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Changes in the gut microbiota of osteoporosis patients based on 16S rRNA gene sequencing:a systematic review and meta-analysis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第12期23卷 1002-1013页

作者： Rui HUANG Pan LIU Yiguang BAI jieqiong HUANG Rui PAN Huihua LI Yeping su Quan ZHOU Ruixin MA Shaohui ZONG Gaofeng ZENG College of Public Hygiene of Guangxi Medical University Nanning 530021China Department of Spine Osteopathic the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Department of Orthopaedics the Third Affiliated Hospital of Xinxiang Medical UniversityNanning 530022China Department of Orthopaedics Nanchong Central Hospitalthe Second Clinical Institute of North Sichuan Medical CollegeXinxiang 45300China Department of Wound Repair the First People’s Hospital of NanningNanchong 637000China

Background:Osteoporosis(OP)has become a major public health issue,threatening the bone health of middle-aged and elderly people from all around the *** in the gut microbiota(GM)are correlated with the maintenance of bone mass and bone ***,research results in this field remain highly controversial,and no systematic review or meta-analysis of the relationship between GM and OP has been *** paper addresses this shortcoming,focusing on the difference in the GM abundance between OP patients and healthy controls based on previous 16S ribosomal RNA(rRNA)gene sequencing results,in order to provide new clinical reference information for future customized prevention and treatment options of ***:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA),we comprehensively searched the databases of Pub Med,Web of Science,Embase,Cochrane Library,and China National Knowledge Infrastructure(CNKI).In addition,we applied the R programming language version 4.0.3 and Stata 15.1 software for data *** also implemented the Newcastle-Ottawa Scale(NOS),funnel plot analysis,sensitivity analysis,Egger’s test,and Begg’s test to assess the risk of ***:This research ultimately considered 12 studies,which included the fecal GM data of 2033 people(604 with OP and 1429 healthy controls).In the included research papers,it was observed that the relative abundance of Lactobacillus and Ruminococcus increased in the OP group,while the relative abundance for Bacteroides of Bacteroidetes increased(except for Ireland).Meanwhile,Firmicutes,Blautia,Alistipes,Megamonas,and Anaerostipes showed reduced relative abundance in Chinese *** the linear discriminant analysis Effect Size(LEfSe)analysis,certain bacteria showed statistically significant results consistently across different ***:This observational meta-analysis revealed that changes in the GM were correlated with OP,and variations in some adva

关键词： Osteoporosis Microbiome Intestinal 16S ribosomal RNA(rRNA)sequencing

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国家生态环境监管执法体制改革方案研究

环境与可持续发展 2015年第5期40卷 7-10页

作者：王金南秦昌波苏洁琼田超环境保护部环境规划院北京100012

为了推进落实十八届三中全会提出的独立进行环境监管和行政执法的改革要求,本文论述了建立独立的生态环境监管执法体制的必要性,评述了目前我国生态环境监管执法体制存在的问题。本研究从法律基础、国家、地方、农村生态环境监察执法体... 详细信息

为了推进落实十八届三中全会提出的独立进行环境监管和行政执法的改革要求,本文论述了建立独立的生态环境监管执法体制的必要性,评述了目前我国生态环境监管执法体制存在的问题。本研究从法律基础、国家、地方、农村生态环境监察执法体制、联合执法机制等五方面设计了体制改革的具体内容,并从各层次执法体制改革、建立统一监管执法体系这两个阶段规划了体制改革的路线图。

关键词：环境监管执法体制改革独立方案

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改革开放40年与中国生态环境规划发展

中国环境管理 2018年第6期10卷 5-18页

作者：王金南万军王倩苏洁琼杨丽阎肖旸生态环境部环境规划院北京100012

改革开放40年,生态环境保护随着社会经济的发展而深入发展,生态环境规划与生态环境保护事业同时起步。40年,来编制了9个五年生态环境规划,经历了从无到有、从简单到完善的发展过程,逐步形成了有层次、分类型、多样化的规划体系,规划理... 详细信息

改革开放40年,生态环境保护随着社会经济的发展而深入发展,生态环境规划与生态环境保护事业同时起步。40年,来编制了9个五年生态环境规划,经历了从无到有、从简单到完善的发展过程,逐步形成了有层次、分类型、多样化的规划体系,规划理念、技术、方法取得了重大进展,规划实践探索丰富多样,对我国生态环境保护工作发挥了统领性作用。十八大以来,生态文明建设体制改革深入推进,十九大确立了美丽中国的宏伟目标,经济高质量发展和生态环境高水平保护统筹推进。在新的历史阶段,生态环境规划将进一步发挥基础性、统领性、战略性和创新性作用,为美丽中国建设作出更大贡献。

