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Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2100-2102页

作者： Yu-Shui Ma Xiao-Feng Wang Fei Yu Ting-Miao Wu Ji-Bin Liu yun-jie zhang Qing Xia Zong-Yuan Jiang Qin-Lu Lin Da Fu Central Laboratory for Medical Research Shanghai Tenth People’s HospitalTongji University School of Medicine200072 ShanghaiChina Cancer Institute Nantong Tumor Hospital226631 NantongChina Department of Nuclear Medicine Shanghai Tenth People’s HospitalTongji University School of Medicine200072 ShanghaiChina Department of Radiology The Fourth Affiliated Hospital of Anhui Medical University230012 HefeiChina Department of Orthopedics Zhongshan HospitalFudan University200032 ShanghaiChina Department of Hand Surgery Shenzhen Longhua District People’s Hospital518109 ShenzhenChina National Engineering Laboratory for Rice and By-product Deep Processing College of Food Science and EngineeringCentral South University of Forestry and Technology410004 ChangshaChina

Dear Editor,Tumor-suppressor protein p53 is important for cell function and genome integrity.1 The decrease of p53 protein is a common feature of human malignant tumors,which leads to the deficiency of cell cycle detection point control and apoptosis *** enormous amount of research effort goes into small molecules that regulate p53,including wild-type repair of mutant p53 gene and interruption of the binding between p53 and an E3-ubiquitin ligase Mdm2 to prevent ubiquitination degradation of p53 and rescue the protein level of p53.2 However,it is not clear whether it is necessary to continue to inhibit the ubiquitin activity of proteasome in order to restore the p53 protein level.

关键词： ubiquitin p53 AP1

Defective IL-4/Stat6 Signaling Correlates with Increased Apoptosis of Human EBV-lymphoblastoid B Cells and Mouse Spleen Cells

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生物医学工程学杂志 2005年第S1期22卷 103-104页

作者： Wen jie zhang~Δ yun-Feng ZHOU Cong-Hua XIE(Department of Radio-Chemotherapy, Zhongnan Hospital and Cancer Research Center,Wuhan University, Wuhan 430071, China) Department of Radio-Chemotherapy Zhongnan Hospital and Cancer Research Center Wuhan University Wuhan 430071 China

1 IntroductionIL-4-induced Stat6 (Signal transducer and activator of transcription 6) pathway is active in many cell types including cancer cells and immune cells which plays an important role in cell differenciation/growth and resistance to apoptosis[1]. IL-4/Stat6 signaling up-regulates cell surface moleculi suchas CD23, MHC class Ⅱ and IL-4Rα, and down-regulates proinflammatory cytokines, i. e,IL-12 and TNFα.

关键词： IL EBV Defective IL-4/Stat6 Signaling Correlates with Increased Apoptosis of Human EBV-lymphoblastoid B Cells and Mouse Spleen Cells

维普期刊数据库

Magnesia base catalyst flue gas denitrate performance study

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Journal of Environmental Science and Engineering 2008年第10期2卷 64-70页

作者： GAO Yu HU Xiao-min LI Peng-jie LI yun zhang Yang LIU Ying School of Resources and Civil Engineering Northeastern University Shenyang 110004 China

To control contamination of flue gas emission NOx, the author mixcd method of preparing new magnesia base catalyst and researched on denitrificating fine gas by directness catalytic decomposition. Usually removal rate of NO is regarded on the main evaluation criteria. The author analyzed calcination temperature of catalyzer manufacturing process, the temperature of flue gas desorption tower, bed height and efficiency denitrification of NO concentration. And discussed the result of both denitrate lore-and-aft of FT-IR and XRD. The experiment indicates that magnesia base catalyst is available to directness catalytic decomposition denitrificate flue gas. Through denitrification rate is from 85% to 95%. The ingredient of magnesia base catalyst is made from magnesia, firming agent, addition agent. Height denitration bed was 4 cm- 5 cm, deuitration reaction temperature is 130℃-170℃, through the analyses above, presumed that magnesia base catalyst exist activating of vice, and analyzed this vice preliminarily.

