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Decoding the inconsistency of six cropland maps in China

The Crop Journal 2024年第1期12卷 281-294页

作者： Yifeng Cui Ronggao Liu Zhichao Li Chao Zhang Xiao-Peng Song jilin Yang Le Yu Mengxi Chen Jinwei dong Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Department of Geographical Sciences University of MarylandCollege ParkMD 20740USA College of Grassland Science and Technology China Agricultural UniversityBeijing 100193China Ministry of Education Ecological Field Station for East Asian Migratory Birds Department of Earth System ScienceInstitute for Global Change StudiesTsinghua UniversityBeijing 100084China Ministry of Education Ecological Field Station for East Asian Migratory Birds Beijing 100084China Tsinghua University(Department of Earth System Science)-Xi’an Institute of Surveying and Mapping Joint Research Center for Next-Generation Smart Mapping Beijing 100084China Institute of Remote Sensing and Geographic Information System Peking UniversityBeijing 100871China Department of Forest and Conservation Sciences University of British ColumbiaVancouverBCV6T 1Z4Canada

Accurate cropland information is critical for agricultural planning and production,especially in foodstressed countries like China.Although widely used medium-to-high-resolution satellite-based cropland maps have been developed from various remotely sensed data sources over the past few decades,considerable discrepancies exist among these products both in total area and in spatial distribution of croplands,impeding further applications of these datasets.The factors influencing their inconsistency are also unknown.In this study,we evaluated the consistency and accuracy of six cropland maps widely used in China in circa 2020,including three state-of-the-art 10-m products(i.e.,Google Dynamic World,ESRI Land Cover,and ESA WorldCover)and three 30-m ones(i.e.,GLC_FCS30,GlobeLand 30,and CLCD).We also investigated the effects of landscape fragmentation,climate,and agricultural management.Validation using a ground-truth sample revealed that the 10-m-resolution WorldCover provided the highest accuracy(92.3%).These maps collectively overestimated Chinese cropland area by up to 56%.Up to 37%of the land showed spatial inconsistency among the maps,concentrated mainly in mountainous regions and attributed to the varying accuracy of cropland maps,cropland fragmentation and management practices such as irrigation.Our work shed light on the promotion of future cropland mapping efforts,especially in highly inconsistent regions.

关键词： Consistency and accuracy 10-and 30 m Cropland mapping Agricultural management China

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Systematic screening reveals synergistic interactions that overcome MAPK inhibitor resistance in cancer cells

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Cancer Biology & Medicine 2022年第2期19卷 229-252页

作者： Yu Yu Minzhen Tao Libin Xu Lei Cao Baoyu Le Na An jilin dong Yajie Xu Baoxing Yang Wei Li Bing Liu Qiong Wu Yinying Lu Zhen Xie Xiaohua Lian Department of Cell Biology Basic Medical CollegeArmy Medical University(Third Military Medical University)Chongqing 400038China MOE Key Laboratory of Bioinformatics and Bioinformatics Division Center for Synthetic and System BiologyDepartment of AutomationBeijing National Research Center for Information Science and TechnologyTsinghua UniversityBeijing 100084China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Thoracic Surgery Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China Beijing Syngentech Co. LtdBeijing 102206China School of Life Sciences Tsinghua UniversityBeijing 100084China The Comprehensive Liver Cancer Center The 5th Medical Center of PLA General HospitalBeijing 100039China

Objective:Effective adjuvant therapeutic strategies are urgently needed to overcome MAPK inhibitor(MAPKi)resistance,which is one of the most common forms of resistance that has emerged in many types of cancers.Here,we aimed to systematically identify the genetic interactions underlying MAPKi resistance,and to further investigate the mechanisms that produce the genetic interactions that generate synergistic MAPKi resistance.Methods:We conducted a comprehensive pair-wise sgRNA-based high-throughput screening assay to identify synergistic interactions that sensitized cancer cells to MAPKi,and validated 3 genetic combinations through competitive growth,cell viability,and spheroid formation assays.We next conducted Kaplan-Meier survival analysis based on The Cancer Genome Atlas database and conducted immunohistochemistry to determine the clinical relevance of these synergistic combinations.We also investigated the MAPKi resistance mechanisms of these validated synergistic combinations by using co-immunoprecipitation,Western blot,qRTPCR,and immunofluorescence assays.Results:We constructed a systematic interaction network of MAPKi resistance and identified 3 novel synergistic combinations that effectively targeted MAPKi resistance(ITGB3+IGF1R,ITGB3+JNK,and HDGF+LGR5).We next analyzed their clinical relevance and the mechanisms by which they sensitized cancer cells to MAPKi exposure.Specifically,we discovered a novel protein complex,HDGF-LGR5,that adaptively responded to MAPKi to enhance cancer cell stemness,which was up-or downregulated by the inhibitors of ITGB3+JNK or ITGB3+IGF1R.Conclusions:Pair-wise sgRNA library screening provided systematic insights into elucidating MAPKi resistance in cancer cells.ITGB3-+IGF1R-targeting drugs(cilengitide+linsitinib)could be used as an effective therapy for suppressing the adaptive formation of the HDGF-LGR5 protein complex,which enhanced cancer stemness during MAPKi stress.

