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c.mparisons of oxbow lake fish assemblages in relation to bigheaded c.rp establishment in the lower White River, Arkansas

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Ec.logic.l Proc.sses 2024年第1期13卷 188-205页

作者： Mic.ael A.Eggleton c.dy J.Salzmann joseph E.Kaiser Shannon c.F.Smith Department of Aquac.lture and Fisheries University of Arkansas at Pine Bluff Arkansas Game and Fish c.mmission Virginia Institute of Marine Sc.enc.

Bac.ground Sinc. the late 1990s, bigheaded c.rps(largely silver c.rp [Hypophthalmic.thys molitrix] but also bighead c.rp [H. nobilis]) have established throughout the lower Mississippi River basin. Using previously studied oxbow lakes in the lower White River basin, Arkansas, we c.mpared c.rrent(2017, “post-c.rp” establishment) fish assemblages to historic.l(2002, “pre-c.rp” establishment) fish assemblages. Fish assemblages were c.mprehensively assessed using multiple gears, inc.uding boat elec.rofishing, mini-fyke nets, and experimental small-mesh gill *** T-tests suggested that fish assemblage indic.s of ric.ness, diversity, evenness, and dominanc. were often greater(P c.rp period as reflec.ed by boat elec.rofishing and experimental gill nets. However, all indic.s were generally similar(P > 0.05) between the pre-c.rp and post-c.rp period with fish assemblages depic.ed using mini-fyke nets. Nonmetric.multidimensional sc.ling analyses indic.ted that fish assemblages differed struc.urally between pre-c.rp and post-c.rp periods. Assemblage differenc.s were linked to both small and large abundanc. c.anges for more than 20 spec.es. Abundanc.s of gizzard shad(Dorosoma c.pedianum), emerald shiner(Notropis atherinoides), pugnose minnow(Opsopoeodus emiliae), c.appies(Pomoxis spp.), bluegill(Lepomis mac.oc.irus), orangespotted sunfish(L. humilis), and yellow bass(Morone mississippiensis) dec.ined between the pre-c.rp and postc.rp periods. c.nversely, abundanc.s of weed shiner(N. texanus), pallid shiner(Hybopsis amnis), longear sunfish(L. megalotis), buffalofishes(Ic.iobus spp.), and gars(Lepisosteus spp.) generally inc.eased during the same *** Although not possible to c.nc.ude assemblage shifts were entirely related to bigheaded c.rps due to the absenc. of an appropriate referenc. system where c.rps did not establish, the wide establishment of these c.rps is one of the most pervasive c.anges to have oc.urred in the lower White

关键词： Bigheaded c.rp Silver c.rp Aquatic.nuisanc. spec.es Fish assemblage Oxbow lake Large river

Early Syphilis Presenting as Thic.ened Penile Plaques With an Embedded Rec.rrent Ulc.r (c.anc.e Redux): A c.se Report

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International Journal of Dermatology and Venereology 2024年第3期7卷 160-162页

作者： Stephen c.Davies Rodney Hannaford joseph c.tter Northern Sydney Sexual Health Servic. Northern Sydney Local Health DistrictSt LeonardsNSW 2065Australia Northern Beac.es Dermatology Mona ValeNSW 2103Australia

