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SARS-CoV-2 triggers Dickkopf-1(Dkk-1)modulation of T helper cells and lung pathology in mice

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Genes & Diseases 2024年第4期11卷 9-12页

作者： Yifan Wu Freedom M.Green Stephen A.Shaw Lauren J.Bonilla Shannon e.Ronca Maria elena Bottazzi Farrah Kheradmand jill e.weatherhead Department of Pathology&Immunology One Baylor PlazaHoustonTX 77030USA Department of Pediatrics One Baylor PlazaHoustonTX 77030USA Department of Medicine One Baylor PlazaHoustonTX 77030USA National School of Tropical Medicine One Baylor PlazaHoustonTX 77030USA Molecular Virology&Microbiology One Baylor PlazaHoustonTX77030USA Biologyof Inflammation Center Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA Michael e.DeBakey VA Center for Translational Research on Inflammatory Diseases HoustonTX 77030USA

Severe acute respiratory syndrome coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)*** viral infections like SARS-CoV-2,a robust anti-viral type 1 immune response,including upregulation of type 1 CD4+T helper cells(Th1),is required for effective viral clearance while minimizing end-organ pathology and collateral tissue damage.

关键词： pathology acute respiratory

primiReference: a reference for analysis of primary-microRNA expression in single-nucleus sequencing data

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Journal of Genetics and Genomics 2023年第2期50卷 108-121页

作者： Amy e.elias Thomas A.Nuñez Bianca Kun jill A.Kreiling Roche WilmingtonMA 01887USA. Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRI02903USA Public Health Genetics University of PittsburghPittsburghPA 15260USA

Single-nucleus RNA-sequencing technology has revolutionized understanding of nuanced changes in gene expression between cell types within ***,our understanding of regulatory RNAs,such as microRNAs(miRNAs),is limited through both single-cell and single-nucleus techniques due to the short length of miRNAs in the cytoplasm and the incomplete reference of longer primary miRNA(pri-miRNA)transcripts in the *** build a custom reference to align and count pri-miRNA sequences in singlenucleus *** young and aged subventricular zone(SVZ)nuclei,we show differential expression of pri-miRNAs targeting genes involved in neural stem cells(NSC)differentiation in the aged ***,using wild-type and 5XFAD mouse model cortex nuclei,to validate the use of primiReference,we find cell-type-specific expression of pri-miRNAs known to be involved in Alzheimer’s disease(AD).pri-miRNAs likely contribute to NSC dysregulation with age and AD *** is paramount in capturing a global profile of gene expression and regulation in single-nucleus data and can provide key insights into cell-type-specific expression of pri-miRNAs,paving the way for future studies of regulation and pathway *** looking at pri-miRNA abundance and transcriptional differences,regulation of gene expression by miRNAs in disease and aging can be further explored.

关键词： Primary-microRNA Aging Subventricular zone Alzheimer’s disease Single-nucleus RNA-Seq microRNA Transcriptomics

Phenotyping for Abiotic Stress Tolerance in Maize

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Journal of Integrative Plant Biology 2012年第4期54卷 238-249页

作者： Benhilda Masuka Jose Luis Araus Biswanath Das Kai Sonder jill e.Cairns International Maize and Wheat Improvement Center(CIMMYT) Unit of Plant Physiology Faculty of BiologyUniversity of Barcelona CIMMYT Km 45 Carretera Mexico-Veracruz

The ability to quickly develop germplasm having tolerance to several complex polygenic inherited abiotic and biotic stresses combined is critical to the resilience of cropping systems in the face of climate change. Molecular breeding offers the tools to accelerate cereal breeding; however, suitable phenotyping proto- cols are essential to ensure that the much-anticipated benefits of molecular breeding can be realized. To facilitate the full potential of molecular tools, greater emphasis needs to be given to reducing the within-experimental site variability, application of stress and characterization of the environment and appropriate phenotyping tools. Yield is a function of many processes throughout the plantcycle, and thus integrative traits that encompass crop performance over time or organization level （i.e. canopy level） will provide a better alternative to instantaneous measurements which provide only a snapshot of a given plant process. Many new phenotyping tools based on remote sensing are now available including non-destructive measurements of growth-related parameters based on spectral reflectance and infrared thermometry to estimate plant water status. Here we describe key field phenotyping protocols for maize with emphasis on tolerance to drought and low nitrogen.

关键词： Drought low nitrogen tolerance maize phenotyping spatial variability.