关键词： denitrification NO flue gas direct catalytic decomposition catalyst

XELOX doublet regimen versus EOX triplet regimen as first-line treatment for advanced gastric cancer:An open-labeled,multicenter,randomized,prospective phase III trial(EXELOX)

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Cancer Communications 2022年第4期42卷 314-326页

作者： Xiao-Dong Zhu Ming-Zhu Huang Yu-Sheng Wang Wan-Jing Feng Zhi-Yu Chen Yi-Fu He Xiao-Wei zhang Xin Liu Chen-Chen Wang Wen zhang jie-Er Ying Jun Wu Lei Yang Yan-Ru Qin Jian-Feng Luo Xiao-Ying Zhao Wen-Hua Li Zhe zhang Li-Xin Qiu Qi-Rong Geng Jian-Ling Zou jie-yun zhang Hong Zheng Xue-Feng Song Shu-Sheng Wu Cheng-Yan zhang Zhe Gong Qin-Qin Liu Xiao-Feng Wang Qi Xu Qi Wang Jian-Mei Ji Jian Zhao Wei-Jian Guo Department of Gastrointestinal Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Department of Gastroenterology Shanxi Cancer HospitalTaiyuanShanxi 030013P.R.China Department of Medical Oncology The First Affiliated HospitalDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230031P.R.China Department of Abdominal Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Cancer and Basic Medicine(IBMC)Chinese Academy of SciencesHangzhouZhejiang 310005P.R.China Department of Medical Oncology The First People’s Hospital of ChangzhouChangzhouJiangsu 213004P.R.China Department of Gastroenterology Nantong Tumor HospitalNantongJiangsu 226006P.R.China Department of Oncology Zhengzhou University First Affiliated HospitalZhengzhouHenan 450052P.R.China Department of Biostatistics School of Public HealthFudan UniversityShanghai 200032P.R.China Department of medical oncology Cancer Hospital of Fudan UniversityMinhang BranchShanghai 200032P.R.China

Background:There is no consensus on whether triplet regimen is better than doublet regimen in the first-line treatment of advanced gastric cancer(AGC).We aimed to compare the efficacy and safety of oxaliplatin plus capecitabine(XELOX)and epirubicin,oxaliplatin,plus capecitabine(EOX)regimens in treating ***:This phase III trial enrolled previously untreated patients with AGC whowere randomly assigned to receive the XELOXor *** primary endpoint was non-inferiority in progression-free survival(PFS)for XELOX as compared with EOX on an intention-to-treat ***:Between April 10,2015 andAugust 20,2020,448AGCpatientswere randomized to receive XELOX(n=222)or EOX(n=226).The median PFS(mPFS)was 5.0 months(95%confidence interval[CI]=4.5-6.0 months)in the XELOX arm and 5.5 months(95%CI=5.0-6.0 months)in the EOX arm(hazard ratio[HR]=0.989,95%CI=0.812-1.203;P_(non-inferiority)=0.003).There was no significant difference inmedian overall survival(mOS)(12.0 vs.12.0months,P=0.384)or objective response rate(37.4%vs.45.1%,P=0.291)between the two *** patients with poorly differentiated adenocarcinoma and liver metastasis,the EOX arm had a significantly longer mOS(P=0.021)and a trend of longer mPFS(P=0.073)than the XELOX *** rate of grade 3/4 adverse events(AEs)was 42.2%(90/213)in the XELOX arm and 72.5%(156/215)in the EOX arm(P=0.001).The global health-related quality of life(QoL)score was significantly higher in the XELOX arm than in the EOX arm during ***:This non-inferiority trial demonstrated that the doublet regimen was as effective as the triplet regimen and had a better safety profile and QoL as a first-line treatment for AGC ***,the triplet regimen might have a survival advantage in patients with poorly differentiated adenocarcinoma and liver metastasis.

关键词： Advanced gastric cancer chemotherapy XELOX doublet regimen EOX triplet regimen noninferiority quality of life phase III trial

电沉积法制备钴与镧、铈的非晶态合金及其晶化动力学研究

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无机材料学报 2002年第6期17卷 1124-1128页

作者：史鸿运邓洁张云黔董俊贵州大学化学系贵阳550025

稀土元素(La,Ce)的标准还原电位较负,在水溶液中很难电沉积出来,通过选用适合的络合剂和工艺条件制备出Co-La,Co-La-P,Co-Ce,Co-Ce-P以及Co-P合金,并具有非晶态的结构.本文对这几种非晶态合金进行了晶化动力学研究,用差示扫描量热法(DSC... 详细信息

稀土元素(La,Ce)的标准还原电位较负,在水溶液中很难电沉积出来,通过选用适合的络合剂和工艺条件制备出Co-La,Co-La-P,Co-Ce,Co-Ce-P以及Co-P合金,并具有非晶态的结构.本文对这几种非晶态合金进行了晶化动力学研究,用差示扫描量热法(DSC)测定了它们的晶化活化能以及所遵守的动力学方程.

