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血液灌流联合盐酸纳洛酮治疗急性重症镇静药物中毒患者的疗效分析

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疑难病杂志 2024年第2期23卷 192-195,201页

作者：段昱毕淑珍陈锦华刘强李卿山西省长治市人民医院急诊科 046000

目的观察血液灌流联合盐酸纳洛酮治疗急性重症镇静药物中毒患者的临床效果。方法选取2019年7月—2023年7月长治市人民医院急诊科治疗的急性重症镇静药物中毒患者120例为研究对象。按照随机数字表法分为对照组和研究组,各60例。对照组给... 详细信息

目的观察血液灌流联合盐酸纳洛酮治疗急性重症镇静药物中毒患者的临床效果。方法选取2019年7月—2023年7月长治市人民医院急诊科治疗的急性重症镇静药物中毒患者120例为研究对象。按照随机数字表法分为对照组和研究组,各60例。对照组给予盐酸纳洛酮静脉滴注,研究组在对照组基础上给予血液灌流治疗。比较2组临床疗效、意识清醒时间、中毒症状消失时间、住院时间、血气指标水平[pH、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]、血清炎性因子水平[白介素-4(IL-4)、IL-6、肿瘤坏死因子-α(TNF-α)]及并发症发生率。结果研究组临床总有效率为93.33%,高于对照组的76.67%(χ^(2)/P=6.536/0.011);治疗后研究组患者意识清醒时间、中毒症状消失时间、住院时间短于对照组(t/P=6.675/<0.001、6.004/<0.001、7.174/<0.001);与治疗前比较,治疗后患者PaCO_(2)、IL-4、IL-6、TNF-α水平均下降,pH、PaO_(2)上升(P<0.05),且研究组降低/升高幅度大于对照组(t/P=6.745/<0.001、5.729/<0.001、6.922/<0.001、6.169/<0.001、2.419/0.017、4.291/<0.001);治疗后研究组并发症总发生率为3.33%,低于对照组的15.00%(χ^(2)/P=4.904/0.027)。结论血液灌流联合盐酸纳洛酮治疗急性重症镇静药物中毒患者,可有效改善血气状况,降低炎性反应,促进患者恢复。

关键词：急性重症镇静药物中毒血液灌流盐酸纳洛酮临床疗效炎性因子

肌电生物反馈治疗仪联合双侧运动训练对卒中后上肢运动功能障碍患者的影响

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中外医学研究 2024年第7期22卷 34-37页

作者：覃朋区瑞庆吴锐江门市人民医院广东江门529000

目的:探讨肌电生物反馈治疗仪联合双侧运动训练对卒中后上肢运动功能障碍患者的影响。方法:选取2022年2月—2023年1月江门市人民医院收治的62例卒中后上肢运动功能障碍患者作为研究对象。根据随机数表法将其分为对照组和观察组,各31例... 详细信息

目的:探讨肌电生物反馈治疗仪联合双侧运动训练对卒中后上肢运动功能障碍患者的影响。方法:选取2022年2月—2023年1月江门市人民医院收治的62例卒中后上肢运动功能障碍患者作为研究对象。根据随机数表法将其分为对照组和观察组,各31例。对照组给予双侧运动训练,观察组给予肌电生物反馈治疗仪联合双侧运动训练。比较两组干预前、干预2周、干预4周时上肢运动功能、日常生活能力、腕伸肌积分肌电值(integrated electromyography,iEMG),干预前后运动功能分级。结果:干预2周、4周,两组上肢Fugl-Meyer运动功能评估量表(Fugl-Meyer assessment scale,FMAS)评分、Barthel指数(Barthel index,bi)评分均升高,观察组两组上肢FMAS评分、bi评分均高于对照组,差异有统计学意义(P<0.05)。干预后,观察组Ⅲ级、Ⅳ级率均低于对照组,Ⅴ级率高于对照组,差异有统计学意义(P<0.05)。干预2周、4周,两组腕伸肌iEMG均升高,观察组腕伸肌iEMG均高于对照组,差异有统计学意义(P<0.05)。结论:卒中后上肢运动功能障碍者接受肌电生物反馈治疗仪联合双侧运动训练,可进一步提升其上肢运动功能,进而改善其日常生活能力。

