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Risk of conduction disturbances following different transcatheter aortic valve prostheses:the role of aortic valve calcifications

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Journal of Geriatric Cardiology 2022年第3期19卷 167-176页

作者： Francesco Pollari Ferdinand Vogt Irena Großmann jill marianowicz Marie Claes Steffen Pfeiffer Johannes Schwab Theodor Fischlein Cardiac Surgery Cardiovascular CenterKlinikum NürnbergParacelsus Medical UniversityNurembergGermany Cardiology Cardiovascular CenterKlinikum NürnbergParacelsus Medical UniversityNurembergGermany Radiology Klinikum NürnbergParacelsus Medical UniversityNurembergGermany

OBJECTIVES To assess the impact of prosthesis choice and aortic valve calcifications on the occurrence of conduction disturb-ances after transcatheter aortic valve implantation(TAVI).METHODS We retrospectively analyzed the preoperative clinical characteristics,electrocardiograms,contrast-enhanced mul-tidetector computed tomography scans and procedural strategies of patients who underwent TAVI in our center between January 2012 and June 2017.Quantification of calcium volume was performed for each aortic cusp above(aortic valve)and below(left ventricular outflow tract,LVOT)the basal plane.Multivariate analysis was performed to evaluate risk factors for the onset of new bundle branch block(BBB),transient and permanent atrioventricular block(tAVB,pAVB).RESULTS A total of 569 patients were included in the study.Six different prostheses were implanted(Edwards Sapien XT,n=162;Edwards Sapien 3,n=240;Medtronic CoreValve,n=27;Medtronic CoreValve Evolut R,n=21;Symetis Acurate,n=56;Sy-metis Acurate neo,n=63).The logistic regression analysis for BBB showed association with baseline left anterior hemiblock.The logistic regression for tAVB,found the prior valvuloplasty and the balloon post-dilatation associated with the outcome.Baseline left and right BBB,degree of oversizing,and LVOT calcification beneath the non-coronary cusp were associated with pAVB.Neither the prosthesis model,nor the use of a self-expandable prosthesis showed statistical significance with the above-men-tioned outcomes on univariate analysis.CONCLUSIONS LVOT calcification beneath the non-coronary cusp,baseline left anterior hemiblock,right BBB,balloon post-dilatation,prior valvuloplasty and oversizing are independently associated with postprocedural conduction disturbances after TAVI.Use of a self-expandable prosthesis may show a lower incidence of AVB,if applied in lower calcified aortic valves.

关键词： aortic balloon conduction

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SARS-CoV-2 triggers Dickkopf-1(Dkk-1)modulation of T helper cells and lung pathology in mice

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Genes & Diseases 2024年第4期11卷 9-12页

作者： Yifan Wu Freedom M.Green Stephen A.Shaw Lauren J.Bonilla Shannon E.Ronca Maria Elena Bottazzi Farrah Kheradmand jill E.Weatherhead Department of Pathology&Immunology One Baylor PlazaHoustonTX 77030USA Department of Pediatrics One Baylor PlazaHoustonTX 77030USA Department of Medicine One Baylor PlazaHoustonTX 77030USA National School of Tropical Medicine One Baylor PlazaHoustonTX 77030USA Molecular Virology&Microbiology One Baylor PlazaHoustonTX77030USA Biologyof Inflammation Center Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA Michael E.DeBakey VA Center for Translational Research on Inflammatory Diseases HoustonTX 77030USA

Severe acute respiratory syndrome coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)pandemic.In viral infections like SARS-CoV-2,a robust anti-viral type 1 immune response,including upregulation of type 1 CD4+T helper cells(Th1),is required for effective viral clearance while minimizing end-organ pathology and collateral tissue damage.

