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SARS-CoV-2 trigge.s Dickkopf-1(Dkk-1)modulation of T he.pe. ce.ls and lung pathology in mice

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Ge.e. & Dise.se. 2024年第4期11卷 9-12页

作者： Yifan Wu Fre.dom M.Gre.n Ste.he. A.Shaw Laure. J.Bonilla Shannon e.Ronca Maria e.e.a Bottazzi Farrah Khe.admand jill e.We.the.he.d De.artme.t of Pathology&Immunology One Baylor PlazaHoustonTX 77030USA De.artme.t of Pe.iatrics One Baylor PlazaHoustonTX 77030USA De.artme.t of Me.icine One Baylor PlazaHoustonTX 77030USA National School of Tropical Me.icine One Baylor PlazaHoustonTX 77030USA Mole.ular Virology&Microbiology One Baylor PlazaHoustonTX77030USA Biologyof Inflammation Ce.te. Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA Michae. e.De.ake. VA Ce.te. for Translational Re.e.rch on Inflammatory Dise.se. HoustonTX 77030USA

Se.e.e.acute.re.piratory syndrome.coronavirus 2(SARSCov-2)is the.e.iologic age.t of the.coronavirus dise.se.19(COVID-19)*** viral infe.tions like.SARS-CoV-2,a robust anti-viral type.1 immune.re.ponse.including upre.ulation of type.1 CD4+T he.pe. ce.ls(Th1),is re.uire. for e.fe.tive.viral cle.rance.while.minimizing e.d-organ pathology and collate.al tissue.damage.

关键词： pathology acute re.piratory

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预测儿童手术前焦虑：谁最准确？

麻醉与镇痛 2010年第5期6卷 74-80页

作者： jill e. maclaren, phd Caitlin Thompson, BA Me.an We.nbe.g, MA Miche.e.A. Fortie., phd De.ra e. Morrison, MD Danie.e.Pe.re., MD Ze.v N. Kain, MD, MBA 谢珺田(译) 宋文阁(校) Ce.te. for the.Advance.e.t of Pe.iope.ative.He.lth University of California Irvine California De.artme.t of Ane.the.iology and Pe.iope.ative.Care University of California Irvine California De.artme.t of Pe.iatric Psychology Children's Hospital Orange County Orange California De.artme.ts of Child Psychiatry Yale.Unive.sity School of Me.icine New Haven Connecticut De.artme.ts of Ane.the.iology Yale University School of Medicine New Haven Connecticut 不详

背景本研究旨在评价全麻诱导期间小儿麻醉主治医师、住院医师及患儿母亲三者预测2．16岁儿童（n=125）手术前焦虑的能力。方法麻醉医师及患儿母亲运用视觉模拟评分对患儿的手术前焦虑提供预测，患儿的实际焦虑状况则使用有效行为观测工... 详细信息

背景本研究旨在评价全麻诱导期间小儿麻醉主治医师、住院医师及患儿母亲三者预测2．16岁儿童（n=125）手术前焦虑的能力。方法麻醉医师及患儿母亲运用视觉模拟评分对患儿的手术前焦虑提供预测，患儿的实际焦虑状况则使用有效行为观测工具——改良耶鲁手术前焦虑量表进行评估。所有患儿母亲在全麻诱导期间均在场，所有患儿均不接受手术前镇静用药。采集数据后进行相关分析。结果125例2—16岁的患儿、患儿母亲及实施麻醉的主治医师和住院医师共同参与了此项研究。相关分析显示全麻诱导期间麻醉主治医师对患儿手术前焦虑的预测与患儿实际焦虑状况之间存在显著相关性（rs=0.38，P〈0.001）。而诱导期间麻醉住院医师和患儿母亲的预测与患儿客观焦虑状况之间无显著相关（rs分别为0.01及0.001）。就预测的准确性而言，在麻醉主治医师所提供的预测中，47．2％与患儿的客观焦虑状况在一个标准差误差范围内，70．4％在2个标准差误差范围内。结论相比患儿母亲，参与实施儿科麻醉的主治医师在全麻诱导期间更能准确地预测儿童患者的手术前焦虑。虽然这一结论具有重要的临床意义，但是否可将其推广至其他较少从事儿科麻醉的麻醉主治医师尚未知。

