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Role of gap junction and connexin-43 in hypoxic-ischemic brain damage

Neural Regeneration Research 2006年第6期1卷 560-562页

作者： jieying lin niyang lin Department of Pediatrica First Hospital Affiliated to Medical College of Shantou University Shantou 515041 Guangdong Province China

OBJEETIVE ： Gap junction （GJ） is the structural basis tor direct intercellular communication OT nerve CellS. Connexin （Cx） is the protein subunit for constructing GJ channel. Among them, Cx43 is closely related with nervous system. Both Cx43 and nervous system play an important role in the pathophysiological development of hypoxic-ischemic injury. We are in attempt to investigate G J, Cx43 and their correlations with hypoxic-ischemic brain damage by research. DATA SOURCES ： Using the terms ＂ brain gap junction＂ in English and ＂gap junction＂ in Chinese, we searched the Medline database and Chinese BioMedical Literature Database as well as China Hospital Knowledge Database to identify the articles published from 1996 to 2006 about GJ and brain hypoxic-ischemic injury. STUDY SELECTION ： The articles were selected firstly and abstracts of 250 articles were read through. Articles in which the experimental design met randomized controlled principle were included, and study articles and case reports with repetitive contents were excluded. DATA EXTRACTION ： Among 53 included correlative articles, 23 were excluded for repetitive contents and the other 30 were analyzed. DATA SYNTHESIS： GJ, widely existing in nervous system, plays a key role in maintaining normal differentiation and development as well as physiological function of brain tissue. GJ channel is a hydrophilic, Iow-selectivity and lowohmic channel, which can provide direct channel for intercellular substance transmission and information communication. It plays an important role in the differentiation and development of nerve cells and regulation of physiological function. The functions of GJ channel are regulated by many factors, which involved intracellular pH value, Ca^2＋ concentration, ATP concentration, phosphorylation of Cx, transchannel pressure, some neurohormonal factors, regulatory factors of protein and so on. Cx43 is the main component of GJ channel in the brain tissues. Its expression in the bra

关键词： brain damage nervous system diseases physiological function information communication gap junction nerve cells intracellular Ph value experimental design Knowledge Database

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Synthesis, crystal structures and electrochemical properties of two new metal-centered ferrocene complexes

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Science China Chemistry 2009年第7期52卷 930-936页

作者： WANG XuChun WU jieying ZHOU HongPing TIAN YuPeng LI lin YANG JiaXiang JIN BaoKang ZHANG ShengYi Department of Chemistry Anhui Province Key Laboratory of Function Inorganic Material ChemistryAnhui UniversityHefei 230039China Department of Chemistry Anhui Science and Technology UniversityFengyang 233100China State Key Laboratory of Crystal Materials Institute of Crystal Materials of Shandong UniversityJinan 250100China

Two new metal-centered ferrocene complexes Ni(SCN)2(L)4 (1) and Cu(OAc)2(L)2 (2) (L = 1-[1-ferrocenylmethyl]imidazole) have been synthesized and characterized by elemental analysis, single crystal X-ray diffraction analysis, spectroscopic and cyclic voltammetric measurements. The geometry of Ni(II) in 1 is octahedral, with four ligands in the equatorial plan and two thiocyanate anions at the axial site, while that of Cu(II) in 2 is a distorted octahedron formed by two chealted OAc? and two ligands. Single crystal X-ray diffraction studies reveal that there is partial electron delocalization from ferrocene to imidazole in the two complexes. Electrochemical measurements exhibit that complexes 1 and 2 undergo similar reversible one electron redox processes, suggesting that the ferrocene moieties are equivalent and there are no interactions among them.

关键词： ferrocene imidazole complex crystal structure electrochemistry

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Nonalcoholic Fatty Liver Disease:Changes in Gut Microbiota and Blood Lipids

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Journal of Clinical and Translational Hepatology 2024年第4期12卷 333-345页

作者： Keen Yang jieying Zeng Huaiyu Wu Huiyu Liu Zhimin Ding Weiyu Liang linghu Wu Ziwei lin Wenhui Huang Jinfeng Xu Fajin Dong Department of Ultrasound Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdongChina

