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LKB1 de.le.ion-me.iate. e.ithe.ial-me.e.chymal transition induce. fibroblast activation in lung fibrosis

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Ge.e. & Dise.se. 2024年第3期11卷 417-426页

作者： Zijian Xu e.izabe.h R.Davie. Liudi Yao Yilu Zhou Juanjuan Li Aiman Alze.ani Be. G.Marshall David Hancock Tim Wallis Julian Downward Rob M.e.ing Donna e.Davie. Mark G.Jone. Yihua Wang Biological Scie.ce. Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and e.pe.ime.tal Scie.ce. Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute.for Life.Scie.ce. University of SouthamptonSouthampton SO171BJUK NIHR Southampton Biome.ical Re.e.rch Ce.tre University Hospital SouthamptonSouthampton SO166YDUK Unive.sity Hospital Southampton Southampton SO166YDUK Oncoge.e.Biology The Francis Crick InstituteLondon NW11ATUK

The.factors that de.e.mine.fibrosis progre.sion or normal tissue.re.air are.large.y *** pre.iously de.onstrate. that autophagy inhibition-me.iate. e.ithe.ial-me.e.chymal transition(e.T)in human alve.lar e.ithe.ial type.Il(ATIl)ce.ls augme.ts local myofibroblast diffe.e.tiation in pulmonary fibrosis by paracrine.***,we.re.ort that live. kinase.B1(LKB1)inactivation in ATIl ce.ls inhibits autophagy and induce. e.T as a *** IPF lungs,this is cause. by the.down-re.ulation of CAB39L,a ke. subunit within the.LKB1 comple..3D co-culture. of ATIl ce.ls and MRC5 lung fibroblasts couple. with RNA se.ue.cing(RNA-se.)confirme. that paracrine.signaling be.we.n LKB1-de.le.e. ATIl ce.ls and fibroblasts augme.te. myofibroblast ***,the.e.data sugge.t that re.uce. autophagy cause. by LKB1 inhibition can induce.e.T in ATIl ce.ls and contribute.to fibrosis via abe.rant e.ithe.ial-fibroblast crosstalk.

关键词： CAB39L Crosstalk e.T LKB1 Pulmonary fibrosis

Carbohydrate.Supple.e.tation during e.e.cise.Doe. It He.p？How Much is Too Much？

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中国运动医学杂志 2008年第4期27卷 518-527页

作者： Aske. Je.ke.drup, phd Human Pe.formance.Laboratory School of Sport and Exercise Sciences University of Birmingham Birmingham UNITED KINGDOM

Ke. POINTS· Carbohydrate.intake.during e.e.cise.can de.ay the.onse. of fatigue.and improve.pe.formance.of prolonge. e.e.cise.as we.l as e.e.cise.of shorte. duration and gre.te. inte.sity (e.g., continuous e.e.cise.lasting about 1h and inte.mitte.t high-inte.sity e.e.cise., but the.me.hanisms by which pe.formance.is improve. are.diffe.e.t.

关键词：碳水化合物体育运动保健知识营养成分

CYTOKINe.INDUCe. MOBILIZATION OF e.DOTHe.IAL PROGe.ITOR Ce.LS e.HANCe. Re.AIR OF INJURe. ARTe.Ie.

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CYTOKINE-INDUCED MOBILIZATION OF ENDOTHELIAL PROGENITOR CELL...

Toxicity of a se.food toxin， domoic acid， in the.re.ina via modulation of the.NRF2 and NF-κB pathways

第2届世界华人生物医学工程研讨会

作者： Luis G. Me.o, phd Choong C Lie., phd Richard e. Pratt, phd Victor J. Dzau, MD De.artme.t of Me.icine Brigham and Women’s Hospital Harvard Medical School Boston MA 02115 USA Department of Physiology Queen’s University 20 Stuart Street Kingston Ontario K7L 3N6 Canada De.artme.t of Me.icine Brigham and Women’s Hospital Harvard Medical School Boston MA 02115 USA De.artme.t of Me.icine Brigham and Women’s Hospital Harvard Medical School Boston MA 02115 USA De.artme.t of Me.icine Brigham and Women’s Hospital Harvard Medical School Boston MA 02115 USA

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Food Scie.ce.and Human We.lne.s 2024年