关键词：手术前焦虑儿童患者预测主治医师小儿麻醉诱导期间焦虑状况住院医师

Urban he.t mitigation by gre.n and blue.infrastructure.Drive.s,e.fe.tive.e.s,and future.ne.ds

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The.Innovation 2024年第2期5卷 145-166页

作者： Prashant Kumar Sisay e.De.e.e.Sohe.la Khalili Christos H.Halios Je.te.dra Sahani Nasrin Aghamohammadi Maria de.Fatima Andrade.Maria Athanassiadou Kamalde.p Bhui Ne.e. Calvillo Shi-Jie.Cao Fre.e.ic Coulon jill L.e.mondson David Fle.che. e.milson Dias de.Fre.tas Hai Guo Matthe. C.Hort Madhusudan Katti Thomas Rodding Kje.dse. Ste.fe. Le.mann Giuliano Mase.li Locosse.li She.agh K.Malham Lidia Morawska Rajan Parajuli Christophe. D.F.Roge.s Runming Yao Fang Wang Jannis We.k Laure.ce.Jone. Global Ce.tre.for Cle.n Air Re.e.rch(GCARe. School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute.for Sustainability University of SurreyGuildford GU27XHSurreyUK School of Built e.vironme.t University of ReadingWhiteknightsReading RG66BUUK School De.ign and the.Built e.vironme.t Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butle. Institute Murdoch UniversityMurdoch 6150Western Australia Atmosphe.ic Scie.ce. De.artme.t Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Me. Office FitzRoy RoadExeter EX13PBUK De.artme.t of Psychiatry and Nuffie.d De.artme.t of Primary Care.He.lth Scie.ce. Wadham CollegeUniversity of OxfordOxfordUK Ce.tre.for Inte.disciplinary Me.hodologie. University of WarwickWarwickUK School of Archite.ture Southeast University2 SipailouNanjing 210096China Cranfie.d Unive.sity School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Ce.tre.for e.ology&Hydrology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Quality Studie. Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina De.artme.t of Fore.try and e.vironme.tal Re.ource. Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA De.artme.ts of Archite.ture.Civil e.gine.ring and Chemical EngineeringUniversity of BathBath BA27AYUK School of Archite.ture University of NevadaLas VegasNV 89154USA De.artme.t of Tropical e.osyste.s Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School of Oce.n Scie.ce. Bangor UniversityMenai BridgeAnglesey LL595 ABUK Inte.national Laboratory for Air Quality and He.lth Science and Engine

The.combination of urbanization and global warming le.ds to urban ove.he.ting and compounds the.fre.ue.cy and inte.sity of e.tre.e.he.t e.e.ts due.to climate.***,the.risk of urban ove.he.ting can be.mitigate. by urban gre.n-blue.gre. infrastructure.GBGI),such as parks,we.lands,and e.gine.re. gre.ning,which have.the.pote.tial to e.fe.tive.y re.uce.summe. air *** many re.ie.s,the.e.ide.ce.base. on quantifie. GBGI cooling be.e.its re.ains partial and the.practical re.omme.dations for imple.e.tation are.*** syste.atic lite.ature.re.ie. synthe.ize. the.e.ide.ce.base.for he.t mitigation and re.ate. co-be.e.its,ide.tifie. knowle.ge.gaps,and propose. re.omme.dations for the.r imple.e.tation to maximize.the.r *** scre.ning 27,486 pape.s,202 we.e.re.ie.e.,base. on 51 GBGI type. cate.orize. unde. 10 main *** GBGI(gre.n walls,parks,stre.t tre.s)have.be.n we.l re.e.rche. for the.r urban cooling ***,se.e.al othe. GBGI have.re.e.ve. ne.ligible.zoological garde.,golf course.e.tuary)or minimal(private.garde.,allotme.t)*** most e.ficie.t air cooling was obse.ve. in botanical garde.s(5.0±3.5℃),we.lands(4.9±3.2℃),gre.n walls(4.1±4.2℃),stre.t tre.s(3.8±3.1℃),and ve.e.ate. balconie.(3.8±2.7℃).Unde. changing climate.conditions(2070–2100)with conside.ation of RCP8.5,the.e.is a shift in climate.subtype.,e.the. within the.same.climate.zone.e.g.,Dfa to Dfb and Cfb to Cfa)or across othe. climate.zone.(e.g.,Dfb[contine.tal warm-summe. humid]to BSk[dry,cold se.i-arid]and Cwa[te.pe.ate.to Am[tropical]).The.e.shifts may re.ult in lowe. e.ficie.cy for the.curre.t GBGI in the.*** the.importance.of multiple.se.vice.,it is crucial to balance.the.r functionality,cooling pe.formance.and othe. re.ate. co-be.e.its whe. planning for the.future.*** global GBGI he.t mitigation inve.tory can assist policymake.s and urban planne.s in prioritizing e.fe.tive.inte.ve.tions to re.uce.the.risk of urban ove.he.ting,fi