关键词：上肢运动功能障碍肌电生物反馈治疗仪双侧运动训练

Boron modulating electronic structure of FeN4C to initiate high-efficiency oxygen reduction reaction and high-performance zinc-air battery

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Journal of Energy Chemistry 2022年第3期31卷 514-524,I0014页

作者： Xue Zhao Xue Li Zenghui bi Yuwen Wang Haibo Zhang Xiaohai Zhou Quan Wang Yingtang Zhou Huaisheng Wang Guangzhi Hu Institute for Ecological Research and Pollution Control of Plateau Lakes School of Ecology and Environmental ScienceYunnan UniversityKunming 650504YunnanChina College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072HubeiChina National Engineering Research Center for Marine Aquaculture Marine Science and Technology CollegeZhejiang Ocean UniversityZhoushan 316004ZhejiangChina School of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252000ShandongChina

The biggest challenge is to develop a low cost and readily available catalyst to replace expensive commercial Pt/C for efficient electrochemical oxygen reduction reaction(ORR).In this research,closo-[B_(12)H_(12)]^(2−)and 1,10-phenanthroline-iron complexes were introduced into the porous metal-organic framework by impregnation method,and further annealing treatment achieved the successful anchoring of single-atom-Fe in B-doped CN Matrix(FeN4CB).The ORR activity of FeN4CB is comparable to the widely used commercial 20 wt%Pt/*** the half-wave potential(E_(1/2))in alkaline medium up to 0.84 V,and even in the face of challenging ORR in acidic medium,the E_(1/2)of ORR driven by FeN4CB is still as high as 0.81 *** FeN4CB was used as air cathode,the open circuit voltage of Zn-air battery reaches 1.435 V,and the power density and specific capacity are as high as 177 mW cm^(−2)and 800 mAh g_(Zn)^(−1)(theoretical value:820 mAh g_(Zn)^(−1)),*** dazzling point of FeN4CB also appears in the high ORR stability,whether in alkaline or acidic media,E_(1/2)and limiting current density are still close to the initial value after 5000 times *** continuously running the charge-discharge test for 220 h,the charge voltage and discharge voltage of the rechargeable zinc-air battery with FeN4CB as the air cathode maintained the initial *** functional theory calculations reveals that introducing B atom to Fe–N4–C can adjust the electronic structure to easily break O=O bond and significantly reduce the energy barrier of the rate-determining step resulting in an improved ORR activity.

关键词： Single-atom Fe B-doped CN Oxygen reduction reaction Zn-air battery Electronic modulation

Prediction of Grinding Force by an Electroplated Grinding Wheel with Orderly-Micro-Grooves

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Chinese Journal of Mechanical Engineering 2023年第4期36卷 56-66页

作者： Cong Mao Jiali Wang Mingjun Zhang Xincheng Wang Yuanqiang Luo Weidong Tang Kun Tang Zhuming bi Yongle Hu Zhenheng Lin Hunan Provincial Key Laboratory of Intelligent Manufacturing Technology for High-performance Mechanical Equipment Changsha University of Science and TechnologyChangsha 410114China Hunan Wuxin Intelligence Technology Co. LtdChangsha 410199China Department of Civil and Mechanical Engineering Purdue University Fort WayneFort WayneIN 46805USA School of Mechanical and Electrical Engineering Putian UniversityPutian 351100China

