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Sperm speed is associated with sex bias of siblings in a human population

Asian Journal of Andrology 2013年第1期15卷 152-154页

作者： jim A Mossman Jon Slate Tim R Birkhead Harry D Moore Allan A Pacey Department of Ecology and Evolutionary Biology Box G Brown University Providence Rhode Island 02912 USA Department of Animal and Plant Sciences University of Sheffield Western Bank Sheffield S10 2TN UK Centre for Stem Cell Biology Department of Biomedical Sciences University of Sheffield Western Bank Sheffield $10 2TN UK Academic Unit of Reproductive and Developmental Medicine Department of Human Metabolism School of Medicine and Biomedical Sciences Sheffield $10 2SF UK

Recent studies investigating possible causes of male subfertility have largely focused on how lifestyle or environmental factors impact on the process of spermatogenesis, Markedly, fewer studies have investigated those risk factors that result in reduced sperm quality, such as poor sperm motility. The speed at which sperm swim is a major predictor of fertility and is extremely variable in human populations. It has been hypothesized that offspring sex may be adaptively manipulated to maximize the offspring＇s reproductive fitness （e.g., parents with genes for good male fertility traits, such as high sperm speed, would produce primarily sons and fewer daughters because the offspring will inherit advantageous male fertility genes）. Conversely, parents with poor male fertility genes would produce primarily daughters, We tested whether there was an association between how fast a man＇s sperm swam and the sex bias of his siblings in a sample of men attending clinic for fertility investigations with their partner and with a wide range of semen characteristics, including sperm speed. We found that the sex bias of a man＇s siblings is associated with his sperm speed; men with female-biased siblings had significantly slower sperm （judged using computer-assisted sperm analysis （CASA）） than men from male-biased sibships. This observation suggests family composition is an important factor that needs to be considered in future eDidemiological and clinical studies of human fertility,

关键词： computer-assisted sperm analysis (CASA) fertility intralocus sexual conflict male offspring sex ratio sexual antagonism

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Excitations of length-of-day seasonal variations:Analyses of harmonic and inharmonic fluctuations

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Geodesy and Geodynamics 2020年第1期11卷 64-71页

作者： Jiesi Luo Wei Chen jim Ray Jiancheng Li Collaborative Innovation Center of Geospatial Technology/Key Laboratory of Geospace Environment and Geodesy School of Geodesy and GeomaticsWuhan UniversityWuhanChina National Oceanic and Atmospheric Administration Silver SpringMarylandUSA

Geophysical excitations of length-of-day(LOD)variations is of great significance in understanding changes in the Earth’s spin rate and interactions between geophysical fluids and the solid Earth,as well as validating the reliability of atmospheric,oceanic and hydrological *** this study seasonal excitations of LOD variation during 06.30,1987-06.30,2017 are investigated using both harmonic and inharmonic *** examined the agreements between the IERS EOP 14C04ΔLOD series and that from the previous version EOP08C04,and analyzed contributions of atmospheric,oceanic,hydrological and sea level angular momenta to seasonal excitations of LOD variations on the bases of the ESMGFZ *** found that the sea level angular momentum plays an important role in global mass conservation and can bring better agreements between the geophysical and geodetic excitations.

关键词： LOD variation Geophysical excitations Sea level angular momentum Wavelet analysis

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Use of new technologies for the promotion of physical activity in patients with mental illness:A systematic review

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World Journal of Psychiatry 2023年第4期13卷 182-190页

作者： Margarita Guerrero-jiménez Marta Ruiz Luis Gutiérrez-Rojas Laura jiménez-Muñoz Enrique Baca-Garcia Alejandro Porras-Segovia Department of Psychiatry Hospital Clínico San CecilioGranada 18014Spain Department of Psychiatry Hospital Rey Juan CarlosMóstoles 28933MadridSpain Department of Psychiatry Hospital Universitario Jiménez DíazMadrid 28040Spain Department of Psychiatry Fundación Jiménez DiazMadrid 28040Spain

BACKGROUND Physical exercise is an underutilized tool for the management of mental *** technologies have made a breakthrough in health care,and one of its possible applications(apps)could be that of customizing exercise programs for special populations,such as patients with mental ***,the app of the so-called e-health to mental health care is still *** To know the efficacy of apps to promote physical activity in patients with mental *** We conducted a systematic review of the PubMed and Embase databases with the aim of exploring the use of new technologies for the enhancement of physical exercise in patients with a psychiatric *** the selection process,10 articles were included in the *** The most commonly used devices in this type of intervention are wearable devices and web *** results in terms of effectiveness and acceptability were obtained in most of the *** Our findings suggest that the use of new technologies in mental health represents a feasible strategy with great potential in clinical practice.

关键词： e-health m-health Physical exercise Mobile applications Wearable device

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作者： jim·Yukich导演

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Diagnosis of clinical and subclinical varicocele： how has it evolved？

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Asian Journal of Andrology 2016年第2期18卷 182-185,J0002,J0003页

作者： Ruth E Belay Gene Omar Huang jim Ken-Chie Shen Edmund Yuey Kun Ko Department of Urology Loma Linda University School of Medicine Loma Linda California USA.

