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郏县汉族女性MTHFR基因C677T、A1298C位点与MTRR基因A66G位点的多态性分布

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精准医学杂志 2023年第1期38卷 81-83页

作者：李会聪吴红果鲁衍强王艳超王秋菊胡季芳杨琦郏县妇幼保健院河南平顶山467100 上海张江普汇转化医学研究院中国疾病预防控制中心妇幼保健中心

目的分析郏县汉族育龄女性叶酸代谢关键酶5,10-亚甲基四氢叶酸还原酶(MTHFR)基因和甲硫氨酸合成酶还原酶(MTRR)基因相关位点多态性分布的特点,旨在为孕妇增补叶酸提供参考。方法采集2017—2019年在郏县妇幼保健院接受孕期检查的554例女... 详细信息

目的分析郏县汉族育龄女性叶酸代谢关键酶5,10-亚甲基四氢叶酸还原酶(MTHFR)基因和甲硫氨酸合成酶还原酶(MTRR)基因相关位点多态性分布的特点,旨在为孕妇增补叶酸提供参考。方法采集2017—2019年在郏县妇幼保健院接受孕期检查的554例女性的口腔黏膜细胞样本,提取DNA,采用相关PCR法对MTRR基因A66G位点、MTHFR基因A1298C、C677T位点多态性进行检测并分析。结果所有样本基因位点多态性分布符合遗传平衡定律。其中MTHFR基因C677T位点TT型、CT型、CC型占比分别为42.8%、43.3%、13.9%;MTHFR基因A1298C位点AA型、AC型、CC型占比分别为77.3%、22.0%、0.7%;MTRR基因A66G位点AA型、AG型、GG型占比分别为56.7%、36.6%、6.7%。郏县汉族育龄女性MTHFR基因C677T和A1298C两位点连锁有7种组合,频率最高的是TT/AA(42.8%),无TT/AC和TT/CC组合,两位点间存在强连锁不平衡(D′=0.984,r^(2)=0.233)。结论郏县汉族育龄女性MTHFR、MTRR基因位点多态性特征与其他地区汉族女性有所区别,具有地域特异性,其中MTHFR基因C677T位点中,TT基因型占比较高,如妊娠期女性为该基因类型,在其妊娠期间应适当增加叶酸量,并根据实际情况增加增补天数。

关键词：亚甲基四氢叶酸还原酶(NADPH) 甲硫氨酸合成酶还原酶多态性,单核苷酸叶酸孕妇

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综合管理模式下个性化氨氯地平服用方案在老年高血压中的应用

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国际老年医学杂志 2021年第1期42卷 20-23页

作者：殷琪何扬利吴晓华孙翠芳李季芳阴彦斌海南省人民医院保健中心海口570311

目的探究综合管理模式下个性化氨氯地平服用方案在老年高血压中的应用及效果。方法选取海南省人民医院2017年6月~2018年9月间收治的老年高血压患者132例,采用随机数字法将患者分为实验组和对照组,对照组采用常规老年高血压治疗方案,实... 详细信息

目的探究综合管理模式下个性化氨氯地平服用方案在老年高血压中的应用及效果。方法选取海南省人民医院2017年6月~2018年9月间收治的老年高血压患者132例,采用随机数字法将患者分为实验组和对照组,对照组采用常规老年高血压治疗方案,实验组采用综合管理模式下个性化氨氯地平服用方案。比较两组患者血压控制情况、治疗效果、生存质量评分及不良事件发生情况。结果治疗后两组患者血压均有所下降,治疗后第1、3、6及12个月实验组与对照组舒张压比较,差异均有统计学意义(P<0.05),治疗后3、6及12个月两组收缩压比较,差异均有统计学意义(P<0.05);实验组治疗有效率明显高于对照组,差异有统计学意义(P<0.05);实验组治疗后的社会功能、躯体功能、躯体疼痛、精神健康及生存质量总评分等均明显高于对照组,差异均有统计学意义(P<0.001);实验组患者不良事件发生率明显低于对照组,差异有统计学意义(P<0.05)。结论采用综合管理模式下个性化氨氯地平服用方案能够有效控制老年高血压,对改善患者生活质量及预后具有积极的意义,有较高临床推广价值。