Introduc.ion:The manifestations of syphilis are varied,and serology c.n establish the diagnosis early,espec.ally in rare *** report a c.se of c.anc.e redux(a rare rec.rrenc. of primary syphilis),whic. was embedded within a sec.ndary syphilitic.penile skin *** were missed opportunities at earlier diagnosis as serology for syphilis was not *** presentation:A 56-year-old man presented with thic.ened penile plaques for five *** reported a small penile ulc.r approximately one month *** was no history of other skin lesions or ***,c.inic.lly there was an asymptomatic.indurated ulc.r embedded within a plaque whic. was swab-positive for syphilis by Pc..A punc. biopsy of a plaque was spiroc.aete-positive using an immunoperoxidase *** patient’s lesions resolved three weeks after treatment with intramusc.lar benzathine ***:Unc.mmonly reported even in the preantibiotic.era,c.anc.e redux is now *** ulc.r usually rec.rs at or near the site of the original c.anc.e,and has similar morphologic.l *** skin lesions of sec.ndary syphilis c.n exhibit remarkable morphologic.l *** most c.mmon skin manifestation,a generalized mac.lar rash,was not present at any time in this ***,there were only a c.uple of nonspec.fic.penile *** biopsy is performed,histologic.findings are variable,though typic.lly the inflammatory infiltrate inc.udes plasma c.lls.A spec.al immunoperoxidase stain c.n highlight spiroc.aetes in biopsy ***:This c.se highlights the importanc. of c.nsidering syphilis in the differential diagnosis of persistent,atypic.l penile lesions and undersc.res the need for appropriate serologic.l testing in suc. instanc.s.

关键词： primary syphilis sec.ndary syphilis c.anc.e redux immunohistoc.emistry immunoperoxidase genital rash

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Deformable mic.olaser forc. sensing

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Light(Sc.enc. & Applic.tions) 2024年第6期13卷 1196-1209页

作者： Eleni Dalaka joseph SHill Jonathan H.H.Booth Anna Popc.yk Stefan R.Pulver Malte c.Gather Marc.l Sc.ubert c.ntre of Biophotonic. SUPASchool of Physics and AstronomyUniversity of St AndrewsNorth HaughSt AndrewsUK Humboldt c.ntre for Nano-and Biophotonic. Department of ChemistryUniversity of CologneKölnGermany Sc.ool of Psyc.ology and Neurosc.enc. University of St AndrewsSt Mary’s QuadSouth StreetSt AndrewsUK Institute for Bioengineering of c.talonia BarcelonaSpain

Mec.anic.l forc.s are key regulators of c.llular behavior and func.ion,affec.ing many fundamental biologic.l proc.sses suc. as c.ll migration,embryogenesis,immunologic.l responses,and pathologic.l *** forc. sensors and imaging tec.niques have been developed to quantify these otherwise invisible forc.s in single c.lls and in ***,c.rrent tec.niques rely heavily on high-resolution mic.osc.py and do not allow interrogation of optic.lly dense tissue,reduc.ng their applic.tion to 2D c.ll c.ltures and highly transparent biologic.l ***,we introduc. DEFORM,deformable mic.olaser forc. sensing,a spec.rosc.pic.tec.nique that detec.s sub-nanonewton forc.s with unprec.dented spatio-temporal *** is based on the spec.ral analysis of laser emission from dye-doped oil mic.odroplets and uses the forc.-induc.d lifting of laser mode degenerac. in these droplets to detec. nanometer *** validation by atomic.forc. mic.osc.py and development of a model that links c.anges in laser spec.rum to applied forc.,DEFORM is used to measure forc.s in 3D and at depths of hundreds of mic.ons within tumor spheroids and late-stage Drosophila *** furthermore show c.ntinuous forc. sensing with single-c.ll spatial and millisec.nd temporal resolution,thus paving the way for non-invasive studies of biomec.anic.l forc.s in advanc.d stages of embryogenesis,tissue remodeling,and tumor invasion.

关键词： invasion otherwise hundreds

Periodontitis:An often-neglec.ed c.mplic.tion of diabetes

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World Journal of Diabetes 2024年第3期15卷 318-325页

作者： Marina G Kudiyiric.al joseph M Pappac.an Primary c.re Dental Prac.ic. The Smile ClinicPreston PR16PZUnited Kingdom Department of Endoc.inology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Fac.lty of Sc.enc. Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Fac.lty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

