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Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks

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Cancer Biology & Medicine 2013年第4期10卷 192-205页

作者： German G.Gomez jill wykosky Ciro Zanca Frank B.Furnari Webster K.Cavenee Ludwig Institute for Cancer Research University of California San Diego

Receptor tyrosine kinases(RTKs)such as the epidermal growth factor receptor(EGFR)regulate cellular homeostatic *** activates downstream signaling cascades that promote tumor cell survival,proliferation and *** of EGFR signaling as a consequence of overexpression,amplification and mutation of the EGFR gene occurs frequently in several types of cancers and many become dependent on EGFR signaling to maintain their malignant ***,concerted efforts have been mounted to develop therapeutic agents and strategies to effectively inhibit ***,limited therapeutic benefits to cancer patients have been derived from EGFR-targeted therapies.A well-documented obstacle to improved patient survival is the presence of EGFR-inhibitor resistant tumor cell variants within heterogeneous tumor cell ***,we summarize the mechanisms by which tumors resist EGFR-targeted therapies and highlight the emerging role of microRNAs(miRs)as downstream effector molecules utilized by EGFR to promote tumor initiation,progression and that play a role in resistance to EGFR *** also examine evidence supporting the utility of miRs as predictors of response to targeted therapies and novel therapeutic agents to circumvent EGFR-inhibitor resistance mechanisms.

关键词： Epidermal growth factor receptor microRNA tyrosine kinase inhibitors therapeutic resistance

Perturbation Theory for Solutions to Second Order Elliptic Operators with Complex Coefficients and the L^p Dirichlet Problem

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Acta Mathematica Sinica,English Series 2019年第6期35卷 749-770页

作者： Martin DINDO? jill PIPHER School of Mathematics The University of Edinburgh and Maxwell Institute of Mathematical Sciences Department of Mathematics Brown University

We establish a Dahlberg-type perturbation theorem for second order divergence form elliptic operators with complex coefficients. In our previous paper, we showed the following result: If L_0 = div A^0(x)? + B^0(x) · ? is a p-elliptic operator satisfying the assumptions of Theorem 1.1 then the LpDirichlet problem for the operator L_0 is solvable in the upper half-space Rn+. In this paper we prove that the Lpsolvability is stable under small perturbations of L_0. That is if L_1 is another divergence form elliptic operator with complex coefficients and the coefficients of the operators L_0 and L_1 are sufficiently close in the sense of Carleson measures, then the LpDirichlet problem for the operator L_1 is solvable for the same value of p. As a corollary we obtain a new result on Lpsolvability of the Dirichlet problem for operators of the form L = div A(x)? + B(x) · ? where the matrix A satisfies weaker Carleson condition(expressed in term of oscillation of coefficients). In particular the coefficients of A need no longer be differentiable and instead satisfy a Carleson condition that controls the oscillation of the matrix A over Whitney boxes. This result in the real case has been established by Dindoˇs,Petermichl and Pipher.

关键词： Complex coefficients elliptic PDEs perturbation theory boundary value problems

Gairvof-function mutant p53:history and speculation

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Journal of Molecular Cell Biology 2019年第7期11卷 605-609页

作者： jill Bargonetti Carol Prives Department of Biological Sciences Hunter College and The Graduate Center City University of New YorkNew YorkNY 10021USA Department of Biological Sciences Columbia UniversityNew YorkNY 10027USA

Arnold Levine and the history of p53 The history of the p53 tumor suppressor (and of the p53 field of research) is quite *** discovered in the late 1970s as a protein associated with the SV40 large tumor antigen (and also as a protein that was found in some nonvirally transformed cells),p53 was commonly viewed as a facilitator of oncogenic cell transformation (for an excellent review of the early history of p53 see Levine and Oren,2009).It took nearly 10 years for the cancer research field to realize that wild-type p53 is a tumor suppressor protein.

