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Recent advances for liquid metals:Synthesis,modification and bio-applications

Journal of Materials Science & Technology 2023年第12期143卷 153-168页

作者： Zhenhu Guo Xiaohan Gao Jingsong Lu Wanling Xu jielin Ye Ying Li Wensheng Xie Lingyun zhao Key Laboratory of Advanced Materials Ministry of Education of ChinaSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China School of Medicine Tsinghua UniversityBeijing 100084China Department of Neurosurgery Yuquan HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 100084China The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 100084China

Considering the application requirements for modern biomedicine,research into novel biomaterials with unusual functions is highly *** an alternative,liquid metals(LMs),a nontraditional family of metal materials,have piqued the interest of biomedical researchers and made significant advances in biomed-ical areas,owing to their shape transformability,self-healing capability,excellent electrical,and thermal *** particular,many functionalized strategies for the preparation and modification of LMs or LMs-based composites to achieve extended biomedical applications have been investigated in recent *** findings provided inspiring while constructive reference for the fabrication and engineering of novel LMs-based ***,in this topic review,we elaborate on the recent advances of LMs-based functional materials,with particular focuses on the synthesis,modification,and bio-applications,especially in antitumor therapy,antibacterial,contrast agent for imaging,bone repair,electronic skin sen-sor,and nerve connection *** on,the current challenges and future prospects of LMs-based composites are carefully discussed.

关键词： Liquid metals Synthesis Composites Antitumor therapy Bio-application

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神农架南坡小叶青冈+曼青冈常绿阔叶林主要木本植物生态位与种间联结

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生态学报 2024年第11期44卷 4889-4903页

作者：陈聪琳赵常明刘明伟徐凯徐文婷熊高明葛结林邓滢申国珍谢宗强中国科学院植物研究所植被与环境变化国家重点实验室北京100093 国家植物园北京100093 中国科学院大学生命科学学院北京101408

为揭示神农架南坡代表性常绿阔叶林主要木本植物的种间生态联系及群落演替趋势,以小叶青冈+曼青冈群系20个主要木本植物的190组种对为研究对象,通过生态位测定并区分生态位特化种和生态位泛化种以及种间联结性检验,分析该群落主要物种... 详细信息

为揭示神农架南坡代表性常绿阔叶林主要木本植物的种间生态联系及群落演替趋势,以小叶青冈+曼青冈群系20个主要木本植物的190组种对为研究对象,通过生态位测定并区分生态位特化种和生态位泛化种以及种间联结性检验,分析该群落主要物种生态位与种间联结特征。主要结果:(1)该常绿阔叶林群落物种丰富,群落组成复杂,小叶青冈(Cyclobalanopsis myrsinifolia)的重要值(11.13%)和生态位宽度(58.3)均最大,占绝对优势,生态位宽度排序和重要值排序不一致,分布频度对生态位宽度影响较大。(2)将20种主要木本植物划分为生态位特化种(6种)、生态位泛化种(3种)、中性类群(11种),生态位分化程度较高,资源利用差异以及生境适应性是影响生态位分化的主要因素。(3)生态位宽度大的物种其生态位重叠和相似度较高,生态位重叠指数总体略低,大部分物种对环境或资源需求相似,但相似度不高,种间竞争较弱,种间关系比较稳定。(4)主要木本植物总体正联结显著(P<0.05),χ^(2)检验、联结系数AC、Spearman秩相关检验结果均显示种间正联结作用占优势,但大多数种对联结不显著,物种趋于独立分布。(5)通过聚类分析,将20种主要木本植物划分三大生态种组:建群种组,共生种组和边缘种组。研究表明,神农架南坡小叶青冈+曼青冈常绿阔叶林目前正处于相对稳定的演替中后期阶段,群落发育较成熟,生态位分化、生境选择以及资源需求互补或互利是影响该群落物种共存的主要原因。研究阐明了神农架南坡代表性常绿阔叶林主要物种之间实际相互作用以及群落特征,为深入理解群落物种共存原因以及群落演替规律提供依据。