Background and Aims:The global prevalence of nonalcoholic fatty liver disease(NAFLD)is 25%.This study aimed to explore differences in the gut microbial community and blood lipids between normal livers and those affected by NAFLD using 16S ribosomal deoxyribonucleic acid ***:Gut microbiome profiles of 40 NAFLD and 20 non-NAFLD controls were *** about four blood lipids and 13 other clinical features was *** were divided into three groups by ultrasound and FibroScan,those with a normal liver,mild FL(FL1),and moderate-to-severe FL(FL2).FL1 and FL2 patients were divided into two groups,those with either hyperlipidemia or non-hyperlipidemia based on their blood *** keystone species within the groups were identified using univariate analysis and a specificity–occupancy *** difference in biochemical parameters ion NAFLD patients and healthy individuals were identified by detrended correspondence analysis and canonical correspondence ***:Decreased gut bacterial diversity was found in patients with ***/Bacteroidetes decreased as NAFLD *** and Ruminococcus 2 were the most representative fatty-related *** pyruvic transaminase,aspartate aminotransferase,and white blood cell count were selected as the most significant biochemical *** of areas under the curve identified two microbiomes combined with the three biochemical indexes that identified normal liver and FL2 very well but performed poorly in diagnosing ***:Faecalibacterium and Ruminococcus 2,combined with glutamate pyruvic transaminase,aspartate aminotransferase,and white blood cell count distinguished *** speculate that regulating the health of gut microbiota may release NAFLD,in addition to providing new targets for clinicians to treat NAFLD.

关键词： Liver Gut microbiota Blood lipids Nonalcoholic fatty liver disease Hyperlipidemia

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Synthesis,photophysical properties and TD-DFT calculation of four two-photon absorbing triphenylamine derivatives

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Science China Chemistry 2013年第1期56卷 106-116页

作者： KONG lin YANG JiaXiang ZHOU HongPing LI ShengLi HAO FuYing ZHANG Qiong TU YuLong WU jieying XUE ZhaoMing TIAN YuPeng Department of Chemistry Key Laboratory of Functional Inorganic Materials of Anhui ProvinceAnhui University State Key Laboratory of Crystal Materials Shandong University State Key Laboratory of Coordination Chemistry Nanjing University

In this study,linear absorption,single-photon excited fluorescence,fluorescence quantum yields,fluorescence lifetime and two-photon excited fluorescence of a series of triphenylamine derivatives (L1,L2,L3 and L4) have been measured.L1 and L3 are D--A type dyes,while L2 and L4 are D--D--A type dyes (D=donor,A=acceptor).The investigated compounds consist of triphenylamine-bearing donor-substituted and/or systematically extended-conjugated length,which are designed to gain insight into the effect of the ethoxyl unit and-linkage length on the linear and nonlinear optical *** influence of solvent polarity on the photophysical properties was *** time-dependent density functional theory (TD-DFT) calculations,the structure-property relationships are discussed.

关键词： triphenylamine derivatives optical properties structure-property relationship TD-DFT calculation

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Insight into stable,concentrated radicals from sulfur-functionalized alkyne-rich crystalline frameworks and application in solar-to-vapor conversion

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Chinese Journal of Structural Chemistry 2024年第8期43卷 65-72页

作者： Jian-Rong Li jieying Hu Lai-Hon Chung Jilong Zhou Parijat Borah Zhiqing lin Yuan-Hui Zhong Hua-Qun Zhou Xianghua Yang Zhengtao Xu Jun He School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou510006China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang515200China Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A^(*)STAR)2 Fusionopolis WaySingapore138634Republic of Singapore

Organic radicals feature versatile unpaired electrons key for photoelectronic and biomedical applications but remain difficult to access in stable concentrated *** disclose easy generation of stable,concentrated radicals from various alkynyl phenyl motifs,including 1)sulfur-functionalized alkyne-rich organic linkers in crystalline frameworks;2)the powders of these molecules alone;3)simple *** Zr-based framework,the generation of radical-rich crystalline framework was achieved by thermal annealing in the range of 300-450℃.For terminal alkynes,electron paramagnetic resonance signals(EPR,indicative of free radicals)arise after air exposure or mild heating(e.g,70℃).Further heating(e.g.,150℃for 3 h)raises the radical concentrations up to 3.30 mol kg^(-1).For more stable internal alkynes,transformations into porous radical solids can also be triggered,albeit at higher temperatures(e.g.,250-500℃).The resulted radical-containing solids are porous,stable to air as well as heat(up to 300-450℃)and exhibit photothermal conversion and solar-driven water evaporation *** formation of radicals can be ascribed to extensive alkyne cycliza-tions,forming defects,dangling bonds and the associated radicals stabilized by polycyclicπ-systems.

