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Potential protein–phenotype correlation in three lipopolysaccharideresponsive beige-like anchor protein-deficient patients

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World Journal of Clinical Cases 2021年第21期9卷 5873-5888页

作者： Wen-Juan Tang Wen-Hui Hu Ying Huang Bing-Bing Wu Xiao-Min Peng Xiao-Wen Zhai Xiao-Wen Qian Zi-Qing Ye Hai-Jiao Xia jie Wu jie-ru shi Department of Gastroenterology Pediatric Inflammatory Bowel Disease Research CenterChildren’s Hospital of Fudan UniversityNational Children's Medical CenterShanghai 201102China The Molecular Genetic Diagnosis Center Children's Hospital of Fudan UniversityShanghai 201102China Department of Hematology Oncology Children's Hospital of Fudan universityNational Children's Medical CenterShanghai 201102China

BACKGROUND Patients with lipopolysaccharide(LPS)-responsive beige-like anchor protein(LRBA)deficiency have a variety of clinical symptoms,but there is no apparent genotype–phenotype correlation,and patients carrying the same mutations may have different ***,it is not easy for doctors to make a decision regarding hematopoietic stem cell transplantation(HSCT)for LRBA-deficient *** hypothesized that there may be a protein–phenotype correlation to indicate HSCT for LRBA-deficient *** To report on three Chinese LRBA-deficient patients and determine the correlation between residual protein expression and disease *** Clinical data of three Chinese LRBA-deficient patients were collected,and protein levels were detected by Western blot *** addition,LRBA mutation information of another 83 previously reported patients was *** All the major clinical findings indicated enteropathy,but patients 1 and 3 presented with more severe symptoms than patient *** and histology indicated nonspecific colitis for patients 1 and 3 but Crohn's disease-like colitis for patient *** heterozygous mutations in LRBA were found in patient 1,and homozygous mutations in LRBA were found in patient 2 and patient *** patient 2 responded well to traditional immunosuppressive *** expression of the LRBA protein in patients 1 and 3 was very low,but in patient 2,a more than 0.5-fold in expression of the LRBA protein was found compared to that in the *** HSCT,patient 1 had increased LRBA protein *** summarized the genetic information of 86 patients,and the mutations in patients 1 and 3 were novel *** We described three Chinese LRBA-deficient patients,two of whom carried novel *** patients had no genotype-phenotype correlations,but their residual LRBA protein expression might be associated with disease outcome and could be an indicator for HSCT.

关键词： LPS-responsive beige-like anchor protein deficiency Chinese Common variable immunodeficiency Gene mutation Chronic diarrhea

Multi-Stream Temporally Enhanced Network for Video Salient Object Detection

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Computers, Materials & Continua 2024年第1期78卷 85-104页

作者： Dan Xu Jiale ru Jinlong shi School of Computer Science Jiangsu University of Science and TechnologyZhenjiang212100China

Video salient object detection(VSOD)aims at locating the most attractive objects in a video by exploring the spatial and temporal *** poses a challenging task in computer vision,as it involves processing complex spatial data that is also influenced by temporal *** the progress made in existing VSOD models,they still struggle in scenes of great background diversity within and between ***,they encounter difficulties related to accumulated noise and high time consumption during the extraction of temporal features over a long-term *** propose a multi-stream temporal enhanced network(MSTENet)to address these *** investigates saliency cues collaboration in the spatial domain with a multi-stream structure to deal with the great background diversity challenge.A straightforward,yet efficient approach for temporal feature extraction is developed to avoid the accumulative noises and reduce time *** distinction between MSTENet and other VSOD methods stems from its incorporation of both foreground supervision and background supervision,facilitating enhanced extraction of collaborative saliency *** notable differentiation is the innovative integration of spatial and temporal features,wherein the temporal module is integrated into the multi-stream structure,enabling comprehensive spatial-temporal interactions within an end-to-end *** experimental results demonstrate that the proposed method achieves state-of-the-art performance on five benchmark datasets while maintaining a real-time speed of 27 fps(Titan XP).Our code and models are available at https://***/ruJiaLe/MSTENet.

关键词： Video salient object detection deep learning temporally enhanced foreground-background collaboration

Quaternion-Based Adaptive Trajectory Tracking Control of a Rotor-Missile with Unknown Parameters Identification

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Defence Technology（防务技术） 2024年第1期31卷 375-386页

作者： jie Zhao Zhongjiao shi Yuchen Wang Wei Wang Beijing Institute of Technology Beijing 100081China

This paper investigates the adaptive trajectory tracking control problem and the unknown parameter identification problem of a class of rotor-missiles with parametric system ***,considering the uncertainty of structural and aerodynamic parameters,the six-degree-of-freedom(6Do F) nonlinear equations describing the position and attitude dynamics of the rotor-missile are established,respectively,in the inertial and body-fixed reference ***,a hierarchical adaptive trajectory tracking controller that can guarantee closed-loop stability is proposed according to the cascade characteristics of the 6Do F ***,a memory-augmented update rule of unknown parameters is proposed by integrating all historical data of the regression *** long as the finitely excited condition is satisfied,the precise identification of unknown parameters can be ***,the validity of the proposed trajectory tracking controller and the parameter identification method is proved through Lyapunov stability theory and numerical simulations.

