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Preliminary single-arm study of brain effects during transcutaneous auricular vagus nerve stimulation treatment of recurrent depression by resting-state functional magnetic resonance imaging

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Journal of Traditional Chinese Medicine 2022年第5期42卷 818-824页

作者： CHEN Limei SUN Jifei GUO Chunlei LI Xiaojiao WANG Zhi Hong Yang fang jiliang Radiology Department Guang'anmen Hospital of China Academy of Chinese Medical SciencesBeijing 10003China

OBJECTIVE:To examine the brain effects of transcutaneous auricular vagus nerve stimulation(ta VNS)treatment of recurrent depression based on the functional brain network by using resting-state functional magnetic resonance imaging(f MRI).METHODS:Twenty-five patients with recurrent depression were enrolled in a single-arm trial of ta VNS treatment for eight *** results were assessed by 17-item Hamilton Depression Rating Scale(HAMD-17),Hamilton Anxiety Scale(HAMA),Self-Rating Depression Scale(SDS),Self-Rating Anxiety Scale(SAS),and Ruminative Response Scale(RRS)***-state f MRI was conducted to explore the brain effects before and after *** the functional connectivity(FC)analysis,the bilateral nucleus accumbens,globus pallidus,caudate,and putamen were selected as ***,the correlations between FC and the clinical scale scores were ***:After treatment,the patients’scores of HAMD-17,HAMA,SDS,SAS,and RRS were significantly decreased(P<0.05).FC was considerably decreased between the following areas:the left globus pallidus and the right postcentral gyrus,inferior parietal gyrus,the right globus pallidus and the left superior marginal gyrus,postcentral gyrus,superior parietal gyrus,inferior parietal gyrus,precuneus,right postcentral gyrus,superior marginal gyrus,and inferior parietal gyrus,between the right caudate and the right lingual gyrus,calcarine gyrus,and *** in FC between the right globus pallidus and the left inferior parietal gyrus,between the left globus pallidus and the right postcentral gyrus were negatively correlated with HAMD-17 scores change before and after treatment(before,P=0.003,r=-0.6;after,P=0.009,r=-0.54).The change of FC between the right globus pallidus and the right postcentral gyrus was negatively correlated with the change in SDS(P=0.026,r=-0.474).The difference in FC between the right globus pallidus and the right postcentral gyrus was negatively correlated with the change in

关键词： recurrence depression magnetic resonance imaging basal ganglia default mode network transcutaneous auricular vagus nerve stimulation

脑功能磁共振成像在中医神经调控领域的应用与展望

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中国中西医结合影像学杂志 2024年第1期22卷 1-3页

作者：王小玲郭春蕾张东友方继良中国中医科学院广安门医院放射科北京100053 湖北省武汉市中西医结合医院湖北武汉430022

fMRI作为脑科学研究的重要工具之一,已逐步应用于我国中医药多个领域,其客观、可视化展示中医药疗效相关的脑功能网络变化,促进了中医药发展与现代脑科学研究的融合,为中医药多领域的神经调控相关理论研究提供了重要证据。总结近年来国... 详细信息

fMRI作为脑科学研究的重要工具之一,已逐步应用于我国中医药多个领域,其客观、可视化展示中医药疗效相关的脑功能网络变化,促进了中医药发展与现代脑科学研究的融合,为中医药多领域的神经调控相关理论研究提供了重要证据。总结近年来国内研究者应用fMRI技术,在针刺、艾灸、推拿及中药领域进行的多方面探索,分析其取得的研究成果及存在的问题,并对该领域相关神经调控的发展方向进行展望。

关键词：脑功能磁共振成像针刺艾灸中药推拿

即刻耳甲电针刺激对轻度认知障碍脑功能影像的影响初探

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阿尔茨海默病及相关病杂志 2024年第2期7卷 94-102,81页

作者：郭春蕾马跃高山山罗屹陈庆燕方继良中国中医科学院广安门医院放射科北京100053

目的:基于静息态功能磁共振成像(rs-fMRI)探讨即刻(30分钟)耳甲电针(taVNS)刺激对轻度认知障碍(MCI)患者脑功能的影响。方法:纳入22例MCI患者,随机分为taVNS组和sham taVNS组,每组各11例,同时纳入11例健康对照(HCs)。3组受试者均进行30... 详细信息

目的:基于静息态功能磁共振成像(rs-fMRI)探讨即刻(30分钟)耳甲电针(taVNS)刺激对轻度认知障碍(MCI)患者脑功能的影响。方法:纳入22例MCI患者,随机分为taVNS组和sham taVNS组,每组各11例,同时纳入11例健康对照(HCs)。3组受试者均进行30分钟耳部电针刺激,其中taVNS组和HCs组接受耳甲刺激位于迷走神经主要分布区,sham taVNS组接受的刺激位于非迷走神经分布的耳舟部,在刺激前后各进行一次rs-fMRI扫描。采用DPABI 8.0软件对rs-fMRI扫描结果进行预处理,随后计算功能连接(FC),对3组受试者刺激前后的FC图像进行比较,并将结果提值,用Graphpad Prism9.0.0进行事后分析,观察taVNS对脑功能的影响。结果:与刺激前相比,刺激后taVNS组右侧海马与右侧小脑_6的FC值显著降低(P<0.005)、左侧尾状核与右侧额上回以及右侧苍白球与左侧尾状核的FC值显著升高(P<0.05);刺激后HCs组左侧尾状核与小脑_8的FC值显著降低(P<0.05)。结论:即刻taVNS可以调节记忆及认知脑区,以及基底节区及小脑等脑功能网络,可能是taVNS治疗MCI的效应靶点。

