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Comparison of clinical features and outcomes of proliferative,fibrotic,and mixed subtypes of IgG4-related disease:A retrospective cohort study

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Chinese Medical Journal 2024年第3期137卷 303-311页

作者： Linyi Peng Xinlu zhang Jiaxin Zhou jieqiong Li Zheng Liu Hui Lu Yu Peng Yunyun Fei Yan Zhao Xiaofeng Zeng Wen zhang Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalNational Clinical Research Center for Dermatologic and Immunologic DiseasesState Key Laboratory of Complex Severe and Rare DiseasesThe Ministry of Education Key LaboratoryBeijing 100730China Institute of Clinical Medicine Peking Union Medical College Hospital(PUMCH)Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Background:Immunoglobulin G4-related disease(IgG4-RD)is a recently recognized immune-mediated disorder that can affect almost any organ in the human body.IgG4-RD can be categorized into proliferative and fibrotic subtypes based on patients’clinicopathological characteristics.This study aimed to compare the clinical manifestations,laboratory findings,and treatment outcomes of IgG4-RD among different subtypes.Methods:We prospectively enrolled 622 patients with newly diagnosed IgG4-RD at Peking Union Medical College Hospital from March 2011 to August 2021.The patients were divided into three groups according to their clinicopathological characteristics:proliferative,fibrotic,and mixed subtypes.We compared demographic features,clinical manifestations,organ involvement,laboratory tests,and treatment agents across three subtypes.We then assessed the differences in treatment outcomes among 448 patients receiving glucocorticoids alone or in combination with immunosuppressants.Moreover,risk factors of relapse were revealed by applying the univariate and multivariate Cox regression analysis.Results:We classified the 622 patients into three groups consisting of 470 proliferative patients,55 fibrotic patients,and 97 mixed patients,respectively.We found that gender distribution,age,disease duration,and frequency of allergy history were significantly different among subgroups.In terms of organ involvement,submandibular and lacrimal glands were frequently involved in the proliferative subtype,while retroperitoneum was the most commonly involved site in both fibrotic subtype and mixed subtype.The comparison of laboratory tests revealed that eosinophils(P=0.010),total IgE(P=0.006),high-sensitivity C-reactive protein(P<0.001),erythrocyte sedimentation rate(P<0.001),complement C4(P<0.001),IgG(P=0.001),IgG1(P<0.001),IgG4(P<0.001),and IgA(P<0.001),at baseline were significantly different among three subtypes.Compared with proliferative and mixed subtypes,the fibrotic subtype showed the lowest rate of relapse(log-rank P=0.014).Conclus

关键词： IgG4-related disease Proliferative subtype Fibrotic subtype Clinical features Treatment outcome

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Nitrogen-doped microporous graphite-enhanced copper plasmonic effect for solar evaporation

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Carbon Energy 2024年第3期6卷 215-223页

作者： Xintao Wu Chengcheng Li Ziqi zhang Yang Cao jieqiong Wang Xinlong Tian Zhongxin Liu Yijun Shen Mingxin zhang Wei Huang School of Marine Science and Engineering School of Chemistry and Chemical EngineeringHainan UniversityHaikouHainanChina Key Laboratory of Child Cognition and Behavior Development of Hainan Province Qiongtai Normal UniversityHaikouHainanChina

Water scarcity is a global challenge,and solar evaporation technology offers a promising and eco-friendly solution for freshwater production.Photothermal conversion materials(PCMs)are crucial for solar evaporation.Improving photothermal conversion efficiency and reducing water evaporation enthalpy are the two key strategies for the designing of PCMs.The desired PCMs that combine both of these properties remain a challenging task,even with the latest advancements in the field.Herein,we developed copper nanoparticles(NPs)with different conjugated nitrogen-doped microporous carbon coatings(Cu@C–N)as PCMs.The microporous carbon enveloping layer provides a highly efficient pathway for water transport and a nanoconfined environment that protects Cu NPs and facilitates the evaporation of water clusters,reducing the enthalpy of water evaporation.Meanwhile,the conjugated nitrogen nodes form strong metal-organic coordination bonds with the surface of copper NPs,acting as an energy bridge to achieve rapid energy transfer and provide high solar-to-vapor conversion efficiency.The Cu@C–N exhibited up to 89.4%solar-to-vapor conversion efficiency and an evaporation rate of 1.94 kgm^(−2) h^(−1) under one sun irradiation,outperforming conventional PCMs,including carbon-based materials and semiconductor materials.These findings offer an efficient design scheme for high-performance PCMs essential for solar evaporators to address global water scarcity.