关键词： Rotor-missile Adaptive control Parameter identification Quaternion control

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Investigation on crystallization behavior between(Sc_(x)Yb_(1−x))O_(1.5)and CMAS:A new insight in the effect of Sc substitution

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Journal of Advanced Ceramics 2024年第6期13卷 789-799页

作者： Guangheng Zhang Jinyu shi jie Zhang Jingyang Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Environmental barrier coatings(EBCs)with thermomechanical robustness against calcium–magnesium–aluminum–silicate(CMAS)deposits are in high *** aim of this work was to clarify the influence of Sc^(3+)on the crystallization behavior of Yb-based coatings against CMAS *** reaction products of solid solutions with compositions traversing the Sc_(2)O_(3)–Yb_(2)O_(3)system indicate that Sc^(3+)tends to form[BO_(6)]coordination polyhedra in the crystal structure to promote the formation of garnet and diopside,while Yb^(3+)occupies 7-,8-,and 9-coordinate sites to crystallize apatite and *** transformation of crystalline products from apatite/silicocarnotite to garnet/diopside greatly improves the efficiency of CMAS melt consumption and facilitates the prevention of its further penetration and *** on the commonality of cation occupancy in crystallography,an A(CaO+YbO_(1.5))–B(ScO_(1.5)+MgO+AlO_(1.5))–T(SiO_(2))pseudoternary phase diagram is established,which has great potential for describing phase equilibrium in coating-deposit systems and can provide guidance for the compositional design of corrosion-resistant coatings.

关键词： crystallization behavior cation partitioning scandium-ytterbium oxide(Sc_(x)Yb_(1−x))O_(1.5)solid solution calcium-magnesium-aluminum-silicate(CMAS)deposit pseudoternary phase diagram

A20 inhibits lipopolysaccharide-induced inflammation in enterocytes

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 540-549页

作者： Cui-Fang Zheng jie-ru shi Ying Huang Sheng-Nan Wang Department of Gastroenterology Children’s Hospital of Fudan University

AIMTo examine the role of A20 in the regulation of intestinal epithelial cells (IECs) inflammation. METHODSUsing gene transfection, both stable overexpression and knockdown A20-expressed HT-29 cell lines were established. Accordingly, the cells were divided into the following groups: The control group, the A20 overexpression group, the A20 knockdown group and the respective controls. A20 was stimulated with lipopolysaccharide (LPS) in a dose- and time-dependent manner and was detected using western blotting and real-time polymerase chain reaction (PCR) analyses. Immunofluorescence and western blotting analyses were performed to investigate the role of A20 in the regulation of nuclear factor (NF)-κB activation and translocation into the nucleus. ELISA and real-time PCR were performed to examine A20 in regulating the release of the following inflammatory cytokines: Tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and IL-8. RESULTSThe expression of A20 in IECs was inducible. When intestinal epithelial cells were subjected to the stimulation of LPS, the expression of A20 was increased, and the expression of A20 was induced in a dose- and time-dependent manner. The expression of A20 was very low in HT-29 cells without LPS stimulation but rapidly increased and was maintained at a high level 2-4 h after stimulation with LPS. These levels gradually declined with a change in time-course, and the expression of A20 increased with increasing LPS stimulation. Western blotting and immunofluorescence revealed that overexpression of A20 can inhibit NF-κB activation and its translocation to the nucleus. The overexpression of A20 can reduce the levels of proinflammatory cytokines involved in the pathophysiology of inflammatory bowel disease. There was no significant difference in the expression of IL-8 mRNA in the control group, A20 overexpression group or A20 knockdown group without LPS stimulation (P > 0.05); however, while after 2 h, 4 h and 8 h stim

关键词： A20 (TNFAIP3) Lipopolysaccharide Nuclear factor-&kappa B Inflammatory bowel disease

Hole mobility enhancement in monolayer WSe2 p-type transistors through molecular doping

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Science China(Information Sciences) 2024年第6期67卷 207-213页

作者： shiyuan LIU Xiong XIONG Xin WANG Xinhang shi ru HUANG Yanqing WU School of Integrated Circuits and Beijing Advanced Innovation Center for Integrated Circuits Peking University Wuhan National High Magnetic Field Center and School of Integrated Circuits Huazhong University of Science and Technology

