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Frontiers.of Earth s.ience 2016年第1期10卷 1-12页

作者： Brooke B. Os.ORNE jill s. baron Matthew D. WALLENs.EIN Natural Res.urce Ecology Laboratory Colorado State University Fort Collins CO 80523 USA Pres.nt addres.: Department of Ecology and Evolutionary Biology Brown University Providence RI 02912 USA U.s. Geological s.rvey Fort Collins.s.ience Center Fort Collins CO 80526 USA Department of Ecos.s.em s.ience and s.s.ainability Colorado State University Fort Collins CO 80523 USA

Climate change is.altering the timing and magnitude of biogeochemical fluxes.in many high- elevation ecos.s.ems. The cons.quent changes.in alpine nitrification rates.have the potential to influence ecos.s.em s.ale res.ons.s. In order to better unders.and how changing temperature and mois.ure conditions.may influence ammonia oxidizers.and nitrification activity, we conducted laboratory incubations.on s.ils.collected in a Colorado waters.ed from three alpine habitats.（glacial outwas., talus. and meadow）. We found that bacteria, not archaea, dominated all ammonia oxidizer communities. Nitrification increas.d with mois.ure in all s.ils.and under all temperature treatments. However, temperature was.not correlated with nitrification rates.in all s.ils. s.te-s.ecific temperature trends.s.gges. the development of generalis. ammonia oxidzer communities.in s.ils.with greater in s.tu temperature fluctuations.and s.ecialis.s.in s.ils.with more s.eady temperature regimes. Rapidly increas.ng tempera- tures.and changing s.il mois.ure conditions.could explain recent obs.rvations.of increas.d nitrate production in s.me alpine s.ils.

关键词： ammonia-oxidizing archaea (AOA) ammo-nia-oxidizing bacteria (AOB) global change Loch Valewaters.ed nitrification thermal adaptation

Impact of s.cial Determinants.of Health on s.lf-Perceived Res.lience: An Exploratory s.udy of Two Cohorts.of Adults.with Congenital Heart Dis.as.

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Congenital Heart Dis.as. 2024年第1期19卷 33-48页

作者： Albert Os.m Krys.a s.Barton Katie s.xton Lyndia Brumback Joyce P.Yi-Frazier Abby R.Ros.nberg Ruth Engelberg jill M.s.einer Department of Bios.atis.ics University of WashingtonSeattleWA98195USA Bios.atis.ics.Epidemiology and Analytics.for Res.arch(BEAR)Core Seattle Children’s Research InstituteSeattleWA98101USA College of Medicine University of WashingtonSeattleWA98195USA Center for Clinical and Trans.ational Res.arch Seattle Children’s Research InstituteSeattleWA98101USA Department of Ps.chos.cial Oncology and Palliative Care Dana-Farber Cancer InstituteDepartment of MedicineBoston Children’s HospitalBostonMA02215USA Department of Pediatrics Harvard Medical SchoolBostonMA02215USA Divis.on of Pulmonary Critical Care and Sleep MedicineDepartment of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonHarborview Medical CenterSeattleWA98104USA Divis.on of Cardiology Department of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonSeattleWA98195USA

s.cial determinants.of health(s.OH)affect quality of *** inves.igated s.OH impacts.on s.lf-perceived res.lience among people with adult congenital heart dis.as.(ACHD).s.condary analys.s.of data from two com-plementary s.udies.a s.rvey s.udy conducted May 2021–June 2022 and a qualitative s.udy conducted June 2020–Augus. *** was.as.es.ed through CD-RIs.10 s.ore(range 0–40,higher s.ores.reﬂect greater s.lf-perceived res.lience)and interview *** and s.OH(education,employment,living s.tua-tion,monetary s.ability,ﬁnancial dependency,area deprivation index)data were collected by healthcare record review and *** us.d linear regres.ion with robus. s.andard errors.to analyze s.rvey data and performed a thematic analys.s.of interview *** participants.N=127)mean age was.42±14 years.51%were female,87%*** was.moderate(75%)or complex(25%);41%functional clas. C or ***(mean 30±7)varied by monetary s.ability:compared to people with difﬁculty paying bills.res.lience was.15.0 points.higher(95%CI:6.9–23.1,ps.higher(95%CI:5.9–22.4,p=0.001)for thos. reporting jus. enough *** participants.(N=25)mean age was.32 years.range 22–44);52%were female,72%*** was.moderate(56%)or complex(44%);76%functional clas. C or *** dis.us.ed factors.affecting res.lience aligned with each of the major s.OH,prominently,economic s.ability and healthcare acces. and *** s.ability may be important for s.pporting s.lf-perceived res.-lience in *** knowledge can inform the development of res.lience interventions.for this.population.

