Hospital Douala Cameroon Faculty of Medicine and Biomedical Sciences The University de Yaounde I Yaounde Cameroon

Background: Gastrointestinal tract (GIT) surgical emergencies represent a significant amount within surgical pathologies, in Africa and throughout the world. Our study was aimed to assess the etiological, therapeutic and prognostic aspects of GIT surgical emergencies in patients from two hospitals in Douala, Cameroon. Patients and Method: A longitudinal prospective study was conducted from December 2018 to May 2019, including 203 patients of all ages and both sexes who presented with a GIT surgical emergency in any clinical form, and who underwent surgery within one of our hospitals. We collected patients’ parameters through a survey, from complete history to clinical examination, then followed them up from surgery to post-operative time. Gathered information was analyzed by IBM Statistical Package for Social Science (SPSS) 23.0 software version. Results: GIT surgical emergencies accounted for 27.5% of all surgical emergencies. Our target population included 55.2% (n = 112) of men, and 44.8% (n = 91) of women, observing a sex-ratio of 1.23. The mean age of the patients was 36.3 ± 17.1 years, with extreme values of 6 months and 86 years. Abdominal pain was the most common symptom, vomiting and lack of bowel movement or gas pass, were the main associated symptoms in 27.6% and 16.7% of cases, respectively. Etiologically, leading pathologies were intestinal obstruction (32.0%, 64 cases), acute appendicitis (24.6%, 50 cases), then came peritononitis and abdominal trauma with respectively 22.7% (46 cases) and 21.7% (43 cases). Most patients underwent surgery within 24 hour. Laparotomy was the primary method used in 90.6%, and laparoscopy (9.4%). Post-operative suture breakage and parietal suppuration were the most common complications post-operatively. Totally, the overall morbidity and mortality rates were respectively 8.9% and 0.98% among our patients. Conclusion: Acute surgical abdomens occupy an impor

关键词： Emergency Digestive Surgery Etiologies Management Douala (Cameroon)

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic Lydia jiménez-Díaz Juan D.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano Sergei A.Kirov Jesús M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

Evaluation of fiber optic methane sensor using a smoke chamber

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International Journal of Mining Science and Technology 2018年第6期28卷 969-974页

作者： Mingming Li thomas Dubaniewicz Heather Dougherty jim Addis National Institute for Occupational Safety and Health Pittsburgh Mining Research Division

This report presents the results of experiments to evaluate a prototype fiber optic methane monitor exposed to smoke using a smoke chamber to simulate atmospheric conditions in an underground coal mine after a fire or explosion. The experiments were conducted using test fires of different combustible sources commonly found in mines —douglas-fir wood, SBR belt, and Pittsburgh seam coal. The experiments were designed to assess the response of the fiber optic methane sensor to different contaminants,different contaminant levels and different contaminant durations produced from the test fires. Since the prototype methane monitor detects methane by measuring absorption at a specific wavelength, optical power at the absorption wavelength(1650 nm) was measured as a function of smoke concentration and duration. The other sensor response parameter-methane response times-were measured between smoke tests to assess the impact of soot accumulation on the sensor. Results indicate that the sensor screen effectively prevented smoke from obscuring the optical beam within the sensor head, with minimal impact on the system optical power budget. Methane response times increased with smoke exposure duration, attributed to soot loading on the protective screen.

关键词： Fiber optic Methane sensor Fires Optical power Response time

How will climate change affect the potential distribution of Eurasian tree sparrows Passer montanus in North America？

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Current Zoology 2011年第5期57卷 648-654页

作者： jim GRAHAM Catherine JARNEVICH Nick YOUNG Greg NEWMAN thomas STOHLGREN Natural Resource Ecology Laboratory Colorado State University Fort Collins CO 80523-1499 USA Fort Collins Science Center U.S. Geological Survey 2150 Centre Ave. Building C Fort Collins CO 80526 USA

Habitat suitability models have been used to predict the present and future potential distribution of a variety of spe- cies. Eurasian tree sparrows Passer montanus, native to Eurasia, have established populations in other parts of the world. In North America, their current distribution is limited to a relatively small region around its original introduction to St. Louis, Missouri. We combined data from the Global Biodiversity Information Facility with current and future climate data to create habitat suitability models using Maxent for this species. Under projected climate change scenarios, our models show that the distribution and range of the Eurasian tree sparrow could increase as far as the Pacific Northwest and Newfoundland. This is potentially important in-formation for prioritizing the management and control of this non-native species [Current Zoology 57 （5）： 648--654, 2011].

关键词： Eurasian tree sparrows Passer montanus Maxent Climate change Distribution model

Lophozonia tree cavities used for nesting by Slender-billed Parakeets(Enicognathus leptorhynchus)in the central valley of southern Chile:a potentially vanishing keystone resource

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Chinese Birds 2017年第1期8卷 25-36页

作者： thomas H.White Jr. Jaime E.jiménez Puerto Rican Parrot Recovery Program United States Fish and Wildlife ServiceBox 1600Rio GrandePR 00745USA Sub-Antarctic Biocultural Conservation Program Department of Biological SciencesUniversity of North TexasDentonTX 76201USA Sub-Antarctic Biocultural Conservation Program Department of Philosophy and ReligionUniversity of North TexasDentonTX 76201USA Omora Etnobotanical Park Universidad de MagallanesPuerto WilliamsChile