Two-dimensional （2D） transition metal dichalcogenide （TMDC） semiconductor materials exhibit extraordinary electrical properties,holding promise for the realization of next-generation complementary metal-oxide-semiconductor （CMOS） devices at ultimate ***,constrained by effective device doping strategies,the hole mobility and device performance of tungsten diselenide （WSe2） p-type transistors,especially monolayer chemical vapor deposition （CVD）-grown WSe2,have not met *** this paper,an effective performance enhancement of monolayer WSe2p-type transistor was achieved through a molecular doping *** monolayer WSe2directly on SiO2back-gated substrates and leveraging energy band alignment design,4-nitrobenzenediazonium tetrafluoroborate （4-NBD） molecular dopant with a concentration of 10 m M was utilized to modulate the Fermi level position of monolayer WSe2for hole *** devices demonstrated a more than 98%increase in hole mobility,reaching up to 97 cm2·V-1·s-1while maintaining the current on/off ratio of *** p-type WSe2transistors with 1μm channel length exhibit a high drive current surpassing 176μA·μm-1,exceeding previous CVD-WSe2devices with similar channel *** straightforward and effective approach to improving the electrical performance of WSe2transistors paves the way for advanced logic technologies based on transition metal dichalcogenide semiconductors.

关键词： CVD-grown WSe$_2$ molecular doping 4-NBD p-type transistors hole mobility

Design strategies and recent advancements of solid-state supercapacitor operating in wide temperature range

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Carbon Energy 2024年第6期6卷 248-281页

作者： jie Zhou Zhengfeng Zhu Wenhui shi Xiangyu shi Zhuoyuan Zheng Ye Xiong Yusong Zhu School of Energy Science and Engineering Nanjing Tech UniversityNanjingJiangsuChina Kucap Smart Technology(Nanjing)Co. Ltd.NanjingJiangsuChina

Solid-state supercapacitors(SSCs)are emerging as one of the promising energy storage devices due to their high safety,superior power density,and excellent cycling ***,performance degradation and safety issues under extreme conditions are the main challenges for the practical *** the expansion of human activities,such as space missions,polar exploration,and so on,the investigation of SSC with wide temperature tolerance,high energy density,power density,and sustainability is highly *** this review,the effects of temperature on SSC are systematically illustrated and clarified,including the properties of the electrolyte,ion diffusion,and reaction dynamics of the ***,we summarize the recent advances in wide-temperature-range SSCs from the aspect of electrolyte modification,electrode design,and interface adjustment between electrode and electrolyte,especially with critical concerns on ionic conductivity and cycling *** the end,a perspective is presented,expecting to promote the practical application of the SSC in harsh conditions.

关键词： electrode interface solid-state electrolyte solid-state supercapacitor wide temperature

Privacy-Preserving Frank-Wolfe on Shuffle Model

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Acta Mathematicae Applicatae Sinica 2024年第4期40卷 887-907页

作者： Ling-jie ZHANG shi-song WU Hai ZHANG School of Mathematics Northwest UniversityXi’an 710127China School of Mathematics and Information Science Baoji University of Arts and SciencesBaoji 721013China China Southern Power Grid Artificial Intelligence Technology Company Limited Guangzhou 510700China

In this paper,we design the differentially private variants of the classical Frank-Wolfe algorithm with shuffle model in the optimization of machine *** weak assumptions and the generalized linear loss(GLL)structure,we propose a noisy Frank-Wolfe with shuffle model algorithm(NoisyFWS)and a noisy variance-reduced Frank-Wolfe with the shuffle model algorithm(NoisyVRFWS)by adding calibrated laplace noise under shuffling scheme in thel_(p)(p∈[1,2])-case,and study their privacy as well as utility guarantees for the H?lder smoothness *** particular,the privacy guarantees are mainly achieved by using advanced composition and privacy amplification by *** utility bounds of the Noisy FWS and NoisyVRFWS are analyzed and obtained the optimal excess population risksO(n-(1+α/4α+log(d)√log(1/δ)/n∈and O(n-1+α/4α+log(d)√log1(+δ)/n^(2)∈with gradient complexity O(n(1+α)^(2)/4α^(2)forα∈[1/√3,1].It turns out that the risk rates under shuffling scheme are a nearly-dimension independent rate,which is consistent with the previous work in some *** addition,there is a vital tradeoff between(α,L)-Holder smoothness GLL and the gradient *** linear gradient complexity O(n)is showed by the parameterα=1.

关键词： differential privacy Frank-Wolfe algorithm privacy amplification shuffle model

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Locally and globally uniform approximations for ruin probabilities of a nonstandard bidimensional risk model with subexponential claims

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 98-113页

作者： LIU Zai-ming GENG Bing-zhen WANG shi-jie School of Mathematics and Statistics Central South UniversityChangsha 410083China School of Big Data and Statistics Anhui UniversityHefei 230601China

Consider a nonstandard continuous-time bidimensional risk model with constant force of interest,in which the two classes of claims with subexponential distributions satisfy a general dependence structure and each pair of the claim-inter-arrival times is arbitrarily *** some mild conditions,we achieve a locally uniform approximation of the finite-time ruin probability for all time horizon within a finite *** we further assume that each pair of the claim-inter-arrival times is negative quadrant dependent and the two classes of claims are consistently-varying-tailed,it shows that the above obtained approximation is also globally uniform for all time horizon within an infinite interval.

关键词： bidimensional risk model asymptotic formula subexponential distribution consistently varying tail ruin probability

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