关键词：常绿阔叶林种群种间关系生态种组物种共存

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二维码技术在传统教学中的应用

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绵阳师范学院学报 2016年第5期35卷 136-139页

作者：张商州赵洁琳商洛学院电子信息与电气工程学院陕西商洛726000

根据移动网络发展的趋势,结合传统教学的特点,将二维码技术应用于传统教学中,具体阐述了二维码技术在教学应用中的特点和应用模式.举例说明二维码技术在理论教学和资源共享方面的应用,证明了将二维码技术应用于传统教学中的可行性和创新... 详细信息

根据移动网络发展的趋势,结合传统教学的特点,将二维码技术应用于传统教学中,具体阐述了二维码技术在教学应用中的特点和应用模式.举例说明二维码技术在理论教学和资源共享方面的应用,证明了将二维码技术应用于传统教学中的可行性和创新性.随着二维码技术的发展,它将不断为传统教学的改革提供新的方法 .

关键词：二维码传统教学滤波器资源共享

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Development of a novel virus-like particle-based vaccine for preventing tick-borne encephalitis virus infection

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Virologica Sinica 2023年第5期38卷 767-777页

作者： jielin Tang Muqing Fu Chonghui Xu Bao Xue Anqi Zhou Sijie Chen He zhao Yuan Zhou Jizheng Chen Qi Yang Xinwen Chen Guangzhou National Laboratory Guangzhou510005China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan430071China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou510530China GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou511436China State Key Laboratory of Respiratory Disease Guangzhou Medical UniversityGuangzhou511436China

Tick-borne encephalitis virus(TBEV)is an important tick-borne pathogen that poses as a serious public health *** coverage and immunogenicity of the currently available vaccines against TBEV are relatively low;therefore,it is crucial to develop novel and effective vaccines against *** present study describes a novel strategy for the assembly of virus-like particles(VLPs)by co-expressing the structural(core/prM/E)and non-structural(NS2B/NS3Pro)proteins of *** efficacy of the VLPs was subsequently evaluated in C57BL/6 mice,and the resultant IgG serum could neutralize both Far-Eastern and European subtypes of *** findings indicated that the VLP-based vaccine elicited the production of cross-subtype reactive *** VLPs provided protection to mice lacking the type I interferon receptor(IFNAR^(-/-))against lethal TBEV challenge,with undetectable viral load in brain and intestinal ***,the group that received the VLP vaccine did not exhibit significant pathological changes and the inflammatory factors were significantly suppressed compared to the control *** with the VLP vaccine induced the production of multiple-cytokine-producing antiviral CD4+T cells in vivo,including TNF-α^(+),IL-2^(+),and IFN-γ^(+)T ***,the findings suggest that noninfectious VLPs can serve as a potentially safe and effective vaccine candidate against diverse subtypes of TBEV.

关键词： Tick-borne encephalitis virus(TBEV) Virus-like particle(VLP) Immunogenicity Neutralization Vaccine

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Inorganic CsPbI3 Perovskites toward High-Efficiency Photovoltaics

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Energy & Environmental Materials 2019年第2期2卷 73-78页

作者： jielin Shi Yong Wang Yixin zhao School of Environmental Science and Engineering Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China

The organic–inorganic hybrid perovskite solar cells(PSCs)have demonstrated their unprecedented high efficiency and potential for *** volatile organic components in the hybrid perovskite crystal structure are still a big challenge for long-term ***,inorganic CsPbI3 perovskite has attracted much attention because of its superior chemical stability over the prevailing hybrid organic–inorganic perovskite and the most suitable band gap among all-inorganic ***,CsPbI3 suffers from phase instability and low photovoltaic(PV)performance due to its undesirable tolerant *** research effort has been devoted into stabilization of *** this perspective,we review the recent progress on chemical engineering processes for the stabilization of inorganic CsPbI3 perovskite for high-efficiency *** also discuss the importance of understanding mechanism behind stabilization of CsPbI3 perovskite film and the development of inorganic CsPbI3-based highly efficient and stable PSCs.

