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Prognostic significance of grade of malignancy based on histopathological differentiation and Ki-67 in pancreatic ductal adenocarcinoma

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Cancer Biology & Medicine 2024年第5期21卷 416-432页

作者： Yuexiang Liang Guannan Sheng Yu Guo Yiping Zou Hanhan Guo Zhifei Li Shaofei Chang Quan Man Song gao jihui Hao Department of Pancreatic Cancer Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer Department of Gastrointestinal Oncology The First Affiliated Hospital of Hainan Medical University Department of Gastrointestinal Pancreatic Surgery Shanxi Provincial People's Hospital

Objective: Tumor cell malignancy is indicated by histopathological differentiation and cell proliferation. Ki-67, an indicator of cellular proliferation, has been used for tumor grading and classification in breast cancer and neuroendocrine tumors. However, its prognostic significance in pancreatic ductal adenocarcinoma(PDAC) remains uncertain.Methods: Patients who underwent radical pancreatectomy for PDAC were retrospectively enrolled, and relevant prognostic factors were examined. Grade of malignancy(GOM), a novel index based on histopathological differentiation and Ki-67, is proposed, and its clinical significance was evaluated.Results: The optimal threshold for Ki-67 was determined to be 30%. Patients with a Ki-67 expression level > 30% rather than ≤ 30% had significantly shorter 5-year overall survival(OS) and recurrence-free survival(RFS). In multivariate analysis, both histopathological differentiation and Ki-67 were identified as independent prognostic factors for OS and RFS. The GOM was used to independently stratify OS and RFS into 3 tiers, regardless of TNM stage and other established prognostic factors. The tumor-nodemetastasis-GOM stage was used to stratify survival into 5 distinct tiers, and surpassed the predictive performance of TNM stage for OS and RFS.Conclusions: Ki-67 is a valuable prognostic indicator for PDAC. Inclusion of the GOM in the TNM staging system may potentially enhance prognostic accuracy for PDAC.

关键词： Ki-67 Pancreatic ductal adenocarcinoma TNM stage differentiation prognosis

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Tuning porosity of coal-derived activated carbons for CO_(2) adsorption

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Frontiers of Chemical Science and Engineering 2022年第9期16卷 1345-1354页

作者： Zhipeng Qie Lijie Wang Fei Sun Huan Xiang Hua Wang jihui gao Guangbo Zhao Xiaolei Fan School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Department of Chemical Engineering and Analytical Science The University of ManchesterManchester M139PLUK China Datang Corporation Renewable Energy Science and Technology Research Institute Beijing 100052China Energy and Bioproducts Research Institute(EBRI) Aston UniversityBirmingham B47ETUK

A simple method was developed to tune the porosity of coal-derived activated carbons,which provided a model adsorbent system to investigate the volumetric CO_(2)adsorption performance.Specifically,the method involved the variation of the activation temperature in a K2CO3 induced chemical activation process which could yield activated carbons with defined microporous(<2 nm,including ultra-microporous<1 nm)and meso-microporous structures.CO_(2)adsorption isotherms revealed that the microporous activated carbon has the highest measured CO_(2)adsorption capacity(6.0 mmol∙g^(–1)at 0℃and 4.1 mmol∙g^(-1)at 25℃),whilst ultra-microporous activated carbon with a high packing density exhibited the highest normalized capacity with respect to packing volume(1.8 mmol∙cm−3 at 0℃and 1.3 mmol∙cm^(–3)at 25℃),which is significant.Both experimental correlation analysis and molecular dynamics simulation demonstrated that(i)volumetric CO_(2)adsorption capacity is directly proportional to the ultra-micropore volume,and(ii)an increase in micropore sizes is beneficial to improve the volumetric capacity,but may lead a low CO_(2)adsorption density and thus low pore space utilization efficiency.The adsorption experiments on the activated carbons established the criterion for designing CO_(2)adsorbents with high volumetric adsorption capacity.

关键词： coal-derived activated carbons porosity CO_(2)adsorption molecular dynamics

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Simultaneous utilization of electro-generated O_(2)and H_(2)for H_(2)O_(2)production:An upgrade of the Pd-catalytic electro-Fenton process for pollutants degradation

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Chinese Journal of Chemical Engineering 2022年第4期35卷 363-368页

作者： Wei Zhou Xiaoxiao Meng Liang Xie Junfeng Li Yani Ding Yanlin Su jihui gao Guangbo Zhao School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China