关键词： Levine suppressor protein

Frame loss error concealment for SVC

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 677-683页

作者： PANDIT Purvin BOYCE jill THOMSON Corporate Research Princeton NJ 08540 USA

Scalable video coding (SVC), as the Scalable Extension of H.264/AVC, is an ongoing international video coding standard designed for network adaptive or device adaptive applications and also offers high coding efficiency. However, packet losses often occur over unreliable networks even for base layer of SVC and have severe impact on the playback quality of compressed video. Until now, no literature has discussed error concealment support for standard SVC bit-stream. In this paper, we provide robust and effective error concealment techniques for SVC with spatial scalability. Experimental results showed that the proposed methods provide substantial improvement, both subjectively and objectively, without a significant complexity overhead.

关键词： Adaptive systems Coding errors Computer networks Image compression Robustness (control systems) Standards

gFACs:Gene Filtering,Analysis,and Conversion to Unify Genome Annotations Across Alignment and Gene Prediction Frameworks

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Genomics, Proteomics & Bioinformatics 2019年第3期17卷 305-310页

作者： Madison Caballero jill Wegrzyn Department of Ecology and Evolutionary Biology University of Connecticut

Published genomes frequently contain erroneous gene models that represent issues associated with identification of open reading frames,start sites,splice sites,and related structural *** source of these inconsistencies is often traced back to integration across text file formats designed to describe long read alignments and predicted gene *** addition,the majority of gene prediction frameworks do not provide robust downstream filtering to remove problematic gene annotations,nor do they represent these annotations in a format consistent with current file *** frameworks also lack consideration for functional attributes,such as the presence or absence of protein domains that can be used for gene model *** provide oversight to the increasing number of published genome annotations,we present a software package,the Gene Filtering,Analysis,and Conversion(gFACs),to filter,analyze,and convert predicted gene models and *** software operates across a wide range of alignment,analysis,and gene prediction files with a flexible framework for defining gene models with reliable structural and functional *** supports common downstream applications,including genome browsers,and generates extensive details on the filtering process,including distributions that can be visualized to further assess the proposed gene *** is freely available and implemented in Perl with support from BioPerl libraries at https://***/PlantGenomicsLab/gFACs.

关键词： Genome annotation Bioinformatics Protein annotation Gene prediction Alignment

Treatment of malignant gastric outlet obstruction with endoscopically placed self-expandable metal stents

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World Journal of Gastroenterology 2009年第35期15卷 4365-4371页

作者： jill KJ Gaidos Peter V Draganov Department of Gastroenterology Hepatologyand NutritionUniversity of Florida

Malignant gastroduodenal obstruction can occur in up to 20%of patients with primary pancreatic,gastric or duodenal *** symptoms include nausea,vomiting,abdominal distention,pain and decreased oral intake which can lead to dehydration, malnutrition,and poor quality of *** stent placement has become the primary therapeutic modality because it is safe,minimally invasive,and a cost-effective option for *** can be successfully deployed in the majority of patients. Stent placement appears to lead to a shorter time to symptomatic improvement,shorter time to resumption of an oral diet,and shorter hospital stays as compared with surgical *** of the obstructive symptoms resulting from stent occlusion,due to tumor ingrowth or overgrowth,can be successfully treated with repeat endoscopic stent placement in the majority of the *** endoscopic stenting and surgical bypass are considered palliative treatments and,to date,no improvement in survival with either modality has been demonstrated.A tailored therapeutic approach,taking into consideration patient preferences and involving a multidisciplinary team including the therapeutic endoscopist,surgeon,medical oncologist, radiation therapist,and interventional radiologist, should be considered in all cases.

关键词： Malignant gastric outlet obstruction Endoscopic self-expandable metal stent Palliativetreatment Endoscopy

Development of spinal deformities in the tight-skin mouse

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Bone Research 2017年第1期5卷 63-71页

作者： Bing Li jill PG Urban Jing Yu Department of Orthopedics Tianjin Hospital Department of Physiology Anatomy and GeneticsUniversity of Oxford