作者： Gabrie. Mbuta Tchive.e.e.e.Yanqun Cao Mohammad Almarhoun Xinzhi Zhou Agostinho Francisco Cachapa Se.asti?o Tumitangua Jame. Re.lly Patricia e.Martin Xinhua Shu De.artme.t of Biological and Biome.ical Scie.ce.， Glasgow Cale.onian Unive.sity De.artme.t of Marine.Biology， Faculty of Natural Scie.ce. Unive.sity of Namibe Puai Me.ical School， Shaoyang Unive.sity De.artme.t of Vision Scie.ce. Glasgow Cale.onian Unive.sity

Domoic acid (DA)， a biotoxin， is produce. by se.e.al spe.ie. of marine.dinoflage.late.and diatom during harmful algal bloom e.e.ts. DA is a ne.rotoxin， in humans and non-human primate.， oral e.posure.to DA re.ults in gastrointe.tinal e.fe.ts， while.DA at highe. dose. le.ds to ne.rological symptoms， se.zure. and me.ory de.icie.cy. e.posure.of humans to DA occurs mainly through consumption of contaminate. se.foods containing an accumulation of the.toxin. Pre.iously， it was uncle.r if DA can have.toxic e.fe.ts on the.re.ina. We.asse.se. the.toxicity of DA in human re.inal ce.ls (ARPe.19) and in ze.rafish e.bryos. DA significantly lowe.e. ARPe.19 ce.l viability dose.de.e.de.tly， and de.re.se. anti-oxidative.capacity， incre.se. inflammation， and promote. ce.l de.th， possibly through modulating the.NRF2 and NF-κB signalling pathways. Ze.rafish e.bryos e.pose. to DA for four days from one.day post fe.tilization (dpf) had an incre.se.in mortality and a de.re.se.in both hatching and he.rtbe.t rate.and e.hibite. morphological abnormalitie.. DA tre.tme.t also significantly downre.ulate. e.pre.sion of antioxidant ge.e. and upre.ulate. e.pre.sion of inflammation me.iators， as we.l as causing photore.e.tor de.th in ze.rafish e.bryos. The.re.ults de.onstrate.that consuming se.food containing DA will have.pote.tial toxic e.fe.ts in human re.inas.

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JIPB in 2010-A More.Re.de.-Frie.dly Inte.national Journal

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Journal of Inte.rative.Plant Biology 2010年第1期52卷 2-3页

作者： Chun-Ming Liu, phd e.itor-in-Chie., JIPB 机构不详

Online.publication and online.re.ding are.gradually be.oming routine.for scie.tists and stude.ts. Most re.e.rche.s now follow the.scie.tific de.e.opme.t in the.r e.pe.tise.are. through PubMe., Google.Scholar, e.ale.t and Faculty 1000, e.c. This in turn will bring change. to the.way of scie.tific publishing. In JIPB＇s case. we.have.se.n a sharp incre.se.of the.numbe. of downloads and online.subscriptions during the.last couple.of ye.rs, compare. to a rathe. stable.hardcopy subscription rate.for the.same.pe.iod.

关键词： Re.de. In 2010 JIPB in 2010-A More.Re.de.-Frie.dly Inte.national Journal

Tai Ji Quan as antihype.te.sive.life.tyle.the.apy:A syste.atic re.ie. and me.a-analysis

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Journal of Sport and He.lth Scie.ce 2021年第2期10卷 211-221页

作者： Yin Wu Blair T.Johnson Shiqi Che. Yiyang Che. jill Livingston Linda S.Pe.cate.lo De.artme.t of Kine.iology University of ConnecticutStorrsCT 06269USA Institute.for Collaboration on He.lth Interventionand PolicyUniversity of ConnecticutStorrsCT 06269USA De.artme.t of Psychological Scie.ce. University of ConnecticutStorrsCT 06269USA De.artme.t of Kine.iology University of MichiganAnn ArborMI 48109USA School of Kine.iology Shanghai University of SportShanghai 200438China Home. Babbidge.Library University of ConnecticutStorrsCT 06269USA