关键词：生态环境规划规划体系改革开放40年五年环境规划美丽中国

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国家生态环境保护规划发展历程及展望

中国环境管理 2021年第5期13卷 21-28,20页

作者：王金南秦昌波万军熊善高苏洁琼肖旸生态环境部环境规划院美丽中国研究中心北京100012

伴随着生态环境保护和生态文明建设工作不断发展,中国的生态环境规划经过近45年的探索发展,规划理念与时俱进,规划层级不断提升,规划体系不断优化,规划技术方法不断探索实践,生态环境规划的发展对促进生态文明建设工作、系统谋划环境污... 详细信息

伴随着生态环境保护和生态文明建设工作不断发展,中国的生态环境规划经过近45年的探索发展,规划理念与时俱进,规划层级不断提升,规划体系不断优化,规划技术方法不断探索实践,生态环境规划的发展对促进生态文明建设工作、系统谋划环境污染治理,改善生态环境质量发挥了重要作用,但还存在着五年综合规划统领作用未有效发挥、规划实施管理较为薄弱、规划技术支撑不足等问题。在生态文明建设进入到以降碳为重点战略方向、推动减污降碳协同增效、促进经济社会发展全面绿色转型、实现生态环境质量改善由量变到质变、美丽中国建设起步开局的关键时期,生态环境规划要健全规划体系、强化规划空间属性、建立全过程实施管理体系,提升规划编制实施管理水平,进一步发挥规划的基础性、统领性、战略性和创新性作用,促进美丽中国建设目标早日实现。

关键词：生态环境规划综合规划规划历程空间管控美丽中国

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2035年美丽中国建设目标及路径机制研究

中国环境管理 2021年第5期13卷 29-36页

作者：万军王金南李新秦昌波强烨苏洁琼生态环境部环境规划院美丽中国研究中心北京100012

建设美丽中国,建设人与自然和谐共生的现代化,是中国特色社会主义现代化建设的重要基础与主要内容。本文通过文献分析、对标分析、模型预测等方法,识别了美丽中国建设的科学内涵及特征要求,分析美丽中国建设中长期面临的形势,基于到203... 详细信息

建设美丽中国,建设人与自然和谐共生的现代化,是中国特色社会主义现代化建设的重要基础与主要内容。本文通过文献分析、对标分析、模型预测等方法,识别了美丽中国建设的科学内涵及特征要求,分析美丽中国建设中长期面临的形势,基于到2035年达到中等发达国家水平、人均GDP翻一番的目标,对标发达国家以及浙江、广东等国内先进地区,构建了美丽中国建设的目标指标体系框架,并从绿色发展、气候变化、生态环境质量、环境治理体系与治理能力等方面,设计美丽中国建设生态环境保护的总体框架与主要路径,提出美丽中国建设的规划建议。

关键词：美丽中国生态环境保护中长期战略战略路径

Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology:Implications for Alzheimer's disease therapy

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1707-1722页

作者： Chuanbin Yang Chengfu su Ashok Iyaswamy Senthil Kumar Krishnamoorthi Zhou Zhu Sichang Yang Benjamin Chunkit Tong Jia Liu Sravan G.Sreenivasmurthy Xinjie Guan Yuxuan Kan Aston Jiaxi Wu Alexis Shiying Huang jieqiong Tan Kingho Cheung Juxian Song Min Li Mr.&Mrs.Ko Chi-Ming Centre for Parkinson’s Disease Research School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Department of Geriatrics Shenzhen People’s Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China Institute for Research and Continuing Education Hong Kong Baptist UniversityShenzhen 518057China College of Pharmacy Henan University of Chinese MedicineZhengzhou 450000China Center for Medical Genetics and Hunan Key Laboratory of Animal Model for Human Diseases School of Life SciencesCentral South UniversityChangsha 410078China Medical College of Acupuncture-Moxibustion and Rehabilitation Guangzhou University of Chinese MedicineGuangzhou 510632China

Alzheimer's disease(AD),characterized by the accumulation of protein aggregates including phosphorylated Tau aggregates,is the most common neurodegenerative disorder with limited therapeutic *** plays a critical role in the degradation of phosphorylated Tau aggregates,and transcription factor EB(TFEB)is a master regulator of autophagy and lysosomal ***,small-molecule autophagy enhancers targeting TFEB hold promise for AD ***,we found that celastrol,an active ingredient isolated from the root extracts of Tripterygium wilfordii(Lei Gong Teng in Chinese)enhanced TFEB-mediated autophagy and lysosomal biogenesis in vitro and in mouse ***,celastrol reduced phosphorylated Tau aggregates and attenuated memory dysfunction and cognitive deficits in P301S Tau and 3xTg mice,two commonly used AD animal *** studies suggest that TFEB-mediated autophagy-lysosomal pathway is responsible for phosphorylated Tau degradation in response to ***,our findings indicate that Celastrol is a novel TFEB activator that promotes the degradation of phosphorylated Tau aggregates and improves memory in AD animal ***,Celastrol shows potential as a novel agent for the treatment and/or prevention of AD and other tauopathies.