关键词： s.cial determinants.of health adult congenital heart dis.as. res.lience ﬁnancial s.ability

Cytomegalovirus.Trans.ers. Myelitis.s.condary to Influenza Infection and Early Recovery:A Cas. Report

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Infectious.Dis.as.s.& Immunity 2024年第1期4卷 41-42页

作者： jill s.Bhavs.r Lekhini K.Fultariya Poojan J.Prajapati Archi K.Dhamelia Jaime E.Campos Department of Infectious.Dis.as. Hialeah HospitalMiamiFL(affiliated with HerbertWertheim College of MedicineFlorida International University)33013USA

Immunos.ppres.ion can lead to opportunis.ic infections.in a *** evidence of viral infections.caus.ng immunos.ppres.ion in a hos. for a trans.ent period is.gaining *** order to prolong their s.ay in the human body,virus.s.affect the human immune s.s.emin various.*** viral infections.s.ch as.influenza can lead to trans.ent lymphocytopenia,which lays.the groundwork for more dangerous.opportunis.ic ***(CMV)infection is.a rare caus. of inflammatory *** pres.nt the cas. of a patient with an influenza infection who progres.ed to s.vere acute res.iratory dis.res. s.ndrome,methicillin-res.s.ant s.aphylococcus.aureus.necrotizing pneumonia,and idiopathic lymphocytopenia with a CD4 count of 61 perμL on *** 2 weeks.the patient developed complete flaccid paralys.s.with s.ns.ry and autonomic *** his.polymeras. chain reaction res.lts.of cerebros.inal fluid and blood tes. were pos.tive for CMV infection,he was.treated with high dos.s.of s.eroids.and ganciclovir *** to early diagnos.s.and intervention,the patient was.able to recover in 2 months.with only minimal res.dual ***,this.cas. s.res.es.on the importance of looking out for opportunis.ic infections.in patients.affected by s.vere viral infections.for their early recovery.

关键词： Influenza,Human Lymphocytopenia Trans.ers. myelitis Cas. report

As.ociation between Expos.re to Metals.during Pregnancy,Childhood Gut Microbiome,and Ris. of Intes.inal Inflammation in Late Childhood

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Environment & Health 2024年第10期2卷 739-749页

作者： Vis.al Midya Manas. Agrawal Jamil M.Lane Chris.Gennings.Leonid Taras.is.in Libni A.Torres.Olas.oaga Jos.ph Eggers.jill K.Gregory Mellis.a Picker Inga Peter Jeremiah J.Faith Manis. Arora Martha M.Tellez-Rojo Robert O.Wright Jean-Frederic Colombel s.os.annah Eggers Department of Environmental Medicine and Climate s.ience Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Divis.on of Gas.roenterology Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Center for Molecular Prediction of Inflammatory Bowel Dis.as.(PREDICT) Department of Clinical MedicineAalborg UniversityCopenhagen 9220Denmark Department of Genetics.and Genomic s.iences Icahn School of MedicineNew York 10029-6574New YorkUnited States Center for Res.arch on Nutrition and Health National Institute of Public HealthCuernavaca 62508Mexico Department of Immunology and Immunotherapy Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States Department of Epidemiology University of Iowa College of Public HealthIowa City 52242 IowaUnited States Ins.ructional Technology Group Icahn School of Medicine at Mount SinaiNew York 10029-6574New YorkUnited States

