检索结果-南通市图书馆

三枚交叉桥架埋头钉与锁定接骨板固定MasonⅢ型桡骨头骨折稳定性的有限元分析

在线全文

学校读者我要写书评

暂无评论

中国骨伤 2024年第1期37卷 57-60页

作者：殷浩李燕赵改谢杰宁仁德周恩昌安徽医科大学第三附属医院骨科安徽合肥230061 山东省聊城市第二医院骨科山东临清252600

目的:利用有限元方法比较3枚交叉桥架埋头钉和锁定接骨板(锁定钢板)固定MasonⅢ型挠骨头骨折的生物力学稳定性。方法:利用逆向建模技术,将1例25岁健康男性青年挠骨CT数据及内固定数据导入相关软件,分别建立MasonⅢ型挠骨头骨折的3枚交... 详细信息

目的:利用有限元方法比较3枚交叉桥架埋头钉和锁定接骨板(锁定钢板)固定MasonⅢ型挠骨头骨折的生物力学稳定性。方法:利用逆向建模技术,将1例25岁健康男性青年挠骨CT数据及内固定数据导入相关软件,分别建立MasonⅢ型挠骨头骨折的3枚交叉桥架构型埋头钉与锁定钢板的三维有限元模型,对挠骨头进行100 n轴向加载,比较两组模型最大位移、内固定上最大Von Mises应力及应力分布等指标。结果:3枚交叉桥架埋头钉组和锁定钢板组最大位移分别为0.069 mm和0.087 mm,内固定上Von Mises应力峰值分别为18.59 MPa和31.85 MPa,3枚交叉桥架埋头钉组应力分布更加均匀。结论:两种内固定方式均能提供良好的固定强度,3枚交叉桥架埋头钉较锁定钢板固定方式更具稳定性,应力分布更均匀。

关键词：桡骨头骨折埋头钉锁定钢板有限元分析

Influence of mass ratio and calcination temperature on physical and photoelectrochemical properties of ZnFe-layered double oxide/cobalt oxide heterojunction semiconductor for dye degradation applications

在线全文

学校读者我要写书评

暂无评论

Particuology 2023年第3期74卷 141-155页

作者： Yufei Zhang Junjie Zheng jiejie n.n.chen.jie gai Qian Shao Vignesh Murugadoss Srihari Maganti nithesh naik Hassan Algadi Mina Huang Ben Bin Xu Zhanhu Guo College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao266590China College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024China Integrated Composites Laboratory(ICL) Department of Chemical and Bimolecular EngineeringUniversity of TennesseeKnoxvilleTN37996United States Department of Mechanical&Manufacturing Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipal576104KarnatakaIndia Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon TyneNE18STUK Department of Electrical Engineering Faculty of EngineeringNajran UniversityNajran11001Saudi Arabia

A visible light-active photoelectrocatalyst,ZnFe-layered double oxide(LDO)/cobalt(II,III)oxide(Co_(3)O_(4))composites were obtained by calcining the Co loaded ZnFe-layered double hydroxide(LDH)prepared by a hydrothermal and microwave hydrothermal *** morphological studies revealed that the ZnFe-LDO/Co_(3)O_(4) composites exhibited a flower-like structure comprising Co_(3)O_(4) nanowires and ZnFe-LDO ***,when the mass ratio of Co(nO_(3))_(2)·6H_(2)O/LDH was 1:1.8 and the calcination temperature was 550℃,the ZnFe-LDO/Co_(3)O_(4) composite exhibited 93.3%degradation efficiency for methylene blue(MB)at the applied voltage of 1.0 V under visible light after 3 ***,the Mott-Schottky model experiments showed that the formation of a p-n heterojunction between ZnFe-LDO and Co_(3)O_(4) could effectively inhibit the recombination of electrons and holes in the photoelectrocatalytic ***,free radical scavenging experiments showed that the active radicals of⋅OH played an important role in the degradation of ***,the photoelectrocatalytic effect of ZnFe-LDO/Co_(3)O_(4) provides a simple and effective strategy for the removal of organic pollutants.

