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Rumen microbial degradation of bromoform from red seaweed(Asparagopsis taxiformis)and the impact on rumen fermentation and methanogenic archaea

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Journal of Animal Science and Biotechnology 2024年第1期15卷 412-426页

作者： Pedro Romero Alejandro Belanche Elisabeth jiménez Rafael Hueso Eva Ramos-Morales Joan king Salwen Ermias Kebreab David R.Yáñez-Ruiz Estacion Experimental del Zaidin Consejo Superior de Investigaciones Cientificas(CSIC)Profesor Albareda 1Granada 18008Spain Department of Animal Production and Food Sciences University of ZaragozaMiguel Servet 177Saragossa 50013Spain Blue Ocean Barns Inc. Redwood CityCAUSA Department of Animal Science University of CaliforniaDavisCA 95618USA

Background The red macroalgae Asparagopsis is an effective methanogenesis inhibitor due to the presence of halogenated methane(CH_(4))analogues,primarily bromoform(CHBr_(3)).This study aimed to investigate the degradation process of CHBr3 from A taxiformis in the rumen and whether this process is *** in vitro batch culture system was used according to a 2×2 factorial design,assessing two A taxiformis inclusion rates[0(CTL)and 2%DM diet(AT)]and two diets[high-concentrate(HC)and high-forage diet(HF)].Incubations lasted for 72 h and samples of headspace and fermentation liquid were taken at 0,0.5,1,3,6,8,12,16,24,48 and 72 h to assess the pattern of degradation of CHBr_(3) into dibromomethane(CH_(2)Br_(2))and fermentation ***,an in vitro experiment with pure cultures of seven methanogens strains(Methanobrevibacter smithii,Methanobrevibacter ruminantium,Methanosphaera stadtmanae,Methanosarcina barkeri,Methanobrevibacter millerae,Methanorhermobacter wolfei and Methanobacterium mobile)was conducted to test the effects of increasing concentrations of CHBr3(0.4,2,10and 50μmol/L).Results The addition of AT significantly decreased CH_(4) production(P=0.002)and the acetate:propionate ratio(P=0.003)during a 72-h *** concentrations of CHBr_(3) showed a rapid decrease with nearly 90%degraded within the first 3 h of *** the contrary,CH_(2)Br_(2) concentration quickly increased during the first 6 h and then gradually decreased towards the end of the *** CHBr_(3) degradation nor CH_(2)Br_(2) synthesis were affected by the type of diet used as substrate,suggesting that the fermentation rate is not a driving factor involved in CHBr_(3)*** in vitro culture of methanogens showed a dose-response effect of CHBr3 by inhibiting the growth of ***,***,***,***,***,***,and *** The present work demonstrated that CHBr_(3) from *** is quickly degrad

关键词： Bromoform metabolism Dibromomethane metabolism Methane mitigation Methanogens Rumen microbiota Seaweed

Limit load and failure mechanisms of a vertical Hoek-Brown rock slope

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1106-1111页

作者： jim Shiau Warayut Dokduea Suraparb Keawsawasvong Pitthaya Jamsawang School of Engineering University of Southern QueenslandToowoomba4350QLDAustralia Department of Civil Engineering Faculty of EngineeringKing Mongkut’s University of Technology ThonburiBangkokThailand Research Unit in Sciences and Innovative Technologies for Civil Engineering Infrastructures Department of Civil EngineeringThammasat School of EngineeringThammasat UniversityPathumthani12120Thailand Soil Engineering Research Center Department of Civil EngineeringKing Mongkut’s University of Technology North BangkokBangkok10800Thailand

The problem considered in this short note is the limit load determination of a vertical rock *** classical limit theorem is employed with the use of adaptive finite elements and nonlinear programming to determine upper and lower bound limit loads of a Hoek-Brown vertical rock *** objective function of the mathematical programming problem is such as to optimize a boundary load,which is known as the limit load,resembling the ultimate bearing capacity of a strip *** focusing on the vertical slope,parametric studies are carried out for several dimensionless ratios such as the dimensionless footing distance ratio,the dimensionless height ratio,and the dimensionless rock strength ratio.A comprehensive set of design charts is presented,and failure envelopes shown with the results explained in terms of three identified failure mechanisms,*** face,the toe,and the Prandtl-type *** novel results can be used with great confidence in design practice,in particularly noting that the current industry-based design procedures for the presented problem are rarely found.

