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Xiao Tan San jie Fang Hampers the Growth of Colon Cancer Stem Cells through the Wnt/β-catenin Signaling Pathway

World Journal of Traditional Chinese Medicine 2024年第2期10卷 171-179页

作者： Yu-Qi Zhou Jun-Fei Yuan Hong-Shi Shen Ya-ping Wang Han-Fei Shi De-Jian Pan Min ye Department of Hematology and Oncology The 904^(th) Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Clinical Laboratory The 904^(th)Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical UniversityShanghaiChina

Objective: The purpose of this research was to examine the potential anticancer properties of Xiao Tan San jie Fang(XTSJF) and its potential mechanism of action against colorectal cancer. Materials and Methods: HCT116 cells were induced into HCT116 spheres in DMEM/F12 medium by treatment with epidermal growth factor + fibroblast growth factor + leukemia inhibitory factor + B27. The proliferation ability and stemness of HCT116 spheres was examined. Various concentrations of XTSJF were used to treat HCT116 spheres to observe the impact on proliferation, apoptosis, and expression of stem cell markers. Next, Wnt/β-catenin pathway-related factor proteins were detected. Results: The findings revealed that XTSJF suppressed cell growth and induced cell death in HCT116 cells in a dosage-dependent manner. Similarly, XTSJF promotes apoptosis, inhibits cell proliferation, prolongs survival, and maintains the expression of stem cells through the Wnt/-catenin/TCF4 axis. XTSJF also inhibits AKT activity and subsequently activates glycogen synthesis kinase-3β expression, inhibiting Wnt/beta-catenin pathway activity and downstream target gene transcript expression. The Wnt/β-catenin signaling pathway is inhibited by the XTSJF, leading to the suppression of colon cancer stem cell proliferation. Conclusion: Xiaotan Sanjie Prescription inhibited colon cancer stem cell growth through Wnt/β-catenin signaling pathway.

关键词： Apoptosis colorectal cancer proliferation traditional Chinese medicine Wnt/β-catenin signaling

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财政省直管县对县级财政收支平衡的改革效应——对地方财政安全的一种解释

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公共管理与政策评论 2024年第2期13卷 30-47页

作者：叶杰浙江工商大学公共管理学院

财政安全是经济安全的基础和保障。财政省直管县改革是构筑县级财政安全防线的重要屏障,是解释中国地方政府财政安全的重要途径。本文选取山西省作为典型案例,以财政省直管县为准自然实验,考察了财政分权改革对县级财政收支平衡度的政... 详细信息

财政安全是经济安全的基础和保障。财政省直管县改革是构筑县级财政安全防线的重要屏障,是解释中国地方政府财政安全的重要途径。本文选取山西省作为典型案例,以财政省直管县为准自然实验,考察了财政分权改革对县级财政收支平衡度的政策效应。采取倾向得分匹配与双重差分法相结合(PSM+DID)的方式,识别出改革对县级财政收支比的因果处置效应,并从社会资源整合能力机制、内部动力机制和外部压力机制三个角度验证了因果处置效应的内在机理。研究表明,财政省直管县改革显著提升试点县6个百分比的财政收支比,且政策效应具有滞后性和持续性。这一结论在通过改变计量方法、更换样本以及安慰剂检验后依然成立。本文从财政体制改革角度为认识地方财政安全提供了解释路径,为持续推进和深化财政省直管县改革提供了学理依据。

关键词：财政安全财政分权省直管县财政收支平衡

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Supercoiled DNA Minicircles under Double-strand Breaks

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Chinese Journal of Polymer Science 2024年第9期42卷 1353-1359,I0007页

作者： ye-Peng Qiao Chun-Lai Ren National Laboratory of Solid State Microstructures and Department of Physics Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing210093China

Understanding how supercoiled DNA releases intramolecular stress is essential for its functional ***,the molecular mechanism underlying the relaxation process remains insufficiently *** we employed MD simulations based on the oxDNA2 model to investigate the relaxation process of a 336-base pair supercoiled minicircular DNA under double-strand breaks with two fixed *** simulations show that the conformational changes in the DNA occur continuously,with intramolecular stress release happening abruptly only when the DNA chain traverses the breakage *** relaxation process is influenced not only by the separation distance between the fixed ends but also their ***,we observe an inhibitory effect on the relaxation characterized by small angles,where short terminal loops impede DNA conformational adjustments,preserving the supercoiled *** findings elucidate the intricate interplay between DNA conformational change,DNA motion and intramolecular stress release,shedding light on the mechanisms governing the relaxation of supercoiled DNA at the molecular level.