关键词： ZnFe-LDO/Co_(3)O_(4) Photoelectrocatalytic p-n heterojunction Methylene blue

In situ Carbon Modification of g-C3n4 from Urea co-Crystal with Enhanced Photocatalytic Activity Towards Degradation of Organic Dyes Under Visible Light

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2020年第6期36卷 1265-1271页

作者： ZHAO Weifeng HAO ning ZHAnG gai MA Aijie chen Weixing ZHOU Hongwei YAnG Dong XU Ben Bin KOnG jie School of Materials and Chemical Engineering Xi'an Technological UniversityXi'an 710021R R.China Department of Applied Chemistry School of ScienceNorthwestern Polytechnical UniversityXi’an 710072P.R.China Department of Mechanical and Construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle upon TyneNE18STUK

An in sitt strategy was introduced for synthesizing carbon modified graphitic carbon nitride(g-C3n4)by using urea/4-aminobenzoic acid(PABA)co-crystal(PABA@Urea)as precursor *** co-calcination of the PABA co-former and the urea in PABA@a Urea co-crystals,C guest species were generated and compounded into g-C3na matrix in situ by replacing the lattice n of the carbon nitride and forming carbon dots onto its layer *** carbon modification dramatically enhanced visible-light harvesting and charge carrier *** light photo-catalytic oxidation of methylene blue(MB)pollution in water over the carbon modified g-C3na(C/g-C3na)was notably *** to 99%of methylene blue(MB)was eliminated within 60 min by the optima sample prepared from the PABA@Urea co-crystal with a PABA content of 0.1%(mass ratio),faster than the degrada-tion rate over bare *** present study demonstrates a new way to boost up the photocatalysis performance of g-C3na,which holds great potential concerning the degradation of organic dyes from water.

关键词： Graphitic carbon nitride Carbon composite Photocatalysis Photodegradation

槲皮素通过SIRT1/STAT3/GSDME抑制炎症和焦亡缓解肾脏足细胞损伤

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国药理学通报 2024年第7期40卷 1279-1287页

作者：王洁琼李戈汪少华万宇刘云黄丛改郭渠莲钟芳芳西南医科大学附属医院细胞病理科四川泸州646000 西南医科大学附属医院泌尿外科四川泸州646000 西南医科大学附属医院儿科儿童血液肿瘤与出生缺陷实验室四川省出生缺陷临床医学研究中心四川泸州646000

目的探讨槲皮素(quercetin,Que)在肾脏足细胞炎症损伤中的作用和机制。方法将MPC5小鼠足细胞分为正常糖对照组(nG)、甘露醇对照组(MA)、高糖组(HG)和高糖+槲皮素组(HG+Que)。CCK-8法和流式细胞仪检测细胞增殖和凋亡情况;Western blot检... 详细信息

目的探讨槲皮素(quercetin,Que)在肾脏足细胞炎症损伤中的作用和机制。方法将MPC5小鼠足细胞分为正常糖对照组(nG)、甘露醇对照组(MA)、高糖组(HG)和高糖+槲皮素组(HG+Que)。CCK-8法和流式细胞仪检测细胞增殖和凋亡情况;Western blot检测SIRT1、STAT3、细胞凋亡相关蛋白(Bax、Bcl-2、caspase-3)和焦亡蛋白GSDME的表达情况;ELISA检测细胞上清中炎症因子(IL-6、TnF-α、IL-18、IL-1β)的表达水平。利用siRnA干扰技术,在高糖诱导+Que干预下,设置干扰对照组(HG+si-nC+Que)和SIRT1干扰组(HG+si-SIRT1+Que),进一步评估SIRT1在高糖诱导+Que作用下的生物学意义。结果与高糖对照组比较,40μmol·L^(-1)的Que能够缓解高糖诱导的MPC5细胞凋亡,降低凋亡蛋白Bax和caspase-3表达,增加抗凋亡蛋白Bcl-2表达;Que能降低高糖诱导的炎症因子TnF-α、IL-6、IL-1β和IL-18表达。机制上,Que能够缓解高糖对SIRT1表达的抑制作用,降低STAT3激活和n-GSDME表达,抑制细胞焦亡。与si-nC对照组比较,si-SIRT1组能够逆转Que对高糖诱导足细胞炎症损伤的保护作用,凋亡蛋白Bax和caspase-3表达升高,抗凋亡蛋白Bcl-2表达降低,细胞上清中炎症因子TnF-α、IL-6、IL-1β和IL-18表达升高,STAT3和n-GSDME表达升高。结论Que通过SIRT1/STAT3/GSDME通路,抑制细胞焦亡,缓解肾脏足细胞的炎症损伤。

关键词：槲皮素 SIRT1 STAT3 足细胞炎症焦亡

Review on niobium application in microalloyed steel

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2022年第10期29卷 1513-1525页

作者： Lu-yan Sun Xiang Liu Xi Xu Shu-wei Lei Hui-gai Li Qi-jie Zhai State Key Laboratory of Advanced Special Steel and Shanghai Key Laboratory of Advanced Ferrometallurgy and School of Materials Science and Engineering Shanghai UniversityShanghai200444China Center for Advanced Solidification Technology(CAST) School of Materials Science and EngineeringShanghai UniversityShanghai200444China Ansteel Group Iron and Steel Research Institute AnsteelAnshan114001LiaoningChina