Background: The Slender-billed Parakeet(Enicognathus leptorhynchus) is a psittacine endemic to southern Chile and an obligate secondary cavity-nester. In the central valley of southern Chile, most(94%) of the known Slender-billed Parakeet nests have occurred in large, mature southern beech(Lophozonia obliqua) trees(locally known as "pellines"). As relicts of the original old-growth forests of southern Chile, most pellines have been lost due to extensive landclearing throughout the region, potentially threatening long-term persistence of the Slender-billed ***: We conducted our study in the central valley of southern Chile, near the city of Osorno during three consecutive nesting seasons(November–January, 2008–2011). Nest trees used by Slender-billed Parakeets were located by direct observation of parakeet activities and through interviews with local residents, some of whom were former parrot nest poachers. Nest cavities were accessed, inspected and measured using single-rope climbing techniques. We report means, standard errors, 95% confidence intervals and ranges for 11 cavity-related variables. We also report clutch sizes encountered in active nests, and age estimates of nest trees based on known growth rates of Lophozonia trees in southern Chile. Linear regressions were used to evaluate potential relationships between cavity-related variables and clutch ***: We located and measured 38 Lophozonia tree cavities used for nesting by Slender-billed Parakeets. Compared to those used by other psittacines, nest trees were relatively large, averaging 30.4 breast height of 134.5 ter ± 1.1 m in height with a mean diameter at ± 4.7 cm. Based on estimated annual diameincrement, ages of nest trees ranged from approximately 209–485 years. Nest cavities entrances averaged 12.5 ± 0.9 m in height above ground level. Cavity entrance widths averaged 51.0 ± 13.3 cm(vertical) by 11.5 ± 0.7 cm(horizontal). Cavity entrance orientations were apparently random, with

关键词： Conservation Deforestation Habitat loss Lophozonia obliqua Pellines Psittacidae Regeneration

SYSTEMIC PATHOLOGIES OF CONFRONTATION:DIAGNOSING SECURITY DISRUPTION

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Journal of Systems Science and Systems Engineering 2009年第4期18卷 423-436页

作者： jim BRYANT Sheffield Business School Sheffield Hallam University

The world post-9/11 is characterised by uncertainty, fear and suspicion. Psychological confrontations amplified by the mass media have even come to dominate physical engagements between warring parties. Drama theory provides a powerful framework for understanding these interactions in much the way that game theory was able to support strategy making by autonomous players in a less inter-connected era, A model of the ＇normal＇ process leading to dramatic resolution is an essential feature of the drama theory approach and is described here. However this process can be derailed or fail in many ways. This paper reviews many of these systemic pathologies and illustrates some Of them through consideration of three high-profile cases. The conclusion is that it is important to recognise and possibly to use pathological behavior as an element of a character＇s interaction strategy.

关键词： Drama theory confrontation conflict resolution systemic pathology

Critical role of risk management in ground engineering and opportunities for improvement

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International Journal of Mining Science and Technology 2017年第5期27卷 725-731页

作者： jim Galvin Mining Engineering University of New South WalesSydney 2283Australia

Green mining is concerned with mining in a sustainable manner, such that the needs of the present are met without compromising future generations. The achievement of this objective depends on balancing social, environmental and economic objectives and has to have regard to both active mining operations and legacy issues associated with mine closure. Ground engineering has a critical role in achieving green mining objectives but its contribution is characterised by pervasive uncertainty. Uncertainty equates to risk. This means that ground engineering should be practiced within a risk management framework that aims to both prevent unwanted outcomes and to mitigate their consequences to an acceptable level. This keynote address presents the fundamentals of risk management and demonstrates its effectiveness by reference to improvements in the safety performance of the NSW coal sector over the past three ***, ground control remains a mix of art and science, relying heavily on judgements which should be premised on knowledge, skill and experience(that is, competence). Risk management has now been enshrined in mining legislation and operating practice in Australia for over two *** this, near-hit and accident and incident investigations, commissions of inquiry and legal proceedings almost invariably identify deficiencies and opportunities for improvements necessary to achieve the objectives of sustainable mining. Three of the more important opportunities which have global application in relation to ground engineering are discussed. These relate to the vexing issue of defining competency in ground engineering; the criteria for undertaking rigorous risk assessment; and the need for ground engineers to become involved in mine rehabilitation and closure planning over the full life cycle of a mine, commencing at the prefeasibility stage.

关键词： Bow tie analysis Mine safety Mine closure Risk assessment Risk management Sustainable mining Uncertainty

Interfacial tension studies between Fe-Cu-Ni sulfide and halo-norilsk basalt slag system

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Science China Earth Sciences 2005年第6期48卷 834-839页

作者： jim Mungall Department of Geology University of Toronto 22 Russell St Toronto Ontario M5S 3B1 Canada

The interfacial tension of the matte/halo-Norilsk basalt slag systems of FeS-Cu2S-Ni3S2 and FeO-FeS were investigated using the sessile drop technique. The results indicate that interfacial tension decreases with increasing copper and nickel contents in the matte of FeS-Cu2S-Ni3S2 system while it increases with increasing oxygen content in the matte of FeO-FeS system. It is inferred from these results that two conditions are critical for the formation of giant Cu-Ni sulfide deposits. One is that ma-fic-ultramafic parent magma of sulfide deposits should be rich in copper and nickel where due to the low interfacial tension, it is difficult to form sulfide droplet in the early stage of magma evolution. In other words, sulfide liquid conglomeration occurs more difficultly. The other condition is that the magma emplacement should be shallow; and a lot of faults occur in the magma emplacement field. Since oxygen content is high in the environment, interfacial tension is high, which helps sulfide liquid conglomeration and consequently Cu-Ni sulfide deposits form.

关键词： matte, slag, interfacial tension, Cu-Ni sulfide deposit.