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Journal of Future Foods 2024年第2期4卷 135-141页

作者： Yanan Liu Huan Li Jian Chen jiesi feng Renjie Lian Linglin Fu Yanbo Wang Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Jinghai Group Co. Ltd.Rongcheng 264300China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China

Indicating hydrogels have shown the advantages of being fast, sensitive, and real-time in demonstrating the freshness of aquatic products due to their noticeable color change. In this work, an anti-freezing hydrogel embedded with pH-sensitive alizarin was developed as an original colorimetric indicator for monitoring the corruption of aquatic products at low temperatures. The anti-freezing hydrogel was prepared from 2-carboxyethyl acrylate, [2-(methacryloyloxy)ethyl]-trimethylammonium chloride, and 2-hydroxyethyl methacrylate monomers with triethylene glycol dimethacrylate as cross-linking agent. The hydrogel showed excellent anti-freezing capability, which was further incorporated with the pH-sensitive dye alizarin to gain the indicating capability. When applied in the indication of the freshness of salmon under low-temperature storage, it was found that the color changes of the indicator corresponded with the total volatile basic nitrogen contents of salmon, the correlation coefficient of which was 0.959 6. These results indicated the application potential of the hydrogels as freshness indicators during low-temperature storage or cold-chain transportation.

关键词： Colorimetric indicator Alizarin Zwitterionic hydrogel Food freshness Visual monitoring

Cancer cell employs a microenvironmental neural signal transactivating nucleus-mitochondria coordination to acquire stemness

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3818-3836页

作者： Bin He Rui Gao Shasha Lv Ailin Chen Junxiu Huang Luoxuan Wang Yunxiu feng jiesi feng Bing Liu Jie Lei Bing Deng Bin He Bai Cui Fei Peng Min Yan Zifeng Wang Eric W-F Lam Bilian Jin Zhiming Shao Yulong Li Jianwei Jiao Xi Wang Quentin Liu State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Medical Oncology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 510275PR China Institute of Cancer Stem Cell Cancer CenterDalian Medical UniversityDalian 116023PR China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080PR China State Key Laboratory of Membrane Biology Peking University School of Life SciencesBeijing 100871PR China Department of Surgery and Cancer Imperial College LondonLondon W120NNUK Department of Breast Surgery Precision Cancer Medicine CenterFudan University Shanghai Cancer CenterShanghai 200032PR China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101PR China

Cancer cell receives extracellular signal inputs to obtain a stem-like status,yet how tumor microenvironmental(TME)neural signals steer cancer stemness to establish the hierarchical tumor architectures remains ***,a pan-cancer transcriptomic screening for 10852 samples of 33 TCGA cancer types reveals that cAMP-responsive element(CRE)transcription factors are convergent activators for cancer *** of transcriptomic profiles,specification of neural markers and illustration of norepinephrine dynamics uncover a bond between TME neural signals and cancer-cell CRE ***,neural signal norepinephrine potentiates the stemness of proximal cancer cells by activating cAMP-CRE axis,where ATF1 serves as a conserved *** activation by norepinephrine,ATF1 potentiates cancer stemness by coordinated trans-activation of both nuclear pluripotency factors MYC/NANOG and mitochondrial biogenesis regulators NRF1/TFAM,thereby orchestrating nuclear reprograming and mitochondrial ***,single-cell transcriptomes confirm the coordinated activation of nuclear pluripotency with mitochondrial biogenesis in cancer stem-like *** findings elucidate that cancer cell acquires stemness via a norepinephrine-ATF1 driven nucleus-mitochondria collaborated program,suggesting a spatialized stemness acquisition by hijacking microenvironmental neural signals.

关键词： Cancer neural architectures

New generation of GRAB sensors enable sensitive and specific monitoring of norepinephrine in vivo

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New generation of GRAB sensors enable sensitive and specific...

