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3D printed grafts with gradient structures for organized vascular regeneration

International Journal of Extreme Manufacturing 2024年第3期6卷 505-520页

作者： Yuewei Chen Zhongfei Zou Tao fu Zhuang Li Zhaojie Zhang Meng Zhu Qing Gao Shaofei Wu Guosheng fu Yong He Jiayin fu State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China School of Mechanical Engineering Guizhou UniversityGuiyang 550025People’s Republic of China Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province Department of CardiologySir Run Run Shaw HospitalZhejiang UniversityHangzhou 310016People’s Republic of China School of Mechanical Engineering Guizhou Institute of TechnologyGuiyang 550003People’s Republic of China Department of Oral and Maxillofacial Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineSchool of Stomatologyand Key Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhouZhejiang 310006People’s Republic of China

Synthetic vascular grafts suitable for small-diameter arteries(<6 mm) are in great ***,there are still no commercially available small-diameter vascular grafts(SDVGs) in clinical practice due to thrombosis and stenosis after in vivo *** designing SDVGs,many studies emphasized reendothelization but ignored the importance of reconstruction of the smooth muscle layer(SML).To facilitate rapid SML regeneration,a high-resolution 3D printing method was used to create a novel bilayer SDVG with structures and mechanical properties mimicking natural *** by the collagen alignment of SML,the inner layer of the grafts had larger pore sizes and high porosity to accelerate the infiltration of cells and their circumferential alignment,which could facilitate SML reconstruction for compliance restoration and spontaneous *** outer layer was designed to induce fibroblast recruitment by low porosity and minor pore size and provide SDVG with sufficient mechanical *** month after implantation,the arteries regenerated by 3D-printed grafts exhibited better pulsatility than electrospun grafts,with a compliance(8.9%) approaching that of natural arteries(11.36%) and significantly higher than that of electrospun ones(1.9%).The 3D-printed vascular demonstrated a three-layer structure more closely resembling natural arteries while electrospun grafts showed incomplete endothelium and immature *** study shows the importance of SML reconstruction during vascular graft regeneration and provides an effective strategy to reconstruct blood vessels through 3D-printed structures rapidly.

关键词： small-diameter vascular graft smooth muscle layer 3D printing endothelialization

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Significantly Enhanced Melt Memory Effect of Metallocene-made Isotactic Polypropylene Containing Talc

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Chinese Journal of Polymer Science 2024年第2期42卷 213-222,I0008页

作者： Hong-Wen Sun fu-Shan Wang Yan Gao fu-Qing Wei Jia-Chun Feng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200433China Lanzhou Petrochemical Corporation of PetroChina Lanzhou730060China Lanzhou Petrochemical Research Center Petrochemical Research Institute of PetroChinaLanzhou730060China

The melt memory effect is a widely observed phenomenon in semi-crystalline polymers. In practical applications, various additives are usually introduced into polymers, which may affect their melt memory behavior. In this work, the effect of talc on the melt memory effect of metallocene-made isotactic polypropylene(M-PP) was investigated in detail by using the differential scanning calorimetry. The results indicated that the introduction of talc significantly strengthened the melt memory effect of M-PP. Specifically, the upper limit temperature of Domain II increased from 161 ℃ to 174 ℃, resulting in a substantial widening of the temperature range of Domain IIa from 1 ℃ to 14 ℃. Analysis of the crystal orientation of the M-PP containing talc cooled from various Ts suggested that the remarkably enhanced melt memory effect could be ascribed to the stabilization of oriented nuclei facilitated by talc. This stabilizing effect was likely attributable to the prefreezing effect or the sorption interaction between talc and the M-PP chains.

关键词： Metallocene-made isotactic polypropylene Talc Melt memory effect Crystal orientation

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Effect of Al content in molten steel on interaction between MgO-C refractory and SPHC steel

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Journal of Iron and Steel Research International 2024年第4期31卷 838-848页

作者： fu-bin Gao fu-ming Wang Xiang Zhang Tian-yu Du Xin-hua Wangg School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Handan Iron and Steel Company Hegang GroupHandan 056015HebeiChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The effect of Al content in molten steel on the interaction between SPHC steel(0.005-0.068 wt.%Al,and 19×10^(-4)-58×10^(-4)wt.%O)and MgO-C refractory(11.63 wt.%C)was ***-metallic inclusions in the steel were examined at various periods(0,5,15,30,45,and 60 min)as well as the MgO-C interface after 60 min of corrosion at 1600℃.The results show that when MgO-C refractory comes into contact with SPHC steel,the refractory interface consists of three layers arranged from the innermost to the outermost,including the original refractory layer,the dense MgO layer,and the iron infiltration *** carbon in the MgO-C refractories and the Al content in the molten steel undergo a reaction with the MgO in the refractories,resulting in an increase in Mg concentration in the *** Al content in the molten steel from 0.005 to 0.068 wt.%causes a spinel layer to appear at the interface,and the disappearance time of Al_(2)O_(3) inclusions in the steel decreases from 60 to 30 min,while the average MgO content in inclusions ***,controlling the Al content in the molten steel and the smelting duration can help regulate the formation of spinel inclusionsinthe steel.