关键词： Bearing capacity Rock slope Vertical slope Finite element limit analysis Hoek-Brown yield criterion

Rumen microbial degradation of bromoform from red seaweed (Asparagopsis taxiformis) and the impact on rumen fermentation and methanogenic archaea

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Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency of CCR9 in a Murine Model of Antigen-Induced Arthritis

畜牧与生物技术杂志(英文版) 2024年第1期

作者： Pedro Romero Alejandro Belanche Elisabeth jiménez Rafael Hueso Eva Ramos-Morales Joan king Salwen Ermias Kebreab DavidR.Yáñez-Ruiz

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Open Journal of Rheumatology and Autoimmune Diseases 2012年第4期2卷 77-84页

作者： Alison Cartwright Sophie king jim Middleton Oksana Kehoe Faculty of Medicine and Dentistry School of Oral and Dental Sciences University of Bristol Bristol UK Keele University at Robert Jones and Agnes Hunt Orthopaedic Hospital Oswestry UK Keele University at Robert Jones and Agnes Hunt Orthopaedic Hospital Oswestry UK Faculty of Medicine and Dentistry School of Oral and Dental Sciences University of Bristol Bristol UK.

Objectives: Monocytes/macrophages accumulate in the synovial membrane in rheumatoid arthritis and play a key role in disease pathogenesis, contributing to inflammation, cartilage destruction and bone erosion. Identification of molecules involved in monocyte/macrophage recruitment in inflammation is crucial for development of therapeutic interventions. Chemokine receptor CCR9 is up-regulated on these cells in peripheral blood and synovium of rheumatoid patients. This study investigated the course of antigen-induced arthritis in CCR9 deficient C57BL/6 mice in comparison to wild type animals to determine whether CCR9 is critical for disease severity and progression. Methods: Methylated bovine serum albumin was used for induction of uni-lateral arthritis by direct injection into the knee joints of preimmunized animals. Arthritis is confined to the injected joint allowing comparison with the normal opposing joint. Clinical severity of arthritis was assessed by measuring swelling in the arthritic joint in comparison to the normal joint. Histological analysis was performed to assess the extent of leukocyte infiltration and cartilage depletion. Results: Levels of swelling were not significantly different between wild type and CCR9 deficient mice. Similarly there was no significant difference in histological severity of arthritis when comparing CCR9-deficient mice to wild type mice. Conclusions: CCR9 was not required for development of synovial inflammation and cartilage destruction in the anti-gen-induced model of arthritis in C57BL/6 mice in this study. This may reflect a true lack of a pathogenic role of CCR9 on monocyte/macrophage function in vivo or it may reflect differences in the current antigen-induced arthritis model when compared to human RA.

关键词： Chemokine Receptor CCR9 Rheumatoid Arthritis Inflammation Antigen-Induced Arthritis Mouse Mod-el Monocytes/Macrophages

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凯瑟琳吉利厄姆大学预科

建筑学报 2013年第8期 73-77页

作者： jim Luckey Trey Laird 邓洁 Daniel Fletcher Mike Hall Amy king SHW建筑设计公司集团

凯瑟琳吉利厄姆大学预科是一所新颖的培养21世纪技能的学校。精心设计的开放空间赋予整个建筑以蓬勃的生命力,激发了使用者的社会和思想交流,对于组织所有功能区域来说这是最有效的途径。室内外空间的设计组织,在反映高校教学环境特征... 详细信息

凯瑟琳吉利厄姆大学预科是一所新颖的培养21世纪技能的学校。精心设计的开放空间赋予整个建筑以蓬勃的生命力,激发了使用者的社会和思想交流,对于组织所有功能区域来说这是最有效的途径。室内外空间的设计组织,在反映高校教学环境特征的同时,给予高中学生必要的监督。

关键词：大学预科吉利设计组织室内外空间开放空间思想交流功能区域环境特征

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睦谷第一巨人

商业周刊（中文版） 2016年第7期 8-9页

作者： jim Aley lan king 沙坞

不苟言笑且执拗粗暴的安迪-格鲁夫培养出一代科技传奇人物，他们则将格鲁夫视作神一样的存在硅谷充满了逻辑绝对主义者。这种人会坚持一个论点一条路走到黑，不管其他人有什么反响。真的有人会郑重其事提议脱离美国，创建一个科技乌托... 详细信息

不苟言笑且执拗粗暴的安迪-格鲁夫培养出一代科技传奇人物，他们则将格鲁夫视作神一样的存在硅谷充满了逻辑绝对主义者。这种人会坚持一个论点一条路走到黑，不管其他人有什么反响。真的有人会郑重其事提议脱离美国，创建一个科技乌托邦。帮助缔造了这个科技乌托邦的安德鲁·格鲁夫（Andrew Grove），在3月21日因帕金森病去世，享年79岁。

关键词：传奇人物绝对主义帕金森病乌托邦科技安德鲁硅谷

精神病的跨诊断维度:对精神疾病的分类学与研究的意义（英文）

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上海精神医学 2015年第2期27卷 82-86页

作者： jim VAN OS Maastricht University Medical Centre South Limburg Mental Health Research and Teaching Network king’s College London King’s Health Partners Department of Psychosis Studies Institute of Psychiatry

