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Biological factors driving colorectal cancer metastasis

World Journal of Gastrointestinal Oncology 2024年第2期16卷 259-272页

作者： Shuai-Xing An Zhao-Jin Yu Chen Fu min-jie wei Long-Hai Shen Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122Liaoning ProvinceChina Liaoning Key Laboratory of Molecular Targeted Antitumor Drug Development and Evaluation Liaoning Cancer Immune Peptide Drug Engineering Technology Research CenterKey Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors(China Medical University)Ministry of EducationShenyang 110122Liaoning ProvinceChina BD Department Greenpine Pharma Group Co.LtdTianjin 300020China Center of Oncology Genertec Liaoyou Gem Flower HospitalPanJin 124010Liaoning ProvinceChina

Approximately 20%of colorectal cancer(CRC)patients present with metastasis at *** Stage I-III CRC patients who undergo surgical resection,18%typically suffer from distal metastasis within the first three years following initial *** median survival duration after the diagnosis of metastatic CRC(mCRC)is only 9 *** is traditionally considered to be an advanced stage malignancy or is thought to be caused by incomplete resection of tumor tissue,allowing cancer cells to spread from primary to distant organs;however,increa-sing evidence suggests that the mCRC process can begin early in tumor *** patients present with high heterogeneity and diverse cancer phenotypes that are classified on the basis of molecular and morphological *** genomic and nongenomic events can induce subclone diversity,which leads to cancer and *** the course of mCRC,metastatic cascades are associated with invasive cancer cell migration through the circulatory system,extravasation,distal seeding,dormancy,and reactivation,with each step requiring specific molecular ***,cancer cells presenting neoantigens can be recognized and eliminated by the immune *** this review,we explain the biological factors that drive CRC metastasis,namely,genomic instability,epigenetic instability,the metastatic cascade,the cancer-immunity cycle,and external lifestyle *** remarkable progress in CRC research,the role of molecular classification in therapeutic intervention remains *** review shows the driving factors of mCRC which may help in identifying potential candidate biomarkers that can improve the diagnosis and early detection of mCRC cases.

关键词： cancer Metastasis cascade Cancer immunity Genomic variation Epigenetic instability Lifestyle factor

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Reversing multidrug resistance by tyrosine kinase inhibitors

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Chinese Journal of Cancer 2012年第3期31卷 126-133页

作者： Miao He min-jie wei Department of Pharmacology Pharmaceutical Collegeof China Medical UniversityShenyangLiaoning 110001P.R.China.

Recently,a large number of tyrosine kinase inhibitors(TKIs) have been developed as anticancer *** TKIs can specifically and selectively inhibit tumor cell growth and metastasis by targeting various tyrosine kinases and thereby interfering with cellular signaling *** therapeutic potential of TKIs has been hindered by multidrug resistance(MDR),which is commonly caused by overexpression of ATP-binding cassette(ABC) membrane ***,some TKIs have also been found to reverse MDR by directly inhibiting the function of ABC transporters and enhancing the efficacy of conventional chemotherapeutic *** this review,we discuss ABC transporter-mediated MDR to TKIs and MDR reversal by TKIs.

关键词：酪氨酸激酶抑制剂多药耐药逆转转运蛋白肿瘤细胞 ABC 抗癌药物信号通路

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Realization of Two-Qutrit Quantum Gates with Control Pulses

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Communications in Theoretical Physics 2009年第4期51卷 653-658页

作者： ZHANG jie DI Yao-min wei Hai-Rui School of Physics ＆ Electronic Engineering Xuzhou Normal University Xuzhou 221116 China

We investigate the realization of 2-qutrit logic gate in a bipartite 3-level system with qusi-Ising interaction. On the basis of Caftan decomposition of matrices, the unitary matrices of 2-qutrit are factorized into products of a series of realizable matrices. It is equivalent to exerting a certain control field on the system, and the control goal is usually gained by a sequence of control pulses. The general discussion on the realization of 2-qutrit logic gate is made first, and then the realization of the ternary SWAP gate and the ternary √SWAP gate are discussed specifically, and the sequences of control pulses and drift processes implementing these gates are given.