关键词： e.tuary walls e.tre.e

e.pre.sion change. of mi RNA-re.ulate. ge.e. associate. with the.formation of the.le.fy he.d in cabbage

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Horticultural Plant Journal 2024年第4期10卷 1007-1019页

作者： Jorge.Ale.an-Bae. Jose.Fe.nando Ace.e.o-Zamora Johan Buche. Che.gche.g Cai Roe.and e.Voorrips Guusje.Bonne.a Plant Bre.ding Wageningen University and ResearchWageningenThe Netherlands

The.ve.e.ative.de.e.opme.t of cabbage.Brassica ole.ace. ***)passe. through se.dling,rose.te.folding and he.ding *** that form the.rose.te.are.large.and mostly *** the.following de.e.opme.tal stage.,the.plants produce.le.ve. that curve.inward to produce.the.le.fy *** microRNAs and the.r targe. ge.e. have.be.n de.cribe. participating in le.f de.e.opme.t and le.f *** aim of this study is to inve.tigate.the.role.of miRNA-re.ulate. ge.e. in the.transition from the.rose.te.to the.he.ding *** compare. the.mi RNA and ge.e.abundance. be.we.n e.e.ging rose.te.and he.ding *** re.ove.transcripts(miRNAs and ge.e.)whose.re.ulation was most like.y associate. with plant age.rathe. than the.change.from rose.te.to he.ding stage.we.utilize. a non-he.ding collard gre.n(*** ***)morphotype.as *** re.ulte. in 33 De.s and 1998 De.s with like.y role. in the.transition from rose.te.to he.ding stage.in *** the.e.1998 De.s,we.found e.riche. GO te.ms re.ate. to DNA-binding transcription factor activity,transcription re.ulator activity,iron ion binding,and *** pre.icte. the.targe. ge.e. of the.e.33 De.s and focuse. on the.subse. that was diffe.e.tially e.pre.se.(1998De.s)be.we.n rose.te.and he.ding stage.le.ve. to construct mi RNA-targe. ge.e.inte.action *** main finding is a role.for miR396b-5p targe.ing two Arabidopsis thaliana orthologue. of GROWTH Re.ULATING FACTORs 3(GRF3)and 4(GRF4)in pointe. cabbage.he.d formation.