关键词： Supercoiled DNA DNA minicircle DNA relaxation oxDNA model MD simulation

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SDGNN: Symmetry-Preserving Dual-Stream Graph Neural Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1717-1719页

作者： Jiufang Chen ye Yuan Xin Luo the College of Computer Science and Technology Chongqing University of Posts and TelecommunicationsChongqing 400065 the Chongqing Key Laboratory of Big Data and Intelligent Computing Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China the College of Computer and Information Science Southwest UniversityChongqing 400715China IEEE

Dear Editor,This letter proposes a symmetry-preserving dual-stream graph neural network(SDGNN) for precise representation learning to an undirected weighted graph(UWG). Although existing graph neural networks(GNNs) are influential instruments for representation learning to a UWG, they invariably adopt a unique node feature matrix for illustrating the sole node set of a UWG.

关键词： representation preserving undirected

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Large-aperture Telescope Tracking Control Based on Time-synchronization Strategy

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Research in Astronomy and Astrophysics 2024年第3期24卷 34-46页

作者： Yun Li Yu ye Shi-Hai Yang Ling-Zhe Xu Jin Xu Hai Wang Zhuang-Zhuang Deng Rui-Qiang Liu Xiao-jie Gu Bo-Zhong Gu Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China University of Chinese Academy of Sciences Beijing 100049China

A time-synchronization strategy for packetized transmission of target position about a large-aperture telescope observation control system has been proposed in this *** with the existing telescope tracking strategy,the target position packing and sending strategy based on the time synchronization method proposed in this paper has the advantages of high stability and ***,the telescope tracking observation control method was elaborated in this paper,including the motion pattern during telescope ***,the strategy for packetizes transmission of target positions based on time-synchronization is established and lists the detailed ***,the performance of the tracking strategy is verified using the 2.5 m telescope for the simulated uniform speed star and the blind-tracking fixed star HIP 31216,*** test results show that the accuracy root mean square of the tracking strategy proposed in this paper is less than 0".02 at 30 minutes,and the performance is much better than the design requirement of 0".*** most important advantage of this tracking strategy is that the telescope can guarantee normal tracking for a certain period of time even if the hardware or software of the host computer is abnormal.

关键词： miscellaneous-telescopes-methods observational-methods analytical

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Distinct clinical profiles and mutation landscapes of gliomas originating from the neocortex,mesocortex,and cerebellum

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Genes & Diseases 2024年第1期11卷 53-56页

作者： ye Cheng Lei Zhang Xiaolong Wu Hiroaki Wakimoto Haoming Geng Yukui Wei Geng Xu Xinru Xiao jie Bai Yaming Wang Zeliang Hu Leiming Wang Qingtang Lian Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Brain Tumor Research Center Massachusetts General HospitalDepartment of NeurosurgeryHarvard Medical SchoolBostonMA02134USA Department of Pathology Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Gliomas originating from anatomically and developmentally distinct brain regions have different clinical ***,the molecular landscape underlying this difference remains *** analyzed key molecular mutations via sequencing and correlated them with clinical characteristics in 180 adult patients with gliomas originating from the neocortex,mesocortex,and *** of cerebellar origin had significantly longer survival than those of supratentorial origin,consistent with higher rates of mutation in key genes associated with supratentorial gliomas.