关键词： pathology acute respiratory

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Impact of Social Determinants of Health on Self-Perceived Resilience: An Exploratory Study of Two Cohorts of Adults with Congenital Heart Disease

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Congenital Heart Disease 2024年第1期19卷 33-48页

作者： Albert Osom Krysta S.Barton Katie Sexton Lyndia Brumback Joyce P.Yi-Frazier Abby R.Rosenberg Ruth Engelberg jill M.Steiner Department of Biostatistics University of WashingtonSeattleWA98195USA Biostatistics Epidemiology and Analytics for Research(BEAR)Core Seattle Children’s Research InstituteSeattleWA98101USA College of Medicine University of WashingtonSeattleWA98195USA Center for Clinical and Translational Research Seattle Children’s Research InstituteSeattleWA98101USA Department of Psychosocial Oncology and Palliative Care Dana-Farber Cancer InstituteDepartment of MedicineBoston Children’s HospitalBostonMA02215USA Department of Pediatrics Harvard Medical SchoolBostonMA02215USA Division of Pulmonary Critical Care and Sleep MedicineDepartment of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonHarborview Medical CenterSeattleWA98104USA Division of Cardiology Department of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonSeattleWA98195USA

Social determinants of health(SDOH)affect quality of life.We investigated SDOH impacts on self-perceived resilience among people with adult congenital heart disease(ACHD).Secondary analysis of data from two com-plementary studies:a survey study conducted May 2021–June 2022 and a qualitative study conducted June 2020–August 2021.Resilience was assessed through CD-RISC10 score(range 0–40,higher scores reﬂect greater self-perceived resilience)and interview responses.Sociodemographic and SDOH(education,employment,living situa-tion,monetary stability,ﬁnancial dependency,area deprivation index)data were collected by healthcare record review and self-report.We used linear regression with robust standard errors to analyze survey data and performed a thematic analysis of interview data.Survey participants(N=127)mean age was 42±14 years;51%were female,87%white.ACHD was moderate(75%)or complex(25%);41%functional class C or D.Resilience(mean 30±7)varied by monetary stability:compared to people with difﬁculty paying bills,resilience was 15.0 points higher(95%CI:6.9–23.1,p<0.001)for people reporting having enough money and 14.2 points higher(95%CI:5.9–22.4,p=0.001)for those reporting just enough money.Interview participants’(N=25)mean age was 32 years(range 22–44);52%were female,72%white.ACHD was moderate(56%)or complex(44%);76%functional class C or D.Participants discussed factors affecting resilience aligned with each of the major SDOH,prominently,economic stability and healthcare access and quality.Financial stability may be important for supporting self-perceived resi-lience in ACHD.This knowledge can inform the development of resilience interventions for this population.

关键词： Social determinants of health adult congenital heart disease resilience ﬁnancial stability

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Finding biomarkers of experience in animals

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Journal of Animal Science and Biotechnology 2024年第3期15卷 925-944页

作者： Sarah Babington Alan J.Tilbrook Shane K.Maloney jill N.Fernandes Tamsyn M.Crowley Luoyang Ding Archa H.Fox Song Zhang Elise A.Kho Daniel Cozzolino Timothy J.Mahony Dominique Blache School of Agriculture and Environment The University of Western AustraliaCrawleyWA 6009Australia Centre for Animal Science The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia School of Veterinary Science The University of QueenslandGattonQLD 4343Australia School of Human Sciences The University of Western AustraliaCrawleyWA 6009Australia School of Medicine Deakin UniversityGeelongVIC 3217Australia Poultry Hub Australia University of New EnglandArmidaleNSW 2350Australia College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China Centre for Nutrition and Food Sciences The Queensland Alliance for Agriculture and Food InnovationThe University of QueenslandSt LuciaQLD 4072Australia

At a time when there is a growing public interest in animal welfare,it is critical to have objective means to assess the way that an animal experiences a situation.Objectivity is critical to ensure appropriate animal welfare outcomes.Existing behavioural,physiological,and neurobiological indicators that are used to assess animal welfare can verify the absence of extremely negative outcomes.But welfare is more than an absence of negative outcomes and an appropriate indicator should reflect the full spectrum of experience of an animal,from negative to positive.In this review,we draw from the knowledge of human biomedical science to propose a list of candidate biological markers(biomarkers)that should reflect the experiential state of non-human animals.The proposed biomarkers can be classified on their main function as endocrine,oxidative stress,non-coding molecular,and thermobiological markers.We also discuss practical challenges that must be addressed before any of these biomarkers can become useful to assess the experience of an animal in real-life.