Tight-skin （TSK） mice are commonly used as an animal model to study the pathogenesis of Marfan syndrome （MFS）, but little is known of their skeletal phenotype and in particular of the development of the spinal deformities, common in MFS. Here we examined growth of the axial skeletons of TSK and wild-type（B6） mice during their period of rapid growth. The whole bodies of mice, 4-12 weeks of age, were scanned after sacrifice, by micro-computed tomography （microCT）. We reconstructed three-dimensional models of the spine and ribs, and measured vertebral body heights and rib lengths using the Mac-based image-processing software ＂OsiriX＂. Although the TSK mice were smaller than the B6 mice at 4 weeks, they experienced an early growth spurt and by 8 weeks the height, but not the width, of the vertebral body was significantly greater in the TSK mice than the B6 mice. Measurement of the angles of scoliotic and kyphotic curves postmortem in the mice was problematic, hence we measured changes that develop in skeletal elements in these disorders. As a marker of kyphosis, we measured anterior wedging of the vertebral bodies; as a marker for scoliosis we measured asymmetries in rib length. We found, unlike in the B6 mice where the pattern was diffuse, wedging in TSK mice was directly related to spinal level and peaked steeply at the thoracolumbar junction. There was also significant asymmetry in length of the ribs in the TSK mice, but not in the B6 mice. The TSK mice thus appear to exhibit spinal deformities seen in MFS and could be a useful model for gaining understanding of the mechanisms of development of scoliosis and kyphosis in this disorder.

关键词： TSK Development of spinal deformities in the tight-skin mouse Figure

Facile Synthesis of FeS2 Quantum-Dots/Functionalized Graphene-Sheet Composites as Advanced Anode Material for Sodium-ion Batteries

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Chinese Journal of Chemistry 2017年第1期35卷 73-78页

作者： Yiben Shao jill Yue Shuo Sun Hui Xia School of Materials Science and Engineering Nanjing University of Science and Technology Nanjing Jiangsu 210094 China Herbert Gleiter Institute ofNanoscience Nanjing University of Science and Technology Nanjing Jiangsu 210094 China

FeS2 quantum-dots/functionalized graphene-sheet （QDs/FGS） composites are prepared by a facile and scalable method. The FeS2 QDs/FGS composites can be used as anode materials for sodium-ion batteries. The FeS2 QDs/FGS composites can achieve large specific discharge and charge capacities of 742 and 683 mAh·g-1 （based on the total mass of the FeS2 QDs/FGS composites） at the current density of 0.5 A·g-1 in the first cycle, respectively, and retain a reversible charge capacity of 552 mAh·g-1 after 100 cycles. The FeS2 QDs/FGS composites can display high specific capacities of 452 and 315 mAh·g-1 at the high current densities of 2 and 5 A·g-1. These results indicate that the FeS2 QDs/FGS composites have good cycle performance and high rate capability, making them promising candidates as anode material for sodium-ion batteries.

关键词： quantum dots FeS2 functionalized graphene-sheet sodium-ion batteries

Understory vascular plant community assembly in relation to time-since-fire and environmental variables in a Chinese boreal forest

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Journal of Mountain Science 2017年第7期14卷 1317-1328页

作者： LIU Bo YANG Jian jill F.JOHNSTONE Key Laboratory of Forest Ecology and Management Institute of Applied Ecology Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Forestry TP Cooper Building University of Kentucky Department of Biology University of Saskatchewan

Understanding the response of understory vegetation to fire disturbance is vital to biodiversity conservation and management of boreal forests. We surveyed understory vascular plant richness and composition, and measured related environmental variables along a toposequence within three successional stages, initial （3 years post-fire）, early （13 years post-fire） and late （〉1oo years post-fire） successional stages. Using permutation multivariate ANOVA and nonmetric multidimensional scaling, we analyzed how understory species richness and composition change as time-since-fire proceeds, and their correlative relationships with environmental variables. Species richness and composition showed significant differences among the three successional stages. Understory species richness and abundance were significantly associated with time-since-fire, topographic position, elevation and organic layer depth. Among these variables, time-since-fire had the strongest effect and topographic position was the second major factor on affecting understorycommunity assembly. In overwhelmed the effects addition, time-since-fire of soil pH in the initial successional stage and gravimetric soil moisture in early and late successional stages on understory species composition

关键词： Understory richness Composition Firedisturbance Succession Great Xing'an Mountains Ordination