Next generation genetically-encoded fluorescent dopamine sensors for in vivo studies

中国生理学会张锡钧基金第十五届全国青年优秀生理学学术论文交流及评奖会议;中国生理学会第十三届全国青年生理学工作者学术会议

作者： jiesi feng Julieta E.Lischinsky Tongrui Qian Jingheng Zhou Guohong Cui Dayu Lin Yulong Li State Key Laboratory of Membrane Biology Peking University School of Life Sciences Neuroscience Institute New York University School of Medicine Neurobiology Laboratory National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle Park

Norepinephrine (NE) plays important roles in a wide range of physiological processes,including conducting sensory information,regulating the sleep-wake/arousal state,and mediating attentional function in the brain,as well as modulating heart function and blood pressure in the sympathetic nervous *** of the noradrenergic signaling is implicated in diseases such as stress,depression,ADHD,and ***,the precise dynamics and regulation remain poorly

关键词： New generation of GRAB sensors enable sensitive and specific monitoring of norepinephrine in vivo

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Next generation genetically-encoded fluorescent dopamine sen...

Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice

2019中国生理学会学术年会暨张锡钧基金第十五届全国青年优秀生理学学术论文交流会及第十三届全国青年生理学工作者学术会议

作者：卓一洲 Fangmiao Sun Jianzhi Zeng Miao Jing Jingheng Zhou jiesi feng Huan Wang Xizi Yang Yu Wei Guohong Cui Yulong Li State Key Laboratory of Membrane Biology Peking University School of Life Sciences PKU-IDG/McGovern Institute for Brain Research Peking-Tsinghua Center for Life Sciences

Dopamine (DA) is a crucial monoamine neurotransmitter involved in many physiological and pathological ***-encoded GPCR activation based sensors for dopamine(GRABDA), are powerful new tools for measuring DA dynamics reliably with high spatiotemporal precision in multiple model systems such as Drosophila, zebrafish and *** we developed next generation GRABDA *** structure-guided protein engineering and high-throughput screening, we newly engineered GRABDA2m (EC50～100nM) and corresponding high affinity

关键词： Next generation genetically-encoded fluorescent dopamine sensors for in vivo studies HEK

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Effects of adolescent social stress and antidepressant treat...

前列欣胶囊对慢性前列腺炎患者临床症状的疗效观察

第二十一届全国心理学学术会议

作者： Hang Xu jiesi Wang Ke Zhang Mei Zhao Bart Ellenbroek feng Shao Weiwen Wang CAS Key Laboratory of Mental Health Institute of Psychology The University of Chinese Academy of Sciences School of Psychology Victoria University of Wellington School of Psychological and Cognitive Sciences Beijing Key Laboratory of Behavior and Mental Health Peking University

Adolescent social stress(ASS) can increase susceptibility to depression in adulthood. However, the underlying psychological and neural mechanisms remain unclear. Cortically mediated cognitive dysfunctions are increasingly recognized as an independent and important risk factor of depression. Using social defeat stress, a classical animal model of depression, our previous studies found that mice subjected to this form of stress during early adolescence displayed cognitive inflexibility(CI) in adulthood. This change was accompanied by a down-regulation of Bdnf gene expression in the medial prefrontal cortex(mPFC);this gene encodes a key molecule involved in depression and antidepressant action. In the present paper, we identified epigenetic modification of Bdnf as a possible mechanism underlying the behavioral and molecular changes. ASS induced a set of depressive phenotypes, including increased social avoidance and CI, as well as reduced levels of total Bdnf and isoform IV but not isoform I or VI transcripts in the mPFC. In parallel with changes in Bdnf gene expression, previously stressed adult mice showed increased levels of dimethylation of histone H3 at lysine K9(H3K9me2) immediately downstream of the Bdnf IV promoter. On the other hand, no differences were found in trimethylation of histone H3 at lysine K4(H3K4me3) or in acetylation of histone H3 at lysine K9(H3K9ac) or at K4(H3K4ac) in the Bdnf IV promoter. Likewise, no alterations were found in DNA methylation of the Bdnf IV promoter. Additionally, treatment with the chronic antidepressant tranylcypromine reversed Bdnf epigenetic changes and related gene transcription while also reversing CI, but not social avoidance, in previously stressed adult mice. These results suggest that epigenetic changes to the Bdnf gene in the mPFC after adolescent social adversity may be involved in the regulation of cognitive dysfunction in depression and antidepressant action in adulthood.