关键词：综合管理模式个性化用药氨氯地平老年高血压

BRAF^V600E突变型晚期结直肠癌靶向治疗的临床分析

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临床肿瘤学杂志 2020年第7期25卷 613-618页

作者：许婷王晰程李健张小田陆明龚继芳刘丹曹彦硕周军彭智齐长松李艳艳沈琳北京大学肿瘤医院暨北京市肿瘤防治研究所消化肿瘤内科恶性肿瘤发病机制及转化研究教育部重点实验室北京100142

目的探讨V-raf鼠肉瘤病毒癌基因同源体B(BRAF)抑制剂联合西妥昔单抗联合或不联合MEK抑制剂治疗中国晚期不可切除BRAF^V600E突变型结直肠癌的安全性及疗效。方法回顾性收集2018年9月至2019年11月接受西妥昔单抗+BRAF抑制剂(维莫非尼11例... 详细信息

目的探讨V-raf鼠肉瘤病毒癌基因同源体B(BRAF)抑制剂联合西妥昔单抗联合或不联合MEK抑制剂治疗中国晚期不可切除BRAF^V600E突变型结直肠癌的安全性及疗效。方法回顾性收集2018年9月至2019年11月接受西妥昔单抗+BRAF抑制剂(维莫非尼11例,达拉非尼2例)治疗的13例BRAF^V600E突变型晚期结直肠癌患者,其中5例在西妥昔单抗+BRAF抑制剂的基础上联合MEK抑制剂(曲美替尼)。采集患者的临床病理信息,统计有效率(RR)、疾病控制率(DCR)、无进展生存时间(PFS)和不良反应。结果13例患者的中位治疗周期数为6个周期(范围:3~16个周期),无CR病例,获PR 4例、SD 7例、PD 2例,RR为30.8%,DCR为84.6%,中位PFS为6.7个月(95%CI:1.7~11.7个月)。所有患者均发生不同程度的不良反应,最常见的不良反应为痤疮样皮疹(69.2%)、发热(46.2%)和关节痛(23.1%),3级及3级以上不良反应的发生率为38.5%,包括低磷血症(15.4%)、痤疮样皮疹(7.7%)、脂膜炎(7.7%)和谷草转氨酶升高(7.7%)。结论BRAF抑制剂联合西妥昔单抗±MEK抑制剂治疗BRAF^V600E突变型中国晚期结直肠癌的疗效较好,经剂量调整后不良反应整体可控。

关键词：结直肠癌 BRAFV600E突变 BRAF抑制剂西妥昔单抗

诺木洪地区油菜生育期对气象条件的适宜性分析

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青海科技 2023年第6期30卷 178-184页

作者：李春晖雷玉红周磊李积芳祁玉佳李金凤刘伟虎格尔木市气象局格尔木816099 诺木洪气象站都兰816102

利用2000-2009年诺木洪气象站观测的油菜生育期资料和同期气象资料,采用统计方法分析了诺木洪地区油菜生育期对气候条件的适应性指标,结果表明:诺木洪地区油菜平均生长周期为139 d;4月上旬至中旬进入播种期,8月下旬进入成熟阶段,生育期... 详细信息

利用2000-2009年诺木洪气象站观测的油菜生育期资料和同期气象资料,采用统计方法分析了诺木洪地区油菜生育期对气候条件的适应性指标,结果表明:诺木洪地区油菜平均生长周期为139 d;4月上旬至中旬进入播种期,8月下旬进入成熟阶段,生育期天数以19.6 d/10 a的速率增加;诺木洪地区气温、日照、降水气候趋势率分别为0.453℃/10 a、-442.1 h/10 a、-26.21 mm/10 a,随着气温升高、日照减少、降水减少,油菜的生长期呈现延长趋势,而有效的水分条件利于生长发育及产量的形成。

关键词：油菜气象条件适宜性指标

First experimental constraints on WIMP couplings in the effective field theory framework from CDEX

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Science China(Physics,Mechanics & Astronomy) 2021年第8期64卷 15-22页

