检索结果-南通市图书馆

C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients

引用

World Journal of Gastrointestinal Oncology 2024年第1期16卷 61-78页

作者： Bai-Bei Li Lei-jie Chen shi-Liu Lu Biao Lei Gui-Lin Yu Shui-Ping Yu Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021Guangxi Zhuang Autonomous RegionChina Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology The Second Xiangya Hospital of Central South UniversityNanning 410011Guangxi Zhuang Autonomous RegionChina Department of Emergency The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Over the years,programmed cell death-1(PD-1)inhibitors have been routinely used for hepatocellular carcinoma(HCC)treatment and yielded improved survival ***,significant heterogeneity surrounds the outcomes of most ***,it is critical to search for biomarkers that predict the efficacy of PD-1 inhibitors in patients with *** To investigate the role of the C-reactive protein to albumin ratio(CAR)in evaluating the efficacy of PD-1 inhibitors for *** The clinical data of 160 patients with HCC treated with PD-1 inhibitors from January 2018 to November 2022 at the First Affiliated Hospital of Guangxi Medical University were retrospectively *** The optimal cut-off value for CAR based on progression-free survival(PFS)was determined to be 1.20 using x-tile *** proportional risk model was used to determine the factors affecting *** Cooperative Oncology Group performance status[hazard ratio(HR)=1.754,95%confidence interval(95%CI)=1.045-2.944,P=0.033],CAR(HR=2.118,95%CI=1.057-4.243,P=0.034)and tumor number(HR=2.932,95%CI=1.246-6.897,P=0.014)were independent prognostic factors for overall ***(HR=2.730,95%CI=1.502-4.961,P=0.001),tumor number(HR=1.584,95%CI=1.003-2.500,P=0.048)and neutrophil to lymphocyte ratio(HR=1.120,95%CI=1.022-1.228,P=0.015)were independent prognostic factors for *** nomograms were constructed based on independent prognostic *** C-index index and calibration plots confirmed that the nomogram is a reliable risk prediction *** ROC curve and decision curve analysis confirmed that the nomogram has a good predictive effect as well as a net clinical *** Overall,we reveal that the CAR is a potential predictor of short-and long-term prognosis in patients with HCC treated with PD-1 *** further verified,CAR-based nomogram may increase the number of markers that predict individualized prognosis.

关键词： C-reactive protein to albumin ratio Hepatocellular carcinoma Programmed cell death-1 inhibitors Prognosis Nomogram

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Primary pancreatic peripheral T-cell lymphoma:A case report

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1668-1675页

作者： Yan-Liang Bai Li-jie Wang Hui Luo Ya-Bin Cui Jin-Hui Xu Hui-jie Nan Pei-Yao Yang Jun-Wei Niu Ming-Yue shi Department of Hematology Zhengzhou University People's Hospital and Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina Department of Hematology Henan University People's Hospital and Henan Provincial People's HospitalZhengzhou 450003Henan ProvinceChina Department of Radiation Oncology The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008Henan ProvinceChina

BACKGROUND Primary pancreatic lymphoma(PPL)is an exceedingly rare tumor with limited mention in scientific *** clinical manifestations of PPL are often nonspecific,making it challenging to distinguish this disease from other panc-reatic-related *** remains the primary treatment for these *** SUMMARY In this case study,we present the clinical details of a 62-year-old woman who initially presented with vomiting,abdominal pain,and dorsal *** further evaluation through positron emission tomography-computed tomography,the patient was considered to have a pancreatic head ***,subsequent endoscopic ultrasonography-guided fine needle aspiration(EUS-FNA)revealed that the patient had pancreatic peripheral T-cell lymphoma,not otherwise specified(PTCL-NOS).There was a substantial decrease in the size of the pancreatic mass after the patient underwent a cycle of chemotherapy comprised of brentuximab vedotin,decitabine,and oxaliplatin(brentuximab vedotin and Gemox).The patient had significant improvement in radiological findings at the end of the first *** Primary pancreatic PTCL-NOS is a malignant and heterogeneous lymphoma,in which the clinical manifestations are often *** is difficult to diagnose,and the prognosis is *** can only be used for auxiliary diagnosis of other *** the help of immunostaining,EUS-FNA could be used to aid in the diagnosis of *** a clear diagnosis,chemotherapy is still the first-line treatment for such patients,and surgical resection is not recommended.A large number of recent studies have shown that the CD30 antibody drug has potential as a therapy for several types of ***,identifying new CD30-targeted therapies for different types of lymphoma is urgently *** the future,further research on antitumor therapy should be carried out to improve the survival prognosis of such patients.