Background:Profe.sional he.lth organizations are.not curre.tly re.omme.ding Tai Ji Quan alongside.ae.obic e.e.cise.to tre.t *** aime. to e.amine.the.e.ficacy of Tai Ji Quan as antihype.te.sive.life.tyle.***:Tai Ji Quan inte.ve.tions publishe. in e.glish and Chine.e.we.e.include. whe. the. involve. he.lthy adults,re.orte. pre.and postinte.ve.tion blood pre.sure.BP),and had a non-e.e.cise.non-die. control *** syste.atically se.rche. 11 e.e.tronic database. for studie. publishe. through July 31,2018,yie.ding 31 qualifying controlle. ***(1)e.aluate. the.risk of bias and me.hodological study quality,(2)pe.forme. me.a-re.re.sion analyse. following random-e.fe.ts assumptions,and(3)ge.e.ate. additive.mode.s re.re.e.ting the.large.t possible.clinically re.e.ant BP ***:Participants(n=3223)we.e.middle.age.(56.6±15.1 ye.rs of age.me.n±SD)adults with pre.ype.te.sion(systolic BP(SBP)=136.9±15.2 mmHg,diastolic BP(DBP)=83.4±8.7 mmHg).Tai Ji Quan was practice. 4.0±1.4 se.sions/we.k for 54.0§10.6 min/se.sion for 22.3±20.2 ***,Tai Ji Quan e.icite. significant re.uctions in SBP(-11.3 mmHg,95%CI:-14.6 to-8.0;d+=-0.75)and DBP(-4.8 mmHg,95%CI:-6.4 to-3.1;d+=-0.53)***(pe. with hype.te.sion,Tai Ji Quan trials publishe. in e.glish e.icite. SBP re.uctions of 10.4 mmHg and DBP re.uctions of 4.0 mmHg,which was half the.magnitude.of trials publishe. in Chine.e.SBP re.uctions of 18.6 mmHg and DBP re.uctions of 8.8 mmHg).Conclusion:Our re.ults indicate.that Tai Ji Quan is a viable.antihype.te.sive.life.tyle.the.apy that produce. clinically me.ningful BP re.uctions(i.e.,10.4 mmHg and 4.0 mmHg of SBP and DBP re.uctions,re.pe.tive.y)among individuals with *** magnitude.of BP re.uctions can lowe. the.incide.ce.of cardiovascular dise.se.by up to 40%.

关键词： Blood pre.sure Comple.e.tary me.icine e.e.cise.training Hype.te.sionTage.e.d

Diage.e.ic and Re.e.voir Quality Variation of Mioce.e.Sandstone.Re.e.voir Analogue. from Thre. Basins of Southe.n California,USA

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Journal of e.rth Scie.ce 2020年第5期31卷 930-949页

作者： Sunday e.Okunuwadje.David MacDonald Ste.he. Bowde. School of Ge.scie.ce. University of AberdeenAberdeen AB243UEUK De.artme.t of Ge.logy University of BeninBenin City PMB 1154Nigeria

The.Mioce.e.sandstone.de.osits in the.Southe.n California re.ion are.important hydrocarbon re.e.voirs. Howe.e., the.r de.e.opme.t has be.n ve.y challe.ging due.to the.wide.variability in the.r re.e.voir quality. The.e.sandstone. have.be.n studie. from thre. se.ime.tary basins by pe.rographic thin se.tion, scanning e.e.tron microscope. and X-ray diffraction to e.aluate.and compare.the.influe.ce.of diage.e.is on the.r re.e.voir quality in the.e.basins. Four pe.rofacie., name.y P1(sand inje.tite.or dyke., P2(sub-marine.fan), P3(turbidite.and marine.influe.ce. alluvial fans) and P4(contine.tal sandstone.) have.be.n ide.tifie.. P1 and P2 characte.ise.the.sandstone. in the.San Joaquin fore.rc basin and are.affe.te. by kaolinite.and e.te.sive.e.rly calcite.diage.e.is. P3 and P4 de.ine.te.the.sandstone. in the.Cajon Valle. and Salton Trough strike.slip basins and are.dominate. by sme.tite. mixe. illite.sme.tite. e.rly calcite.and late.calcite.diage.e.is. e.rly calcite.ce.e.t in P3 and P4 is in lowe. proportion than in P1 and P2. Although the.dissolution of the.e.sandstone. by acidic fluids did not have.a patte.n, it, howe.e., has the.most conside.able.influe.ce.on P2 cre.ting moldic pore. which are.e.pe.te. to incre.se.pore.conne.tivity. The.re.ative.y abundant dissolution pore. in P2, toge.he. with the.abse.ce.of late.authige.ic calcite.and illite.clay in comparison to the.othe. pe.rofacie. studie. are.like.y to make.this sandstone.facie. the.be.t re.e.voir targe.s in the.Southe.n California re.ion. The.e.rocks are.analogous to producing re.e.voirs in the.re.ion. Howe.e., be.ause. pe.role.m accumulation in the.e.re.e.voirs are.compartme.talize. by e.rly calcite.ce.e.t, maximum re.ove.y using acidifie. fluids is re.omme.de. to dissolve.the.calcite.fille. pore. in orde. to incre.se.conne.tivity of the.r pore.ne.work and e.hance.flow pote.tial.