The Electro-Fenton(EF)process is one of the promising advanced oxidation processes(AOPs)for environmental remediation.The H_(2)O_(2) yield of EF process largely determines its performance on organic pollutants degradation.Conventional Pd-catalytic EF process generates H_(2)O_(2) via the combination reaction of anodic O_(2) and cathodic H;.However,the relatively expensive catalyst limits its application.Herein,a hybrid Pd/activated carbon(Pd/AC)-stainless steel mesh(SS)cathode(PACSS)was proposed,which enables more efficie nt H_(2)O_(2)generation.It utilizes AC,the support of Pd catalyst,as part of cathode for H_(2)O_(2) generation via 2-electron anodic O_(2) reduction,and SS serve as a current distributor.Moreover,H_(2)O_(2) could be catalytically decomposed upon AC to generate highly reactive·OH,which avoids the use of Fe;.Compared with conventional Pd catalyst,H_(2)O_(2) concentration obtained by PACSS cathode is248.2%higher,the O_(2)utilization efficiency was also increased from 3.2%to 10.8%.Within 50 min,26.3%,72.5%,and 94.0%H_(2)O_(2) was decomposed by Pd,AC,and Pd/AC.Fluorescence detection results implied that Pd/AC is effective upon H_(2)O_(2) activation for·OH generation.Finally,iron-free EF process enabled by PACSS cathode was examined to be effective for reactive blue 19(RB19)degradation.After continuous running for 10 cycles(500 min),the PACSS cathode was still stable for H_(2)O_(2)generation,H_(2)O_(2)activation,and RB19 degradation,showing its potential application for organic pollutants degradation without increase in the running cost.

关键词： Electro-Fenton Hydrogen peroxide Hydroxyl radicals Oxygen reduction reaction Organic pollutants

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肿瘤类器官在胰腺癌综合治疗中的应用及研究进展

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中华外科杂志 2024年第7期62卷 710-713页

作者：王宏伟马晓青高松郝继辉天津医科大学肿瘤医院胰腺肿瘤防治中心天津市消化系统肿瘤重点实验室天津市恶性肿瘤临床医学研究中心国家恶性肿瘤临床医学研究中心天津

胰腺癌的恶性程度高, 5年生存率约13%。早期诊断困难、肿瘤异质性高、肿瘤原发性耐药和缺乏有效新药是胰腺癌治疗效果差的主要原因。传统的细胞模型无法模拟人体内的肿瘤生长环境, 不能体现胰腺癌的异质性, 而动物模型培养周期长, 无法... 详细信息

胰腺癌的恶性程度高, 5年生存率约13%。早期诊断困难、肿瘤异质性高、肿瘤原发性耐药和缺乏有效新药是胰腺癌治疗效果差的主要原因。传统的细胞模型无法模拟人体内的肿瘤生长环境, 不能体现胰腺癌的异质性, 而动物模型培养周期长, 无法进行高通量筛选。胰腺癌类器官可以在体外不断扩增培养, 可真实地反映胰腺癌的异质性并进行高通量药物筛选, 是胰腺癌个体化精准诊疗的理想工具。本文回顾了近年来利用胰腺癌类器官评估临床药物有效性的研究, 发现胰腺癌类器官药物敏感性与临床药效高度一致, 论证了通过胰腺癌类器官的药物敏感性指导临床用药方案的可行性, 以及通过胰腺癌类器官高通量药物筛选发现潜在新药的能力, 同时回顾了胰腺癌类器官作为能够体现胰腺癌特殊微环境的模型, 对于新药研发和微环境评价的作用。胰腺癌类器官及器官芯片是肿瘤精准诊疗和新药研发的有力工具。

关键词：胰腺肿瘤肿瘤治疗方案类器官高通量筛选器官芯片肿瘤微环境

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基于分工和模糊控制的粒子群算法

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复杂系统与复杂性科学 2024年第1期21卷 109-118页

作者：李金张纪会高学柳张保华青岛大学复杂性科学研究所山东青岛266071 青岛大学山东省工业控制技术重点实验室山东青岛266071 青岛港国际股份有限公司山东青岛266011

为解决粒子群算法在求解复杂优化问题时容易陷入局部最优、寻优精度低、后期收敛慢等问题,提出一种基于分工和模糊控制的粒子群算法,使用分工、参数自适应调整和融合距离因素的模拟退火三种策略对粒子群算法进行改进。将粒子分为侦察粒... 详细信息