关键词： Pancreatic cancer Lymphoma Chemotherapy Primary pancreatic lymphoma Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Juvenile hormone induces reproduction via miR-1175-3p in the red imported fire ant, Solenopsis invicta

引用

Insect Science 2024年第2期31卷 371-386页

作者： jie Chen Ziying Guan Yunjie Ma Qingxing shi Ting Chen Muhammad Irfan WarisLihua Lyu Lihua Lyu Yongyue Lu Guojun Qi Institute of Plant Protection Guangdong Academy of Agricultural SciencesKey Laboratory of Green Prevention and Control on Fruits and Vegetables in South China Ministry of Agriculture and Rural AffairsGuangdong Provincial Key Laboratory of High Technology for Plant ProtectionGuangzhouChina Department of Entomology College of Plant ProtectionSouth China Agricultural UniversityGuangzhouChina

Juvenile hormone(JH)acts in the regulation of caste differentiation between queens and workers(i.e.,with or without reproductive capacity)during vitellin synthesis and oogenesis in social ***,the regulatory mechanisms have not yet been ***,we identified a highly expressed microRNA(miRNA),miR-1175-3p,in the red imported fire ant,Solenopsis *** found that miR-1175-3p is prominently present in the fat bodies and ovaries of ***,miR-1175-3p interacts with its target gene,broad-complex core(Br-C),in the fat *** utilizing miR-1175-3p agomir,we successfully suppressed the expression of the Br-C protein in queens,resulting in reduced vitellogenin expression,fewer eggs,and poorly developed ***,decreasing miR-1175-3p levels led to the increased expression of Br-C and vitellogenin in workers,triggering the“re-development”of the ***,when queens were fed with JH,the expression of miR-1175-3p decreased,whereas the expression of vitellogenin-2 and vitellogenin-3 ***,the suppression of fertility in queens caused by treatment with agomir miR-1175-3p was completely rescued by the increased vitellogenin expression induced by being fed with *** results suggest the critical role of miR-1175-3p in JH-regulated reproduction,shedding light on the molecular mechanism underlying miRNA-mediated fecundity in social insects and providing a novel strategy for managing ***.

关键词： juvenile hormone miR-1175-3p red imported fire ant reproduction social insects vitellogenin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research progress on venous thrombosis development in patients with malignant tumors

引用

World Journal of Clinical Cases 2024年第11期12卷 1900-1908页

作者： Teng-Fei Wang Qian Chen jie Deng shi-Liang Li Yuan Xu Si-Xing Ma Department of Vascular Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina Department of Organ Transplantation The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

The coexistence of venous thromboembolism(VTE)within patients with cancer,known as cancer-associated thrombosis(CAT),stands as a prominent cause of mortality in this *** recent years,the incidence of VTE has demonstrated a steady increase across diverse tumor types,influenced by several factors such as patient management,tumor-specific risks,and treatment-related ***,mutations in specific genes have been identified as potential contributors to increased CAT occurrence in particular cancer *** conducted an extensive review encompassing pivotal historical and ongoing studies on *** review elucidates the risks,mechanisms,reliable markers,and risk assessment methodologies that can significantly guide effective interventions in clinical practice.