关键词： TFEB Autophagy Lysosome biogenesis Alzheimer’s disease(AD) Tau Celastrol mTOR Therapeutic target

Introduction of a multicenter online database for non-metastatic breast cancer in China

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Science China(Life Sciences) 2020年第9期63卷 1417-1420页

作者： Yaping Yang jieqiong Liu Min Peng Fengxi su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Breast Tumor CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Diseases Registry Center of sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120China Department of Breast Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Breast surgery Breast Cancer CenterAffiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhou 450008China The Breast Center Shantou University Medical College Cancer HospitalShantou 515041China Department of Breast and Thyroid surgery Peking University Shenzhen HospitalShenzhen 518036China Department of Breast and Thyroid surgery Shenzhen People’s HospitalShenzhen 518020China Breast and Thyroid surgery Department Jiangmen Central HospitalJiangmen 529030China Department of Breast surgery Dongguan People’s HospitalDongguan 523059China Department of Breast surgery Gaozhou People’s HospitalGaozhou 525200China Department of Breast Disease Maoming People’s HospitalMaoming 525000China Department of Breast surgery Yangjiang People’s HospitalYangjiang 29500China Breast Disease Treatment Center The First People’s Hospital of ZhaoqingZhaoqing 526000China Department of Oncology Guangdong Agricultural Reclamation Center HospitalZhanjiang 524002China Guangzhou Regenerative Medicine and Health Guangdong Laboratory Guangzhou 510005China Fountain-Valley Institute for Life Sciences 4th FloorBuilding DGuangzhou Institute of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China

Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016).

关键词： breast Cancer Breast

A group of suVH methyl-DNA binding proteins regulate expression of the DNA demethylase ROS_1 in Arabidopsis

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Journal of Integrative Plant Biology 2019年第2期61卷 110-119页

作者： Xinlong Xiao jieqiong Zhang Tao Li Xing Fu Viswanathan Satheesh Qingfeng Niu Zhaobo Lang Jian-Kang Zhu Mingguang Lei Shanghai Center for Plant Stress Biology Center for Excellence in Molecular Plant SciencesChinese Academy of Sciences The University of Chinese Academy of Sciences Department of Horticulture and Landscape Architecture Purdue University

DNA methylation is typically regarded as a repressive epigenetic marker for gene ***-wide DNA methylation patterns in plants are dynamically regulated by the opposing activities of DNA methylation and demethylation reactions. In Arabidopsis, a DNA methylation monitoring sequence(MEMS) in the promoter of the DNA demethylase gene ROS_1 functions as a methylstat that senses these opposing activities and regulates genome DNA methylation levels by adjusting ROS_1 expression. How DNA methylation in the MEMS region promotes ROS_1 expression is not known. Here, we show that several su(var)3-9 homologs(suVHs) can sense DNA methylation levels at the MEMS region and function redundantly to promote ROS_1 expression. The suVHs bind to the MEMS region, and the extent of binding is correlated with the methylation level of the *** in the suVHs lead to decreased ROS_1 expression, causing DNA hypermethylation at more than 1,000 genomic regions. Thus, the suVHs function to mediate the activation of gene transcription by DNA methylation.

关键词： DNA ROS Figure

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风电场监控软件集成服务模型设计与应用

电力系统自动化 2008年第10期32卷 88-93,107页

作者：段斌邹吉昌苏永新朱洁琼湘潭大学信息工程学院湖南省湘潭市411105

大型风电场中的风电机组和监控系统一般由多个厂商提供,相互兼容困难,难以进行统一维护与管理。遵循IEC61400-25标准的信息模型、信息交换模型及对Web Services的映射方法,设计了基于Web Services的风电场监控软件集成服务模型,讨论了... 详细信息

大型风电场中的风电机组和监控系统一般由多个厂商提供,相互兼容困难,难以进行统一维护与管理。遵循IEC61400-25标准的信息模型、信息交换模型及对Web Services的映射方法,设计了基于Web Services的风电场监控软件集成服务模型,讨论了基于该模型的多个异构风电机组与服务端互联互通的问题,给出了风电机组标准服务接口的定义方法和安全通信机制。通过对该模型的工程实现与应用分析,论证了所做工作对风电机组的统一监控和集成管理等问题的解决具有现实意义与应用价值。

关键词： IEC 61400—25 Web服务风电场风电机组集成监控