为解决粒子群算法在求解复杂优化问题时容易陷入局部最优、寻优精度低、后期收敛慢等问题,提出一种基于分工和模糊控制的粒子群算法,使用分工、参数自适应调整和融合距离因素的模拟退火三种策略对粒子群算法进行改进。将粒子分为侦察粒子和后卫粒子,侦察粒子负责进行探索,后卫粒子向个体最优解和全局最优解学习,保证种群多样性并加快搜索速度;使用Sigmoid函数调节惯性权重,模糊逻辑控制学习因子,以平衡算法的探索和开发能力;以模拟退火机制更新全局最优粒子,同时兼顾距离因素,增强算法跳出局部最优解的能力。采用25个标准测试函数进行仿真实验,仿真结果表明,改进算法在收敛精度、速度和稳定性上都有更好表现。

关键词：群体智能粒子群算法个体最优更新率分工策略模糊逻辑模拟退火

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Nitrogen-rich carbon spheres made by a continuous spraying process for high-performance supercapacitors

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Nano Research 2016年第11期9卷 3209-3221页

作者： Fei Sun Haobin Wu Xin Liu Fang Liu Huihui zhou jihui gao Yunfeng Lu School of Energy Science and Engineering Harbin Institute of Technology Harbin 150001 China Department of Chemical and Biomolecular Engineering University of California Los Angeles CA 90095 USA

Supercapacitors have high power densities, high efficiencies, and long cycling lifetimes; however, to enable their wider use, their energy densities must be significantly improved. The design and synthesis of improved carbon materials with better capacitance, rate performance, and cycling stability has emerged as the main theme of supercapacitor research. Herein, we report a facile synthetic method to prepare nitrogen-rich carbon particles based on a continuous aerosol- spraying process. The method yields particles that have high surface areas, a uniform microporous structure, and are highly N-doped, resulting in a synergism that enables the construction of supercapacitors with high energy and power density for use in both aqueous and commercial organic electrolytes. Furthermore, we have used density functional theory calculations to show that the improved performance is due to the enhanced wettability and ion adsorption interactions at the carbon/electrolyte interface that result from nitrogen doping. These findings provide new insights into the role of heteroatom doping in the capacitance enhancement of carbon materials; in addition, our method offers an efficient route for large-scale production of doped carbon.

关键词： nitrogen doping,carbon spheres,scalable,supercapacitors,density functional theory（DFT）

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Fe-N-C氧还原电催化剂的失活机制及延寿策略

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化学进展 2024年第3期36卷 376-392页

作者：李隆浩周伟谢亮杨潮伟孟晓晓高继慧哈尔滨工业大学城市水资源与水环境国家重点实验室哈尔滨150090 哈尔滨工业大学能源科学与工程学院哈尔滨150001

在质子交换膜燃料电池(PEMFC)中,Fe-N-C催化剂是最有希望替代Pt的非贵金属氧还原(ORR)催化剂。然而目前高活性Fe-N-C催化剂的实际应用仍然受限于其稳定性不足。本文系统总结了Fe-N-C催化剂常见的合成方法(空间限制法和模板法等),概括了... 详细信息

在质子交换膜燃料电池(PEMFC)中,Fe-N-C催化剂是最有希望替代Pt的非贵金属氧还原(ORR)催化剂。然而目前高活性Fe-N-C催化剂的实际应用仍然受限于其稳定性不足。本文系统总结了Fe-N-C催化剂常见的合成方法(空间限制法和模板法等),概括了用于评估催化剂稳定性的半电池与单电池测试方法,分析了两种测试结果存在差异的原因,阐述了Fe-N-C催化剂的4种失活机理,从构筑稳定的碳载体、构筑稳定的活性位点和避免发生Fenton反应三个角度总结了提升稳定性的方法。最后展望了Fe-N-C催化剂未来的发展方向。

关键词：质子交换膜燃料电池氧还原 Fe-N-C催化剂稳定性失活机制延寿策略

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Vapor deposition of aluminium oxide into N-rich mesoporous carbon framework as a reversible sulfur host for lithium-sulfur battery cathode

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Nano Research 2021年第1期14卷 131-138页

作者： Fei Sun Zhibin Qu Hua Wang Xiaoyan Liu Tong Pei Rui Han jihui gao Guangbo Zhao Yunfeng Lu School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Department of Chemistry Shanghai Normal UniversityShanghai 150001China Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesCA 90095USA