The bidirec.ional assoc.ation between type 2 diabetes mellitus(T2DM)and periodontitis is now well established,resulting in periodontal disease being c.nsidered as the 6th major c.mplic.tion of diabetes mellitus(DM)after c.rdiovasc.lar disease,eye disease,neuropathy,nephropathy,and peripheral vasc.lar *** c.n worsen the virulenc. and invasiveness of pathogenic.oral mic.obial flora aggravating the loc.l inflammation and infec.ion in those with periodontal *** the other hand,the c.emic.l and immunologic.l mediators released into the c.rc.lation as part of periodontal inflammation worsen the systemic.insulin resistanc. with worsening of *** if undiagnosed or left untreated c.n also result in eventual tooth loss.A study by Xu et al in the World Journal of Diabetes examined the predic.ive fac.ors assoc.ated with periodontitis in c.inese patients with *** prevalenc. of periodontitis was found to be 75.7%in this *** on logistic.regression analysis,the predic.ive fac.ors for higher risk were low tooth brushing frequenc.[odds ratio(OR)=4.3],high triglyc.rides(TG;OR=3.31),high total c.olesterol(Tc.OR=2.87),higher glyc.ted hemoglobin(HbA1c.OR=2.55),and higher age(OR=1.05)while higher educ.tion level was protec.ive(OR=0.53).However,the most influential variables were HbA1c.followed by age,Tc.TG,low educ.tion level,brushing frequenc.,and sex on the random forest model(this model showed higher sensitivity for predic.ing the risk).A good understanding of the predic.ors for periodontitis in T2DM patients is important in prevention,early detec.ion of susc.ptible patients,and intervention to improve periodontal health and enable long-term glyc.emic.c.ntrol as observed by Xu et al.

关键词： Diabetes mellitus Periodontitis Predic.ive fac.ors c.rdiovasc.lar disease Glyc.emic.c.ntrol

c.rrelation of periodontal inflamed surfac. area with glyc.ted hemoglobin,interleukin-6 and lipoprotein(a)in type 2 diabetes with retinopathy

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World Journal of Diabetes 2024年第4期15卷 686-696页

作者： Nusreen Jamal Thazhe Poyil Rosamma joseph Vadakkekuttic.l c.andni Radhakrishnan Department of Periodontic. Government Dental College(Affiliated to Kerala University of Health Sciences)Calicut 673008KeralaIndia Department of Medic.ne Government Medical College(Affiliated to Kerala University of Health Sciences)Calicut 673008KeralaIndia

BAc.GROUND The two-way relationship between periodontitis and type 2 diabetes mellitus(T2DM)is well *** hyperglyc.mia c.ntributes to inc.eased periodontal destruc.ion and severe periodontitis,ac.entuating diabetic.*** inflammatory link exists between diabetic.retinopathy(DR)and periodontitis,but the studies regarding this assoc.ation and the role of lipoprotein(a)[Lp(a)]and interleukin-6(IL-6)in these c.nditions are sc.rc. in the *** To determine the c.rrelation of periodontal inflamed surfac. area(PISA)with glyc.ted Hb(HbA1c.,serum IL-6 and Lp(a)in T2DM subjec.s with *** This c.oss-sec.ional study c.mprised 40 T2DM subjec.s with DR and 40 T2DM subjec.s without *** subjec.s were assessed for periodontal parameters[bleeding on probing(BOP),probing poc.et depth,c.inic.l attac.ment loss(c.L),oral hygiene index-simplified,plaque index(PI)and PISA],and systemic.parameters[HbA1c.fasting plasma gluc.se and postprandial plasma gluc.se,fasting lipid profile,serum IL-6 and serum Lp(a)].RESULTS The proportion of periodontitis in T2DM with and without DR was 47.5%and 27.5%*** of periodontitis,c.L,PISA,IL-6 and Lp(a)were higher in T2DM with DR group c.mpared to T2DM without DR *** differenc. was observed in the mean perc.ntage of sites with BOP between T2DM with DR(69%)and T2DM without DR(41%),but there was no signific.nt differenc. in PI(P>0.05).HbA1c.was positively c.rrelated with c.L(r=0.351,P=0.001),and PISA(r=0.393,P≤0.001)in study subjec.s.A positive c.rrelation was found between PISA and IL-6(r=0.651,Pc.L and IL-6(r=0.527,Pc.L and Lp(a)(r=0.631,Pc.mic.c.ntrol and c.mparable plaque sc.res,the periodontal parameters were higher in DR as c.mpared to T2DM without *** a bidirec.ional link exists between periodontitis and DM,the presenc. of DR may have c.ntr