关键词： MgO-C refractory SPHC steel Inclusion-Spinel Al-killed steel Interfacial reaction

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百灵调肝汤加减治疗肝郁气滞型多囊卵巢综合征不孕症的价值

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中医临床研究 2020年第17期12卷 119-121页

作者：付继锋甘肃省庆阳市妇幼保健计划生育服务中心甘肃庆阳745000

目的:百灵调肝汤加减治疗肝郁气滞型多囊卵巢综合征不孕症的价值。方法:选择在我中心进行肝郁气滞型多囊卵巢综合征不孕症治疗的80例病人进行调查,将病人分为两组,每组40例。对比组采用了常规治疗方式。实验组在此基础上采用了百灵调肝... 详细信息

目的:百灵调肝汤加减治疗肝郁气滞型多囊卵巢综合征不孕症的价值。方法:选择在我中心进行肝郁气滞型多囊卵巢综合征不孕症治疗的80例病人进行调查,将病人分为两组,每组40例。对比组采用了常规治疗方式。实验组在此基础上采用了百灵调肝汤加减治疗方式。分析两组最终的治疗效果。结果:治疗后两组病人卵巢体积均有所改善,但对比组卵巢体积大于实验组,差异明显,P=0.0000。治疗后对比组病人子宫内膜薄于实验组,差异明显,P=0.0000。对比组中医症状评分和实验组相比较高,差异明显,P=0.0000。结论:在多囊卵巢综合征不孕症治疗中,可采取百灵调肝汤加减治疗方式,效果优异,值得应用。

关键词：多囊卵巢不孕症百灵调肝汤

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An Example of Embedded Singular Continuous Spectrum for Discrete Schrödinger Operators

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Acta Mathematica Sinica,English Series 2024年第8期40卷 1837-1849页

作者： Zheng Qi fu Xiong LI Laboratory of Mathematics and Complex Systems(Ministry of Education) School of Mathematical SciencesBeijing Normal UniversityBeijing 100875P.R.China

We present an example of a potential such that the corresponding discrete Schrödinger operator has singular continuous spectrum embedded in the absolutely continuous spectrum.

关键词： Sparse potentials singular continuous spectrum Prüfer variables

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Both gain-and loss-of-function variants of KCNA1 are associated with paroxysmal kinesigenic dyskinesia

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Journal of Genetics and Genomics 2024年第8期51卷 801-810页

作者： Wan-Bing Sun Jing-Xin fu Yu-Lan Chen Hong-fu Li Zhi-Ying Wu Dian-fu Chen Department of Medical Genetics and Center for Rare Diseases and Department of Neurologyand Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical Translation in Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Nanhu Brain-computer Interface Institute HangzhouZhejiang 314050China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang 310012China

KCNA1 is the coding gene for Kv1.1 voltage-gated potassium-channelα*** variants of KCNA1 have been reported to manifest as paroxysmal kinesigenic dyskinesia(PKD),but the correlation between them remains unclear due to the phenotypic complexity of KCNA1 variants as well as the rarity of PKD *** the whole exome sequencing followed by Sanger sequencing,we screen for potential pathogenic KCNA1 variants in patients clinically diagnosed with paroxysmal movement disorders and identify three previously unreported missense variants of KCNA1 in three unrelated Chinese *** proband of one family(c.496G>A,p.A166T)manifests as episodic ataxia type 1,and the other two(c.877G>A,p.V293I and c.1112C>A,p.T371A)manifest as *** pathogenicity of these variants is confirmed by functional studies,suggesting that p.A166T and p.T371A cause a loss-of-function of the channel,while p.V293I leads to a gain-of-function with the property of voltage-dependent gating and activation kinetic *** reviewing the locations of PKD-manifested KCNA1 variants in Kv1.1 protein,we find that these variants tend to cluster around the pore domain,which is similar to ***,our study strengthens the correlation between KCNA1 variants and PKD and provides more information on genotype–phenotype correlations of KCNA1 channelopathy.