关键词： Animal experience Animal welfare Biomarker Stress Welfare assessment

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Cytomegalovirus Transverse Myelitis Secondary to Influenza Infection and Early Recovery:A Case Report

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Infectious Diseases & Immunity 2024年第1期4卷 41-42页

作者： jill S.Bhavsar Lekhini K.Fultariya Poojan J.Prajapati Archi K.Dhamelia Jaime E.Campos Department of Infectious Disease Hialeah HospitalMiamiFL(affiliated with HerbertWertheim College of MedicineFlorida International University)33013USA

Immunosuppression can lead to opportunistic infections in a host.The evidence of viral infections causing immunosuppression in a host for a transient period is gaining attention.In order to prolong their stay in the human body,viruses affect the human immune systemin various ways.Common viral infections such as influenza can lead to transient lymphocytopenia,which lays the groundwork for more dangerous opportunistic infections.Cytomegalovirus(CMV)infection is a rare cause of inflammatory myelopathy.We present the case of a patient with an influenza infection who progressed to severe acute respiratory distress syndrome,methicillin-resistant Staphylococcus aureus necrotizing pneumonia,and idiopathic lymphocytopenia with a CD4 count of 61 perμL on arrival.After 2 weeks,the patient developed complete flaccid paralysis with sensory and autonomic dysfunction.Because his polymerase chain reaction results of cerebrospinal fluid and blood test were positive for CMV infection,he was treated with high doses of steroids and ganciclovir intravenously.Due to early diagnosis and intervention,the patient was able to recover in 2 months with only minimal residual weakness.Thus,this case stresses on the importance of looking out for opportunistic infections in patients affected by severe viral infections for their early recovery.

关键词： Influenza,Human Lymphocytopenia Transverse myelitis Case report

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九龙峰下儿童营地,尊重自然的乌托邦

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艺术与设计 2024年第2期 124-127页

作者：吉丽无不详罗宇杰工作室

在黄山九龙峰自然保护区中,出现了一座怪异的、与周遭建筑格格不入的,却又带着温度的建筑。这是前不久获得法国Créateurs设计奖(The Créateurs Design Awards)的九龙峰下儿童营地。奖项设立于2020年,每年举办一届,旨在表彰建筑、室内... 详细信息

在黄山九龙峰自然保护区中,出现了一座怪异的、与周遭建筑格格不入的,却又带着温度的建筑。这是前不久获得法国Créateurs设计奖(The Créateurs Design Awards)的九龙峰下儿童营地。奖项设立于2020年,每年举办一届,旨在表彰建筑、室内设计、产品设计、摄影、新闻和策展方面的杰出作品。

关键词：室内设计产品设计设计奖乌托邦尊重自然营地九龙

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阿拉伯字体设计,探寻神秘的桥梁

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艺术与设计 2024年第2期 20-61页

作者：吉丽 Thames&Hudson(图) 不详

全球超过4.4亿人讲阿拉伯语,但阿拉伯国家与其他国家之间的文化差异所带来的认知鸿沟依然存在,固然神秘,但也为全球化浪潮中的文化交融与碰撞带来困难。语言是文化的载体,也是交流的桥梁。当我们尝试跨越这道桥梁,走向一个陌生而又庞大... 详细信息

全球超过4.4亿人讲阿拉伯语,但阿拉伯国家与其他国家之间的文化差异所带来的认知鸿沟依然存在,固然神秘,但也为全球化浪潮中的文化交融与碰撞带来困难。语言是文化的载体,也是交流的桥梁。当我们尝试跨越这道桥梁,走向一个陌生而又庞大的阿拉伯语使用者群体时,理解其背后的历史、宗教、文化细微差别,就显得尤为重要。

关键词：字体设计细微差别阿拉伯语全球化浪潮认知鸿沟文化差异交流的桥梁神秘

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Urban heat mitigation by green and blue infrastructure:Drivers,effectiveness,and future needs

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The Innovation 2024年第2期5卷 145-166页