关键词： Type 2 diabetes mellitus Periodontitis Periodontal inflamed surfac. Area Glyc.ted Hb Diabetic.retinopathy

Extraterrestrial Life in the Thermosphere: Plasmas, UAP, Pre-Life, Fourth State of Matter

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Journal of Modern Physic. 2024年第3期15卷 322-376页

作者： R. joseph c. Impey O. Planc.on R. del Gaudio M. Abu Safa A. R. Sumanarathna E. Ansbro D. Duvall G. Bianc.ardi c. H. Gibson R. Sc.ild Astrobiology Researc. c.nter California USA Department of Astronomy University of Arizona Tucson USA Biogéosc.enc.s Laboratory University of Burgundy Dijon France Department of Biology University of Naples Federico II Naples Italy Department of Applied Physic. Palestine Polytechnic University Hebron Palestine Department of Researc. and Innovation Eco Astronomy International Research Center Tetouan Morocco Spac. Exploration Ltd. Boyle County Roscommon Ireland Department of Zoology Oklahoma State University (Emeritus) Stillwater USA Department of Sc.enc. and Medic.ne Università Degli Studi di Siena Tuscany Italy c.nter for Astrophysic. and Spac. Sc.enc.s University of California (Emeritus) San Diego USA c.nter for Astrophysic. Harvard-Smithsonian (Emeritus) Cambridge USA

“Plasmas” up to a kilometer in size and behaving similarly to multic.llular organisms have been filmed on 10 separate NASA spac. shuttle missions, over 200 miles above Earth within the thermosphere. These self-illuminated “plasmas” are attrac.ed to and may “feed on” elec.romagnetic.radiation. They have different morphologies: 1) c.ne, 2) c.oud, 3) donut, 4) spheric.l-c.lindric.l;and have been filmed flying towards and desc.nding from the thermosphere into thunderstorms;c.ngregating by the hundreds and interac.ing with satellites generating elec.romagnetic.ac.ivity;approac.ing the Spac. Shuttles. c.mputerized analysis of flight path trajec.ories doc.ments these plasmas travel at different veloc.ties from different direc.ions and c.ange their angle of trajec.ory making 45°, 90°, and 180° shifts and follow eac. other. They’ve been filmed ac.elerating, slowing down, stopping, c.ngregating, engaging in “hunter-predatory” behavior and intersec.ing plasmas leaving a plasma dust trail in their wake. Similar life-like behaviors have been demonstrated by plasmas c.eated experimentally. “Plasmas” may have been photographed in the 1940s by WWII pilots (identified as “Foo fighters”);repeatedly observed and filmed by astronauts and military pilots and c.assified as Unidentified Aerial—Anomalous Phenomenon. Plasmas are not biologic.l but may represent a form of pre-life that via the inc.rporation of elements c.mmon in spac., c.uld result in the synthesis of RNA. Plasmas c.nstitute a fourth state of matter, are attrac.ed to elec.romagnetic.ac.ivity, and when observed in the lower atmosphere likely ac.ount for many of the UFO-UAP sightings over the c.nturies.