关键词： diage.e.is pe.rofacie. re.e.voir quality Mioce.e California

Validating Acade.ic Training ve.sus Organizational Training： An Analysis in the.e.te.prise.Re.ource.Planning （e.P） Fie.d

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通讯和计算机（中英文版） 2013年第10期10卷 1261-1270页

作者： jill O'Sullivan Compute. Syste.s De.artme.t School of Business Farmingdale State College NY 11735 US

e.P (e.te.prise.re.ource.planning) syste.s are.package. software.applications that support most of an organization"s informational ne.ds within and across functional are.s of the.organization. Mode.n e.P syste.s se.ve.as the.foundation for a wide.range.of e.busine.s mode.s within one.company, as we.l as throughout the.value.chain. This study e.plore. industry e.P training of e.ploye.s ne. to e.P, and compare. this latte. group to colle.e.stude.ts pre.are. with e.P skills from a colle.e.e.P class. The.stude.ts re.ote.y acce.se. the.e.P syste.s fe.ture. he.e.for class re.uire.e.ts. Unive.sity and industry collaborations allow for a hands-on e.pe.ie.ce.in the.classroom that re.licate. industry applications by using re.l world tools. This syne.gistic re.ationship provide. opportunitie. for stude.ts to acquire.knowle.ge.using a tangible.tool that imitate. what is utilize. in the.industry. The.study note. that schools supporte. by se.e.al e.P ve.dor initiative. are.incre.singly inte.rating e.te.prise.syste.s in the.r curricula. The.re.ultant data ide.tifie. pe.tine.t information that busine.se. conside. valuable.in the.r e.ploye.s" e.P training. This note.orthy corre.ation, be.we.n colle.e.pre.are. stude.ts and e.ploye.s ne. to e.P who have.gone.through e.P training, e.amine. case.studie. of stude.ts who are.now in the.workforce. This study e.pose. the.e.stude.ts" distinct advantage.be.ause.of the.r e.P le.rning e.pe.ie.ce. and compare. it to companie." e.P training practice.. The.inte.t, as in any e.ucational e.vironme.t, is not only to he.p stude.ts attain an unde.standing of the.mate.ial, but to also maste. that mate.ial in the.e.vironme.t in which the. will be.re.uire. to use.it.

关键词： e.P系统企业资源规划组织培训学术验证电子商务模式行业应用大学生

Varying Track e.ch Rate. along the.Fission Fragme.ts＇ Traje.torie. in CR-39 De.e.tors

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Chine.e.Physics Le.te.s 2010年第5期27卷 76-79页

作者： N. All e. U. Khan A. Wahe.d S. Karim F. Khan A. Maje.d DPAM PLEAS P.O. Nilore Islamabad Pakistan P.D PINSTECH P.O. Nilore Islamabad Pakistan Inte.national Islamic Unive.sity Islamabad Pakistan De.artme.t of Physics CIIT Islamabad Pakistan

We.de.e.mine.the.be.avior of track e.ch rate.VT along the.tracks in CR-39 de.e.tors e.pose. to fission fragme.ts from ^252Cf source. CR-39 de.e.tors are.e.che. at 70℃ in diffe.e.t conce.trations of Na2COa-mixe. 6M NaOH solutions for diffe.e.t e.ching time.inte.vals of 5-10min starting from 15 min up to 210min. Two value. of track e.ch rate.are.de.e.mine. along the.fission fragme.t traje.torie.. The.variation in VT is corre.ate. with the.e.e.gy loss rate.of the.fission fragme.t in the.de.e.tor mate.ial.

关键词： track e.ch e.ch rate rate