The ability to predict a grinding force is important to control,monitor,and optimize the grinding *** theoretical models were developed to predict grinding forces when a structured wheel was used in a grinding *** paper aimed to establish a single-grit cutting force model to predict the ploughing,friction and cutting forces in a grinding *** took into the consideration of actual topography of the grinding wheel,and a theoretical grinding force model for grinding hardened AISI 52100 by the wheel with orderly-micro-grooves was *** model was innovative in the sense that it represented the random thickness of undeformed chips by a probabilistic expression,and it reflected the microstructure characteristics of the structured wheel *** that the microstructure depended on the randomness of the protruding heights and distribution density of the grits over the *** proposed force prediction model was validated by surface grinding experiments,and the results showed(1)a good agreement of the predicted and measured forces and(2)a good agreement of the changes of the grinding forces along with the changes of grinding parameters in the prediction model and *** research proposed a theoretical grinding force model of an electroplated grinding wheel with orderly-micro-grooves which is accurate,reliable and effective in predicting grinding forces.

关键词： Electroplated grinding wheel Orderly-micro-grooves Grinding force Force prediction Undeformed chip thickness Experimental validation

Research on the appropriate way to transfer exogenous substances into chicken embryos

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Journal of Integrative Agriculture 2017年第10期16卷 2257-2263页

作者： WANG Yi-lin JIN Kai HE Na-na CHENG Shao-ze ZUO Qi-sheng LI Dong WANG Ying-jie WANG Fei JI Yan-qing LU Zhen-yu ZHANG Chen WANG Man ZHAO Rui-feng YU Xin-jian ZHANG Ya-ni ZHAO Wen-ming LI bi-chun College of Animal Science and Technology/Jiangsu Province Key Laboratory of Animal Breeding and Molecular Design Yangzhou University Yangzhou 225009 P.R.China

In biological research, chicken embryos are a classic experimental model for the exploration of the embryonic development and cell differentiation. Transferring exogenous substances into chicken embryos for producing medical antibodies has been widely used in the production practice. However, there are few studies about the effect of the different injection site and dosage on chicken embryos. The aim of this study was to explore the effects of different injection sites and dosages on chicken embryo hatching rate and development, so as to provide a basis for further studies using the chicken embryo model. Freshly laid eggs （Rugao yellow chicken） were injected with different doses of saline at the tip, equatorial plane and the blunt end of the egg shell, respectively. Egg hatching rate was recorded and compared among injection sites and different doses. A trypan blue stain was also injected at the aforementioned sites and the growth of chicken embryos was observed. The SPSS （statistical package for the social science） software was used to analyze the relationship between the chicken eggs hatching rate and the different injection sites or the different dosages. The experimental results showed that there were significant differences on egg hatching rates among the different injection sites and doses （P〈0.05）. The hatchability of the blunt end injection group was significantly higher than that of the other two sites. The egg hatching rate decreased with increased saline doses. The egg hatching rate of the 100 pL saline injection group was higher than the 200 and 300 μL dosage groups. Ultimately, we suggest that the optimal chicken embryo injection process is during early development, at the blunt end site with a dose less than 100 μL to minimize damage to the egg.

关键词： chicken embryos injection dosage hatchability chick embryo development

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基于注意力机制和边缘生成的图像修复研究

宁德师范学院学报（自然科学版） 2024年第3期36卷 262-272页

作者：岳贺飞刘华明王秀友毕学慧阜阳师范大学计算机与信息工程学院安徽阜阳236000

针对图像中大面积缺失区域修复产生纹理结构不清晰和上下文语义内容不协调的问题,提出基于注意力机制和边缘生成的图像修复算法.以生成对抗网络作为整体架构,添加边缘生成网络和ECA注意力机制模块,旨在强调破损区域内部边缘的修复,重点... 详细信息

针对图像中大面积缺失区域修复产生纹理结构不清晰和上下文语义内容不协调的问题,提出基于注意力机制和边缘生成的图像修复算法.以生成对抗网络作为整体架构,添加边缘生成网络和ECA注意力机制模块,旨在强调破损区域内部边缘的修复,重点突出感兴趣区域与图像内容整体的一致性;采用感知损失函数进一步约束图像内容的生成,使纹理细节修复更加清晰.在CelebA和Paris Street View数据集上进行测试,实验结果表明,算法在峰值信噪比和结构相似度两项指标上均有所提升,对图像修复实践具有一定的参考价值.