关键词： Porous coordination polymers Persistent radicals Nanographene Photothermal conversion Solar-to-vapor conversion

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Cx43在缺氧缺血新生大鼠脑组织中的表达及意义

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中国现代医生 2007年第07Z期45卷 18-20,9页

作者：林洁英林霓阳黄广汕头大学医学院第一附属医院儿科广东汕头515041

目的目的研究Cx43在新生大鼠HIBD的表达,探讨其在HIBD的作用及意义。方法7d龄健康SD大鼠128只,随机分为对照组和缺氧缺血组,每组64只。两组大鼠根据处死时相点每组再随机分为6h、24h、48h、72h四个小组,每组16只。每组大鼠取8只,采用HE... 详细信息

目的目的研究Cx43在新生大鼠HIBD的表达,探讨其在HIBD的作用及意义。方法7d龄健康SD大鼠128只,随机分为对照组和缺氧缺血组,每组64只。两组大鼠根据处死时相点每组再随机分为6h、24h、48h、72h四个小组,每组16只。每组大鼠取8只,采用HE染色、DNA原位末端标记法、免疫组化染色方法观察各组新生大鼠脑组织病理变化、细胞凋亡及Cx43表达、分布情况;每组另外8只应用Western-blot定量分析Cx43蛋白在皮层及海马的表达。结果对照组各时相点皮层、海马未见DNA原位末端标记法阳性细胞;缺氧缺血组24h组开始细胞凋亡细胞逐渐增多,缺氧缺血组24h、48h、72h组的凋亡阳性细胞分别为15.12±2.68、30.24±3.65、68.72±5.60,各组差异有显著性意义,P0.05;缺氧缺血后6h、24h、48h、72h组Cx43染色阳性面积分别为(18.64±0.30)%、(29.65±0.26)%、(35.34±0.21)%、(42.05±0.31)%,随着缺氧缺血后时间的推移,Cx43阳性表达逐渐增加,各组对比,差异有显著意义,P0.05。结论缺氧缺血后Cx43的表达逐渐增加,其变化规律与神经细胞凋亡严重程度及光镜观察到的脑损伤进展的时间框架相吻合,且发生时间早于细胞凋亡,提示Cx43表达的增加参与了新生大鼠HIBD的病理形成过程,推测其通过缝隙连接增强传播和放大细胞损伤,在HIBD早期发挥“姐妹杀伤效应”,导致和加重脑损害。

关键词：缝隙连接连接蛋白43 脑缺氧脑缺血新生大鼠细胞凋亡

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Analyzing the risk of drug abuse for morphine-containing Chinese patent medicines in China

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Journal of Chinese Pharmaceutical Sciences 2017年第2期26卷 139-146页

作者： jieying lin Jingjing Liu Yaning Qi Chunming Wang Department of Sociology Faculty of Social Sciences University of Macao Macao SAR 999078 China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Maeau Maeau SAR 999078 China Choi Kai Yau College University of Macao Macao SAR 999078 China Shiu Pong College University of Macao Macao SAR 999078 China

Chinese patent medicines（CPMs） are widely used across China, and they are differently administrated from chemical drugs. For traditional reasons, CPMs may contain opium-derived compounds, such as morphine, which may pose the issues of drug abuse and addiction. In the present study, we aimed to evaluate the present risk of morphine-containing CPMs in causing drug abuse and addiction, based on a questionnaire-based approach and from a medicinal administrative perspective. We chose 76 CPMs containing morphine from government document and set them as the study group, and 10 chemical drugs containing morphine were set as the control group. Because there is no ready-made method, we created an evaluation sheet consisting of five questions to evaluate each drug and generate a risk-value score. Crosstabs analysis using SPSS 15.0 was conducted to obtain the influencing factors. We found that the study group obtained a mean score of 2.04 for the risk value, which was five times of that of the control group. Specifically, no maximum limit of morphine or codeine was set in product quality standards for more than four-fifth of the drugs. Moreover, 46.0% of package inserts failed to show any warning about addiction or prohibition over the long-term use of the drugs. The number of ingredients, as well as the functions of the drugs, was found to correlate with the risk value. Our findings suggested that CPMs were more risky in causing drug abuse and addiction than chemical drugs. Approaches, such as i） controlling the number of ingredients, ii） setting up maximum limit of morphine or codeine in quality standard, iii） providing more information on the package insert of drugs and iv） monitoring the drug containing both morphine and ephedrine, will be effective in reducing the risk of drug abuse and addiction.