Dissecting Maize Productivity:Ideotypes Associated with Grain Yield under Drought Stress and Well-watered Conditions

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Journal of Integrative Plant Biology 2012年第12期54卷 1007-1020页

作者： jill e.Cairns Ciro Sanchez Mateo Vargas Raziel Ordoez Jose Luis Araus Global Maize Program International Maize and Wheat Improvement Center(CIMMYT)Mexico D.F.Mexico Bioinformatics and Statistics Unit International Maize and Wheat Improvement Center(CIMMYT)Mexico D.F.Mexico Unit of Plant Physiology Department of Plant BiologyUniversity of BarcelonaBarcelonaSpain

To increase maize （Zea mays L.） yields in drought-prone environments and offset predicted maize yield losses under future climates, the development of improved breeding pipelines using a multi-disciplinary approach is essential. elucidating key growth processes will provide opportunities to improve drought breeding progress through the identification of key phenotypic traits, ideotypes, and donors. In this study, we tested a large set of tropical and subtropical maize inbreds and single cross hybrids under reproductive stage drought stress and well-watered conditions. Patterns of biomass production, senescence, and plant water status were measured throughout the crop cycle. Under drought stress, early biomass production prior to anthesis was important for inbred yield, while delayed senescence was important for hybrid yield. Under well-watered conditions, the ability to maintain a high biomass throughout the growing cycle was crucial for inbred yield, while a stay-green pattern was important for hybrid yield. While new quantitative phenotyping tools such as spectral reflectance （Normalized Difference Vegetation Index, NDVI） allowed for the characterization of growth and senescence patterns as well as yield, qualitative measurements of canopy senescence were also found to be associated with grain yield.

关键词： Climate change drought stress ideotypes maize senescence spectral reflectance.

Cases on human performance improvement technologies

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Cases on human performance improvement technologies

Diabetes mellitus increases risk for colorectal adenomas in younger patients

作者： jill e. Stefaniak.

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World Journal of Gastroenterology 2014年第22期20卷 6946-6952页

作者： Hongha T Vu Nneka Ufere Yan Yan Jean S Wang Dayna S early jill e elwing Division of Gastroenterology Washington UniversitySt. LouisMO 63110United States

AIM: To determine if diabetes mellitus (DM) is associated with increased risk of colorectal adenomas in younger subjects.

关键词： Adenoma Colorectal cancer Diabetes mellitus Colonoscopy Risk factor

In vivo percutaneous reflectance spectroscopy of fatty liver development in rats suggests that the elevation of the scattering power is an early indicator of hepatic steatosis

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Journal of Innovative Optical Health Sciences 2018年第4期11卷 53-71页

作者： Daqing Piao Jerry W.Ritchey GReed Holyoak Corey R.Wall Nigar Sultana jill K.Murray Kenneth e.Bartels School of electrical and Computer engineering Oklahoma State University 202 Engineering South StillwaterOK 74078USA Department of Veterinary Clinical Sciences Center for Veterinary Health Sciences 002 VTH Oklahoma State University StillwaterOK 74078USA Department of Veterinary Pathobiology Center for Veterinary Health Sciences Oklahoma State University 250 McElroy Hall StillwaterOK 74078USA Graduate Program on Interdisciplinary Sciences Oklahoma State University StillwaterOK 74078USA

This study assessed whether there was a scat tering spectral mar ker quantifiable by reflectance measurements that could indicate early development of hepatic steatosis in rats for potential applications to pre procurement organ *** rats were fed a methionine choline-deficient(MCD)diet and eight rats were fed a normal *** assessment of the liver parenchyma of rats in vivo was performed by percut aneous reflect ance spectroscopy using a single fiber probe at the beginning of diet-intake and arbitrary post-diet-intake times up to 11 weeks to render longitudinal *** sampling of the liver over the duration of diet adm inistration was performed on two MCD diet treated rats and one control rat eutha-nized after reflectance spectroscopy *** images of hematoxylin/eosin-stained liver specimens were analyzed morphometrically to evahuate the lipid size changes associated with the level of *** MCD-diet-treated group(n=16)had mild steatosis in seven rats,moderate in three rats,severe in six rats,and no other significant *** control rats(n=8)developed hepatic *** the parameters retrieved from per-SfS,only the scat tering power(can be either positive or negative)appeared to be statist ically diferent between MCD-treated and control *** scattering power for the 16 MCD-diet-treated livers at the time of euthanasia and presenting various levels of steatosis was 033±0.21,in comparison to 0.036±0.25 of the eight control livers(p=0.0189).When evaluated at days 12 and 13 combined,the scattering power of the 16 MCD-diet-treated livers was 032±0.17,in comparison to 0.10±0.11 of the eight control livers(p=0.0017).All of four MCD-treated livers harvested at days 12 and 13 presented mild steatosis with sub-micron size lipid droplets,even though none of the MCD-treated livers were sonogr aphically remarkable for fatty *** elevation of the scattering power may be a valuable marker indicating ear