关键词：图像修复边缘生成注意力机制感知损失

5,5'-(2-三氟甲基)-咪唑-4,5-二(1H-四唑)及其含能离子盐的合成与表征

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含能材料 2017年第4期25卷 315-320页

作者：吴敏杰毕福强周彦水翟连杰王伯周西安近代化学研究所陕西西安710065 氟氮化工资源高效开发与利用重点实验室陕西西安710065

以二氨基马来腈为原料,经过与三氟乙酸酐缩合、环化,与叠氮化纳再次缩合,合成得到了新型含能化合物5,5'-(2-三氟甲基)-咪唑-4,5-二(1H-四唑),收率61.3%;基于该化合物的酸性,设计合成了2种含能离子盐5,5'-(2-三氟甲基)-咪唑-4,5-二(1H-四... 详细信息

以二氨基马来腈为原料,经过与三氟乙酸酐缩合、环化,与叠氮化纳再次缩合,合成得到了新型含能化合物5,5'-(2-三氟甲基)-咪唑-4,5-二(1H-四唑),收率61.3%;基于该化合物的酸性,设计合成了2种含能离子盐5,5'-(2-三氟甲基)-咪唑-4,5-二(1H-四唑)的羟胺盐和胍盐。利用红外光谱、核磁共振和元素分析对中间体及产物结构进行了表征。探讨了生成5,5'-(2-三氟甲基)-咪唑-4,5-二(1H-四唑)过程中影响四唑环化反应的关键因素,确定的最佳反应条件为:反应介质为水,n(2-三氟甲基-4,5-二氰基咪唑)∶n(Na N3)=1∶2.4,反应温度98℃,反应时间4 h。收率最高达86.3%。通过DSC-TG研究了5,5'-(2-三氟甲基)-咪唑-4,5-二(1H-四唑)的热分解性能,热分解曲线表明化合物直到223.65℃才开始分解,整个分解过程经历了两个主要的放热分解阶段和热失重阶段,最大放热峰温度为285.78℃,说明该化合物结构比较稳定。

关键词： 5,5'-(2-三氟甲基)-咪唑-4,5-二(1H-四唑) 含能离子盐合成表征

基于自噬途径探讨补肾益精方对RPE细胞氧化应激损伤的保护机制研究

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中国中医眼科杂志 2024年第8期34卷 706-712页

作者：毕鸿昊郭惠怡刘新宇莫亚欣陈强中国中医科学院眼科医院北京100040 潍坊护理职业学院潍坊262500

目的基于自噬途径探讨补肾益精方(BSYJ)对氧化应激状态下的视网膜色素上皮(RPE)细胞的保护机制。方法制备补肾益精方含药血清和空白血清,将体外培养的RPE细胞分为6组,对照组(CG)常规培养,模型组(MG)以90μmol/L氢醌处理24 h,空白血清组(... 详细信息