关键词： Adolescent Social stress Cognitive inflexibility Brain-derived neurotrophic factor(BDNF) Epigenetic mechanism

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中国性科学 2020年第6期29卷 89-91页

作者：姚伊冯雪花姜洁思张斌闻姬山东中医药大学第二附属医院生殖医学中心济南250001

目的研究前列欣胶囊对慢性前列腺炎患者临床症状的疗效。方法根据纳入标准选取2018年1月至2019年2月山东中医药大学第二附属医院接受助孕的160例慢性前列腺炎患者作为研究对象。患者口服前列欣胶囊每次3g,每日3次,治疗1个月,且治疗前后... 详细信息

目的研究前列欣胶囊对慢性前列腺炎患者临床症状的疗效。方法根据纳入标准选取2018年1月至2019年2月山东中医药大学第二附属医院接受助孕的160例慢性前列腺炎患者作为研究对象。患者口服前列欣胶囊每次3g,每日3次,治疗1个月,且治疗前后均使用NIH-CPSI评分量表测试,并观察患者治疗前后白细胞数量及卵磷脂小体数量的变化。结果患者经前列欣胶囊治疗后,NIH-CPSI评分较治疗前明显改善,总有效率达81.25%,其疼痛不适症状、排尿症状及生活质量也明显改善,差异具有统计学意义(P<0.05);且治疗后白细胞数量明显降低,卵磷脂小体数量显著增多,差异具有统计学意义(P<0.05)。结论前列欣胶囊能够改善湿热下注型慢性前列腺炎患者临床症状,疗效明显,有助于改善患者生活质量。

关键词：前列欣胶囊慢性前列腺炎临床症状

音乐疗法联合经皮穴位电刺治疗体外受精-胚胎移植患者的焦虑情绪的临床观察

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中国性科学 2017年第6期26卷 140-142页

作者：冯雪花许丹姜洁思孙伟闻姬山东中医药大学第二附属医院生殖医学中心济南250001

目的:研究音乐疗法联合经皮穴位电刺激治疗对体外受精-胚胎移植(IVF-ET)患者焦虑情绪的疗效。方法:选择在我院行体外受精-胚胎移植的焦虑患者300例,随机分为对照组和治疗组,每组150例,对照组按IVF-ET超促排方案常规治疗,治疗组在IVF-ET... 详细信息

目的:研究音乐疗法联合经皮穴位电刺激治疗对体外受精-胚胎移植(IVF-ET)患者焦虑情绪的疗效。方法:选择在我院行体外受精-胚胎移植的焦虑患者300例,随机分为对照组和治疗组,每组150例,对照组按IVF-ET超促排方案常规治疗,治疗组在IVF-ET中超促排的同时应用音乐疗法和经皮穴位电刺激治疗。结果:治疗组患者的焦虑程度治疗前后有显著性差异(P0.05),治疗组患者治疗后焦虑程度明显低于对照组,有统计学差异(P<0.05);治疗组生化妊娠率、临床妊娠率均高于对照组,差异有统计学意义(P<0.05)。结论:应用音乐疗法结合经皮穴位电刺激治疗可缓解IVF-ET患者焦虑心理,稳定情绪,提高临床妊娠率。

关键词：音乐疗法经皮穴位电刺激焦虑情绪妊娠率

重组禽流感病毒(H5+H7)三价灭活疫苗和鸡新城疫、禽流感(H9亚型)、禽腺病毒病(Ⅰ群4型)三联灭活疫苗联合免疫效果研究

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中国家禽 2024年第6期46卷 105-111页

作者：沈亚菊陶建丰冯高乐邵高姜永其黄杰偲倪征张存林瑞平平湖市畜牧兽医站浙江嘉兴314200 平湖市动物监督所浙江嘉兴314200 浙江群大畜牧养殖有限公司浙江嘉兴314200 浙江省农业科学院畜牧兽医研究所浙江杭州310000

为评价重组禽流感病毒(H5+H7)三价灭活疫苗和鸡新城疫、禽流感(H9亚型)、禽腺病毒病(Ⅰ群4型)三联灭活疫苗混合后的联合免疫效果,试验将120只11日龄健康商品代黄羽肉鸡随机分成4组,设混苗联合免疫组、分点免疫组和单苗免疫组,分别接种疫... 详细信息