关键词： Hepatic steatosis difuse reflect ance spectroscopy liver transplant

Roles of the eye care workforce for task sharing in management of diabetic retinopathy in Cambodia

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International Journal of Ophthalmology(english edition) 2018年第1期11卷 101-107页

作者： Mufarriq Shah Gail M.Ormsby Ayesha Noor Rahul Chakrabarti Manfred Morchen Fakir MAmirul Islam CAlex Harper jill e Keeffe Pakistan Institute of Community Ophthalmology Hayatabad Medical Complex Peshawar 25000Pakistan Centre for eye Research Australia Department of Ophthal-mologyUniversity of MelbourneRoyal Victorian Eye and Ear HospitalMelbourneVIC 302Australia Faculty of education Science and BusinessLifestyle Research CentreAvondale College of Higher EducationCooranbongNSW 2265Australia Vision and Dental Care Clinic Peshawar 25000Pakistan CARITAS Takeo eye Hospital Krong Doun Kaev 21151Cambodia Regional office Asia South east CBM International Unit 604 Alabang Business Tower 1216 Acacia AveMuntinlupa City 1799Philippines Statistics Data Science and EpidemiologySwinburne University of TechnologyHawthornVIC 3122Australia LV Prasad eye Institute Hyderabad 500034India

AIM： To identify the current roles of eye and health care workers in eye care delivery and investigate their potential roles in screening and detection for management of diabetic retinopathy（DR） through task ***： Purposive sampling of 24 participants including health administrators, members from non-government organizations and all available eye care workers in Takeo province were recruited. This cross sectional mixed method study comprised a survey and in-depth interviews. Data were collected from medical records at Caritas Takeo eye Hospital（CTeH） and Kiri Vong District Referral Hospital Vision Centre, and a survey and interviews with participants were done to explore the potential roles for task sharing in DR management. Qualitative data were transcribed into a text program and then entered into N-Vivo（version 10） software for data management and analysis. ReSULTS： From 2009 to 2012, a total of 105 178 patients were examined and 14 030 eye surgeries were performed in CTeH by three ophthalmologists supported by ophthalmic nurses in operating and eye examination for patients. Between January 2011 and September 2012, 151 patients（72 males） with retinal pathology including 125（83%） with DR visited CTeH. In addition 170 patients with diabetes were referred to CTeH for eye examinations from Mo Po Tsyo screening programs for people with diabetes. Factors favouring task sharing included high demand for eye care services and scarcity of ***： Task sharing and team work for eye care services is functional. Participants favor the potential role of ophthalmic nurses in screening for DR through task sharing.

关键词： task sharing diabetes diabetic retinopathy human resources Cambodia

平衡越好，跌倒越少鼓励老年女性参与平衡训练

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英国医学杂志中文版 2015年第11期18卷 633-634页

作者： Sarah e Lamb jill e Lamb 沈赟 Botnar Research Centre Nuffield Department of OrthopaedicsRheculoskeletal SciencesUniversity of OxfordOxford OX3 7LD UK Ormskirk UK 上海交通大学附属第六人民医院内分泌代谢科

跌倒是老年人群的一个重大问题，因为其常见并可能导致受伤以及生活质量降低。年龄相关的肌肉强度和神经系统减退会引起行走不稳。进一步引起行动时缺乏信心，某些人会发生严重跌倒。众所周知，强度和平衡训练在预防跌倒和改善行动能力... 详细信息

跌倒是老年人群的一个重大问题，因为其常见并可能导致受伤以及生活质量降低。年龄相关的肌肉强度和神经系统减退会引起行走不稳。进一步引起行动时缺乏信心，某些人会发生严重跌倒。众所周知，强度和平衡训练在预防跌倒和改善行动能力及信心方面效果显著。大多数研究持续最多1年，研究项目需要老年人的时问和精力投入，并不总为大众所接受。

关键词：老年女性平衡训练锻炼方法保健知识