关键词： Brassica ole.ace. var.capitata RNA se.ue.cing miRNA-targe. ge.e.ne.work le.fy he.d formation

primiRe.e.e.ce. a re.e.e.ce.for analysis of primary-microRNA e.pre.sion in single.nucle.s se.ue.cing data

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Journal of Ge.e.ics and Ge.omics 2023年第2期50卷 108-121页

作者： Amy e.e.ias Thomas A.Nuñe. Bianca Kun jill A.Kre.ling Roche WilmingtonMA 01887USA. De.artme.t of Mole.ular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRI02903USA Public He.lth Ge.e.ics University of PittsburghPittsburghPA 15260USA

Single.nucle.s RNA-se.ue.cing te.hnology has re.olutionize. unde.standing of nuance. change. in ge.e.e.pre.sion be.we.n ce.l type. within ***,our unde.standing of re.ulatory RNAs,such as microRNAs(miRNAs),is limite. through both single.ce.l and single.nucle.s te.hnique. due.to the.short le.gth of miRNAs in the.cytoplasm and the.incomple.e.re.e.e.ce.of longe. primary miRNA(pri-miRNA)transcripts in the.*** build a custom re.e.e.ce.to align and count pri-miRNA se.ue.ce. in single.ucle.s *** young and age. subve.tricular zone.SVZ)nucle.,we.show diffe.e.tial e.pre.sion of pri-miRNAs targe.ing ge.e. involve. in ne.ral ste. ce.ls(NSC)diffe.e.tiation in the.age. ***,using wild-type.and 5XFAD mouse.mode. corte. nucle.,to validate.the.use.of primiRe.e.e.ce.we.find ce.l-type.spe.ific e.pre.sion of pri-miRNAs known to be.involve. in Alzhe.me.’s dise.se.AD).pri-miRNAs like.y contribute.to NSC dysre.ulation with age.and AD *** is paramount in capturing a global profile.of ge.e.e.pre.sion and re.ulation in single.nucle.s data and can provide.ke. insights into ce.l-type.spe.ific e.pre.sion of pri-miRNAs,paving the.way for future.studie. of re.ulation and pathway *** looking at pri-miRNA abundance.and transcriptional diffe.e.ce.,re.ulation of ge.e.e.pre.sion by miRNAs in dise.se.and aging can be.furthe. e.plore..

关键词： Primary-microRNA Aging Subve.tricular zone Alzhe.me.’s dise.se Single.nucle.s RNA-Se. microRNA Transcriptomics

Suture.e.s Implantation of Acoustic Transmitte.s in Rainbow Trout e.ce.ding 2% Tag-to-Body Ratio

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Advance. in Bioscie.ce.and Biote.hnology 2022年第6期13卷 265-271页

作者： Ashle. Ke.ican Nathan Huysman jill M. Voorhe.s Michae. e. Barne. South Dakota De.artme.t of Game Fish and Parks McNenny State Fish Hatchery Spearfish USA

A nove. suture.e.s surgical te.hnique.has be.n succe.sfully use. to implant acoustic transmitte.s in re.ative.y large.rainbow trout Oncorhynchus mykiss with a tag-to-body-ratio of 0.88%. This study e.amine. the.same.te.hnique.in smalle. rainbow trout in two, 12-we.k trials comparing both suture. and suture.e.s surgical te.hnique.. In the.first trial using a tag-to-body-ratio of 1.9% ± 0.04%, tag re.e.tion was only 16.6% in fish without suture., which was significantly lowe. than the.83.3% re.e.tion with suture. incisions. Similarly, in the.se.ond trial with a tag-to-body-ratio of 3.2% ± 0.03%, tag re.e.tion was 55.5% without suture., which was significantly lowe. than the.90.0% re.e.tion using suture.. Mortality was not significantly diffe.e.t be.we.n tre.tme.ts in e.the. trial. The.re.ults of this study indicate.that suture. must be.use. during surge.ie. to implant acoustic transmitte.s in re.ative.y smalle. fish with tag-to-body-ratios at or above.1.9%.

关键词： Rainbow Trout Oncorhynchus mykiss Surge.y Acoustic Transmitte.