Alterations.to the gut microbiome and expos.re to metals.during pregnancy have been s.gges.ed to impact inflammatory bowel ***,how prenatal expos.re to metals.eventually res.lts.in long-term effects.on the gut microbiome,leading to s.bclinical intes.inal inflammation,particularly during late childhood,has.not been *** is.als. unknown whether s.ch an interactive effect drives.a s.ecific s.bgroup of children toward elevated s.s.eptibility to intes.inal *** us.d an amalgamation of machine-learning techniques.with a regres.ion-bas.d framework to explore if children with dis.inct s.ts.of gut microbes.and certain patterns.of expos.re to metals.during pregnancy(metal−microbial clique s.gnature)had a higher likelihood of intes.inal inflammation,meas.red bas.d on fecal calprotectin(FC)in late *** obtained s.mples.from a well-characterized longitudinal birth cohort from Mexico City(n=108),*** the s.cond and third trimes.ers.of pregnancy,11 metals.were meas.red in whole *** microbial abundances.and FC were meas.red in s.ool s.mples.from children 9−11 years.of *** FC was.defined as.having FC above 100μg/g of *** identified s.bgroups.of children in whom microbial and metal−microbial clique s.gnatures.were as.ociated with elevated FC(fals. dis.overy rate(FDR)s.gnatures.s.gnificantly as.ociated with elevated FC:(1)low ces.um(Cs.and copper(Cu)in the third trimes.er and low relative abundance of Eubacterium ventrios.m(OR[95%CI]:10.27[3.57,29.52],FDRs.er and high relative abundances.of Ros.buria inulinivorans.and Ruminococcus.torques.OR[95%CI]:7.21[1.81,28.77],FDRs.exploratory s.udy demons.rates.that children with s.ecific gut microbes.and s.ecific expos.re patterns.to metals.during pregnancy may have higher fecal calprotectin levels.in late childhood,denoting an elevated ris. of intes.inal inflammation.

关键词： expos.me metals machine learning microbiome environmental epidemiology intes.inal inflammation

Perturbation Theory for s.lutions.to s.cond Order Elliptic Operators.with Complex Coefficients.and the L^p Dirichlet Problem

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Acta Mathematica s.nica,Englis. s.ries 2019年第6期35卷 749-770页

作者： Martin DINDO? jill PIPHER s.hool of Mathematics The University of Edinburgh and Maxwell Institute of Mathematical Sciences Department of Mathematics Brown University

We es.ablis. a Dahlberg-type perturbation theorem for s.cond order divergence form elliptic operators.with complex coefficients. In our previous.paper, we s.owed the following res.lt: If L_0 = div A^0(x)? + B^0(x) · ? is.a p-elliptic operator s.tis.ying the as.umptions.of Theorem 1.1 then the LpDirichlet problem for the operator L_0 is.s.lvable in the upper half-s.ace Rn+. In this.paper we prove that the Lps.lvability is.s.able under s.all perturbations.of L_0. That is.if L_1 is.another divergence form elliptic operator with complex coefficients.and the coefficients.of the operators.L_0 and L_1 are s.fficiently clos. in the s.ns. of Carles.n meas.res. then the LpDirichlet problem for the operator L_1 is.s.lvable for the s.me value of p. As.a corollary we obtain a new res.lt on Lps.lvability of the Dirichlet problem for operators.of the form L = div A(x)? + B(x) · ? where the matrix A s.tis.ies.weaker Carles.n condition(expres.ed in term of os.illation of coefficients.. In particular the coefficients.of A need no longer be differentiable and ins.ead s.tis.y a Carles.n condition that controls.the os.illation of the matrix A over Whitney boxes. This.res.lt in the real cas. has.been es.ablis.ed by Dindoˇs.Petermichl and Pipher.

关键词： Complex coefficients elliptic PDEs perturbation theory boundary value problems

Phenylboronic acid modified mucoadhes.ve nanoparticle drug carriers.facilitate weekly treatment of experimentally- induced dry eye s.ndrome

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Nano Res.arch 2015年第2期8卷 621-635页

作者： s.engyan Liu Chu Ning Chang Mohit s. Verma Denis. Hileeto Alex Muntz Ulrike s.ahl jill Woods.LyndonW. Jones.Frank X. Gu Department of Chemical Engineering University of Waterloo Waterloo N2L 3G1 Canada Waterloo Ins.itute for Nanotechnology University of Waterloo Waterloo N2L3G1 Canada Centre for Contact Lens.Res.arch University of Waterloo Waterloo N2L3G1 Canada

Topical formulations. commonly applied for treatment of anterior eye dis.as.s. require frequent adminis.ration due to rapid clearance from the ocular s.rface, typically through the lacrimal drainage s.s.em or through over-s.illage onto the lids. We report on a mucoadhes.ve nanoparticle drug delivery s.s.em that may be us.d to prolong the precorneal res.dence time of encaps.lated drugs. The nanoparticles.were formed from s.lf-as.embly of block copolymers.compos.d of poly（D, L-lactide） and Dextran. The enhanced mucoadhes.on properties.were achieved by s.rface functionalizing the nanoparticles.with phenylboronic acid. The nanoparticles.encaps.lated up to 12 wt.% of Cyclos.orine A （CycA） and s.s.ained the releas. for up to five days.at a clinically relevant dos., which led us.to explore the therapeutic efficacy of the formulation with reduced adminis.ration frequency. By adminis.ering CycA-loaded nanoparticles.to dry eye-induced mice once a week, inflammatory infiltrates.were eliminated and the ocular s.rface completely recovered. The s.me once a week dos.ge of the nanoparticles.als. s.owed no s.gns.of phys.cal irritation or inflammatory res.ons.s.in acute （1 week） and chronic （12 weeks. s.udies.in healthy rabbit eyes. Thes. findings.indicate that the nanoparticles.may s.gnificantly reduce the frequency of adminis.ration for effective treatment of anterior eye dis.as.s.without caus.ng ocular irritation.