关键词： Chinese patent medicines Morphine Opium poppy Risk of drug addiction and abuse

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Seedling Production from Seeds of a Wild Ecotype of Vetiver Grass (<i>Vetiveria zizanioides</i>L.) in Southern China

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American Journal of Plant Sciences 2021年第3期12卷 394-405页

作者： Wangou Liu Xueyi lin jieying Luo Meiling Yao Yeting Gu Meinan Xie Jinxiang Liu Qifu Ma Life Science and Technology School Lingnan Normal University Zhanjiang China School of Veterinary and Life Sciences Murdoch University Murdoch Australia

Vetiver grass (Vetiveria zizanioides L.) is widely used for soil and water conservation, and land management. In practice, all vetiver seedlings are propagated via ramets or tillers, which cannot meet the market demand and would also destroy the original habitat. Most vetiver genotypes flower but do not produce seeds. A wild ecotype of vetiver grass originated in southern China is fertile, but the rate of seed germination is very low. This study aimed to develop a novel method to improve its seed germination and seedling establishment. In the field, the inflorescences of wild vetiver were wrapped using a transparent plastic bag with a pot containing wet soils. The effects of inflorescence bagging and Tween 80 application on seed germination and seedling growth were examined. The results showed that seed development was characterized by low seed setting rate (19.2%), uneven maturity time, easy shedding (more than 95% of spikelets shed off 20 days after flowering), therefore difficult harvest of viable seeds. Bagging the inflorescence with moist soils in pot ensured the mature seeds falling onto the nursery soil surface and absorbing water for germination while the immature seeds continued to grow on the inflorescence. Bigging not only improved seed development and maturity, saved the procedure of seed collection and storage, but also provided a humid micro-environment for seed germination and seedling growth. Tween 80 as a surfactant promoted seed water absorption, germination and seedling growth. This simple and novel method has integrated the procedures of seed collection, storage, germination and seedling establishment, and enables the produc

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基于空间网格视角的企业绩效影响因素的实证检验——以中原地区房地产行业为例

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长沙大学学报 2020年第5期34卷 80-85页

作者：林洁莹福建船政交通职业学院交通经济系福建福州350007

国内外学者分别从不同视角对企业绩效问题进行了有益探索,这一领域的研究日渐丰富.但如何结合空间网格集聚理论从企业全面管理的视角展开其绩效发展水平的考量,尚有部分问题亟需探讨,故文章以空间网格、核密度估值等理论为依托,以中部... 详细信息

国内外学者分别从不同视角对企业绩效问题进行了有益探索,这一领域的研究日渐丰富.但如何结合空间网格集聚理论从企业全面管理的视角展开其绩效发展水平的考量,尚有部分问题亟需探讨,故文章以空间网格、核密度估值等理论为依托,以中部地区房地产行业的50家企业为例,选取这50家企业的空间地理距离、资本回报率、资产负债率、区域内人均收入水平等指标的动态面板数据,运用杜宾空间面板模型进行基于空间网格视角的企业绩效影响因素的动态检验,发现企业间的空间地理距离、资本回报率、资产负债率、区域内人均收入水平等指标均与企业绩效发展水平间存在较显著的相关性,且企业相关政策的变动均会对空间邻近企业产生一定的影响,故企业应充分重视本企业资本回报率、资产负债率等要素的作用,同时也应注意空间邻近企业相关政策变动的影响,进而促进空间邻近企业间的协调发展.

关键词：空间网格企业绩效核密度资本回报率

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基于鲁棒规划的综合能源微网孤岛划分方法

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电力系统自动化 2020年第10期44卷 32-40页

作者：陈伯达林楷东苏洁莹张勇军杨银智慧能源工程技术研究中心华南理工大学电力学院广东省广州市510640 广东工业大学自动化学院广东省广州市510006

针对综合能源微网系统孤岛划分问题,考虑可再生能源和电气热负荷需求的不确定性,将微能源网的能源转换和储存设备作为调度资源,以故障发生后最优化孤岛划分方案为目标,建立了考虑孤岛持续运行的鲁棒孤岛划分模型。在该模型中,以违背停... 详细信息

针对综合能源微网系统孤岛划分问题,考虑可再生能源和电气热负荷需求的不确定性,将微能源网的能源转换和储存设备作为调度资源,以故障发生后最优化孤岛划分方案为目标,建立了考虑孤岛持续运行的鲁棒孤岛划分模型。在该模型中,以违背停电最短通知时间约束为目标函数惩罚项,为负荷预留一定的故障应对时间,以及避免孤岛负荷因源荷功率波动导致重复接入和切除的问题。基于鲁棒离散优化理论,将不确定性约束转化为确定性约束,构建了混合整数线性规划模型,利用全局鲁棒调节系数改善鲁棒优化的保守性,平衡好孤岛划分方案的经济性和可操作性,以满足不同决策需求。最后通过算例验证了所提模型和求解方法的有效性。

关键词：综合能源微网(微电网) 孤岛划分鲁棒离散优化

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