关键词： Pair-wise sgRNA library genetic interactions MAPKi resistance combinatorial therapy cancer stemness

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A coating strategy on titanium implants with enhanced photodynamic therapy and CO-based gas therapy for bacterial killing and inflammation regulation

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Chinese Chemical Letters 2024年第2期35卷 386-395页

作者： Liang Cheng Bingshuai Zhou Manlin Qi Xiaolin Sun Shujun dong Yue Sun Biao dong Lin Wang Yingwei Yang Department of Oral Implantology Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering School and Hospital of StomatologyJilin UniversityChangchun 130021China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130021China College of Chemistry Jilin UniversityChangchun 130012China

Antimicrobial photodynamic therapy(aPDT)has been considered a noninvasive and effective modality against the bacterial infection of peri‑implantitis,especially the aPDT triggered by near-infrared(NIR)light due to the large penetration depth in tissue.However,the complexity of hypoxia microenvironments and the distance of aPDT sterilization still pose challenges before realizing the aPDT clinical application.Due to the long lifespan and transmission distance of therapeutic gas molecules,we design a multi-functional gas generator that combines aPDT as well as O_(2) and CO gas release function,which can solve the problem of hypoxia(O_(2))in PDT and the problem of inflammation regulation(CO)in the distal part of peri‑implant inflammation under near-infrared(NIR)irradiation.In the composite nanoplatform that spin-coated on the surface of titanium implants,up-conversion nanoparticles(UCNPs)were involved in converting the NIR to visible,which further excites the partially oxidized stannic sulfide(SnS_(2)),realizing the therapeutic gas release.Indocyanine green(ICG)was further integrated to enhance the aPDT performance(Ti-U@SnS_(2)/I).Therefore,reactive oxygen species(ROS),CO,and O_(2) can be controllably administered via a composite nano-platform mediated by a single NIR light(808 nm).This implant surface modification strategy could achieve great self-enhancement antibacterial effectiveness and regulate the lingering questions,such as relieving the anoxic microenvironment and reaching deep infection sites,providing a viable antibiotic-free technique to combat peri‑implantitis.

关键词： Photodynamic therapy Biomaterials Dental implant Reactive oxygen species Carbon monoxide Hybrid nanoplatform

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Laryngopharyngeal reflux disease:Updated examination of mechanisms,pathophysiology,treatment,and association with gastroesophageal reflux disease

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World Journal of Gastroenterology 2024年第16期30卷 2209-2219页

作者： Na Cui Ting Dai Yang Liu Ya-Yu Wang Jia-Yu Lin Qing-Fan Zheng dong-dong Zhu Xue-Wei Zhu Department of Otorhinolaryngology Head and Neck Surgery China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Ultrasound China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Gastroenterology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

Laryngopharyngeal reflux disease(LPRD)is an inflammatory condition in the laryngopharynx and upper aerodigestive tract mucosa caused by reflux of stomach contents beyond the esophagus.LPRD commonly presents with symptoms such as hoarseness,cough,sore throat,a feeling of throat obstruction,excessive throat mucus.This complex condition is thought to involve both reflux and reflex mechanisms,but a clear understanding of its molecular mechanisms is still lacking.Currently,there is no standardized diagnosis or treatment protocol.Therapeutic strategies for LPRD mainly include lifestyle modifications,proton pump inhibitors and endoscopic surgery.This paper seeks to provide a comprehensive overview of the existing literature regarding the mechanisms,pathophysiology and treatment of LPRD.We also provide an in-depth exploration of the association between LPRD and gastroesophageal reflux disease.