With the rapid development of high-strength low-alloy(HSLA)steel,nb as an important microalloying element has received more and more attention in recent *** application and behavior of nb in HSLA steel,including microstructures optimization,refining grain size,and precipitation behavior of nb-containing phases,were *** could play an important role in following manners:(1)nb-containing phases promote ferrite formation,and nb solute promotes bainite formation.(2)nb solute atoms and nb-containing phases can inhibit the growth of austenite grains and austenite recrystallization.(3)nb(C,n)that precipitates in ferrite/bainite can provide more significant strengthening contribution(more than 300 MPa)than that in austenite(about 100 MPa).Some reasonable suggestions for the production of nb-bearing HSLA steel with excellent mechanical properties were put forward.

关键词： niobium Precipitate Microalloying High-strength low-alloy steel

Adjuvant effects mediated by the carbohydrate recognition domain ofAgrocybe aegerita lectin interacting with avian influenza H9n2 viral surface glycosylated proteins

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2017年第8期18卷 653-661页

作者： Li-bao MA Bao-yang XU Min HUAnG Lv-hui SUn Qing YAnG Yi-jie chen Ya-lin YIn Qi-gai HE Hui SUn College of Animal Sciences and Technology Huazhong Agricultural University Wuhan 430070 China College of Life Sciences Wuhan University Wuhan 430072 China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery Ministry of Education Wuhan 430071 China State Key Laboratory of Virology Wuhan University Wuhan 430072 China

Objective: To evaluate the potential adjuvant effect of Agrocybe aegerita lectin(AAL), which was isolated from mushroom, against a virulent H_9n_2 strain in vivo and in vitro. Methods: In trial 1, 50 BALB/c male mice(8 weeks old) were divided into five groups(n=10 each group) which received a subcutaneous injection of inactivated H_9n_2(control), inactivated H_9n_2+0.2%(w/w) alum, inactivated H_9n_2+0.5 mg recombinant AAL/kg body weight(BW), inactivated H_9n_2+1.0 mg AAL/kg BW, and inactivated H_9n_2+2.5 mg AAL/kg BW, respectively, four times at 7-d intervals. In trial 2, 30 BALB/c male mice(8 weeks old) were divided into three groups(n=10 each group) which received a subcutaneous injection of inactivated H_9n_2(control), inactivated H_9n_2+2.5 mg recombinant wild-type AAL(AAL-wt)/kg BW, and inactivated H_9n_2+2.5 mg carbohydrate recognition domain(CRD) mutant AAL(AAL-mut R63H)/kg BW, respectively, four times at 7-d intervals. Seven days after the final immunization, serum samples were collected from each group for analysis. Hemagglutination assay, immunogold electron microscope, lectin blotting, and coimmunoprecipitation were used to study the interaction between AAL and H_9n_2 in vitro. Results: Ig G, Ig G1, and Ig G2 a antibody levels were significantly increased in the sera of mice co-immunized with inactivated H_9n_2 and AAL when compared to mice immunized with inactivated H_9n_2 alone. no significant increase of the Ig G antibody level was detected in the sera of the mice co-immunized with inactivated H_9n_2 and AAL-mut R63 H. Moreover, AAL-wt, but not mutant AAL-mut R63 H, adhered to the surface of H_9n_2 virus. The interaction between AAL and the H_9n_2 virus was further demonstrated to be associated with the CRD of AAL binding to the surface glycosylated proteins, hemagglutinin and neuraminidase. Conclusions: Our findings indicated that AAL could be a safe and effective adjuvant capable of boosting humoral immunity against H_9n_2 viruses in mice through its

关键词： Adjuvant Agrocybe aegerita lectin Carbohydrate recognition domain Glycosylated protein Avian influenza H_9n_2 virus

Cysteamine increases expression and activity of H^1-K^+-ATPase of gastric mucosal cells in weaning piglets

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第42期11卷 6707-6712页

作者： Zhi-Min Shi gai-Mei Du Xi-Hui Wei Lei Zhang jie chen Ru-Qian Zhao Key Laboratory of Animal Physiology andBiochemistry Ministry of Agriculture Nanjing AgriculturalUniversity Nanjing 210095 Jiangsu Province China