关键词： Caftan decomposition 2-qutrit system ternary SWAP gate ternary √SWAP gate

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The review of RFID applications in global postal and courier services

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The Journal of China Universities of Posts and Telecommunications 2006年第4期13卷 106-110页

作者： ZHANG Xiao-dan YUE Shu-jie WANG wei-min Postal communication management department Shijiazhuang Post and Telecommunication Technical College Shijiazhuang 050021 China

On the basis of several practical applications in many countries, this article reviews the potential market scale of radio frequency identification （RFID） and its applications in global postal and courier services through studies and analyses. It gives some suggestions and options in the development of RFID and its application in postal and courier services.

关键词： RFID application tag postal service courier

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CHEBYSHEV FINITE SPECTRAL METHOD FOR 2-D EXTENDED BOUSSINESQ EQUATIONS

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Journal of Hydrodynamics 2011年第1期23卷 1-11页

作者： LI Yok-sheung ZHAN jie-min, SU wei Department of Civil and Structural Engineering The Hong Kong Polytechnic University Hong Kong China Department of Applied Mechanics and Engineering Sun Yat-sen University Guangzhou 510275 China

In this article,an accurate Chebyshev finite spectral method for the 2-D extended Boussinesq equations is *** method combines the advantages of both the finite difference and spectral *** Adams-Bashforth predictor and the fourth-order Adams-Moulton corrector are adopted for the numerical solution of the governing differential *** efficient wave absorption strategy is also proposed to effectively absorb waves at outgoing wave boundaries and reflected waves from the interior of the computational domain due to barriers and bottom slopes at the incident wave boundary to avoid contamination of the specified incident wave *** proposed method is verified by a case where experimental data are available for comparison for both regular and irregular *** case is wave diffraction over a shoal reported by Vincent and *** results agree very well with the corresponding experimental data.

关键词： Chebyshev polynomial finite spectral method irregular waves

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LncRNA C9orf139 can regulate the growth of pancreatic cancer by mediating the miR-663a/Sox12 axis

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World Journal of Gastrointestinal Oncology 2020年第11期12卷 1272-1287页

作者： Jin-Nian Ge Di Yan Chun-Lin Ge min-jie wei Department of General Surgery The First Affiliated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Intensive Care Unit The Central Affiliated Hospital of Shenyang Medical CollegeShenyang 110024Liaoning ProvinceChina Department of Pharmacology School of PharmacyChina Medical UniversityShenyang 110122Liaoning ProvinceChina

BACKGROUND Recent studies have proved the important role of many oncogenic long noncoding RNAs(lncRNAs) in the progression of pancreatic cancer, but little is known about the mechanisms of tumor suppression in pancreatic *** To evaluate the function of tumor suppressor lncRNA C9orf139 in pancreatic cancer progression and to study the underlying *** We assigned 54 patients with pancreatic ductal adenocarcinoma treated at our hospital to the patient group and 30 normal subjects undergoing physical examination to the control group. RT-qPCR was used to measure the relative expression of C9orf139 in the tissue and serum of patients, in an attempt to investigate the prognostic value of C9orf139 in pancreatic cancer patients. The luciferase reporter gene assay was performed to determine the interaction between C9orf139 and miR-663 a. The biological function of C9orf139 was assessed by in vitro assays and in vivo subcutaneous tumor formation tests in animal models. To figure out the molecular mechanism of C9orf139 to act on miR-663 a/Sox12, RNA pull-down, Western blot assay, RNA immunoprecipitation assay, and co-immunoprecipitation assay were *** C9orf139 level significantly increased in the tissue and serum of patients, which had clinical diagnostic value for pancreatic cancer. Patients with high C9orf139 expression had a higher risk of progressing to stage Ⅲ + Ⅳ, lymph node metastasis, and poor differentiation. Cox regression analysis suggested that C9orf139, tumor-node-metastasis stage, and lymph node metastasis were independent prognostic factors in patients. The underlying mechanism of C9orf139 was that it promoted the growth of pancreatic cancer cells by modulating the miR-663 a/Sox12 *** C9orf139 is highly expressed in pancreatic cancer, qualified to be used as a potential diagnostic and prognostic marker for pancreatic cancer. Its promotion of pancreatic cancer cell growth is achieved by mediating the miR-663 a/Sox12 ax