In this review, we examine the evolution and application of various diagnostic modalities for varicoceles starting with venography, scintigraphy, and thermography and their role in the evaluation of a varicocele patient. Some of these methods have been supplanted by less invasive and more easily performed diagnostic modalities, especially ultrasound and Doppler examination of the scrotum. Advances in ultrasound and magnetic resonance imaging hold the potential to expand the role of imaging beyond that of visual confirmation and characterization of varicoceles. The ability to identify the early indicators of testicular dysfunction based on imaging findings may have implications for the management of varicoceles in the future.

关键词： scrotum testis varicocele

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Noether conserved quantities and Lie point symmetries of difference Lagrange-Maxwell equations and lattices

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Chinese Physics B 2009年第7期18卷 2634-2641页

作者：傅景礼聂宁明黄健飞 jiménez Salvador 唐贻发 Vzquez Luis 赵维加 Institute of Mathematical Physics Zhejiang Sci-Tech University State Key Laboratory of Scientific and Engineering Computing ICMSECAcademy of Mathematics and Systems ScienceChinese Academy of Sciences Department of Mathematics Qingdao University Departamento de Matema'tica Aplicada TTII E.T.S.I.Telecomunicacio'nUniversidad Polit'ecnica de Madrid28040-MadridSpain Departamento de Matemática Aplicada Facultad de MatemáticasInstituto de Matemática Interdisciplinar(IMI)Universidad Complutense de Madrid28040-MadridSpain Departamento de Matemática Aplicada Facultad de InformáticaInstituto de Matemática Interdisciplinar(IMI)Universidad Complutense de Madrid28040-MadridSpain

This paper presents a method to find Noether-type conserved quantities and Lie point symmetries for discrete mechanico-electrical dynamical systems,which leave invuriant the set of solutions of the corresponding difference scheme. This approach makes it possible to devise techniques for solving the Lagrange Maxwell equations in differences which correspond to mechanico-electrical systems,by adapting existing differential *** particular,it obtains a new systematic method to determine both the one-parameter Lie groups and the discrete Noether conserved quantities of Lie point symmetries for mechanico-electrical *** an application,it obtains the Lie point symmetries and the conserved quantities for the difference equation of a model that represents a capacitor microphone.

关键词： Lagrange Maxwell equation Lie point symmetry discrete mechanico-electrical system conserved quantity

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The relation between ductility at high temperature and solid solution in Mg alloys

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Journal of Magnesium and Alloys 2022年第1期10卷 241-256页

作者： D.F.Shi C.M.Cepeda-jiménez M.T.Pérez-Prado IM DEA Materials Institute C/Eric Ka ridel228906 GetafeMadridSpain Department of Materials Science Polytechnic University of Madrid/Universidad Politecnica de MadridE.T.S.de Ingenieros de Caminos28040MadridSpain Department of Physical Metallurgy CENIMCSICAv.Gregorio del Amo 828040 MadridSpain

This work investigates the effect of solid solution on ductility and on the activation of individual deformation mechanisms at moderate temperatures and at quasi-static strain rates in Mg-Zn and Mg-Al alloys. With that aim, four solid solution Mg-Zn and Mg-Al binary alloy ingots containing 1 and 2 wt.% solute atoms were subjected to hot rolling and subsequent annealing to generate polycrystals with similar average grain size and basal-type texture for each composition. The activity of the different slip systems after tensile testing at 150°C and at 250°C was evaluated in pure Mg and in the alloys by EBSD-assisted slip trace analysis. In addition, segregation of Zn and Al atoms at grain boundaries during the thermo-mechanical processing was characterized by HAADF-STEM and EDX. It was found that while the addition of Al and Zn atoms to pure Mg does not lead to major changes in the mechanical strength at the investigated temperatures, it does enhance ductility significantly, especially at 250℃. Our results show that this increase in ductility cannot be attributed to a higher activation of non-basal systems in the alloys, as reported earlier, as the incidence of non-basal systems is indeed considerably higher in pure Mg. This work suggests, on the contrary, that the ductility increase may be attributed to the presence of a more homogenous basal activity in the alloys due to a lower degree of orientation clustering, to grain boundary solute segregation, and to a higher slip diffusivity at grain interiors.

关键词： Magnesium Solute segregation Slip trace analysis Ductility Deformation mechanisms

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Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway

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Cellular & Molecular Immunology 2017年第6期14卷 529-545页

作者： Rong Wang Aizhang Xu Xueying Zhang Jie Wu Andrew Freywald Jianqing Xu jim Xiang Cancer Research Cluster Saskatchewan Cancer Agency Saskatoon Saskatchewan Canada S7N4H4 School of Public Health University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 Department of Pathology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5 Shanghai Public Health Clinical Center Fudan University Shanghai 201508 China Department of Oncology College of Medicine University of Saskatchewan Saskatoon Saskatchewan Canada S7N 5E5