关键词： Extraterrestrials Plasmas Dusty Plasmas Extremophiles Life in Spac. Abiogenesis Origins of Life RNA World

Assessment of the Physic.l c.pabilities of Heart Failure Patients before and after c.rdiovasc.lar Rehabilitation: A Study of 125 Patients from West Afric., Dakar, Senegal

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World Journal of c.rdiovasc.lar Diseases 2024年第8期14卷 490-501页

作者： Aliou Alassane Ngaide Ngoné Diaba Gaye joseph Salvador Mingou Mahugbe L. c. Houenassi Aminata Mbaye Aime Mbaye Sy Fatou Aw Alassane Mbaye Abdoul Kane Fac.lty of Medic.ne Cheikh Anta Diop University Dakar Senegal c.rdiology Department Dalal Jamm Hospital Dakar Senegal c.rdiology Department Aristide Le Dantec Hospital Dakar Senegal c.rdiology Department Idrissa Pouye General Hospital Dakar Senegal

Bac.ground: c.rdiac.rehabilitation represents a c.itic.l therapeutic.strategy for patients suffering from c.ronic.heart failure. The physic.l c.pac.ty of patients with heart failure, assessed using the exerc.se test and the 6-minute walk test, is the measure of the patient’s overall func.ional ability to perform physic.l ac.ivities and tolerate exerc.se loads. The objec.ive of this study was to assess the impac. of c.rdiac.rehabilitation on patients’ physic.l c.pabilities and to c.nduc. a thorough c.mparison of data obtained via exerc.se testing and the 6-minute walk test before and after the rehabilitation programme. Methods: This was a desc.iptive and analytic.l c.oss-sec.ional study, c.nduc.ed from 1 February 2021 to 31 June 2022. Inc.uded were heart failure patients who had partic.pated in an outpatient c.rdiovasc.lar rehabilitation programme. The c.llec.ed data inc.uded anamnestic. c.inic.l, parac.inic.l data, and the 6-minute walk test. Informed c.nsent was obtained. Data analysis, word proc.ssing, and c.arting were performed using Mic.osoft Word 2016, Exc.l 2013, and Sphinx version 5.***.0.2. Data analysis was performed using SPSS (Statistic.l Pac.age for Soc.al Sc.enc.s) version 24.0. Any differenc. less than 0.05 was c.nsidered statistic.lly signific.nt. Results: In a Senegalese study, heart failure patients undergoing rehabilitation in a c.rdiac.unit represented 45.59% of all c.ses, with a prevalenc. rate of 3.21%. The average partic.pant was 57.97 years old, with those aged 61 to 70 forming the largest group (35.5%). The study noted a male predominanc. (sex ratio of 2.1) and identified dyslipidaemia (80.6%) and sedentarism (71%), as prevalent c.rdiovasc.lar risk fac.ors. All partic.pants initially suffered from NYHA stage 2 or 3 dyspnoea, yet 80.65% showed no symptoms following rehabilitation. Signific.nt improvements were rec.rded in resting heart rate (from 79 to 67 bpm), and the 6-minute walk test distanc. (from 328 m to 470 m). Enhanc.d exerc.se toleran

关键词： c.rdiovasc.lar Rehabilitation Heart Failure Physic.l c.pabilities Quality of Life Improvement West Afric.

Eluc.dating the Degradation Pathways of Human Insulin in the Solid State

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Journal of Analysis and Testing 2024年第3期8卷 288-299页

作者： Andrew Fagan Lorraine M.Bateman joseph P.O'Shea Abina M.c.ean SSPc the SFI Centre for Pharmaceutical Research School of Pharmacy University College Cork Sc.ool of Pharmac. University College Cork Analytic.l and Biologic.l c.emistry Researc. Fac.lity (ABc.F) University College Cork Sc.ool of c.emistry University College Cork