关键词： C9orf139 miR-663a Sox12 Pancreatic cancer Prognosis Tumor formation in nude mice

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BRAF and KRAS mutations in metastatic colorectal cancer:future perspectives for personalized therapy

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Gastroenterology Report 2020年第3期8卷 192-205,I0001页

作者： Zi-Nan Li Lin Zhao Li-Feng Yu min-jie wei Department of Pharmacology School of PharmacyChina Medical UniversityShenyangLiaoningP.R.China Liaoning Engineering Technology Research Center China Medical UniversityShenyangLiaoningP.R.China

Colorectal cancer(CRC)is one of the most commonly diagnosed cancers worldwide and 30%of patients with CRC experience *** with metastatic colorectal cancer(mCRC)have a 5-year overall survival rate of<10%.V-raf murine sarcoma viral oncogene homolog B1(BRAF)and V-Ki-ras2 Kirsten ratsarcoma viral oncogene homolog(KRAS)mutations are mostly studied in mCRC,as clinical trials found that first-line chemotherapy with anti-epidermal growth factor receptor agent confers limited efficacy for *** decisions for early-stage mCRC do not consider BRAF or KRAS mutations,given the dramatically poor prognosis conferred by these mutations in clinical ***,it is necessary to identify patients with mCRC harboring BRAF or KRAS mutations to formulate rational therapeutic strategies to improve prognosis and *** and KRAS mutations occur in10%and44%of patients with mCRC,*** the survival rate of patients with mCRC has improved in recent years,the response and prognosis of patients with the aforementioned mutations are still *** is a substantial unmet need for prospective personalized therapies for patients with BRAF-or KRAS-mutant *** this review,we focus on BRAF and KRAS mutations to understand the mechanisms underlying resistance and improving the response rate,outcomes,and prognosis of patients with mCRC bearing these mutations and to discuss prospective personalized therapies for BRAF-and KRAS-mutant mCRC.

关键词： metastatic colorectal cancer epidermal growth factor receptor KRAS mutation BRAF mutation personalized therapy

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Macroscopic polarization enhancement boosting piezo-photocatalytic performance via Nb-doping on B-site of Bi_(4)Ti_(3)O_(12)nanosheets

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Journal of Advanced Ceramics 2024年第4期13卷 437-446页

作者： Hongjian Yu Xindong wei min Wang Yan Zhang Zheng Wu Fan Guo jie Han School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Engineering Research Center of ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastesNational Laboratory of Mineral MaterialsSchool of Material Sciences and TechnologyChina University of Geosciences(Beijing)Beijing 100083China School of Environmental and Chemical Engineering Xi’an Key Laboratory of Textile Chemical Engineering AuxiliariesXi'an Polytechnic UniversityXi'an 710048China

The development of a high-performance ferroelectric piezo-photocatalyst is an efficient strategy for advancing sustainability within the environmental and energy ***,a major challenge lies in the creation of a strong polarized electric field that can effectively hinder charge recombination,both within the bulk and on the surface of ***,we synthesize a series of Nb-doped Bi_(4)Ti_(3)O_(12)nanosheets via a facile one-pot hydrothermal method to achieve synergistically enhanced piezo-photocatalytic performance in CO_(2)reduction and pollutant *** optimized doped Bi_(4)Ti_(3)O_(12)demonstrates remarkable efficiency in the conversion of CO_(2)into CO,with a high production rate of 72.7μmol∙g−1∙h−1 without using co-catalysts or any sacrificial agent,surpassing the performance of unmodified Bi_(4)Ti_(3)O_(12)by up to 4.69 ***,our catalyst demonstrates ultra-fast piezo-photocatalytic degradation of organic pollutant Rhodamine B(RhB)at low concentrations and exceptional piezo-photocatalytic activity at high concentrations,outperforming most previously reported state-of-the-art *** systematic corroboration of catalyst characterization and experimental analysis reveals that the synergistic effect arises from the amplified macroscopic polarization induced by lattice distortion caused by the larger Nb ions,thereby improving piezo-photocatalytic *** research thus offers valuable insights into the direct design and fabrication of versatile catalytic systems,with applications spanning CO_(2)valorization and beyond.