作者： Yi Wang Zhi Zeng qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong qiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao qiYuan Nie JinHua Ning Hui Pan NingChun qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao jifang Zhou ZuYing Zhou JingJun Zhu Key Laboratory of Particle and Radiation Imaging(Ministry of Education) Department of Engineering PhysicsTsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Institute of Physics Academia SinicaTaipei 11529China NUCTECH Company Beijing 100084China YaLong River Hydropower Development Company Chengdu 610051China College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China College of Physics Sichuan UniversityChengdu 610065China School of Physics Peking UniversityBeijing 100871China Sino-French Institute of Nuclear and Technology Sun Yet-sen UniversityZhuhai 519082China Department of Nuclear Physics China Institute of Atomic EnergyBeijing 102413China Department of Physics Banaras Hindu UniversityVaranasi 221005India Department of Physics Beijing Normal UniversityBeijing 100875China School of Physics Nankai UniversityTianjin 300071China

We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region.

关键词： WIMP EFT CDEX dark matter annual modulation

First result from the Jinping Underground Nuclear Astrophysics experiment JUNA:precise measurement of the 92 keV ^(25)Mg(p,γ)^(26)Al resonance

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Science Bulletin 2022年第2期67卷 125-132,M0003页

作者： Jun Su Hao Zhang Zhihong Li Paolo Ventura Yunju Li Ertao Li Chen Chen Yangping Shen Gang Lian Bing Guo Xinyue Li Liyong Zhang Jianjun He Yaode Sheng Yinji Chen Luohuan Wang Long Zhang Fuqiang Cao Wei Nan Weike Nan Gexing Li Na Song Baoqun Cui Lihua Chen Ruigang Ma Zhicheng Zhang Taoyu Jiao Bingshui Gao Xiaodong Tang qi Wu Jiaqing Li Liangting Sun Shuo Wang Shengquan Yan Junhui Liao Youbao Wang Sheng Zeng Ding Nan qiwen Fan Ningchun qi Wenliang Sun Xuyuan Guo Peng Zhang Yunhua Chen Yong Zhou jifang Zhou Jinrong He Changsong Shang Mingchuan Li Jianping Cheng Weiping Liu JUNA Collaboration China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 101408China INAF Osservatorio Astronomico di RomaVia Frascati 33Monte Porzio Catone(RM)00077Italy College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai 264209China Yalong River Hydropower Development Company Chengdu 610051China 不详

The ^(25)Mg(p,γ)^(26)Al reaction plays an important role in the study of cosmic 1.809 MeV γ-ray as a signature of ongoing nucleosynthesis in the *** astrophysical temperature around 0.1 GK,the ^(25)Mg(p,γ)^(26)Al reaction rates are dominated by the 92 keV resonance capture *** report a precise measurement of the 92 keV ^(25)Mg(p,γ)^(26)Al resonance in the day-one experiment at Jinping Underground Nuclear Astrophysics experiment(JUNA)facility in the China Jinping Underground Laboratory(CJPL).The resonance strength and ground state feeding factor are determined to be 3.8±0.3×10^(-10) eV and 0:660:04,*** results are in agreement with those reported in the previous direct underground measurement within uncertainty,but with significantly reduced ***,we recommend new ^(25)Mg(p,γ)^(26)Al reaction rates which are by a factor of 2.4 larger than those adopted in REACLIB database at the temperature around 0.1 *** new results indicate higher production rates of ^(26g)Al and the cosmic 1.809 MeV γ-*** implication of the new rates for the understanding of other astrophysical situations is also discussed.

关键词： Nuclear astrophysics Underground laboratory Cosmic c ray Resonance reaction 26Al

疏肝汤联合西药治疗冠心病血运重建术后心绞痛随机平行对照研究

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实用中医内科杂志 2015年第4期29卷 100-101页

作者：梁宏宇李典鸿卞继芳李博广东省第二中医院心血管科广州510095

[目的]观察疏肝汤联合西药治疗冠心病血运重建术后心绞痛疗效。[方法]使用随机平行对照方法,将82例住院患者按病志号抽签简单随机分为两组。冠心病二级预防,双联抗血小板,他汀,β受体阻断剂,硝酸酯类等。对照组41例复方丹参滴丸,270mg/... 详细信息

