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Mortality and morbidity in patients with atrial fibrillation and liver cirrhosis

World Journal of Cardiology 2020年第7期12卷 342-350页

作者： Yousef H Darrat Aiman Smer Claude-Samy Elayi Gustavo X Morales Fahad Alqahtani Mohamad Alkhouli John Catanzaro jignesh shah Mohsin Salih Department of Internal Medicine Veterans Affairs Medical CenterLexingtonKY 40515United States Department of Internal Medicine Creighton UniversityOmahaNE 68178United States Department of Internal Medicine University of FloridaJacksonvilleFL 32211United States Cardiac Electrophysiology Grandview Medical CenterBirminghamAL 35243United States Department of Internal Medicine University of KentuckyLexingtonKY 40536United States Department of Internal Medicine West Virginia UniversityMorgantownWV 26506United States Cardiac Electrophysiology Boulder HeartBoulderCO 80303United States Department of Internal Medicine University of Southern IllinoisSpringfieldIL 62702United States

BACKGROUND Atrial fibrillation(AF)is the most common cardiac arrhythmia encountered in clinical ***,the outcomes associated with AF in hospitalized patients with liver cirrhosis are *** To determine the outcomes of hospitalized patients with liver cirrhosis and *** In this study,we examined morbidity and mortality of patients with concomitant AF and liver cirrhosis from the National Inpatient Sample database,the largest publicly available inpatient healthcare database in the United *** A total of 696937 patients with liver cirrhosis were included,45745 of whom had concomitant AF(6.6%).Liver cirrhosis patients with AF had higher rates of inhospital mortality(12.6%vs 10.3%,P<0.001),clinical stroke(1.6%vs 1.1%,P<0.001),and acute kidney injury(28.2%vs 25.1%,P<0.001),and less gastrointestinal bleeding(4.4%vs 5.1%,P<0.001)and blood transfusion(22.5%vs 23.8%,P<0.001)compared with those who did not have the *** addition,they had a longer length of stay(8±10 d vs 7±8 d,P<0.001)and higher hospitalization costs(20720±33210$vs 16272±24166$,P<0.001).CONCLUSION In subjects with liver cirrhosis,AF is associated with higher rates of inpatient mortality,stroke,and acute kidney injury compared to those who do not have the cardiac arrhythmia.

关键词： Atrial fibrillation Liver cirrhosis Mortality Stroke Acute kidney injury Prolonged hospitalization

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Application of an LC–MS/MS method for the analysis of amlodipine,valsartan and hydrochlorothiazide in polypill for a bioequivalence study

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Journal of Pharmaceutical Analysis 2017年第5期7卷 309-316页

作者： Jaivik V.shah jignesh M.Parekh Priyanka A.shah Priya V.shah Mallika Sanyal Pranav S.Shrivastav Department of Chemistry School of Sciences Gujarat University Department of Chemistry St.Xavier's College Department of Pharmacy M.S.University

A sensitive and selective method has been proposed for the simultaneous determination of amlodipine(AML),valsartan(VAL) and hydrochlorothiazide(HCTZ) in human plasma by liquid chromatography–tandem mass spectrometry(LC–MS/MS). The analytes and their deuterated analogs were quantitatively extracted from100 μL human plasma by solid phase extraction on Oasis HLB cartridges. The chromatographic separation of the analytes was achieved on a Chromolith RP18 e(100 mm × 4.6 mm) analytical column within 2.5 min. The resolution factor between AML and VAL, AML and HCTZ, and VAL and HCTZ was 2.9, 1.5 and 1.4, respectively,under isocratic conditions. The method was validated over a dynamic concentration range of 0.02–20.0 ng/m L for AML, 5.00–10,000 ng/m L for VAL and 0.20–200 ng/m L for HCTZ. Ion-suppression/enhancement effects were investigated by post-column infusion technique. The mean IS-normalized matrix factors for AML, VAL and HCTZ were 0.992, 0.994 and 0.998, respectively. The intra-batch and inter-batch precision(% CV) across quality control levels was ≤ 5.56% and the recovery was in the range of 93.4%–99.6% for all the analytes. The method was successfully applied to a bioequivalence study of 5 mg AML + 160 mg VAL + 12.5 mg HCTZ tablet formulation(test and reference) in 18 healthy Indian males under fasting. The mean log-transformed ratios of C max, AUC0–120 h and AUC0-inf and their 90% CIs were within 90.2%–102.1%. The assay reproducibility was demonstrated by reanalysis of 90 incurred samples.

关键词： Amlodipine Valsartan Hydrochlorothiazide LC–MS/MS Polypill Bioequivalence

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召回和安全警告对自动体外除颤器的影响

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美国医学会杂志（中文版） 2007年第3期26卷 186-186页

作者： jignesh S. shah, MD William H. Maisel, MD, MPH 孙静（译）

背景：自动体外除颤器（automated external ***）在社区心脏骤停患者心肺复苏中起着关键作用，其效果已被证实。尽管AEDs是一种复杂的急救医疗设备，但其可靠性尚不清楚。

关键词：自动体外除颤器安全警告召回急救医疗设备心肺复苏心脏骤停 AEDs 可靠性

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