作者： Prashant Kumar Sisay E.Debele Soheila Khalili Christos H.Halios Jeetendra Sahani Nasrin Aghamohammadi Maria de Fatima Andrade Maria Athanassiadou Kamaldeep Bhui Nerea Calvillo Shi-Jie Cao Frederic Coulon jill L.Edmondson David Fletcher Edmilson Dias de Freitas Hai Guo Matthew C.Hort Madhusudan Katti Thomas Rodding Kjeldsen Steffen Lehmann Giuliano Maselli Locosselli Shelagh K.Malham Lidia Morawska Rajan Parajuli Christopher D.F.Rogers Runming Yao Fang Wang Jannis Wenk Laurence Jones Global Centre for Clean Air Research(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for Sustainability University of SurreyGuildford GU27XHSurreyUK School of Built Environment University of ReadingWhiteknightsReading RG66BUUK School Design and the Built Environment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butler Institute Murdoch UniversityMurdoch 6150Western Australia Atmospheric Sciences Department Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK Department of Psychiatry and Nuffield Department of Primary Care Health Sciences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interdisciplinary Methodologies University of WarwickWarwickUK School of Architecture Southeast University2 SipailouNanjing 210096China Cranfield University School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecology&Hydrology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Quality Studies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Forestry and Environmental Resources Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA Departments of Architecture&Civil Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK School of Architecture University of NevadaLas VegasNV 89154USA Department of Tropical Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School of Ocean Sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International Laboratory for Air Quality and Health Science and Engine

The combination of urbanization and global warming leads to urban overheating and compounds the frequency and intensity of extreme heat events due to climate change.Yet,the risk of urban overheating can be mitigated by urban green-blue-grey infrastructure(GBGI),such as parks,wetlands,and engineered greening,which have the potential to effectively reduce summer air temperatures.Despite many reviews,the evidence bases on quantified GBGI cooling benefits remains partial and the practical recommendations for implementation are unclear.This systematic literature review synthesizes the evidence base for heat mitigation and related co-benefits,identifies knowledge gaps,and proposes recommendations for their implementation to maximize their benefits.After screening 27,486 papers,202 were reviewed,based on 51 GBGI types categorized under 10 main divisions.Certain GBGI(green walls,parks,street trees)have been well researched for their urban cooling capabilities.However,several other GBGI have received negligible(zoological garden,golf course,estuary)or minimal(private garden,allotment)attention.The most efficient air cooling was observed in botanical gardens(5.0±3.5℃),wetlands(4.9±3.2℃),green walls(4.1±4.2℃),street trees(3.8±3.1℃),and vegetated balconies(3.8±2.7℃).Under changing climate conditions(2070–2100)with consideration of RCP8.5,there is a shift in climate subtypes,either within the same climate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or across other climate zones(e.g.,Dfb[continental warm-summer humid]to BSk[dry,cold semi-arid]and Cwa[temperate]to Am[tropical]).These shifts may result in lower efficiency for the current GBGI in the future.Given the importance of multiple services,it is crucial to balance their functionality,cooling performance,and other related co-benefits when planning for the future GBGI.This global GBGI heat mitigation inventory can assist policymakers and urban planners in prioritizing effective interventions to reduce the risk of urban overheating,filling research gaps,and promoting community resi

关键词： estuary walls extreme

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瓦莱里奥·佩莱格里尼:寻找个人风格的平衡

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艺术与设计 2024年第3期 36-37页

作者：吉丽三度(图) 不详

瓦莱里奥·佩莱格里尼(Valerio Pellegrini)以其浓烈的色彩和精心设计的图形而备受关注。在米兰理工大学获得传播设计硕士学位后,佩莱格里尼成为了一名传播设计师,专注于数据可视化、平面设计、插图和编辑设计。

关键词：硕士学位数据可视化瓦莱里奥平面设计米兰理工大学个人风格佩莱格里尼插图

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安东尼奥·法拉奇:严谨与美感的视觉表达

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艺术与设计 2024年第3期 38-39页

作者：吉丽三度(图) 不详

“信息图表设计是通过科学严谨性和艺术美感将数据转化为视觉表达的过程。”安东尼奥·法拉奇(Antonio Farach)出生于中美洲的洪都拉斯,在信息图表领域工作已经超过二十年。法拉奇就职于马斯喀特媒体集团,是阿曼苏丹国领先的媒体集团,... 详细信息

“信息图表设计是通过科学严谨性和艺术美感将数据转化为视觉表达的过程。”安东尼奥·法拉奇(Antonio Farach)出生于中美洲的洪都拉斯,在信息图表领域工作已经超过二十年。法拉奇就职于马斯喀特媒体集团,是阿曼苏丹国领先的媒体集团,旗下拥有多份阿拉伯语和英语的报纸和周刊。

关键词：安东尼奥法拉奇视觉表达阿曼苏丹国信息图表设计数据转化科学严谨性阿拉伯语

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