如果精神病是一种跨诊断的维度,精神病性症状的出现受动态变化的情境和情感因素左右,而后者又是可治疗的,那么目前精神科疾病的分类学和治疗研究的方法可能需要修改。迄今为此,无论在临床工作上还是在疾病概念上,占主导地位的方法是将... 详细信息

如果精神病是一种跨诊断的维度,精神病性症状的出现受动态变化的情境和情感因素左右,而后者又是可治疗的,那么目前精神科疾病的分类学和治疗研究的方法可能需要修改。迄今为此,无论在临床工作上还是在疾病概念上,占主导地位的方法是将精神病性症状置于精神分裂症的框架中。然而,终生患病率为1%的精神分裂症只代表了部分预后不佳的精神病谱系障碍,而后者发生更多,终生患病率为3.5%。因此,精神分裂症的研究结果可能反映了预后相关的机制,而非精神病和其他症状维度之间本质上的相关性。同样,常见的非精神病性精神障碍中高达30%的个体有阈下精神病性症状,他们会被归于精神病的跨诊断维度之下,这些精神症状还会影响临床严重程度和治疗有效性。上述发现也同样提示武断区分"精神病性"与"非精神病性"的做法妨碍了临床实践和研究。精神病学诊断手册可以借鉴跨诊断维度(包括精神病的跨诊断维度)的体系。引入跨诊断维度,则既能根据原则进行分类诊断(即疾病分组的特异性),又可结合个体特有的多维度综合评分(即个体特异性)。这样的益处在于促使人们思考在精神病理学中症状之间是如何动态地交互作用的,并思考社会环境是如何影响精神病理症状的。

关键词：精神病分类学尺寸疾病精神分裂症临床实践情感因素精神障碍

Empowerment according to Persons with Severe Mental Illness: Development of the Netherlands Empowerment List and Its Psychometric Properties

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Open Journal of Psychiatry 2017年第1期7卷 18-30页

作者： Wilma Boevink Hans Kroon Philippe Delespaul jim Van Os Trimbos Institute Department of Reintegration Utrecht The Netherlands Department of Psychiatry and Psychology School of Mental Health and Neuroscience EURON Maastricht University Medical Centre Maastricht The Netherlands king’s College London King’s Health Partners Department of Psychosis Studies Institute of Psychiatry London UK

Objectives. It is unclear whether and to what extent purportedly empowering practices in mental health care, like rehabilitation programs, recovery-supporting mental health care environments and peer-run services, contribute to the process of empowerment. Several American empowerment questionnaires have been developed in recent years, facilitating the measurement of empowerment outcomes. Given likely major transatlantic cultural differences in a value-sensitive concept such as empowerment, this article describes the development of the Netherlands Empowerment List (NEL) and its psychometric properties. Methods. Patients in Dutch mental health services provided meaning to the empowerment concept from which the NEL was derived. Based on 531 completed questionnaires, analyses in agreement with COSMIN criteria examined aspects of internal consistency, content validity, structural validity, convergent validity, discriminant validity, reproducibility and responsiveness of the NEL. Results. The NEL is a 40-item self-report questionnaire with six subscales: Social support, Professional help, Connectedness, Confidence and purpose, Self-management and Caring community. Internal consistency (Cronbach’s alpha = 0.94), aspects of validity, reproducibility (intraclass correlation = 0.79) and responsiveness were good. Correlation with existing scales was the highest for the Mental Health Confidence Scale (r = 0.78) and the lowest for the Boston Empowerment Scale (r = 0.61). Conclusion. The NEL appears to be a suitable instrument to capture the dimension of empowerment in European mental health settings.

关键词： Empowerment Psychotic Disorder Recovery

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流程成熟度与CRM选择

中国计算机用户 2002年第43期 41-41页

作者： jim Dickie Sophie king

市场上的CRM解决方案多达上千种,到底哪个最适合自己呢? 这是困扰很多企业的一个问题。常听到的判断标准有价格、性能以及供应商的服务等等。鞋子舒不舒服,要脚说了算。选什么样的软件,也要看企业自身的条件。与客户相关之流程的成熟度... 详细信息

市场上的CRM解决方案多达上千种,到底哪个最适合自己呢? 这是困扰很多企业的一个问题。常听到的判断标准有价格、性能以及供应商的服务等等。鞋子舒不舒服,要脚说了算。选什么样的软件,也要看企业自身的条件。与客户相关之流程的成熟度和选定CRM系统组件之间存在怎样一种关系? 本文作者为我们提供了一个思路。

关键词：企业 CRM系统流程供应商客户市场服务组件软件解决方案