为评价重组禽流感病毒(H5+H7)三价灭活疫苗和鸡新城疫、禽流感(H9亚型)、禽腺病毒病(Ⅰ群4型)三联灭活疫苗混合后的联合免疫效果,试验将120只11日龄健康商品代黄羽肉鸡随机分成4组,设混苗联合免疫组、分点免疫组和单苗免疫组,分别接种疫苗,检测免疫前和免疫后14、21、28和35 d鸡血清中特异性抗体水平,评估两种疫苗混合后联合免疫的安全性和免疫效果。结果显示:免疫后1周内各组鸡精神、食欲、呼吸等生理活动均无异常;混苗联合免疫组免疫后14 d,6种病原抗体滴度均升高,免疫后21 d均达到理想水平,免疫后28 d抗体滴度均高于5 log2;混苗联合免疫组抗体水平和抗体消长规律与其他组基本一致。研究表明,两种禽流感疫苗混合后联合免疫的安全性和免疫效果与单苗免疫相当,无干扰现象,可减少鸡群应激,节省人工,为养禽场免疫程序优化提供参考。

关键词：鸡新城疫禽流感禽腺病毒病联合免疫免疫效果

儿童非高危急性早幼粒细胞白血病诱导期加一剂蒽环类治疗的疗效和安全性SCCLG/SCCCG-APL协作组

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中国小儿血液与肿瘤杂志 2024年第2期29卷 86-90,96页

作者：樊重杨良春陈以乔万伍卿麦惠容杨丽华兰和魁周敦华李婉丽郭碧赟何飞廖柳华陈惠芹甄子俊贺湘玲冯晓勤陈国华吉训琦陈沫黎巧茹龙兴江田川符莹罗杰思黄丹萍张晓莉唐燕来王丽娜李毓李彬黄礼彬罗学群中山大学附属第一医院广州510080 中南大学湘雅医院长沙410119 福建医科大学附属协和医院福州350001 中南大学湘雅二医院长沙410011 深圳市儿童医院深圳518038 南方医科大学珠江医院广州510145 中山大学孙逸仙纪念医院广州510120 湖南省儿童医院长沙410007 厦门大学附属第一医院厦门361003 江西省儿童医院南昌330006 惠州市中心人民医院惠州516001 中山大学附属第三医院广州510630 中山大学附属肿瘤医院广州510060 湖南省人民医院长沙410005 南方医科大学南方医院广州510510 惠州市第一人民医院惠州516003 海南省人民医院海口570311 中山大学附属第五医院珠海519000 中山市人民医院中山528400 柳州市人民医院柳州545006 广东医科大学附属医院湛江524001 广东医科大学附属顺德妇女儿童医院顺德528300 中山大学附属第一医院临床研究中心广州510080

目的成人非高危急性早幼粒细胞白血病(NHR-APL)的去化疗诱导治疗,其疗效和安全性在儿童患者中尚未得到验证,需开展儿童的研究。方法数据来自华南儿童APL协作组的前瞻性研究资料,≤16岁、完成诱导治疗的NHR-APL患儿纳入分析。在砷剂+全... 详细信息

目的成人非高危急性早幼粒细胞白血病(NHR-APL)的去化疗诱导治疗,其疗效和安全性在儿童患者中尚未得到验证,需开展儿童的研究。方法数据来自华南儿童APL协作组的前瞻性研究资料,≤16岁、完成诱导治疗的NHR-APL患儿纳入分析。在砷剂+全反式维甲酸诱导治疗的基础上,比较加或不加1剂量去甲氧柔红霉素/米托蒽醌10mg/m^(2)(化疗或无化疗组)的缓解情况和不良事件率。结果化疗组139例,无化疗组27例,两组的诱导治疗结果比较:达血液学完全缓解的中位天数分别为26.0(22.0,31.5)d和31.0(27.5,35.0)d(P=0.002);分子学完全缓解分别有29.5%和3.7%(P=0.005);外周血白细胞计数>10×10^(9)/L分别有43.2%和74.1%(P=0.003);最高白细胞中位数分别为8.6(IQR 4.9,18.4)×10^(9)/L和22.7(IQR 16.0,41.7)×10^(9)/L(P0.1)。结论儿童NHR-APL可能有别于成人患者,与无化疗比较,诱导治疗加1剂量蒽环类疗效更好,并发症的风险更低。

关键词：急性早幼粒细胞白血病儿童化疗