关键词： CsPbI3 inorganic perovskite solar cells

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新型液晶可调电容器的研究

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电视技术 2019年第20期43卷 64-66页

作者：李策武玉英何晓卉马智浩赵洁琳河北工业职业技术学院河北石家庄050091

液晶盒受到外加电压后,液晶有效介电常数会发生改变,导致液晶盒电容变化。改变液晶盒外加电压的数值,可以实现自主调节液晶盒的电容数值。文章以液晶的弹性理论和经典变分原理为分析手段,研究了受到挠曲电效应影响下的强锚定平行排列和... 详细信息

液晶盒受到外加电压后,液晶有效介电常数会发生改变,导致液晶盒电容变化。改变液晶盒外加电压的数值,可以实现自主调节液晶盒的电容数值。文章以液晶的弹性理论和经典变分原理为分析手段,研究了受到挠曲电效应影响下的强锚定平行排列和混合排列向列相液晶盒的电容特性,为液晶可调电容器的设计研发及挠曲电系数的测量提供了科学理论依据。

关键词：液晶可调电容器挠曲电效应平行排列向列相混合排列向列相

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Melatonin restores normal Bax and Bcl-2 protein expression in the subgranular zone of the dentate gyrus in pinealectomized rats

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Neural Regeneration Research 2011年第27期6卷 2129-2133页

作者： Shengchang Zhang Shuang zhao Lu Bai Mingming Guan jielin Mo Ling Lan Department of Human Anatomy Basic Medical College Guangxi Medical University Nanning 530021 Guangxi Zhuang AutonomousRegion China Department of Pathophysiology Youjiang Medical College for Nationalities Baise 533000 Guangxi Zhuang Autonomous Region China

In this study, we sought to elucidate the effects of melatonin on learning and memory as well as apoptosis and expression of the Bax or Bcl-2 proteins in the subgranular zone of the dentate gyrus in pinealectomized rats. Using the Morris water maze and the olfactory memory tests, we found that the average escape latency in pinealectomized rats was clearly increased compared with sham-operated rats. Moreover, the average escape latency in the melatonin-treated and pinealectomized rats was longer than that in the sham-operated rats and shorter than that in the pinealectomized and untreated rats. Immunohistochemistry and terminal-deoxynucleoitidyl transferase mediated nick end labeling （TUNEL） showed that there were fewer Bax immunoreactive cells and TUNEL-positive （apoptotic） cells but more Bcl-2 immunoreactive cells in the melatonin-treated rats compared with the pinealectomized rats. The sham-operated rats showed numbers of these cells similar to the melatonin-treated rats. These experimental findings demonstrate that melatonin treatment may reduce abnormal apoptosis by promoting gene expression of Bax and suppressing gene expression of Bcl-2 in the subgranular zone of the dentate gyrus in pinealectomized rats. These effects appear to result in the inhibition of cellular apoptosis and the improvement of spatial learning and memory in pinealectomized rats.

关键词： melatonin subgranular zone Bax Bcl-2 apoptosis learning and memory neural regeneration

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Application of image alignment and time averaging methods in AFM detection for single DNA molecules

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Chinese Science Bulletin 2010年第16期55卷 1613-1618页

作者： WANG ChunMei SUN jielin LONG Fei zhao Jun HU Jun School of Life Science and Biotechnology Shanghai Jiao Tong University Shanghai 200240 China Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China