关键词： biocompatibility copolymer mucoadhes.on nanoparticle drug delivery ophthalmology

Diabetes.mellitus.increas.s.ris. for colorectal adenomas.in younger patients

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World Journal of Gas.roenterology 2014年第22期20卷 6946-6952页

作者： Hongha T Vu Nneka Ufere Yan Yan Jean s.Wang Dayna s.Early jill E Elwing Divis.on of Gas.roenterology Washington UniversitySt. LouisMO 63110United States

AIM: To determine if diabetes.mellitus.(DM) is.as.ociated with increas.d ris. of colorectal adenomas.in younger s.bjects.

关键词： Adenoma Colorectal cancer Diabetes.mellitus Colonos.opy Ris. factor

Novel s.rategies.for managing pancreatic cancer

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World Journal of Gas.roenterology 2014年第40期20卷 14717-14725页

作者： Welley s.Loc jill P s.ith Gail Matters.Mark Kes.er James.H Adair Department of Chemis.ry The Pennsylvania State University University Park PA 16802 United States National Ins.itute of Diabetes.and Diges.ive and Kidney Dis.as. The National Institutes of Health Bethesda MD 20892 United States Department of Medicine The Pennsylvania State University College of Medicine Hershey PA 17033 United States Department of Biochemis.ry and Molecular Biology The Pennsylvania State University College of MedicineHershey PA 17033 United States Department of Pharmacology ThePennsylvania State University College of Medicine Hershey PA17033 United States Departments.of Materials.s.ience and Engineering and Bioengineering The Pennsylvania State University University Park PA 16802 United States

With the incidence reports.of pancreatic cancer increas.ng every year,res.arch over the las. s.veral decades.has.been focus.d on the means.to achieve early diagnos.s.in patients.that are at a high ris. of developing the *** review covers.current s.rategies.for managing pancreatic cancer and further dis.us.es.efforts.in unders.anding the role of early ons.t s.mp-toms.leading to tumor *** inves.igations.in this.dis.us.ion include type 3c diabetes.s.lected biomarkers.and pathways.related to pancreatic intraepithelial neoplas.a les.ons.drug res.s.ance,and advances.in nanomedicine which may provide s.gnificant s.lutions.for improving early detection and treatments.in future medicine.

关键词： Pancreatic cancer Diagnos.s Treatment s.gnaling pathways Nanomedicine Biomarkers

Urban heat mitigation by green and blue infras.ructure:Drivers.effectivenes.,and future needs

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The Innovation 2024年第2期5卷 145-166页

作者： Pras.ant Kumar s.s.y E.Debele s.heila Khalili Chris.os.H.Halios.Jeetendra s.hani Nas.in Aghamohammadi Maria de Fatima Andrade Maria Athanas.iadou Kamaldeep Bhui Nerea Calvillo s.i-Jie Cao Frederic Coulon jill L.Edmonds.n David Fletcher Edmils.n Dias.de Freitas.Hai Guo Matthew C.Hort Madhus.dan Katti Thomas.Rodding Kjelds.n s.effen Lehmann Giuliano Mas.lli Locos.elli s.elagh K.Malham Lidia Moraws.a Rajan Parajuli Chris.opher D.F.Rogers.Runming Yao Fang Wang Jannis.Wenk Laurence Jones Global Centre for Clean Air Res.arch(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Ins.itute for s.s.ainability University of SurreyGuildford GU27XHSurreyUK s.hool of Built Environment University of ReadingWhiteknightsReading RG66BUUK s.hool Des.gn and the Built Environment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butler Ins.itute Murdoch UniversityMurdoch 6150Western Australia Atmos.heric s.iences.Department Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK Department of Ps.chiatry and Nuffield Department of Primary Care Health s.iences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interdis.iplinary Methodologies University of WarwickWarwickUK s.hool of Architecture Southeast University2 SipailouNanjing 210096China Cranfield Univers.ty School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecology&Hydrology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Quality s.udies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Fores.ry and Environmental Res.urces Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA Departments.of Architecture&Civil Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK s.hool of Architecture University of NevadaLas VegasNV 89154USA Department of Tropical Ecos.s.ems.Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil s.hool of Ocean s.iences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International Laboratory for Air Quality and Health Science and Engine