关键词： Malignant tumor Venous thromboembolism Cancer-associated thrombosis Research progress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Emerging role of exosomes in ulcerative colitis: Targeting NOD-like receptor family pyrin domain containing 3 inflammasome

引用

World Journal of Gastroenterology 2024年第6期30卷 527-541页

作者： Xin Li Li-Jiang Ji Kai-Di Feng Hua Huang mei-Rou Liang shi-Jin Cheng Xiu-Dong Meng School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550025Guizhou ProvinceChina Department of Anorectal Surgery Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu 215500Jiangsu ProvinceChina College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China

Ulcerative colitis(UC)is a chronic recurrent inflammatory bowel *** ongoing advances in our understanding of UC,its pathogenesis is yet unelu-cidated,underscoring the urgent need for novel treatment strategies for patients with *** are nanoscale membrane particles that mediate intercellular communication by carrying various bioactive molecules,such as proteins,RNAs,DNA,and *** NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome is a cytosolic tripartite protein complex whose activation induces the maturation and secretion of proinflammatory cytokines interleukin-1β(IL-1β)and IL-18,triggering the inflammatory response to a pathogenic agent or *** evidence suggests that exosomes are new modulators of the NLRP3 inflammasome,with vital roles in the pathological process of ***,recent evidence is reviewed on the role of exosomes and NLRP3 inflammasome in ***,the dual role of exosomes on NLRP3 inflammasome and the effect of NLRP3 inflammasome on exosome secretion are ***,an outlook on the directions of exosome-NLRP3 inflammasome crosstalk research in the context of UC is proposed and areas of further research on this topic are high-lighted.

关键词： Ulcerative colitis Exosomes Inflammasome Evidence Therapeutics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural product-induced oxidative stress-synergistic anti-tumor effects of chemotherapeutic agents

引用

Traditional Medicine Research 2024年第3期9卷 10-23页

作者： Shu-Fan Wang shi-Qi Dong Quan Dong Wen-Xin Lin mei Dong Duo Liu Department of Pharmacy Harbin Medical University Cancer HospitalHarbin 150086China

Reactive oxygen species are closely related to tumor *** recent years,reactive oxygen species has become a hot spot in tumor therapy,and many natural substances in nature contain compound components with anti-tumor ***,there is a lack of discussion on the synergistic anti-tumor effects of natural products in combination with chemotherapeutic drugs through reactive oxygen *** terms“natural products”,“reactive oxygen species”,“anti-tumor”,and“chemotherapy”were used to identify the synergistic effects of natural *** conducted a systematic literature search in PubMed and Web of Science databases for relevant research articles and reviews published in recent *** systematically summarized the studies related to anti-tumor active ingredients in natural compounds in the field of reactive oxygen species in recent years.A total of 77 relevant literatures were *** them,45 literatures containing various natural products such as terpenoids,flavonoids,alkaloids,*** anti-tumor effects by regulating reactive oxygen species levels,and 32 literatures regarding adjunctive role of natural products in anti-tumor *** this study,we found that natural products exert anti-tumor effects by elevating reactive oxygen species *** provides strong theoretical support for future clinical studies.

关键词： nature products tumor reactive oxygen species combination chemotherapy oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The MYC2-PUB22-JAZ4 module plays a crucial role in jasmonate signaling in tomato

引用

Molecular Plant 2024年第4期17卷 598-613页

作者： Shaofang Wu Chaoyi Hu Changan Zhu Yanfen Fan jie Zhou Xiaojia Xia Kai shi Yanhong Zhou Christine H.Foyer Jingquan Yu Department of Horticulture Zijingang CampusZhejiang UniversityHangzhou 310058China Hainan Institute Zhejiang UniversityYazhou Bay Science and Technology CitySanya 572025China College of Horticulture Northwest Agriculture&Forestry UniversityXianyang 712100China School of Biosciences College of Life and Environmental SciencesUniversity of BirminghamEdgbaston B152TTUK Key Laboratory of Horticultural Plants Growth and Development Agricultural Ministry of ChinaZhejiang UniversityHangzhou 310058China