[目的]观察疏肝汤联合西药治疗冠心病血运重建术后心绞痛疗效。[方法]使用随机平行对照方法,将82例住院患者按病志号抽签简单随机分为两组。冠心病二级预防,双联抗血小板,他汀,β受体阻断剂,硝酸酯类等。对照组41例复方丹参滴丸,270mg/次,3次/d。治疗组41例疏肝汤(柴胡、枳壳、川芎、延胡索、丹参各10g,白芍15g,香附10g,甘草5g;气郁化火加钩藤15g,去香附;腹胀纳差、苔白腻加白术12g,莱菔子15g),1剂/d,水煎200m L,早晚口服。连续治疗28d为1疗程。观测临床症状、心绞痛、不良反应。治疗1疗程,判定疗效。[结果]治疗组显效27例,有效11例,无效3例,总有效率92.68%。对照组显效14例,有效15例,无效12例,总有效率70.73%。治疗组疗效优于对照组(P<0.05)。硝酸甘油两组用量均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。[结论]疏肝汤联合西药治疗冠心病血运重建术后心绞痛疗效满意,无严重不良反应,值得推广。

关键词：心绞痛冠心病血运重建术疏肝法复方丹参滴丸中西医结合治疗随机平行对照研究

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徐振晔治疗恶性肿瘤骨转移经验探析

山东中医杂志 2017年第2期36卷 148-150页

作者：罗琴琴杨继芳李敏徐振晔上海中医药大学附属龙华医院上海200032 上海闵行区中医医院上海201100

骨转移是中晚期恶性肿瘤(如乳腺癌、肺癌、前列腺癌)患者较为常见的病变。徐振晔教授通过辨别邪正虚实,辨证和辨病相结合,以及综合性疗法治疗骨转移疗效显著。同时,对于临床不同恶性肿瘤骨转移疼痛的治疗,徐教授结合传统中医理论和现代... 详细信息

骨转移是中晚期恶性肿瘤(如乳腺癌、肺癌、前列腺癌)患者较为常见的病变。徐振晔教授通过辨别邪正虚实,辨证和辨病相结合,以及综合性疗法治疗骨转移疗效显著。同时,对于临床不同恶性肿瘤骨转移疼痛的治疗,徐教授结合传统中医理论和现代中药研究,根据多年的临床用药经验总结出了治疗骨转移的经验方——骨痛灵方。附病案1则。

关键词：骨转移辨证辨病综合治疗

Neutron-induced nuclear recoil background in the PandaX-4T experiment

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Chinese Physics C 2022年第11期46卷 262-274页

作者： Zhou Huang Guofang Shen qiuhong Wang Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Chencheng Han Ke Han Changda He Jinrong He Di Huang Yanlin Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Mingchuan Li Shu Li Shuaijie Li qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Wenbo Ma Yugang Ma Yajun Mao Yue Meng Xuyang Ning Ningchun qi Zhicheng qian Xiangxiang Ren Nasir Shaheed Changsong Shang Lin Si Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Jijun Yang Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Dan Zhang Minzhen Zhang Peng Zhang Tao Zhang Li Zhao qibin Zheng jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China School of Physics Beihang UniversityBeijing 102206China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary SciencShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai200240China School of Physics Nankai UniversityTianjin 300071China School of Physics Peking UniversityBeijing 100871China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing102206China School of Physics and Microelectronics Zhengzhou UniversityZhengzhouHenan 450001China School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Physics University of MarylandCollege ParkMaryland 20742USA School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China SJTU Paris Elite Institute of Technology Shanghai Jiao Tong UniversityShanghai200240China

Neutron-induced nuclear recoil background is critical to dark matter searches in the PandaX-4T liquid xenon *** this study,we investigate the features of neutron background in liquid xenon and evaluate its contribution in single scattering nuclear recoil events using three *** first method is fully based on Monte Carlo *** last two are data-driven methods that also use multiple scattering signals and high energy signals in the *** the PandaX-4T commissioning data with an exposure of 0.63 tonne-year,all these methods give a consistent result,i.e.,there are 1.15±0.57 neutron-induced backgrounds in the dark matter signal region within an approximated nuclear recoil energy window between 5 and 100 keV.

关键词： dark matter neutron background multiple scattering high energy gamma