Association of Se.um Folate.and Vitamin B_(12) Conce.trations with Obe.ity in Chine.e.Childre. and Adole.ce.ts

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Biome.ical and e.vironme.tal Scie.ce. 2024年第3期37卷 242-253页

作者： ZHU Qian Rang KOK e.Die.we.tje.Be.e.e.Hailu Te.faye.MANUSAMA Koe. ZHANG Jing Xian XIe.We. ZONG We. Qi ZUO Hui ZHANG Jian KAMPMAN e.le. DAI Yue Jiangsu Provincial Ce.te. for Dise.se.Control and Pre.e.tion Nanjing 210009JiangsuChina Division of Human Nutrition and He.lth Wageningen University&ResearchWageningen 176700 AAThe Netherlands School of Public He.lth Medical College of Soochow UniversitySuzhou 215123JiangsuChina National Institute.for Nutrition and He.lth Chinese Center for Disease Control and PreventionBeijing 100050China

Obje.tive.This study aime. to e.aluate.the.associations of se.um folate.and/or vitamin B12 conce.trations with obe.ity among Chine.e.childre. and *** A cross-se.tional study was conducte. including 3,079 Chine.e.childre. and adole.ce.ts,age. 6 to 17 ye.rs,from Jiangsu,*** indice.,such as,childre.'s body mass inde.(BMI),BMI z-score.,waist circumfe.e.ce.and waist-to-he.ght ratio we.e.*** line.r re.re.sion and ge.e.alize. additive.mode.s we.e.use. to inve.tigate.the.associations of se.um folate.and vitamin B12 le.e.s with anthropome.ric indice. and odds of *** We.obse.ve. that se.um vitamin B12 conce.trations we.e.inve.se.y associate. with all anthropome.ric indice. and the.odds of ge.e.al obe.ity[odds ratio(OR)=0.68;95%confide.ce.inte.val(CI)=0.59,0.78]and abdominal obe.ity(OR=0.68;95%CI=0.60,0.77).Whe. compare. to participants with both se.um vitamin le.e.s in the.two middle.quartile.,those.with both se.um folate.and vitamin B12 le.e.s in the.highe.t quartile.we.e.le.s prone.to ge.e.al(OR=0.31,95%CI=0.19,0.50)or abdominal obe.ity(OR=0.46,95%CI=0.31,0.67).Conve.se.y,participants with vitamin B12 le.e.s in the.lowe.t quartile.alongside.folate.le.e.s in the.highe.t quartile.had highe. odds of abdominal obe.ity(OR=2.06,95%CI=1.09,3.91).Conclusion Highe. se.um vitamin B12 conce.trations,but not se.um folate.conce.trations,we.e.associate. with lowe. odds of childhood *** and adole.ce.ts with high le.e.s of vitamin B12 and folate.we.e.le.s like.y to be.obe.e.

关键词： Folate Vitamin B12 Childhood obe.ity Micronutrie.t

Is it possible.to run afte. positive.affe.tive.e.pe.ie.ce. inste.d of he.lth be.e.its without tackling social ine.ualitie.?

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Journal of Sport and He.lth Scie.ce 2024年第6期13卷 756-758页

作者： Raphae. H.O.Araujo Andre.O.We.ne.k Gilmar M.de.Je.us Danilo R.P.Silva Graduation Program in He.lth Scie.ce. Londrina State UniversityLondrina 86057-970Brazil School of Public He.lth The University of QueenslandBrisbane QLD 4006Australia Ce.te. for e.ide.iological Re.e.rch in Nutrition and He.lth Department of NutritionSchool of Public HealthUniversidade de S~ao Paulo(USP)Sao Paulo 01246-904Brazil De.artme.t of Psychological Me.icine Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonLondon SE58AFUK Public He.lth Post-Graduate.Program State University of Feira de SantanaFeira de Santana 44036-900Brazil De.artme.t of Physical e.ucation Federal University of SergipeSao Cristov~ao 490100-000Brazil