关键词： nanoconfinement photothermal conversion materials plasmonic resonance seawater desalination solar evaporation

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Ultrastable graphene isolated Au Ag nanoalloy for SERS biosensing and photothermal therapy of bacterial infection

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Chinese Chemical Letters 2024年第3期35卷 198-203页

作者： Shengkai Li Zhiyang Li Qing Hao Shen Wang Yanxia Yang jieqiong Xu Zhiwei Yin Liang zhang Zhuo Chen Molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical EngineeringCollege of BiologyAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China School of Chemistry and Chemical Engineering/Guangzhou Key Laboratory for Clean Energy and Materials/Key Laboratory for Water Quality and Conservation of the Pearl River Delta Ministry of EducationGuangzhou UniversityGuangzhou 510006China

Plasmonic metal nanomaterials with intrinsic surface–enhanced Raman scattering(SERS)and photothermal properties,especially AuAg nanoalloys with both the outstanding merits of Au and Ag nanocrystals,show huge application prospects in bacterial theranostics.However,the direct exposure of AuAg nanoalloys in external conditions probably cause undesirable reactions and poisonous metal ion leakage during SERS detection and photothermal antibacterial therapy process,which severely hinder bacterial theranostics applications.Herein,we report an ultrastable graphene–isolated AuAg nanoalloy(GAA)with AuAg core confined in few–layer graphitic shell as a versatile platform for bacterial detection and therapy.The encapsulation of graphene ensures the good stability of AuAg core,that its superior SERS and photothermal properties are therefore further guaranteed.GAA is used for SERS detection of two vital bacterial biomarkers(including corrosive cyanide and pyocyanin),exhibiting good SERS quantitative and multiplexing ability.GAA is further used for photothermal antibacterial therapy application,and ultrahigh antibacterial efficacies for both Gram–negative Escherichia coli and Gram–positive Staphylococcus aureus are achieved under 808 nm laser irradiation.This work proposes a valuable method to develop robust bacterial theranostic platform.

关键词： Localized surface plasmon resonance Graphitic shell isolated AuAg nanoalloy(GAA) Surface–enhanced Raman scattering(SERS) Bacterial biomarker detection Photothermal antibacterial therapy

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High transcriptome plasticity drives phosphate starvation responses in tomato

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Stress Biology 2022年第1期2卷 458-480页

作者： Viswanathan Satheesh jieqiong zhang Jinkai Li Qiuye You Panfeng Zhao Peng Wang Mingguang Lei Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China School of Life Science and Technology Tongji UniversityShanghai 200092China University of Chinese Academy of Sciences Beijing 100049China

Tomato is an important vegetable crop and fluctuating available soil phosphate(Pi)level elicits several morpho-physiological responses driven by underlying molecular responses.Therefore,understanding these molecular responses at the gene and isoform levels has become critical in the quest for developing crops with improved Pi use efficiency.A quantitative time-series RNA-seq analysis was performed to decipher the global transcriptomic changes that accompany Pi starvation in tomato.Apart from changes in the expression levels of genes,there were also alterations in the expression of alternatively-spliced transcripts.Physiological responses such as anthocyanin accumulation,reactive oxygen species generation and cell death are obvious 7 days after Pi deprivation accompanied with the maximum amount of transcriptional change in the genome making it an important stage for in-depth study while studying Pi stress responses(PSR).Our study demonstrates that transcriptomic changes under Pi deficiency are dynamic and complex in tomato.Overall,our study dwells on the dynamism of the transcriptome in eliciting a response to adapt to low Pi stress and lays it bare.Findings from this study will prove to be an invaluable resource for researchers using tomato as a model for understanding nutrient deficiency.

关键词： Tomato Pi starvation Transcriptome Gene expression Alternative splicing Co-expression network

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堆内自给能中子探测器信号电流计算方法研究

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核技术 2024年第3期47卷 84-92页

作者：吴雄张香菊罗世杰蒋洁琼中国科学技术大学合肥230026 中国科学院合肥物质科学研究院核能安全技术研究所合肥230031 中广核研究院有限公司深圳518031

自给能中子探测器(Self-Powered Neutron Detectors,SPNDs)是核反应堆监测和保护系统的核心设备,其测量到的电流直接反映堆芯功率的大小和分布。探测器绝缘体是影响信号电流计算精度的主要因素,在SPND的研发设计中占有重要地位。为进一... 详细信息