AIM: To determine the in vivo andin vivo effects of cysteamine (CS) on expression and activity of H+-K+-ATPase of gastric mucosal cells in weaning ***: Eighteen litters of newborn Xinhuai piglets were employed in the in vivo experiment and allocated to control and treatment groups. From 12 d of age (D12), piglets in control group were fed basal diet, while the treatment group received basal diet supplemented with 120 mg/kg CS. Piglets were weaned on D35 in both groups. Six piglets from each group (n = 6) were slaughtered on D28 (one week before weaning), D35(weaning), D36.5, D38, D42, and D45 (36 h, 72 h,one week and 10 d after weaning), respectively. Semiquantitative RT-PCR was performed todetermine the levels of H+-K+-ATPase mRnA in gastric mucosa. H+-K+-ATPase activity in gastric mucosa homogenate was also determined. Gastric mucosal epithelial cells from piglets through primary cultures were used to further elucidate the effect of CS on expression and activity of H+-K+-ATPase in vivo. Cells were treated for 20 h with 0.001,0.01, and 0.1 mg/mL of CS (n = 4), respectively. The mRnA expression of H+-K+-ATPase and somatostatin (SS)as well as the H+-K+-ATPase activity were ***: in vivo, both mRnA expression and activity of H+-K+-ATPase in gastric mucosa of control group exhibited a trend to increase from D28 to D45, reaching a peak on D45, but did not show significant age differences. Furthermore, neither the mRnA expression nor the activity of H+-K+-ATPase was affected significantly by weaning. CS increased the mRnA expression of H+-K+-ATPase by 73%, 53%, 30% and 39% on D28(P = 0.014), D35 (P = 0.017), D42 (P = 0.013) and D45(P = 0.046), respectively. In accordance with the mRnA expression, H+-K+-ATPase activities were significantly higher in treatment group than in control group on D35(P = 0.043) and D45 (P = 0.040). In vivo, CS exhibited a dose-dependent effect on mRnA expression and activity of H+-K+-ATPase. Both H+-K+-ATPase mRnA expre

关键词： Cysteamine Weaning piglets H^+ -K^+-ATPase Gastric mucosal cells Somatostatin

A multi-center,open-label,randomized,parallel-controlled phase II study comparing pharmacokinetic,pharmacodynamics and safety of ripertamab(SCT400)to rituximab(Mab Thera?)in patients with CD20-positive B-cell non-Hodgkin lymphoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2022年第6期34卷 601-611页

作者： Xiaohong Han Mingzhi Zhang Huaqing Wang Qingyuan Zhang Wei Li Miaowang Hao Yuhuan Gao jie Jin Hanyun Ren Yun Tang Xiaonan Hong Xiaoyan Ke Hang Su Lin Gui Jianmin Luo Liangzhi Xie Wenlin gai Yuankai Shi Clinical Pharmacology Research Center Peking Union Medical College HospitalState Key Laboratory of Complex Severe and Rare DiseasesNMPA Key Laboratory for Clinical Research and Evaluation of DrugBeijing Key Laboratory of Clinical PK&PD Investigation for Innovative DrugsChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Oncology the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Medical Oncology Tianjin People's HospitalTianjin 300121China Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150081China Oncology Department of Cancer Center the First Hospital of jilin UniversityChangchun 130021China Department of Hematology Tangdu HospitalAir Force Medical UniversityXi'an 710038China Department of Hematology the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011China Department of Hematology the First Affliated Hospital of Zhejiang UniversityHangzhou 310003China Department of Hematology Peking University First HospitalBeijing 100034China Department of Hematology West China HospitalSichuan UniversityChengdu 610041China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 2032China Department of Hematology Peking University Third HospitalBeijing 100191China Department of Lymphoma the Fifth Medical Center of PLA General HospitalBeijing 100071China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijing 100021China Department of Hematology the Second Hospital of Hebei Medical UniversityShijazhuang 050000China Beijing Engineering Research Center of Protein and Antibody Sinocelltech Ltd.Beijing 100176China