关键词： clinical cortex glioma

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Study on Static Deflection Model of MEMS Capacitive Microwave Power Sensors

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Chinese Journal of Electronics 2024年第5期33卷 1188-1195页

作者： ye JIN Debo WANG College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts and Telecommunications College of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications

In this paper, a static deflection model of MEMS cantilever beam is proposed, which can better study the force deformation of micro-electro-mechanical system(MEMS) cantilever beam and the output characteristics of capacitive microwave power sensor. The deflection curve is used to describe the deformation of the cantilever beam and then the overload power and sensitivity of this power sensor are derived. It is found that the overload power decreases with the beam length, and increases with the initial height of beam. The sensitivity increases with the beam length, and has a linear growth relationship with the measuring electrode width. A MEMS dual-channel microwave power sensor is designed, fabricated and measured. At a microwave signal frequency of 10 GHz, the sensitivity of the sensor is measured to be 0.11 V/W for the thermoelectric detection channel and 65.17 fF/W for the capacitive detection channel. The sensitivity calculated by the lumped model is 92.93 fF/W, that by the pivot model is 50.88 fF/W,and that by the deflection model proposed in this work is 75.21 fF/W. Therefore, the theoretical result of the static deflection model is more consistent with the measured result and has better accuracy than the traditional lumped model and pivot model.

关键词： Microwave measurement Micromechanical devices Microelectromechanical systems Sensitivity Voltage measurement Accuracy Deformation Micro-electro-mechanical system (MEMS) cantilever beam Static deflection model Power sensor Overload power

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Commentary:Gut microbiota reduce the risk of hyperuricemia and gout in the human body

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Acta Pharmaceutica Sinica B 2024年第1期14卷 433-435页

作者： Lin Wang Jianping ye Metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Gout,a prevalent and painful metabolic disease often associated with obesity and aging,is caused by the deposition of urate crystals in joints,bones,or soft *** is an intermediate metabolite within the purine degradation pathway,predominantly derived from uric acid under physiological pH *** occurs due to excessive uric acid production or insufficient excretion2,which is associated with various chronic diseases,including type 2 diabetes.

关键词： Uric acid Gout Microbiota Gut Uricase

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Enhancing blocking temperature using inverse hydrogen bonds for non-radical bridged dimeric Dy(Ⅲ)single-molecule magnets

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Science China Chemistry 2024年第10期67卷 3328-3338页

作者： Peng-Bo Jin Qian-Cheng Luo ye-ye Liu Yan-Zhen Zheng Frontier Institute of Science and Technology State Key Laboratory of Electrical Insulation and Power EquipmentMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed MatterXi’an Key Laboratory of Electronic Devices and Material Chemistry and School of ChemistryXi’an Jiaotong UniversityXi’an 710054China

Single-molecule magnets(SMMs)are a kind of nanosized magnetic materials that are capable of storing massive bytes of *** coupling the spin centers in a proper manner is a usual approach to promote the working temperature(or blocking temperature)for *** delocalized radicals have been widely employed to accomplish this ***,we show a new manner by using weak but multiple B–H^(δ-)···Dy^(3+)inverse hydrogen bonding(IHB)interactions to control the magnetic couplings in a series of dimeric dysprosiacaborane *** approach leads to a record high T_(B)^(100s)of 10 K among non-radical bridged dimeric SMMs,which is mainly ascribed to strong ferromagnetic coupling(4.38 cm^(-1))and the proper alignment of the magnetic principle axes of the adjacent dysprosium(Ⅲ)*** verifying by theoretical calculations,these results demonstrate that IHB interactions can be used to construct strong axial ferromagnetic coupling and enhancing magnetic blocking temperature for SMMs.

关键词： single-molecule magnets carborane dysprosium ferromagnetic coupling inverse hydrogen bond

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A DERIVATIVE-HILBERT OPERATOR ACTING FROM LOGARITHMIC BLOCH SPACES TO BERGMAN SPACES

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Acta Mathematica Scientia 2024年第5期44卷 1916-1930页

作者： Shanli ye Yun XU School of Science Zhejiang University of Science and TechnologyHangzhou310023China

Letμbe a positive Borel measure on the interval[0,1).The Hankel matrix■with entriesμn,k=μn+k,whereμn=⨜[0,1)tndμ(t),induces,formally,the operator■where■is an analytic function *** characterize the measuresμfor which■is bounded(resp.,compact)operator from the logarithmic Bloch space■into the Bergman space■,where 0≤α<∞,0

关键词： derivative-Hilbert operator logarithmic Bloch space Carleson measure

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