关键词： Laryngopharyngeal reflux Gastroesophageal reflux Head neck surgery Laryngitis Otolaryngology

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Primary biliary cholangitis presenting with granulomatous lung disease misdiagnosed as lung cancer:A case report

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World Journal of Clinical Cases 2024年第2期12卷 354-360页

作者： Shan-Li Feng Jun-Yao Li Chun-Ling dong Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

BACKGROUND There are few cases of pulmonary granulomatous changes secondary to primary biliary cirrhosis(PBC).No case of granulomatous lung disease secondary to PBC misdiagnosed as lung cancer had been reported.CASE SUMMARY A middle-aged woman presented with lung nodules and was misdiagnosed with lung cancer by positron emission tomography/computed tomography.She underwent left lobectomy,and the pathology of the nodules showed granulomatous inflammation,which was then treated with antibiotics.However,a new nodule appeared.Further investigation with lung biopsy and liver serology led to the diagnosis of PBC,and chest computed tomography indicated significant reduction in the pulmonary nodule by treatment with methylprednisolone and ursodeoxycholic acid.CONCLUSION Diagnosis of pulmonary nodules requires integrating various clinical data to avoid unnecessary pulmonary lobectomy.

关键词： Granulomatous lung diseases Primary biliary cirrhosis Differential diagnosis Misdiagnosis Lung cancer Case report

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Nano-effect enhanced cooperative luminescence of Yb^(3+) clusters in bulk materials

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Journal of Rare Earths 2024年第3期42卷 473-478,I0002页

作者： Daguang Li Jiahao Cui Yanhui dong Hao Cui Dan Zhao Weiping Qin State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun130012China

In order to improve the multi-ion cooperative transition, we proposed and exploited a novel nanoscale effect, namely the nanoshell effect in bulk materials. Based on the effect, an optimal material structure was designed by coating the surfaces of Ca F_(2):Yb^(3+)micron size particles with ZrO_(2). An about 2 times higher intensity of cooperative luminescence is observed upon laser excitation at 980 nm. Dynamical analysis exhibits that the novel effect plays a key role in improving the performance of cooperative transitions. Our results also suggest that the nanoshell effect in bulk materials is likely to be significant in some special cases, which have not been reported yet in the literature.

关键词： Yb^(3+)cluster ZrO_(2) Nanoshell Enhancement Cooperative luminescence Rare earths

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Gaussian Backbone-Based Spherical Evolutionary Algorithm with Cross-search for Engineering Problems

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Journal of Bionic Engineering 2024年第2期21卷 1055-1091页

作者： Yupeng Li dong Zhao Ali Asghar Heidari Shuihua Wang Huiling Chen Yudong Zhang College of Computer Science and Technology Changchun Normal UniversityChangchun130032JilinChina School of Surveying and Geospatial Engineering College of EngineeringUniversity of TehranTehranIran School of Computing and Mathematical Sciences University of LeicesterLeicesterLE17RHUK Department of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou215123JiangsuChina Key Laboratory of Intelligent Informatics for Safety and Emergency of Zhejiang Province Wenzhou UniversityWenzhou325035China School of Computer Science and Engineering Southeast UniversityNanjing210096China

In recent years,with the increasing demand for social production,engineering design problems have gradually become more and more complex.Many novel and well-performing meta-heuristic algorithms have been studied and developed to cope with this problem.Among them,the Spherical Evolutionary Algorithm(SE)is one of the classical representative methods that proposed in recent years with admirable optimization performance.However,it tends to stagnate prematurely to local optima in solving some specific problems.Therefore,this paper proposes an SE variant integrating the Cross-search Mutation(CSM)and Gaussian Backbone Strategy(GBS),called CGSE.In this study,the CSM can enhance its social learning ability,which strengthens the utilization rate of SE on effective information;the GBS cooperates with the original rules of SE to further improve the convergence effect of SE.To objectively demonstrate the core advantages of CGSE,this paper designs a series of global optimization experiments based on IEEE CEC2017,and CGSE is used to solve six engineering design problems with constraints.The final experimental results fully showcase that,compared with the existing well-known methods,CGSE has a very significant competitive advantage in global tasks and has certain practical value in real applications.Therefore,the proposed CGSE is a promising and first-rate algorithm with good potential strength in the field of engineering design.

