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中国金融 2024年第9期 84-85页

作者：徐彤恒丰银行

汽车产业作为强金融驱动产业,无论从制造端、消费端或是供应链来看都离不开金融业的有力支撑。就商业银行而言,汽车金融是其核心业务板块之一,往往投入较多资源,尤其在居民购车、加油、投保等环节积极开展金融服务场景建设,并在部分领... 详细信息

汽车产业作为强金融驱动产业,无论从制造端、消费端或是供应链来看都离不开金融业的有力支撑。就商业银行而言,汽车金融是其核心业务板块之一,往往投入较多资源,尤其在居民购车、加油、投保等环节积极开展金融服务场景建设,并在部分领域取得明显成效。

关键词：汽车产业业务板块供应链金融服务商业银行金融衍生金融业投保

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高定品牌的价值支撑与进化方向

家具与室内装饰 2024年第1期31卷 1-4页

作者：许柏鸣南京林业大学家居与工业设计学院江苏南京210037

文章以价值为核心,对高定家居的供给侧现状做了深度剖析,对价值的概念与含义进行了全面和深刻的诠释,拓宽了对价值认知的视野和边界,分析了高定品牌进阶与价值支撑的关系,并指出了进化的方向。

关键词：高定家居价值主张

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雅可比-旋量在模切机装配公差分析中的应用

机械设计与制造 2024年第8期402卷 242-248页

作者：王皓徐旭松刘艳旭卢恒江苏理工学院机械工程学院江苏常州213001 江苏麒浩精密机械股份有限公司江苏宝应225800

在模切纸品的生产过程中,为了减少或避免不合格品的出现,需对模切机弧切刀具的装配精度进行严格控制,将其刀尖偏移量限定在一定范围内,以保证纸品的切割质量。针对以上几何需求,研究了模切机中各个零部件间存在的连接、接触、配合方式,... 详细信息

在模切纸品的生产过程中,为了减少或避免不合格品的出现,需对模切机弧切刀具的装配精度进行严格控制,将其刀尖偏移量限定在一定范围内,以保证纸品的切割质量。针对以上几何需求,研究了模切机中各个零部件间存在的连接、接触、配合方式,根据平面和圆柱特征的特点对特征元素进行公差旋量表达,将各旋量纳入雅可比矩阵中构建模切机的装配公差分析模型,并按极值法进行计算分析,得出影响刀尖偏差的敏感环,从而为公差优化提供依据。

关键词：公差分析几何公差雅可比-旋量公差建模

基于AEViT与先验知识的胶质瘤IDH1突变状态预测

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智能系统学报 2024年第4期19卷 952-960页

作者：徐华畅许倩赵钰琳梁峰宁徐凯朱红徐州医科大学医学信息与工程学院江苏徐州221000 徐州医科大学附属医院医学影像科江苏徐州221000

针对目前预测胶质瘤异柠檬酸脱氢酶1(isocitrate dehydrogenase1,IDH1)突变状态存在的数据不足、准确率较低等问题,提出一种基于AEViT(auto-encoder vision Transformer)与先验知识的胶质瘤IDH1突变状态预测方法。首先使用改进的K-Mean... 详细信息

针对目前预测胶质瘤异柠檬酸脱氢酶1(isocitrate dehydrogenase1,IDH1)突变状态存在的数据不足、准确率较低等问题,提出一种基于AEViT(auto-encoder vision Transformer)与先验知识的胶质瘤IDH1突变状态预测方法。首先使用改进的K-Means聚类算法为无IDH1突变状态标签的胶质瘤磁共振成像(magnetic resonance imaging,MRI)数据标注伪标签,并采用ViT(vision Transformer)网络对伪标签进行修正,得到最终的胶质瘤IDH1突变状态。为避免不准确的伪标签数据影响模型精度,采用果蝇优化算法为伪标签数据赋予最优权重;然后提出基于Auto-Encoder和ViT的分类模型AEViT,利用Auto-Encoder提取胶质瘤MRI特征;再将特征输入ViT中对胶质瘤IDH1突变状态进行分类;最后将基于胶质瘤位置信息的先验知识加入模型,达到99.01%的预测准确率。结果表明该方法优于其他现有模型,能够实现胶质瘤数据扩增和术前无创、准确地预测胶质瘤IDH1突变状态,从而辅助诊疗过程。

关键词：胶质瘤异柠檬酸脱氢酶1 K-Means聚类算法伪标签 Auto-Encoder vision Transformer 果蝇优化算法先验知识

The development of local ambient air quality standards: A case study of Hainan Province, China

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Eco-Environment & Health 2024年第1期3卷 11-20页

作者： Qian Song Nannan Zhang Yanning Zhang Dejia Yin Jiming Hao Shuxiao Wang Shengyue Li Wenshuai xu Weijun Yan Xinxin Meng Xinghong xu Xiaochen Wu Donghai Xie Yun Zhu Qipeng Qu xuan Hou Yueqi Jiang Zhaoxin Dong Haotian Zheng Yisheng Sun Zeqi Li Bin Zhao State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing 100084China Institute of Strategic Planning Chinese Academy of Environmental PlanningBeijing 100041China Hainan Research Academy of Environmental Sciences Haikou 571126China Hainan Provincial Ecological and Environmental Monitoring Center Haikou 570206China Hainan Radiation Environmental Monitoring Station Haikou 571126China Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control College of Environment and EnergySouth China University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou 510006China