Jasmonates(JAs),a class of lipid-derived stress hormones,play a crucial role across an array of plant physiological processes and stress *** JA signaling is thought to rely predominantly on the degradation of specific JAZ proteins by SCF^(COI1),it remains unclear whether other pathways are involved in the regulation of JAZ protein ***,we report that PUB22,a plant U-box type E3 ubiquitin ligase,plays a critical role in the regulation of plant resistance against Helicoverpa armigera and other JA responses in *** COI1 physically interacts with JAZ1/2/5/7,PUB22 physically interacts with JAZ1/3/4/***22 ubiquitinates JAZ4 to promote its degradation via the 26S proteasome ***,we observed that pub22 mutants showreduced resistance to ***,whereas jaz4 single mutants and jaz1 jaz3 jaz4 jaz6 quadruple mutants have enhanced *** hypersensitivity of pub22 mutants to herbivores could be partially rescued by JAZ4 ***,we found that expression of PUB22 can be transcriptionally activated by MYC2,thus forming a positive feedback circuit in JA *** noticed that the PUB22-JAZ4 module also regulates other JA responses,including defense against ***,inhibition of root elongation,and anthocyanin *** together,these results indicate that PUB22 plays a crucial role in plant growth and defense responses,together with COI1-regulated JA signaling,by targeting specific JAZs.

关键词： PUB22 JAZ COI1 MYC2 JA signaling Solanum lycopersicum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Al-doped ZnO/WO_(3) heterostructure films prepared by magnetron sputtering for isopropanol sensors

引用

Rare Metals 2024年第1期43卷 247-256页

作者： Wei-Xiang Gao Xue-Ting Chang Xiao-jie Zhu Jun-Feng Li Ying-Chang Jiang Dong-Sheng Wang Chuan-Xiao Yang shi-Bin Sun College of Logistics Engineering Shanghai Maritime UniversityShanghai 201306China College of Ocean Science and Engineering Shanghai Maritime UniversityShanghai 201306China Institute of Logistics Science and Engineering Shanghai Maritime UniversityShanghai 201306China

Metal oxide semiconductors(MOSs) are ideal sensing materials for detecting volatile organic compounds due to their low cost, diversity, high stability, and ease of production. However, it remains a grand challenge to develop the MOSs-based gas sensors for sensing isopropanol with desired performance via a simple, effective,and controllable method. Herein, we reported the preparation of the Al-doped Zn O(AZO)/WO_(3) heterostructure films by directly depositing the AZO coating onto the WO_(3) coating using a strategy of magnetron sputtering. The AZO/WO_(3) heterostructure films were constructed by numbers of irregular nanoparticles that were interconnected with each other. The AZO/WO_(3) heterostructure films-based gas sensors exhibited excellent isopropanolsensing performance with high response, promising selectivity, low detection limit, fast response rate, wide detection range, and ideal reproducibility. The promising isopropanol-sensing performance of the AZO/WO_(3) heterostructure films arises mainly from their high uniformity, unique microstructures with high surface roughness,and the construction of the heterostructure between the AZO and WO_(3) coatings. This work provides a versatile approach to prepare the MOSs-based heterostructure films for assembling the gas sensors.

关键词： Metal oxide semiconductors Gas sensors Aldoped ZnO/WO_(3) Heterostructure films Isopropanol Magnetron sputtering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Warming intensified the effects of nitrogen addition on N_(2)O emissions from alpine meadow in the northern Qinghai-Tibet Plateau

引用

Advances in Climate Change Research 2024年第1期15卷 101-112页

作者： Ming-jie LI Yi-Qing GE Hasbagan GANJURJAV Guo-Zheng HU Hong-Bao WU Jun YAN shi-Cheng HE Qing-Zhu GAO Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China National Agricultural Experimental Station for Agricultural Environment Nagqu 852100China Ecology and Nature Conservation Institute Chinese Academy of ForestryBeijing 100091China College of Resource and Environment Anhui Science and Technology UniversityFengyang 233100China Nagqu Agriculture Animal Husbandryand Prataculture Science and Technology Research and Extension CenterNagqu 852100China Tongliao Experimental Middle School Tongliao 028000China