关键词： Paroxysmal kinesigenic dyskinesia KCNA1 Loss-of-function Gain-of-function Channelopathy Episodicataxiatype1

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Mathematics of multi-agent learning systems at the interface of game theory and artificial intelligence

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Science China(Information Sciences) 2024年第6期67卷 445-447页

作者： Long WANG Feng fu Xingru CHEN Center for Systems and Control College of EngineeringPeking University Center for Multi-Agent Research Institute for Artificial IntelligencePeking University Department of Mathematics Dartmouth College Department of Biomedical Data Science Geisel School of Medicine at Dartmouth School of Science Beijing University of Posts and Telecommunications

Evolutionary game theory (EGT) and artificial intelligence(AI) are two fields that,at first glance,might seem distinct,but they have notable connections and *** former focuses on the evolution of behaviors (or strategies)in a population,where individuals interact with others and update their strategies based on imitation (or social learning).

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“辩学”——颜元哲学思想体系内在理路的开端

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河海大学学报（哲学社会科学版） 2007年第2期9卷 5-8页

作者：傅济锋苏州学院基础部江苏苏州215104

颜元哲学是一个有着内在理路的思想体系。这个内在理路始于“辩学”对问题的提出与辩驳,经由“明道”之论证,最后落实于“致用”。其中,“辩学”是颜元循着“东林”以来理学批判的余绪,在“经世致用”时代精神的导引下,反思晚明以来“... 详细信息

颜元哲学是一个有着内在理路的思想体系。这个内在理路始于“辩学”对问题的提出与辩驳,经由“明道”之论证,最后落实于“致用”。其中,“辩学”是颜元循着“东林”以来理学批判的余绪,在“经世致用”时代精神的导引下,反思晚明以来“反王尊朱”的学术趋向而根本否定理学,倡导复兴周、孔“习行六艺”之学、教,从而展开其全部学术批判与建构的逻辑起点,这是其哲学思想体系构建的内在理路的开端。

关键词：辩学内在理路开端颜元哲学

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西南喀斯特岩生木本食用油料资源及其开发利用

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中国油脂 2019年第5期44卷 149-155页

作者：傅籍锋王霖娇盛茂银贵州师范大学喀斯特研究院贵阳550001 国家喀斯特石漠化防治工程技术研究中心贵阳550001 贵州省喀斯特石漠化防治与衍生产业工程实验室贵阳550001

我国西南喀斯特地区蕴藏着丰富的岩生木本食用油料植物资源,合理地开发和利用这部分资源对于实现喀斯特脆弱生态系统植被修复与重建,扭转农村产业结构、实现地区扶贫开发乃至促进我国食用油料的木本化、保障国家粮油安全均具有重要的意... 详细信息

我国西南喀斯特地区蕴藏着丰富的岩生木本食用油料植物资源,合理地开发和利用这部分资源对于实现喀斯特脆弱生态系统植被修复与重建,扭转农村产业结构、实现地区扶贫开发乃至促进我国食用油料的木本化、保障国家粮油安全均具有重要的意义和价值。基于文献资料,对于在我国西南喀斯特地区具有产业化开发潜力的岩生木本食用油料资源的地理分布、生理生态习性及其开发利用价值进行了初步讨论,并阐述了岩生木本食用油料资源开发利用前景及对石漠化治理的启示,旨在推进喀斯特山区特色木本食用油料产业建设,实现喀斯特山区生态建设和区域经济协调发展,维护国家粮油安全。

关键词：喀斯特石漠化治理岩生植物木本食用油料开发利用

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Ultrafast optical investigation of carrier and spin dynamics in low-dimensional perovskites

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Science China(Technological Sciences) 2024年第1期67卷 2-18页

作者： fu JinYue JIANG Ying FANG HongHua Key Laboratory for Micro-Nano Physics and Technology of Hunan Province School of Physics and ElectronicsHunan UniversityChangsha 410012China State Key Laboratory of Precision Measurement Technology and Instruments Department of Precision InstrumentTsinghua UniversityBeijing 100084China

Low-dimensional perovskite(PVK)materials have attracted significant research interest,because of their quantum-confined effect,tunable band gap structures,and higher stability than that of three-dimensional(3D)*** semiconductor optoelectronic devices,high speed and small size are closely *** development of high-speed devices requires researchers to fully understand the properties of materials,especially the dynamic processes such as carrier recombination,separation,and transport,which often play a crucial role in the performance of *** an indispensable part of dynamic research,spin relaxation is also of great significance in studying the properties of materials and explore possible *** halide PVK materials have strong spin-orbit coupling(SOC),which provides a basis for information storage and processing by using spin degrees of ***,studying the carrier and spin dynamics of low-dimensional PVKs is an effective way to understand the internal properties of low-dimensional PVKs *** paper summarizes the latest research progress on the ultrafast carrier and spin dynamics in low-dimensional PVKs,to comprehensively understand their carrier and spin behaviors and present an outlook for relevant studies in this area.

关键词： low-dimensional perovskites carrier dynamics spin dynamics optoelectronic devices

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