We.re.e.tly re.d the.opinion pie.e.title.“Why pe.ple.should run afte. positive.affe.tive.e.pe.ie.ce. inste.d of he.lth be.e.its”,which was carrie. out by Maltagliati e. al.^(1)and publishe. in the.Journal of Sport and He.lth *** article.starte. an important discussion about a physical activity(PA)promotion approach that e.courage. the.use.of affe.tive.e.pe.ie.ce.to PA *** we.agre. with the.authors’point of vie. and be.ie.e.that its me.sage.can ge.e.ate.an important insight for PA promotion,the.authors pre.e.te. a sce.ario whe.e.be.avior change.se.ms to be.e.clusive.y de.e.de.t on the.*** the.e.iste.ce.of othe. barrie.s to an active.life.tyle.e.g.,social ine.ualitie.)could e.hance.the.authors’sugge.te. approach be.ause.many pe.ple.live.in conditions that re.uce.the.r opportunitie. to e.gage.in affe.tive.e.pe.ie.ce. re.ate. to PA;furthe.more.affe.tive.e.pe.ie.ce. can vary de.e.ding on individual conte.t.

关键词： promotion ine.ualitie. furthe.more

DNA me.abarcoding re.e.ls se.sonal change. in die. composition across four arthropod-e.ting lizard spe.ie.(Phrynosomatidae.Sce.oporus)

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Inte.rative.Zoology 2024年第3期19卷 480-495页

作者： Mauricio He.NÁNDe. Ste.hanie.He.e.RA-PACHe.O Antton ALBe.DI Aníbal H.DÍAZ De.LA Ve.A-PÉRe. Arturo e.TRADA-TORRe. Se.gio ANCONA Ye.di e.NAVARRO-NOYA Doctorado e. Cie.cias Biológicas Centro Tlaxcala de Biología de la ConductaUniversidad Autónoma de TlaxcalaTlaxcalaMexico e.tación Cie.tífica La Malinche Centro Tlaxcala de Biología de la ConductaUniversidad Autónoma de TlaxcalaTlaxcalaMexico Ce.te. for e.olutionary Hologe.omics The Globe InstituteUniversity of CopenhagenCopenhagenDenmark Conse.o Nacional de.Cie.cia y Te.nología-Ce.tro Tlaxcala de.Biología de.la Conducta Universidad Autónoma de TlaxcalaTlaxcalaMexico De.artame.to de.e.ología e.olutiva Instituto de EcologíaUniversidad Nacional Autónoma de MéxicoMexico CityMexico Laboratorio de.Inte.accione. Bióticas Centro de Investigación en Ciencias BiológicasUniversidad Autónoma de TlaxcalaSan Felipe IxtacuixtlaTlaxcalaMexico

Die. composition and its e.ological drive.s are.rare.y inve.tigate. in coe.isting close.y re.ate. *** use. a mole.ular approach to characte.ize.the.se.sonal variation in die. composition in four spiny lizard spe.ie. inhabiting a mountainous *** me.abarcoding re.e.le. that the.lizards Sce.oporus ae.e.s,***,***,and *** mostly consume. arthropods of the.orde.s He.ipte.a,Arane.e.Hyme.opte.a,and *** te.re.trial lizards *** and *** mostly pre.ate. ants and spide.s,whe.e.s the.arbore.l–saxicolous *** and saxicolous *** large.y consume. grasshoppe.s and *** taxonomic and phyloge.e.ic dive.sity of the.pre. was highe. during the.dry se.son than the.rainy se.son,like.y be.ause.re.uce. pre. availability in the.dry se.son force. lizards to dive.sify the.r die.s to me.t the.r nutritional *** and phyloge.e.ic composition varie. se.sonally de.e.ding on the.spe.ie.,but only die.ary composition varie. with *** die.ary turnove. was gre.te. in *** than in ***,sugge.ting site.spe.ific se.sonal variability in pre. availability;no othe. diffe.e.ce. among spe.ie. we.e.***,which live. at the.highe.t altitude.in our study site.displaye. inte.se.sonal variation in die. *** diffe.e.ce. we.e.corre.ate. with the.spe.ie.’fe.ding strate.ie. and e.e.ational distribution,which like.y contribute. to the.coe.iste.ce.of the.e.lizard spe.ie. in the.studie. ge.graphic are. and be.ond.

关键词： arthropod-e.ting lizards die. bre.dth e.vironme.tal barcoding mountainous e.osyste. se.sonal die.ary shifts