Restraining the shuttle effects of lithium polysulfides is the key to improve the cycling reversibility and stability of lithium-sulfur(Li-S)batteries for which design of robust sulfur hosts has been regarded as the most effective strategy.In this work,we report a new type of hybrid sulfur host which is composed of Al_(2)O_(3) homogenously decorated in nitrogen-rich mesoporous carbon framework(NMC-Al_(2)O_(3)).The NMC-Al_(2)O_(3) hybrid host features a poly-dispersed spherical morphology and a mesoporous configuration with high surface area and large pore volume that can accommodate a high sulfur content up to 73.5 wt.%.As a result,the fabricated NMC-Al_(2)O_(3)-S cathode exhibits all-round improvements in electrochemical properties in term of capacities(1,212 mAh·g^(-1)at 0.2 C;755 mAh·g^(-1)at 2 C),cycling charge-discharge reversibility(sustainably 100%efficiencies)and stability(1,000 cycles with only 0.023%capacity decay per cycle at 0.5 C).By contrast,the Al_(2)O_(3)-free NMC-S cathode shows both decreased capacities and rapidly descending Coulombic efficiencies during cycling.Density functional theory(DFH")calculations further reveal that the implanted Al_(2)O_(3) can greatly enhance the chemical adsorption and catalytic conversion for various lithium polysulfides and thereby effectively prevent the polysulfide shuttling and significantly improve the utilizability,reversibility and stability of sulfur cathode.

关键词： lithium-sulfur battery aluminium oxide sulfur host nitrogen-rich carbon mesoporous structure

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基于DHSVM模型的退耕还林还草措施对黄土高原小流域径流过程影响的研究

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吉林水利 2024年第6期 33-40页

作者：杨博文高吉惠四川大学水利水电学院四川成都610065 四川大学水力学与山区河流开发保护国家重点实验室四川成都610065

黄土高原是我国水土流失最严重的地区之一,为探究退耕还林还草措施对黄土高原小流域径流过程的影响,以陕西省韭园沟流域为例,利用DHSVM模型对韭园沟流域进行水文建模。模拟结果表明,坡度6°以上的退耕还林还草措施对径流深以及径流峰值... 详细信息

黄土高原是我国水土流失最严重的地区之一,为探究退耕还林还草措施对黄土高原小流域径流过程的影响,以陕西省韭园沟流域为例,利用DHSVM模型对韭园沟流域进行水文建模。模拟结果表明,坡度6°以上的退耕还林还草措施对径流深以及径流峰值的削减作用最强;从植被种类上看,森林对径流深的削减程度最强,优于灌木和草地;灌木对径流峰值的削减作用最强,优于森林和草地。因此,退耕还林还草措施可以有效削减黄土高原小流域的径流量和径流峰值,有效防止水土流失。

关键词：黄土高原韭园沟流域径流模拟 DHSVM模型

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Preoperative ultrasound combined with routine blood tests in predicting the malignant risk of pancreatic cystic neoplasms

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Cancer Biology & Medicine 2022年第10期19卷 1503-1516页

作者： Xiuchao Wang Junjin Wang Xi Wei Lihui Zhao Bo Ni Zekun Li Chuntao gao Song gao Tiansuo Zhao Jian Wang Weidong Ma Xiao Hu jihui Hao Department of Pancreatic Cancer Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Diagnostic and Therapeutic Ultrasonography Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Hepatobiliary and Pancreatic Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266000China

Objective:Accurate preoperative identification of benign or malignant pancreatic cystic neoplasms(PCN)may help clinicians make better intervention choices and will be essential for individualized treatment.Methods:Preoperative ultrasound and laboratory examination findings,and demographic characteristics were collected from patients.Multiple logistic regression was used to identify independent risk factors associated with malignant PCN,which were then included in the nomogram and validated with an external cohort.The Net Reclassification Index(NRI)and Integrated Discrimination Improvement(IDI)were calculated to evaluate the improvement in the predictive power of the new model with respect to that of a combined imaging and tumor marker prediction model.Results:Malignant PCN were found in 83(40.7%)and 33(38.7%)of the model and validation cohorts,respectively.Multivariate analysis identified age,tumor location,imaging of tumor boundary,blood type,mean hemoglobin concentration,neutrophil-tolymphocyte ratio,carbohydrate antigen 19-9,and carcinoembryonic antigen as independent risk factors for malignant PCN.The calibration curve indicated that the predictions based on the nomogram were in excellent agreement with the actual observations.A nomogram score cutoff of 192.5 classified patients as having low vs.high risk of malignant PCN.The model achieved good C-statistics of 0.929(95%CI 0.890–0.968,P<0.05)and 0.951(95%CI 0.903–0.998,P<0.05)in predicting malignancy in the development and validation cohorts,respectively.NRI=0.268;IDI=0.271(P<0.001 for improvement).The DCA curve indicated that our model yielded greater clinical benefits than the comparator model.Conclusions:The nomogram showed excellent performance in predicting malignant PCN and may help surgeons select patients for detailed examination and surgery.The nomogram is freely available at https://wangjunjinnomogram.***.io/DynNomapp/.

关键词： Pancreatic cystic neoplasms malignancy prediction nomogram ultrasound blood routine

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