Enhancement of the SNR (signal to noise ratio) in single-molecule imaging is significantly important for improving image resolu-tion and distinguishing the fine structures of single molecules at a higher precision *** processing techniques have dem-onstrated the remarkable capability to improve the SNR and the resolution level by breaking through some inherent limitations unresolved by instrument hardware *** this paper, we focus on single-biomolecule imaging using atomic force mi-croscopy (AFM), a unique method in separated single-biomolecule imaging, and there was few suitable image processing tech-niques reported to increase the SNR of a single molecule’s AFM *** the typical samples of separately dispersed DNA molecules, we replaced the classified averaging method, which is usually used when the molecules’ structure can be easily and repeatedly prepared, with the time averaging method to improve the SNR in a single molecule’s AFM *** the time averaging technique with the image alignment method for the series of time-lapse AFM images of a single DNA molecule, we were able to improve the image’s SNR and recover some buried signals from the background ***, the fine structures of single molecules can potentially be further resolved if other image processing techniques are applied collaboratively with some newly developed imaging methods like Vibrating Mode Scanning Polarization Force Microscopy (VSPFM), and such combination will also be advantageous for the manipulation of single-biomolecules by *** addition, the proposed algorithms for the estimations of drift, distortion and SNR are applicable for quantitative status characterization of AFM imaging.

关键词：图象排列 DNA AFM 时间平均 SNR

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Histone deacetylase 4 inhibits NF-κB activation by facilitating IκBα sumoylation

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Journal of Molecular Cell Biology 2020年第12期12卷 933-945页

作者： Qi Yang jielin Tang Chonghui Xu He zhao Yuan Zhou Yanyi Wang Min Yang Xinwen Chen Jizheng Chen Department of Gastroenterology Guangzhou Women and Children's Medical CenterGuangzhou 510623China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China

Protein modification by small ubiquitin-like modifier(SUMO)is an important regulatory mechanism for multiple cellular *** the canonical pathway involving the ubiquitylation or phosphorylation of IκBα has been well characterized,little is known about the sumoylation of IkBa in the control of NF-κB ***,we find that histone deacetylase 4(HDAC4)negatively regulates tumor necrosis factor-alpha-or lipopolysaccharide-triggered NF-κB ***4 belongs to the SUMO E3 ligase family and can directly sumoylate IκBα.The cytoplasm location of HDAC4 is essential for IκBα*** Cys292 of HDAC4 is a key site for its SUMO E3 ligase *** sumoylation of IkBc prevents its polyubiquitination and degradation be-cause these two modifications occur both at the *** findings reveal a previously undiscovered role for HDAC4 in the inflammatory response as a SUMO E3 ligase for IκBα*** work provides insight into mechanisms ensuring optimal mediation of the NF-κB pathway.

关键词： histone deacetylase 4 sumoylation IκBα NF-κB SUMO E3 ligase

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Host HDAC4 regulates the antiviral response by inhibiting the phosphorylation of IRF3

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Journal of Molecular Cell Biology 2019年第2期11卷 158-169页

作者： Qi Yang jielin Tang Rongjuan Pei XiaoXiao Gao Jing Guo Chonghui Xu Yun Wang QianWang Chunchen Wu Yuan Zhou Xue Hu He zhao Yanyi Wang Xinwen Chen Jizheng Chen State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Human Functional Genomics of Jiangsu Province School of Basic Medical Science Nanjing Medical University Nanjing 210093 China

Class II HDACs, such as HDAC4, are critical regulators of the immune response in various immune cells;however, its role in innate immunity remains largely ***, we report that the overexpression of HDAC4 suppresses the production of type I interferons triggered by pattern-recognition receptors (PRRs). HDAC4 repressed the translocation of transcription factor IRF3 to the nucleus, thereby decreasing IRF3-mediated IFN-β expression. In particular, we also determined that HDAC4 can be phosphorylated and simultaneously block the phosphorylation of IRF3 at Ser386 and Ser396 by TBK1 and IKKε, respectively, by interacting with the kinase domain of TBK1 and IKKε. Furthermore, IFN-β may stimulate the expression of HDAC4. Our findings suggest that HDAC4 acts as a regulator of PRR signaling and is a novel mechanism of negative feedback regulation for preventing an overreactive innate immune response.

关键词： HDAC4 antiviral response IRF3 TBK1 IKKε

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