关键词： CO_(2)reduction dye degradation piezo-photocatalysis Nb-doped Bi_(4)Ti_(3)O_(12) macroscopic polarization regulation

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Infrared microspectroscopy beamline BL06B at SSRF

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Nuclear Science and Techniques 2024年第1期35卷 10-17页

作者： Te Ji Hua-Chun Zhu wei-wei Peng jie Wang Hong-wei Zhao Ai-Guo Li min Chen Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China

The infrared microspectroscopy beamline(BL06B) is a phase Ⅱ beamline project at the Shanghai Synchrotron Radiation Facility(SSRF). The construction and optical alignment of BL06B were completed by the end of 2020. By 2021, it became accessible to users. The synchrotron radiation infrared(SRIR) source included edge radiation(ER) and bending magnet radiation(BMR). The extracted angles in the horizontal and vertical directions were 40 and 20 mrad, respectively. The photon flux, spectral resolution, and focused spot size were measured at the BL06B endstation, and the experimental results were consistent with theoretical calculations. SRIR light has a small divergence angle, high brightness, and a wide wavelength range. As a source of IR microscopy, it can easily focus on a diffraction-limited spatial resolution with a high signal-to-noise ratio(SNR). The BL06B endstation can be applied in a wide range of research fields, including materials, chemistry, biology, geophysics, and pharmacology.

关键词： Synchrotron radiation Infrared beamline Infrared microspectroscopy

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Low Surface Brightness Galaxies Selected by Different Model Fitting

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Research in Astronomy and Astrophysics 2024年第1期24卷 223-236页

作者： Bing-Qing Zhang Hong Wu wei Du Pin-Song Zhao min He Feng-jie Lei Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

We present a study of low surface brightness galaxies(LSBGs) selected by fitting the images for all the galaxies inα.40 SDSS DR7 sample with two kinds of single-component models and two kinds of two-component models(disk+bulge):single exponential,single sersic,exponential+deVaucular(exp+deV),and exponential+sérsic(exp+ser).Under the criteria of the B band disk central surface brightness μ_(0,disk)(B)≥22.5 mag arcsec^(-2) and the axis ratio b/a> 0.3,we selected four none-edge-on LSBG samples from each of the models which contain 1105,1038,207,and 75 galaxies,*** are 756 galaxies in common between LSBGs selected by exponential and sersic models,corresponding to 68.42% of LSBGs selected by the exponential model and 72.83% of LSBGs selected by the sersic model,the rest of the discrepancy is due to the difference in obtaining μ_(0) between the exponential and sersic *** on the fitting,in the range of 0.5≤n≤1.5,the relation of μ_(0) from two models can be written as μ_(0,sérsic)-μ_(0,exp)=-1.34(n-1).The LSBGs selected by disk+bulge models(LSBG_(2)comps) are more massive than LSBGs selected by single-component models(LSBG_1comp),and also show a larger disk *** the bulges in the majority of our LSBG_(2)comps are not prominent,more than 60% of our LSBG_(2)comps will not be selected if we adopt a single-component model *** also identified 31 giant low surface brightness galaxies(gLSBGs) from LSBG_(2)*** are located at the same region in the color-magnitude diagram as other *** we compared different criteria of gLSBGs selection,we find that for gas-rich LSBGs,M_(*)> 10^(10)M_⊙ is the best to distinguish between gLSBGs and normal LSBGs with bulge.

关键词： catalogs galaxies:spiral galaxies:bulges methods:data analysis methods:statistical

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