自给能中子探测器(Self-Powered Neutron Detectors,SPNDs)是核反应堆监测和保护系统的核心设备,其测量到的电流直接反映堆芯功率的大小和分布。探测器绝缘体是影响信号电流计算精度的主要因素,在SPND的研发设计中占有重要地位。为进一步提升SPND信号电流计算方法的精度,本文根据SPND电流产生机理以及绝缘体中固有的空间电场效应,提出了三种不同的中子、光子电流计算方法,并进行了详细的对比验证。结果表明:三种方法计算结果的差异小于1%,显示了相当的精度。此外,以反应堆工程中应用广泛的铑SPND为例,计算结果表明其信号电流主要由中子产生,光子引起的电流一般不超过5%。本文所提出的电流计算方法在反应堆上经过了大量的实验验证,理论和实验结果的差异均小于3%,证明了其有效性和精度。该方法已经应用于中国第三代先进大型压水反应堆——“华龙一号”,并具有通用性。它可用于不同类型自给能探测器的电流分析,也可为其他反应堆(如第四代快中子堆和后续的聚变堆)的堆芯监测系统提供有益的参考。

关键词：自给能中子探测器绝缘体空间电场效应信号电流蒙特卡罗方法

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加载速率对锈蚀钢筋与混凝土粘结性能的影响

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材料导报 2024年第8期38卷 150-158页

作者：金浏张晓旺郭莉吴洁琼杜修力北京工业大学城市减灾与防灾防护教育部重点实验室北京100124

为探究加载速率对锈蚀钢筋与混凝土粘结性能的影响,开展16根RC梁(质量损失率0%~8.7%)在不同加载速率(0.5~300 mm/min)下的粘结性能测试,据此提出考虑加载速率和钢筋锈蚀影响的粘结强度计算公式,并开展锈蚀钢筋混凝土梁粘结力学行为的数... 详细信息

为探究加载速率对锈蚀钢筋与混凝土粘结性能的影响,开展16根RC梁(质量损失率0%~8.7%)在不同加载速率(0.5~300 mm/min)下的粘结性能测试,据此提出考虑加载速率和钢筋锈蚀影响的粘结强度计算公式,并开展锈蚀钢筋混凝土梁粘结力学行为的数值模拟,分析高加载速率(30~30000 mm/min,应变率10^(-4)~10^(-1)s^(-1))下锈蚀梁的粘结滑移力学行为。研究表明:(1)加载速率对锈蚀钢筋混凝土梁式试件的粘结应力-滑移曲线形状以及粘结强度与残余粘结强度的比值影响不大;(2)随着加载速率的增加,锈蚀钢筋与混凝土的粘结强度和残余粘结强度显著增加,粘结区应力峰值显著增加并逐渐向加载端靠近;(3)本工作提出的考虑加载速率和钢筋锈蚀影响的粘结强度计算公式在0.5~30000 mm/min的加载速率范围内有很好的适用性。

关键词：加载速率钢筋锈蚀粘结性能数值模拟

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Physical Mechanism and Performance Factors of Metal Oxide Based Resistive Switching Memory:A Review

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Journal of Materials Science & Technology 2016年第1期32卷 1-11页

作者： Cong Ye Jiaji Wu Gang He jieqiong zhang Tengfei Deng Pin He Hao Wang Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Hubei Key Laboratory of Ferroelectric and Dielectric Materials and DevicesFaculty of Physics and Electronic ScienceHubei University School of Physics and Materials Science Radiation Detection Materials & Device LabAnhui University Department of Electrical Engineering City University of Hong KongHong Kong Special Administrative Region

This review summarizes the mechanism and performance of metal oxide based resistive switching memory. The origin of resistive switching （RS） behavior can be roughly classified into the conducting filament type and the interface type. Here, we adopt the filament type to study the metal oxide based resistive switch- ing memory, which considers the migration of metallic cations and oxygen vacancies, as well as discuss two main mechanisms including the electrochemical metallization effect （ECM） and valence change memory effect （VCM）. At the light of the influence of the electrode materials and switching layers on the RS char- acteristics, an overview has also been given on the performance parameters including the uniformity, endurance, the retention, and the multi-layer storage. Especially, we mentioned ITO （indium tin oxide） electrode and discussed the novel RS characteristics related with ITO. Finally, the challenges resistive random access memory （RRAM） device is facing, as well as the future development trend, are expressed.