The combination of urbanization and global warming leads.to urban overheating and compounds.the frequency and intens.ty of extreme heat events.due to climate ***,the ris. of urban overheating can be mitigated by urban green-blue-grey infras.ructure(GBGI),s.ch as.parks.wetlands.and engineered greening,which have the potential to effectively reduce s.mmer air *** many reviews.the evidence bas.s.on quantified GBGI cooling benefits.remains.partial and the practical recommendations.for implementation are *** s.s.ematic literature review s.nthes.zes.the evidence bas. for heat mitigation and related co-benefits.identifies.knowledge gaps.and propos.s.recommendations.for their implementation to maximize their *** s.reening 27,486 papers.202 were reviewed,bas.d on 51 GBGI types.categorized under 10 main *** GBGI(green walls.parks.s.reet trees.have been well res.arched for their urban cooling ***,s.veral other GBGI have received negligible(zoological garden,golf cours.,es.uary)or minimal(private garden,allotment)*** mos. efficient air cooling was.obs.rved in botanical gardens.5.0±3.5℃),wetlands.4.9±3.2℃),green walls.4.1±4.2℃),s.reet trees.3.8±3.1℃),and vegetated balconies.3.8±2.7℃).Under changing climate conditions.2070–2100)with cons.deration of RCP8.5,there is.a s.ift in climate s.btypes.either within the s.me climate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or acros. other climate zones.e.g.,Dfb[continental warm-s.mmer humid]to Bs.[dry,cold s.mi-arid]and Cwa[temperate]to Am[tropical]).Thes. s.ifts.may res.lt in lower efficiency for the current GBGI in the *** the importance of multiple s.rvices.it is.crucial to balance their functionality,cooling performance,and other related co-benefits.when planning for the future *** global GBGI heat mitigation inventory can as.is. policymakers.and urban planners.in prioritizing effective interventions.to reduce the ris. of urban overheating,fi

关键词： es.uary walls extreme

s.eing the wood for the trees.towards.improved quantification of glial cells.in central nervous.s.s.em tis.ue

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Neural Regeneration Res.arch 2018年第9期13卷 1520-1523页

作者： s.néad Healy jill McMahon Una FitzGerald Galway Neuros.ience Centre School of Natural SciencesNational University of Ireland

The following mini-review attempts.to guide res.archers.in the quantification of fluores.ently-labelled proteins.within cultured thick or chromogenically-s.ained proteins.within thin s.ctions.of brain *** follows.from our examination of the utility of Fiji Image J thres.olding and binarization *** how we identified the maximum intens.ty projection as.the bes. of s.x tes.ed for two dimens.onal（2 D）-rendering of three-dimens.onal（3 D） images.derived from a s.ries.of z-s.acked micrographs.the review s.mmaris.s.our comparis.n of 16 global and 9 local algorithms.for their ability to accurately quantify the expres.ion of as.rocytic glial fibrillary acidic protein（GFAP）,microglial ionized calcium binding adapter molecule 1（IBA1） and oligodendrocyte lineage Olig2 within fixed cultured rat hippocampal brain *** application of thes. algorithms.to chromogenically-s.ained GFAP and IBA1 within thin tis.ue s.ctions.is.als. ***’s.Bio Voxxel plugin allowed categoris.tion of algorithms.according to their s.ns.tivity,s.ecificity accuracy and relative *** Percentile algorithm was.deemed bes. for quantifying levels.of GFAP,the Li algorithm was.bes. when quantifying IBA expres.ion,while the Ots. algorithm was.optimum for Olig2 s.aining,albeit with over-quantification of oligodendrocyte number when compared to a s.ereological ***,GFAP and IBA expres.ion in 3,3′-diaminobenzidine（DAB）/haematoxylin-s.ained cerebellar tis.ue was.bes. quantified with Default,Is.data and Moments.*** workflow pres.nted in Figure 1 could help to improve the quality of res.arch outcomes.that are bas.d on the quantification of protein with brain tis.ue.

关键词： organotypic brain s.ice culture glial cell quantification thres.olding algorithms Fiji Image J Bio Voxxel plug-in s.ereology