The ambient air quality standard(AAQS)is a vital policy instrument for protecting the environment and human *** Province is at the forefront of China's efforts to protect its ecological environment,with an official goal to achieve world-leading air quality by ***,neither the national AAQS nor the World Health Organization guideline offers sufficient guidance for improving air quality in Hainan because Hainan has well met the former while the latter is excessively ***,the establishment of Hainan's local AAQS becomes ***,research regarding the development of local AAQS is scarce,especially in comparatively more polluted countries such as *** relatively high background values and significant interannual fluctuations in air pollutant concentrations in Hainan present challenges in the development of local *** research proposes a world-class local AAQS of Hainan Province by reviewing the AAQS in major countries or regions worldwide,analyzing the influence of different statistical forms,and carefully evaluating the attainability of the *** the proposed AAQS,the annual mean concentration limit for PM2.5,the annual 95th percentile of daily maximum 8-h mean(MDA8)concentration limit for O_(3),and the peak season concentration limit for O_(3) are set at 10,120,and 85μg/m^(3),*** study indicates that,with effective control policies,Hainan is projected to achieve compliance with the new standard by *** implementation of the local AAQS is estimated to avoid 1,526(1,253–1,789)and 259(132–501)premature deaths attributable to longterm exposure to PM2.5 and O_(3) in Hainan in 2035,respectively.

关键词： Local ambient air quality standard Statistical form Feasibility Health effects Hainan province

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展览,为了作品的“增殖”

美术观察 2024年第9期 32-36页

作者：徐累中国艺术研究院文学艺术院

作品是对“世界”的诠释,展览是对“世界”的抵达,两者内外有别,各有使命。本文通过对几个展览案例的自述,解析如何因地制宜,巧立展题,借用博物馆的固有资源,让作品在公共空间中获取整体性的开放意义,其实践过程也引入文学、戏剧、建筑... 详细信息

作品是对“世界”的诠释,展览是对“世界”的抵达,两者内外有别,各有使命。本文通过对几个展览案例的自述,解析如何因地制宜,巧立展题,借用博物馆的固有资源,让作品在公共空间中获取整体性的开放意义,其实践过程也引入文学、戏剧、建筑、园林等其他机制拟化“视觉艺术”,使得展览在“时间”序列中扩大“空间”维度的想象力,并以故事性的叙事形态,更好取得观众对展览内容的感知,从而使作品达到“增殖”的效应。

关键词：共性时间复调真幻事件

2023年江苏省优质课评比创新点赏析——以“光电效应”教学为例

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物理教学 2024年第6期46卷 19-21,62页

作者：徐超南京市教学研究室江苏210001

“光电效应”是一节概念理解课,也是规律探究课,精心设计的教学实验能让学生经历科学探究,培养学生的思维,提升创新能力。文章介绍了在准备这样的课程中所做的教学实验、教学思路、学生活动以及教学语言方面的创新工作,以使教学更好地... 详细信息

“光电效应”是一节概念理解课,也是规律探究课,精心设计的教学实验能让学生经历科学探究,培养学生的思维,提升创新能力。文章介绍了在准备这样的课程中所做的教学实验、教学思路、学生活动以及教学语言方面的创新工作,以使教学更好地符合学生学习规律,培养学生的学科素养。

关键词：光电效应教学创新自制教具

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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肝静脉阻塞型布加综合征的研究进展

临床肝胆病杂志 2024年第1期40卷 13-18页

作者：郭旭吴浩四川大学华西医院消化内科成都610041

布加综合征作为一种罕见的肝血管疾病,根据肝脏流出道阻塞部位不同可分为肝静脉阻塞型、下腔静脉阻塞型和混合型。本文将着重于肝静脉阻塞型,对其流行病学、亚型分型、临床诊断、治疗策略等方面进行论述。

关键词： Budd-Chiari综合征诊断治疗学

Heterologous expression， purification and characterization of Lactobacillus acidophilus CICC6074-derived slpX protein and the molecular mechanism of its anti-inflammatory effect on LPS-induced RAW264.7 cells

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Food Science and Human Wellness 2024年

作者： Yingying Cao Xiankang Fan Zihang Shi Mingzhen Liu Jue xu Tao Zhang Xiaoqun Zeng Zhen Wu Daodong Pan State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products， Ningbo University Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province College of Food and Pharmaceutical Sciences， Ningbo University

The role of S-layer proteins (SLP)， which form the outermost layer of cell walls in lactic acid bacteria (LAB)， plays a crucial role in regulating immune-stimulating activity， thereby closely influencing LAB's ability to boost host immunity. In this study， the heterologous expression， purification， and characterization of L. acidophilus CICC6074-derived slpX protein and the molecular mechanism of its anti-inflammatory effect on LPS-induced RAW264.7 cells were investigated. Initially， the PCR results were shown to successfully clone the slpX DNA sequence by homologous recombination to obtain the pet-32a-slpX recombinant plasmid. SDS-PAGE results revealed that slpX protein with a molecular weight of 54 kDa was successfully obtained under 0.7 mmol/L IPTG-induced conditions， which was further demonstrated by western blot(WB) and LC-MS/MS. ELISA， WB and molecular docking results indicated that slpX protein can inhibit LPS-induced cellular inflammatory responses by linking to TLR4 and MD2 via hydrogen bonding and increasing the levels of anti-inflammatory factor IL-10 and decreasing the levels of inflammatory factors (TNF-α， IL-6， NO) and ROS via MAPK and NF-κB signaling pathways. The study is essential for the preparation of pure slpX protein and revealing its anti-inflammatory molecular mechanism.

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