Objective:This multi-center,open-label,randomized,parallel-controlled phaseⅡstudy aimed to compare the pharmacokinetics(PK),pharmacodynamics(PD)and safety profile of ripertamab(SCT400),a recombinant antiCD20 monoclonal antibody,to rituximab(MabThera^(■))in patients with CD20-positive B-cell non-Hodgkin lymphoma(nHL).Methods:Patients with CD20-positive B-cell nHL who achieved complete remission or unconfirmed complete remission after standard treatment were randomly assigned at a 1:1 ratio to receive a single dose of ripertamab(375mg/m^(2))or rituximab(MabThera^(■),375 mg/m^(2)).PK was evaluated using area under the concentration-time curve(AUC)from time 0 to d 85(AUC_(0-85d)),AUC from time 0 to week 1(AUC0-1 w),AUC from time 0 to week 2(AUC_(0-2 w)),AUC from time 0 to week 3(AUC_(0-3 w)),AUC from time 0 to week 8(AUC_(0-8 w)),maximum serum concentration(C_(max)),terminal half-life(T_(1/2)),time to maximum serum concentration(T_(max))and clearance(CL).Bioequivalence was confirmed if the 90%confidence interval(90%CI)of the geometric mean ratio of ripertamab/rituximab was within the pre-defined bioequivalence range of 80.0%-125.0%.PD,immunogenicity,and safety were also ***:From December 30,2014 to november 24,2015,a total of 84 patients were randomized(ripertamab,n=42;rituximab,n=42)and the PK analysis was performed on 76 patients(ripertamab,n=38;rituximab,n=38).The geometric mean ratios of ripertamab/rituximab for AUC_(0-85d),ATC_(0-inf),and Cmaxwere 96.1%(90%CI:87.6%-105.5%),95.9%(90%CI:86.5%-106.4%)and 97.4%(90%CI:91.6%-103.6%),*** PK parameters met the pre-defined bioequivalence range of 80.0%-125.0%.For PD and safety evaluation,there was no statistical difference in peripheral CD 19-positive B-cell counts and CD20-positive B-cell counts at each visit,and no difference in the incidence of anti-drug antibodies was observed between the two *** incidences of treatment-emergent adverse events and treatment-related adverse events were a

关键词： Anti-CD20 monoclonal antibody non-Hodgkin lymphoma pharmacokinetics ripertamab rituximab safety

Measurement of Br(n,γ)cross sections up to stellar s-process temperatures at the CSnS Back‑n

在线全文

学校读者我要写书评

暂无评论

nuclear Science and Techniques 2023年第11期34卷 226-241页

作者： Gao‑Le Yang Zhen‑Dong An Wei Jiang Xian‑Kai Li Wei‑Wei Qiu Zheng‑Fa Liao Zi‑Yue Zhuang Xiao‑Ping Zhang Sheng‑Li chen chen‑chen Guo Er‑Xi Xiao Xiao Fang Xin‑Xiang Li Xin‑Rong Hu Bing Jiang Jin‑cheng Wang jie Ren Wen Luo Zhi‑Chao Zhu Hao‑Yang Lan Zong‑Wei Cao Xu Ma Ying‑Du Liu Pu‑Sen Wang Yi Yang Ping Su Xian‑gai Deng Wan‑Bing He Chun‑Wang Ma Yu‑Ting Wang Zhi‑Tao Dai Peng‑Qin He Ren‑Guang Tang Tao Zhou Jing Wang Han Yi Yue Zhang Yong‑Hao chen Rui‑Rui Fan Ke‑Qing Gao Qiang Li Kang Sun Zhi‑Xin Tan Min‑Hao Gu Han‑Tao Jing Jing‑Yu Tang School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China CnSA Macao Center for Space Exploration and Science Macao 999078China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation neutron Source Science Center Dongguan 523803China School of nuclear Science and Technology University of South ChinaHengyang 421001China Sino‑French Institute of nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of nuclear Data China Institute of Atomic EnergyBeijing 102413China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411100China Key Laboratory of nuclear Physics and Ion‑beam Application(MOE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghai 200433China Institute of Particle and nuclear Physics Henan Normal UniversityXinxiang 453007China School of Physics Henan Normal UniversityXinxiang 453007China Shenzhen Center Cancer hospitalChinese Academy of Medical SciencesShenzhen 518100China School of nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China

The neutron capture cross sections(n,γ)of bromine were obtained using the time-of-flight technique at the Back-n facility of the China Spallation neutron ***γ-rays originating from neutron-induced capture events were detected using four C_(6)D_(6) *** pulse-height weighting technique and double-bunch unfolding method based on Bayesian theory were used in the data *** deductions,normalization,and corrections were carefully considered to obtain reliable measurement *** multilevel R-matrix Bayesian code SAMMY was used to extract the resonance parameters in the resolved resonance region(RRR).The average cross sections in the unresolved resonance region(URR)were obtained from 10 to 400 *** experimental results were compared with data from several evaluated libraries and previous experi-ments in the RRR and *** TALYS code was used to describe the average cross sections in the *** astrophysical Maxwell average cross sections(MACSs)of ^(79,81)Br from kT=5 to 100 keV were calculated over a sufficiently wide range of neutron *** a thermal energy of kT=30 keV,the MACS value for ^(79)Br 682±68 mb was in good agreement with the KADoniS v1.0 recommended *** contrast,the value of 293±29 mb for ^(81)Br was substantially higher than that of the evaluated database and the KADoniS v1.0 recommended value.

关键词： Time-of-flight technique neutron capture cross sections Maxwell average cross sections