CD8＋ cytotoxic T lymphocyte （CTL） exhaustion is a chief issue for ineffective virus elimination in chronic infectious diseases. We generated novel ovalbumin （OVA）-specific OVA-Texo and HIV-specific Gag-Texo vaccines inducing therapeutic immunity. To assess their therapeutic effect in chronic infection, we developed a new chronic infection model by i.v. infecting C57BL/6 mice with the OVA-expressing adenovirus AdVova. During chronic AdVova infection, mouse CTLs were found to express the inhibitory molecules programmed cell-death protein-1 （PD-1） and lymphocyte-activation gene-3 （LAG-3） and to be functionally exhausted, showing a significant deficiency in T-cell proliferation, IFN-7 production and cytolytic effects. Naive CD8＋ T cells upregulated inhibitory PD-ligand 1 （PD-L1）, B- and T-lymphocyte attenuator and T-cell anergy-associated molecules （Grail and Itch） while down-regulating the proliferative response upon stimulation in mice with chronic infection. Remarkably, the OVA-Texo vaccine counteracted T-cell anergy and converted CTL exhaustion. The latter was associated with （i） the upregulation of a marker for CTL functionality, diacetylated histone-H3 （diAcH3）, （ii） a fourfold increase in CTLs, occurring independent of host DCs or CD4＋ T cells, and （iii） the restoration of CTL IFN-7 production and cytotoxicity. In vivo OVA-Texo-stimulated CTLs upregulated the activities of the mTORC1 pathway-related molecules Akt, S6, elF4E and T-bet, and treatment of the CTLs with an mTORC1 inhibitor, rapamycin, significantly reduced the OVA-Texo- induced increase in CTLs. Interestingly, OVA-Texo-mediated CD40L signaling played a critical role in the observed immunological effects. Importantly, the Gag-Texo vaccine induced Gag-specific therapeutic immunity in chronic infection. Therefore, this study should have a serious impact on the development of new therapeutic vaccines for human immunodeficiency virus （HIV-1） infection.

关键词： anti-CD40 Ab CD40L signaling chronic infection CTL exhaustion HIV Gag mTORC1 pathway T-cellanergy therapeutic T-cell vaccine

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Constructing an unbalanced structure toward high working voltage for improving energy density of non-aqueous carbon-based electrochemical capacitors

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Chinese Chemical Letters 2020年第3期31卷 903-908页

作者： Junsheng Zheng Nan Qin Liming Jin Xin Guo Chao Shen Qiang Wu jim PZheng Clean Energy Automotive Engineering Center Tongji University(Jiading Campus)Shanghai 201804China School of Automotive Studies Tongji University(Jiading Campus)Shanghai 201804China Department of Electrical and Computer Engineering Florida A&M University-Florida State University College of EngineeringFL 32304United States

The energy density of non-aqueous carbon-based electrochemical capacitors(cEC)is mainly determined by the specific capacitance and operational voltage *** this study,we propose to construct an unbalanced structure to make full use of stable voltage range for improving energy *** stable voltage range is firstly carefully explored using cyclic *** an unbalanced carbon-based electrochemical capacitor(ucEC)is constructed with an optimized positive electrode to negative electrode weight ratio and voltage *** electrochemical performance is comprehensively investigated,including energy density,power density as well as cycle *** ucEC is capable to deliver an improved energy density up to 64.9 Wh/kg(1.4 times as high as a general cEC)without sacrificing the power density and cycle *** electrode properties after cycling are also analyzed,illustrating the change of electrode potential caused by unbalanced *** proposed structure demonstrates a great potential for improving the energy density at little cost of electrode design and cell configuration.

关键词： Unbalanced electrochemical capacitor Non-aqueous electrolyte High working voltage Practical application High energy density

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Digital thermal monitoring of the Amazon forest:an intercomparison of satellite and reanalysis products

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International Journal of Digital Earth 2016年第5期9卷 477-498页

作者： Juan C.jiménez-Muñoz Cristian Mattar José A.Sobrino Yadvinder Malhi Global Change Unit Image Processing LaboratoryUniversity of ValenciaPaternaSpain Laboratory for Analysis of the Biosphere Department of Environmental Sciences and Renewable Natural ResourcesUniversity of ChileLa PintanaChile School of Geography and Environment Environmental Change InstituteUniversity of OxfordOxfordUK

Remote sensing and climate digital products have become increasingly available in recent *** to these products has favored a variety of Digital Earth studies,such as the analysis of the impact of global warming over different *** study of the Amazon forest response to drought has recently received particular attention from the scientific community due to the occurrence of extreme droughts and anomalous warming over the last *** paper focuses on the differences observed between surface thermal anomalies obtained from remote sensing moderate resolution imaging spectroradiometer(MODIS)and climatic(ERA-Interim)monthly products over the Amazon *** a few exceptions,results show that the spatial pattern of standardized anomalies is similar for both *** terms of absolute anomalies,the differences between the two products show a bias near to zero with a standard deviation of around 0.2 K,although the differences can be up to 1 K over particular regions and *** this general agreement,the proper filtering of MODIS daily values in order to construct a new monthly product showed a dramatic reduction in the number of reliable pixels during the rainy season,while for the dry season this reduction is only seen in Northern Amazonia.

关键词： Thermal anomalies Amazon forest MODIS ERA interim thermal Amazonia

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