关键词：轻度认知障碍耳甲电针静息态功能磁共振成像功能连接

耳甲电针(taVNS)治疗轻度认知障碍研究进展

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阿尔茨海默病及相关病杂志 2024年第2期7卷 142-146页

作者：陈庆燕高山山郭春蕾闫华杨戈方继良中国中医科学院广安门医院放射科北京100053 中国中医科学院北京100700 中国中医科学院广安门医院老年科北京100053

轻度认知障碍的治疗是老年健康需要解决的难题。基于中医“脑病耳治”理论的新型神经调控技术——耳甲电针(taVNS),可辅助治疗多种神经、精神系统疾病,近年研究发现其对轻度认知障碍有效。对目前国内外耳甲电针治疗轻度认知障碍的研究... 详细信息

轻度认知障碍的治疗是老年健康需要解决的难题。基于中医“脑病耳治”理论的新型神经调控技术——耳甲电针(taVNS),可辅助治疗多种神经、精神系统疾病,近年研究发现其对轻度认知障碍有效。对目前国内外耳甲电针治疗轻度认知障碍的研究现状进行综述,探讨其疗效、机制,展示其研究成果,提出进一步研究方向。将为MCI非药物疗法提供可借鉴的新思路,为广大老年患者的认知功能改善和生活品质提高提供新技术。

关键词：轻度认知障碍耳甲电针经皮耳穴迷走神经刺激术神经调控研究进展

Transcutaneous auricular vagus nerve stimulation would be an alternative to implantable cervical vagus nerve stimulation in some situation

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Journal of Traditional Chinese Medicine 2023年第3期43卷 627-630页

作者： HE Jiakai ZHANG Jinling WANG Yu LI Shaoyuan fang jiliang ZHANG Shuai ZHAO Yanan ZHAI Weihang GAO Deqiang LI Ran JIANG Yuhang CHEN Zehao JIA Baohui RONG Peijing Department of Physiology Institute of Acupuncture and MoxibustionChina Academy of Chinese Medical SciencesBeijing 100700China Department of Physical Medicine and Rehabilitation Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

Implantable cervical vagus nerve stimulation(i VNS) is a representative and promising ***,the invasive nature restricts its *** auricular acupuncture treatment has a long *** auricular branch of the vagus nerve(ABVN) is a branch on the surface of the *** studies demonstrates that transcutaneous auricular vagus nerve stimulation(ta VNS) would achieve similar effects as i *** VNS and i VNS share a common anatomical basis and acting *** this article,we made a comparison between i VNS and ta VNS in indications and *** recent studies have revealed similar clinical efficacy of ta VNS,ta VNS would expand the indication of i *** clinical evidences are needed before ta VNS become be an alternative of i VNS.

关键词： transcutaneous auricular vagus nerve stimulation auricular branch of vagus nerve neuromodulation efficacy

Effects of three needling manipulations of the right-side Zusanli(ST 36) on brain using functional magnetic resonance imaging

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Journal of Traditional Chinese Medicine 2017年第3期37卷 298-307页

作者： Lu Fengyan Gao Junhong Wang Yuanyuan Dai Qiufu Bao Yan Hong Yang Zhang Guolei Xin Juanjuan Zhao Yuxue Wu Shuyang Chen Yuanyuan Li Xiaojiao fang jiliang Yu Xiaochun Department of Needling Manipulation Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences Department of medical imaging Guang An Men Hospital China Academy of Chinese Medical Sciences

OBJECTIVE: To investigate the effects on the brain using three needling manipulations(twirling, lifting-thrusting, and twirling plus lifting-thrusting)when the right-side Zusanli(ST 36) acupoint was stimulated with ***: Seventeen healthy subjects accepted three needling manipulations stimulating the right Zusanli(ST 36) over separate days. Functional magnetic resonance imaging was used to detect changes in the brain during the manipulations, and then the needling sensations were recorded using the MGH acupuncture sensation scale(MASS) after each scan. f MRI data were processed using Statistical Parametric Mapping 8 to analyze the positiveand negative activation in the brain induced by different acupuncture ***: The individual needling sensations showed no statistically significant differences among the three manipulations. However, the MASS index showed that lifting-thrusting > twirling plus lifting-thrusting > twirling. Lifting-thrusting activated left premotor cortex, left postcentral,right middle frontal gyrus, left inferior frontal gyrus,right lingual gyrus, left insula, right putamen, bilateral cingulate gyrus and right cerebellum; and deactivated bilateral hippocampus and left *** activated bilateral orbital middle frontal gyrus, left opercular and triangular inferior frontal gyrus, and right middle occipital gyrus; and deactivated bilateral precuneus, right amygdala, left anterior cingulate gyrus, right inferior temporal gyrus,right middle frontal gyrus, right supplementary motor gyrus, and left postcentral. Twirling plus lifting-thrusting activated bilateral postcentral, left inferior occipital gyrus, left insula, left thalamus, left cingulate gyrus, and right putamen; and deactivated right superior frontal gyrus, right superior parietal gyrus, right temporal gyrus, right middle occipital gyrus, right insula, and left lingual gyrus. Pairwise comparisons of the three manipulations showed that signals induced by lifti