关键词： RRAM （resistive random access memory） Transition metal oxide Conductive filament Resistive switching

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A group of SUVH methyl-DNA binding proteins regulate expression of the DNA demethylase ROS_1 in Arabidopsis

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Journal of Integrative Plant Biology 2019年第2期61卷 110-119页

作者： Xinlong Xiao jieqiong zhang Tao Li Xing Fu Viswanathan Satheesh Qingfeng Niu Zhaobo Lang Jian-Kang Zhu Mingguang Lei Shanghai Center for Plant Stress Biology Center for Excellence in Molecular Plant SciencesChinese Academy of Sciences The University of Chinese Academy of Sciences Department of Horticulture and Landscape Architecture Purdue University

DNA methylation is typically regarded as a repressive epigenetic marker for gene expression.Genome-wide DNA methylation patterns in plants are dynamically regulated by the opposing activities of DNA methylation and demethylation reactions. In Arabidopsis, a DNA methylation monitoring sequence(MEMS) in the promoter of the DNA demethylase gene ROS_1 functions as a methylstat that senses these opposing activities and regulates genome DNA methylation levels by adjusting ROS_1 expression. How DNA methylation in the MEMS region promotes ROS_1 expression is not known. Here, we show that several Su(var)3-9 homologs(SUVHs) can sense DNA methylation levels at the MEMS region and function redundantly to promote ROS_1 expression. The SUVHs bind to the MEMS region, and the extent of binding is correlated with the methylation level of the MEMS.Mutations in the SUVHs lead to decreased ROS_1 expression, causing DNA hypermethylation at more than 1,000 genomic regions. Thus, the SUVHs function to mediate the activation of gene transcription by DNA methylation.

关键词： DNA ROS Figure

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Statistical Inference for Multicomponent System Stress-Strength Model with Bounded Strengths

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Journal of Systems Science & Complexity 2023年第2期36卷 755-770页

作者： BAI Xuchao zhang jieqiong CHAI Jian School of Economics and Management Xidian UniversityXi'an 710126China School of Mathematics Northwest UniversityXi'an 710127China

In this paper,the statistical inference for system stress-strength reliability with bounded strength is discussed.When the stress and strength variables follow the three-parameter Exponentiated-Weibull distributions with unequal scale and shape parameters,the maximum likelihood estimator(MLE)and bootstrap-p confidence interval for system reliability are derived.In addition,combining the score equations which are got by taking the first derivative of the log-likelihood function with respect to the model parameters,the modified generalized pivotal quantity for the system reliability is obtained.After that,two point estimators and a modified generalized confidence interval based on the modified generalized pivotal quantity for the system reliability are derived.Monte Carlo simulations are performed to compare the performances of the proposed point estimators and confidence intervals.Finally,a real data analysis is provided to illustrate the proposed procedures.

关键词： Exponentiated-Weibull distribution modified generalized confidence interval modified generalized pivotal quantity stress-strength reliability survival signature

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不确定环境下潜艇综合防御鱼雷的作战决策分析与优化方法

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兵工学报 2024年第2期45卷 564-573页

作者：杨静陆铭华郭力强马洁琼吴金平张会国防科技大学系统工程学院湖南长沙410073 海军潜艇学院山东青岛266041 92020部队山东青岛266001

针对潜艇综合防御决策时存在的目标类型不明、目标运动信息解算不明、对抗环境信息不明3类信息不确定问题,构建基于不确定信息的潜艇防御鱼雷组合优化框架,设计基于蒙特卡洛模拟的随机搜索优化模型,采用基于离散边界收缩的粒子群优化(Pa... 详细信息

针对潜艇综合防御决策时存在的目标类型不明、目标运动信息解算不明、对抗环境信息不明3类信息不确定问题,构建基于不确定信息的潜艇防御鱼雷组合优化框架,设计基于蒙特卡洛模拟的随机搜索优化模型,采用基于离散边界收缩的粒子群优化(Particle Swarm Optimization,PSO)方法计算局部最优决策。建立战术对抗仿真模型对潜艇防御鱼雷策略进行选择与优化,针对不同鱼雷报警位置和行动策略,以安全余量作为评价标准,综合考虑3类不明条件下使用潜艇转向+定深规避与潜艇转向+使用水声器材防御两种策略,并结合PSO方法与过程仿真分别给出两类策略的选择边界条件及不同作战态势下的决策建议。防御效能分析结果表明:目标解算不收敛是最主要的防御行动影响因素,基于PSO方法的潜艇转向角度决策精度为±10°/20°;在相同的条件下,组合优化框架的决策加速比相比于传统搜索方法达到92~156,相比于并行计算方法达到10~16,在满足决策实时性的基础上可以为潜艇防御鱼雷争取更大的防御决策时间。

关键词：不确定信息潜艇防御鱼雷粒子群优化方法过程仿真

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