目的基于自噬途径探讨补肾益精方(BSYJ)对氧化应激状态下的视网膜色素上皮(RPE)细胞的保护机制。方法制备补肾益精方含药血清和空白血清,将体外培养的RPE细胞分为6组,对照组(CG)常规培养,模型组(MG)以90μmol/L氢醌处理24 h,空白血清组(BSG)以空白血清+氢醌处理,低剂量补肾益精方组(L-BSYJ)以2.5%含药血清+氢醌处理,高剂量补肾益精方组(H-BSYJ)以10%含药血清+氢醌处理,自噬抑制剂3-甲基腺嘌呤组(3-MA)以10 mmol/L 3-MA+10%含药血清+氢醌处理。细胞计数试剂-8(CCK-8)法检测各组RPE细胞活力,透射电镜观察RPE细胞自噬小体形态及数量,实时荧光定量PCR(qRT-PCR)检测RPE细胞Kelch样环氧氯丙烷相关蛋白-1(Keap1)、核因子E2相关因子2(Nrf2)、肌球蛋白样卷曲螺旋蛋白1(Beclin1)和自噬相关基因5(Atg5)mRNA表达,Western Blot法检测Keap1、微管相关蛋白1轻链3(LC3)、Nrf2、磷酸化哺乳动物雷帕霉素靶蛋白(p-mTOR)、Beclin1蛋白表达。结果(1)细胞活力:MG组细胞活力低于CG组(t=19.277,P=0.000),LBSYJ组、H-BSYJ组细胞活力均高于MG组(tL-BSYJ=7.688、tH-BSYJ=10.433,均P=0.000),3-MA组细胞活力低于H-BSYJ组(t=2.426,P=0.023),差异均有统计学意义。(2)自噬:CG组RPE细胞自噬小体极少,MG组较多,L-BSYJ组自噬小体数量少于MG组,3-MA组较L-BSYJ组进一步减少。(3)相关因子mRNA:MG组细胞中Atg5、Beclin1、Keap1表达高于CG组(t_(Atg5)=18.191、t_(Beclin1)=16.766、t_(Keap1)=13.361,均P=0.000),Nrf2表达低于CG组(t=5.494,P=0.000);L-BSYJ组的Atg5、Beclin1、Keap1表达低于MG组(t_(Atg5)=4.958、t_(Beclin1)=7.831、t_(Keap1)=7.488,均P=0.000),Nrf2表达高于MG组(t=16.141,P=0.000);H-BSYJ组的Atg5、Beclin1、Keap1表达低于MG组(t_(Atg5)=12.791、t_(Beclin1)=12.683、t_(Keap1)=14.920,均P=0.000),Nrf2表达高于MG组(t=32.582,P=0.000);3-MA组的Atg5、Beclin1、Keap1表达低于H-BSYJ组(t_(Atg5)=5.243、t_(Beclin1)=9.320、t_(Keap1)=8.879,均P=0.000),Nrf2表达高于H-BSYJ组(t=8.060,P=0.000),差异均有统计学意义。(4)相关蛋白:MG组的Beclin1、LC3、Keap1表达高于CG组(t_(Beclin1)=18.328、t_(LC3)=13.930、t_(Keap1)=20.720,均P=0.000);p-mTOR、Nrf2表达低于MG组(t_(p-mTOR)=21.515、t_(Nrf2)=21.244,均P=0.000);L-BSYJ组的Beclin1、LC3、Keap1表达低于MG组(t_(Beclin1)=6.987,P=0.000;t_(LC3)=4.767,P=0.001;t_(Keap1)=22.070,P=0.000),p-mTOR、Nrf2表达高于MG组(t_(p-mTOR)=11.351、t_(Nrf2)=23.551,均P=0.000);H-BSYJ组的Beclin1、LC3、Keap1表达低于MG组(t_(Beclin1)=14.266、t_(LC3)=9.116、t_(Keap1)=40.284,均P=0.000),pmTOR、Nrf2表达高于L-BSYJ组(t_(p-mTOR)=28.164、t_(Nrf2)=43.930,均P=0.000);3-MA组Beclin1、LC3、Keap1表达低于H-BSYJ组(t_(Beclin1)=5.362、t_(LC3)=5.000、t_(Keap1)=20.817,均P=0.000),p-mTOR、Nrf2表达高于H-BSYJ组(t_(p-mTOR)=10.449、t_(Nrf2)=20.571,均P=0.000),差异均有统计学意义。结论补肾益精方可降低RPE细胞由于氧化应激而导致的自噬水平提高,减轻氧化应激对RPE细胞的损伤。

关键词：补肾益精方视网膜色素上皮细胞氧化应激自噬

Fabrication of Ytterbium-doped titanium dioxide nanoparticles using Collagen as template

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Fabrication of Ytterbium-doped titanium dioxide nanoparticle...