Warming and nitrogen(N)addition may impact soil nitrous oxide(N_(2)O)emissions,but the relationship between plant community composition and soil microbial activities remains *** a two-year field study in the Qinghai-Tibet Plateau,open-top chambers were used to quantify the effects of warming,N-addition,and their interactions on N_(2)O *** found that the N-addition greatly increased N_(2)O emissions by 77.4%in 2018 when compared to the control *** contrast,warming showed little effect on N_(2)0 emissions but did increase the activity of enzymes associated with soil nitrification and denitrification.A combined effect of warming and N-addition of resulted in 208.6%(2018)and 90.8%(2019)increase in N_(2)0 emissions,respectively,compared to the individual treatments of warming or *** warming in alpine meadows is causally linked to increased legume biomass which is further intensified with the *** legume biomass(p<0.05),soil moisture(p<0.001)and enzyme activity(p<0.001)had a positive effect on N_(2)0 emissions,while diminished microbial carbon/nitrogen(MBC/MBN)(p<0.05)correlated with reduced N_(2)O *** results indicated that N-addition has a positive effect on N_(2)O emissions,and the addition of warming further intensifies this *** increased dominance of legumes and microbial N content contributes to this *** outcomes suggest that warming and atmospheric N deposition can stimulate N_(2)O emissions of alpine meadows inthefuture.

关键词： Alpine meadow Community composition Nitrogen addition Nitrous oxide flux Qinghai-Tibet Plateau Warming

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of desert plant communities on soil enzyme activities and soil organic carbon in the proluvial fan in the eastern foothills of the Helan Mountain in Ningxia,China

引用

Journal of Arid Land 2024年第5期16卷 725-737页

作者： SHEN Aihong shi Yun MI Wenbao YUE Shaoli SHE jie ZHANG Fenghong GUO Rui HE Hongyuan WU Tao LI Hongxia ZHAO Na College of Forestry and Prataculture of Ningxia University Yinchuan 750021China School of Geography and Planning of Ningxia University Yinchuan 750021China Ningxia Hui Autonomous Region Agricultural Comprehensive Development Center Yinchuan 750002China Ningxia Helan Mountain National Nature Reserve Administration Yinchuan 750021China Yinchuan Yinxi Ecological Protection Forest Management Center Yinchuan 750002China

It is of great significance to study the effects of desert plants on soil enzyme activities and soil organic carbon(SOC)for maintaining the stability of the desert *** this study,we studied the responses of soil enzyme activities and SOC fractions(particulate organic carbon(POC)and mineral-associated organic carbon(MAOC))to five typical desert plant communities(Convolvulus tragacanthoides,Ephedra rhytidosperma,Stipa breviflora,Stipa tianschanica ***,and Salsola laricifolia communities)in the proluvial fan in the eastern foothills of the Helan Mountain in Ningxia Hui Autonomous Region,*** recorded the plant community information mainly including the plant coverage and herb and shrub species,and obtained the aboveground biomass and plant species diversity through sample surveys in late July *** samples were also collected at depths of 0–10 cm(topsoil)and 10–20 cm(subsoil)to determine the soil physicochemical properties and enzyme *** results showed that the plant coverage and aboveground biomass of *** community were significantly higher than those of ***,***,and *** *** communities(P<0.05).Soil enzyme activities varied among different plant *** the topsoil,the enzyme activities of alkaline phosphatase(ALP)andβ-1,4-glucosidas(βG)were significantly higher in *** and *** *** communities than in other plant communities(P<0.05).The topsoil had higher POC and MAOC contents than the ***,the content of POC in the topsoil was 18.17%–42.73%higher than that in the *** structural equation model(SEM)indicated that plant species diversity,soil pH,and soil water content(SWC)were the main factors influencing POC and *** soil pH inhibited the formation of POC and promoted the formation of ***,SWC stimulated POC production and hindered MAOC *** study aimed to gain insight into the effects of desert plant c

关键词： proluvial fan desert plant community soil enzyme activity particulate organic carbon mineral-associated organic carbon Helan Mountain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：