关键词：钴镧铈非晶态合金非晶态镀层电沉积晶化动力学稀土合金

维普期刊数据库

Dynamic behaviors of graphene platelets-reinforced metal foam piezoelectric beams with velocity feedback control

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 63-80页

作者： jie CHEN Xinyue zhang Mingyang FAN School of Mathematics Statistics and Mechanics Beijing University of Technology College of Mechanical & Energy Engineering Beijing University of Technology

Graphene platelets(GPLs)-reinforced metal foam structures enhance the mechanical properties while maintaining the lightweight characteristics of metal foams. Further bonding piezoelectric actuator and sensor layers on the surfaces of GPLs-reinforced metal foam beams enables active vibration control, greatly expanding their applications in the aerospace industry. For the first time, this paper investigates the vibration characteristics and active vibration control of GPLs-reinforced metal foam beams with surfacebonded piezoelectric layers. The constant velocity feedback scheme is used to design the closed-loop controller including piezoelectric actuators and sensors. The effects of the GPLs on the linear and nonlinear free vibrations of the beams are numerically *** Newmark-β method combined with Newton's iteration technique is used to calculate the nonlinear responses of the beams under different load forms including harmonic loads,impact loads, and moving loads. Additionally, special attention is given to the vibration reduction performance of the velocity feedback control on the responses of the beam.

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A New Deployment Strategy with Robustness in Heterogeneous WSN

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A New Deployment Strategy with Robustness in Heterogeneous W...

Overexpression of p27^(KIP1)induced cell cycle arrest in G_1 phase and subsequent apoptosis in HCC-9204 cell line

2010 International Colloquium on Computing,Communication, Control, and Management (CCCM2010)

作者： Tingting Shi College of Information Engineering Yangzhou University Yangzhou,Jiangsu,China yun Yang,jie Chen,yun zhang College of Information Engineering Yangzhou University Yangzhou,Jiangsu,China

In wireless sensor networks,deploying moderate heterogeneous sensor nodes can obvious heighten the success ratio of data transmission and extend network *** paper proposed a new deployment strategy with robustness in heterogeneous WSNs in connection with the application of real-time monitoring network,discussed the deployment strategy of network nodes in the heterogeneous networks,and analyzed the number of heterogeneous nodes and the location method for the normal sensor *** simulation shows this method can enhance the success ratio of data transmission effectively,reduce the energy consumption of normal network nodes,and extend the lifetime of network.

关键词： Node deployment Heterogeneous Robustness

来源： cnki会议评论

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World Journal of Gastroenterology 2000年第4期6卷 513-521页

作者： Jiang Li Xin Ke Yang Xin Xin Yu Meng Liang Ge Wen Liang Wang jie zhang yun De Hou Department of Pathology,Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China State Key Laboratory for Molecular Virology and Genetic Engineering,Beijing 100052,China Department of Dermatology,Beijing Hospital,Beijing 100016,China Institute of Radiation Medicine,Beijing 100085,China 第四军医大学陕西西安中国预防医学科学院病毒所北京中国预防医学科学院病毒所分子病毒基因工程国家重点实验室北京北京医院北京解放军军事医学科学院放射医学所北京

AIM We have previously reported that inducible over-expresaion of Bak may prolong cell cycle in G1 phase and lead to apoptosis in HCC-9204 cells. This study is to investigate whether p27KIP1 plays an important role in this process. MEHODS In order to elucidate the exact function of p27KIP1 in this process, a zinc inducible p27KIP1 stable transfectant and transient p27KIP1- GFP fusion transfectant were constructed. The effects of inducible p27KIP1 on cell growth, cell cycle arrest and apoptosis were examined in the mock, control pMD vector, and pMD-KIP1 transfected HCC-9204 cells. RESULTS This p27KIP1-GFP transfectant may transiently express the fusion gene. The cell growth was reduced by 35% at 48 h of p27KIP1 induction with zinc treatment as determined by trypan blue exclusion assay. These differences remained the same after 72 h of p27KIP1 expression, p27KIP1 caused cell cycle arrest after 24 h of induction, with 40% increase in G1 population. Prolonged p27KIP1 expression in this cell line induced apoptotic cell death reflected by TUNEL assay. Fourty-eight h and 72 h of p27KIP1 expression showed a characteristic DNA ladder on agarose gel electrophoresis.

关键词： p27^(KIP1) apoptosis cell cycle inducible expression system carcinoma hepatocellular liver neoplasms

Direct Asymmetric Mannich Reactions Catalyzed by 4-Long Chain Alkoxyl-L-Proline

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Direct Asymmetric Mannich Reactions Catalyzed by 4-Long Chai...