关键词： Meta-heuristic algorithms Engineering optimization Spherical evolution algorithm Global optimization

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The etching strategy of zinc anode to enable high performance zinc-ion batteries

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Journal of Energy Chemistry 2024年第1期88卷 125-143,I0004页

作者： Xueqing Fu Gaopeng Li Xinlu Wang Jinxian Wang Wensheng Yu Xiangting dong dongtao Liu School of Chemistry and Environmental Engineering Changchun University of Science and TechnologyChangchun 130022JilinChina Department of Chemistry Northeast Normal UniversityChangchun 130024JilinChina

Zinc-ion batteries(ZIBs)are considered to be one of the most promising candidates to replace lithium-ion batteries(LIBs)due to the high theoretical capacity,low cost and intrinsic safety.However,zinc dendrites,hydrogen evolution reaction,surface passivation and other side reactions will inevitably occur during the charging and discharging process of Zn anode,which will seriously affect the cycle stability of the battery and hinder its practical application.The etching strategy of Zn anode has attracted wide attention because of its simple operation and broad commercial prospects,and the etched Zn anode can effectively improve its electrochemical performance.However,there is no comprehensive review of the etching strategy of Zn anode.This review first summarizes the challenges faced by Zn anode,then puts forward the etching mechanisms and properties of acid,salt and other etchants.Finally,based on the above discussion,the challenges and opportunities of Zn anode etching strategy are proposed.

关键词： Zinc-ion batteries Zn anode Etching 3D structures Dendrite-free

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Overview of the immunological mechanisms in hepatitis B virus reactivation:Implications for disease progression and management strategies

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World Journal of Gastroenterology 2024年第10期30卷 1295-1312页

作者： Hui Ma Qing-Zhu Yan Jing-Ru Ma dong-Fu Li Jun-Ling Yang Department of Clinical Laboratory The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Ultrasound Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Digestive Diseases Center Department of Hepatopancreatobiliary MedicineThe Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

Hepatitis B virus(HBV)reactivation is a clinically significant challenge in disease management.This review explores the immunological mechanisms underlying HBV reactivation,emphasizing disease progression and management.It delves into host immune responses and reactivation’s delicate balance,spanning innate and adaptive immunity.Viral factors’disruption of this balance,as are interac-tions between viral antigens,immune cells,cytokine networks,and immune checkpoint pathways,are examined.Notably,the roles of T cells,natural killer cells,and antigen-presenting cells are discussed,highlighting their influence on disease progression.HBV reactivation’s impact on disease severity,hepatic flares,liver fibrosis progression,and hepatocellular carcinoma is detailed.Management strategies,including anti-viral and immunomodulatory approaches,are critically analyzed.The role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent reactivation.In conclusion,this compre-hensive review furnishes a holistic view of the immunological mechanisms that propel HBV reactivation.With a dedicated focus on understanding its implic-ations for disease progression and the prospects of efficient management stra-tegies,this article contributes significantly to the knowledge base.The more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches,ultimately enhancing disease management and elevating patient outcomes.The dynamic landscape of management strategies is critically scrutinized,spanning anti-viral and immunomodulatory approaches.The role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.

关键词： Hepatitis B virus reactivation Immunological mechanisms Disease progression Management strategies Immune response

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Molecule aging induced by electron attacking

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Journal of Energy Chemistry 2024年第6期93卷 519-525,I0013页

作者： Ping Song Yining dong Xue Gong Mingbo Ruan Baoxin Ni Xuanhao Mei Kun Jiang Weilin Xu State Key Laboratory of Electroanalytical Chemistry and jilin Province Key Laboratory of Low Carbon Chemical Power Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022JilinChina School of Applied Chemistry and Engineering University of Science and Technology of Chin1Hefei 230026AnhuiChina Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryFudan UniversityShanghai 200438China

Here we propose a new concept of"molecule aging":with some special treatment,a molecule could be"aged"by losing some unknown tiny particles or pieces from atoms in the molecule,Such"aging"or loss of unknown tiny particles does not change apparently its molecular structure or chemical composition,but some physicochemical properties could be changed irreversibly.We further confirm such"molecule aging"via a long-term electron attacking to age water(H_(2)O)molecules.The IR spectra show no structural difference between the fresh water and the aged one,while the NMR spectra show that the electron attacking can decrease the size of water clusters.Such facts indicate that the electron attacking indeed can"affect"the structure of water molecule slightly but without damaging to its basic molecule frame.Further exploration reveals that the hydrogen evolution reaction(HER)activity of the aged water molecule is lower than the fresh water on the same Pt/C electrocatalyst.The density functional theory calculations indicate that the shortened O-H bond in H_(2)O indeed can present lower HER activity,so the observed size decrease of water clusters from NMR probably could be attributed to the shortening of O-H bond in water molecules.Such results indicate significantly that the molecule aging can produce materials with new functions for new possible applications.

关键词： Aging of molecules Electron attacking Full width at half maxima Hydrogen evolution reaction

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