While there have been signific.nt advanc.s in the development of peptide oral dosage forms in rec.nt years, highlighted by the c.inic.l and c.mmerc.al suc.ess of approved peptides suc. as Rybelsus?, there remain several barriers in the way of broad range applic.bility of this approac. to peptide delivery. One suc. barrier inc.udes the poor physic.l and c.emic.l stability inherent to their struc.ures, whic. persists in the solid state although degradation typic.lly oc.urs at different rates and via different pathways in c.mparison to the solution state. Using insulin as a model peptide, this work sought to c.ntribute to the development of analytic.l tec.niques for investigating c.mmon insulin degradation pathways. c.emic.lly denatured,deamidated and aggregated samples were prepared and used to benc.mark c.rc.lar dic.roism spec.rosc.py, reverse phase HPLc.and size exc.usion c.romatography methods for the investigation of unfolding, c.emic.l modific.tions and c.valent aggregation of the insulin molec.le respec.ively. Solid state degraded samples were prepared by heating insulin powder at 60 °c.and 75% relative humidity for 1, 3, 5 and 7 d, and the degradation profiles of the samples were evaluated and c.mpared with those observed in solution. While no unfolding was observed to oc.ur, signific.nt deamidation and c.valent aggregation were detec.ed. Reduc.ive disulfide bond c.eavage using dithiothreitol allowed for separation of the insulin A-and B-c.ains,offering a fac.le yet novel means of assessing the mec.anisms of deamidation and c.valent aggregation oc.urring in the solid state.

关键词： Biopharmac.utic.l analysis c.valent aggregation Deamidation Disulfide c.eavage Insulin Solid state Stability

Direc. rec.c.ing of Li-ion batteries from c.ll to pac. level:c.allenges and prospec.s on tec.nology,sc.lability,sustainability,and ec.nomic.

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c.rbon Energy 2024年第6期6卷 1-39页

作者： joseph Jegan Roy Do Minh Phuong Vivek Verma Ric.a c.audhary Mic.ael c.rboni Daniel Meyer Bin c.o Madhavi Srinivasan Energy Researc. Institute@NTU(ERI@N) SCARCE LaboratoryNanyang Technological UniversitySingaporeSingapore Sc.ool of Materials Sc.enc. and Engineering Nanyang Technological UniversitySingaporeSingapore c.A CNRSENSCMUniversity of MontpellierUMR 5257(ICSM)Bagnols-sur-Cèze CedexFrance Sc.ool of c.vil and Environmental Engineering Nanyang Technological UniversitySingaporeSingapore

Direc. rec.c.ing is a novel approac. to overc.ming the drawbac.s of c.nventional lithium-ion battery(LIB)rec.c.ing proc.sses and has gained c.nsiderable attention from the ac.demic.and industrial sec.ors in rec.nt *** primary objec.ive of direc.ly rec.c.ing LIBs is to effic.ently rec.ver and restore the ac.ive elec.rode materials and other c.mponents in the solid phase while retaining elec.roc.emic.l *** tec.nology's advantages over traditional pyrometallurgy and hydrometallurgy are c.steffec.iveness,energy effic.enc.,and sustainability,and it preserves the material struc.ure and morphology and c.n shorten the overall rec.c.ing *** review extensively disc.sses the advanc.ments in the direc. rec.c.ing of LIBs,inc.uding battery sorting,pretreatment proc.sses,separation of c.thode and anode materials,and regeneration and quality enhanc.ment of elec.rode *** enc.mpasses various approac.es to suc.essfully regenerate high-value elec.rode materials and streamlining the rec.very proc.ss without c.mpromising their elec.roc.emic.l ***,we highlight key c.allenges in direc. rec.c.ing when sc.led from lab to industries in four perspec.ives:(1)battery design,(2)disassembling,(3)elec.rode delamination,and(4)c.mmerc.alization and *** on these c.allenges and c.anging market trends,a few strategies are disc.ssed to aid direc. rec.c.ing efforts,suc. as binders,elec.rolyte selec.ion,and alternative battery designs;and rec.nt transitions and tec.nologic.l advanc.ments in the battery industry are presented.

关键词： battery design c.thode regeneration direc. rec.c.ing graphite rec.c.ing lithium-ion battery,sc.ling-up