关键词： Needling methods Point ST 36 (Zusan-li) Magnetic resonance imaging Limbic system Neocortex

Quasinormal modes and isospectrality of Bardeen(Anti-)de Sitter black holes

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Chinese Physics C 2024年第3期48卷 191-202页

作者：赵莹刘文韬张超房熊俊荆继良 Department of Physics Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of Educationand Synergetic Innovation Center for Quantum Effects and ApplicationsInstitute of Interdisciplinary StudiesHunan Normal UniversityChangsha 410081China Department of Physics Faculty of ScienceTokyo University of Science1-3KagurazakaShinjuku-kuTokyo 162-8601Japan

Black holes(BHs)exhibiting coordinate singularities but lacking essential singularities throughout the spacetime are referred to as regular black holes(RBHs).The initial formulation of RBHs was presented by Bardeen,who considered the Einstein equation coupled with a nonlinear electromagnetic *** this study,we investigate the gravitational perturbations,including the axial and polar sectors,of the Bardeen(Anti-)de Sitter black *** derive the master equations with source terms for both axial and polar perturbations and subsequently compute the quasinormal modes(QNMs)through numerical *** the Bardeen de Sitter black hole,we employ the 6thorder WKB *** numerical results reveal that the isospectrality is broken in this ***,the QNM frequencies are calculated using the HH method for the Bardeen Anti-de Sitter black hole.

关键词： Bardeen quasinormal modes master equation

THE BRAIN NETWORK INVOLVING IN ACUPUNCTURE IN TREATING FUNCTIONAL DYSPEPSIA — A RESTING STATE fMRI STUDY

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Journal of Integrative Medicine 2014年第3期 244-244页

作者： jiliang fang Guang ’anmen Hospital China Academy of Chinese Medical Sciences

Background: Acupuncture has been used to treat GI symptoms by altering acid secretion, GI motility, and visceral ***,the mechanism behind the beneficial effects remains *** this study, effects of acupuncture on the brain in treating functional dyspepsia(FD) are investigated by ***: Eight FD patients were recruited according to the Rome III criteria, with 8 healthy volunteers as *** resting fMRI was conducted in patients as well as the healthy subjects before and after one-month ***, the Symptom Index of Dyspepsia was scored, and the gastric motility barium meal dynamic radiography was monitored in one-minute video,and the serum gastrin(GS) was tested before and after *** clinical data were analyzed with SPSS *** resting fMRI data, the degree of local connectivity(LC) at each voxel of the brain and the functional connectivity(FC) maps based on a set of seeds were computed, then the comparison between patients and the control was conducted, the regions showing patient/control difference were then masked with the regions showing changes before/after ***: LC and FC were reduced in FD patients, and were improved after acupuncture *** score of Symptom Index of Dyspepsia in FD was significantly higher than healthy subjects before treatment, while it was decreased after *** imaging indices of gastric motility and GAS were close to the normal level after acupuncture, including the height of gastric retention liquid, the width of midgastric transverse band, the frequency of peristole and the time of ***: Acupuncture improved the brain network of FD involving the attention, emotion, cognition, control and default *** is consistent with the acupuncture effects for relieving clinical symptoms, enhancing gastric motility and increasing the level of gastrin.

关键词： fMRI A RESTING STATE fMRI STUDY THE BRAIN NETWORK INVOLVING IN ACUPUNCTURE IN TREATING FUNCTIONAL DYSPEPSIA

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CT定位下风府穴安全进针深度研究

中国针灸 2000年第12期20卷 729-730页

作者：方继良张民王映辉中国中医研究院广安门医院北京100053

本文初步研究了CT定位下风府穴安全进针深度 ,说明其与颈围、体重有较好的直线相关性 ,可利用此两指标求得相应个体的安全深度。结果显示 :鼻尖方向针刺风府穴可损伤延髓 ,针刺安全深度男性为 5 5 71± 7 1 8mm ,女性为 43 83± 5 81m... 详细信息

本文初步研究了CT定位下风府穴安全进针深度 ,说明其与颈围、体重有较好的直线相关性 ,可利用此两指标求得相应个体的安全深度。结果显示 :鼻尖方向针刺风府穴可损伤延髓 ,针刺安全深度男性为 5 5 71± 7 1 8mm ,女性为 43 83± 5 81mm ,有显著差异。

关键词：针刺深度 CT定位风府穴安全深度