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p75 neurotrophin receptor signal pathway influence on apoptosis in anterior horn neurons of the spinal cord in a rat model of cauda equina compression injury

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Neural Regeneration Research 2009年第12期4卷 979-985页

作者： Haopeng li jie chen Xijing He Siyue Xu Yu liu Department of Orthopaedics Second Affiliated Hospital College of Medicine Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China

BACKGROUND： Studies have demonstrated that cauda equina compression results in apoptosis of motor neurons in the spinal cord. The combination of p75 neurotrophin receptor （p75NTR） and precursor of nerve growth factor （pro-NGF） expression initiates the apoptotic pathway and induces neuronal apoptosis. However, few reports have focused on the p75-mediated mechanism of neuronal apoptosis following cauda equine compression injury OBJECTIVE： To determine apoptosis of spinal cord neurons and activation of the pro-NGF-p75NTR-JNK（c-Jun N-terminal kinase） signal pathway in rats following cauda equina compression, and to verify experimental outcomes. DESIGN, TIME AND SETTING： A randomized, controlled, in vivo experiment was performed at the Medical Experimental Center of Xi＇an Jiaotong University between April and November in 2008. MATERIALS： Streptavidin-perosidase kit was purchased from Wuhan Boster, China; in situ end labeling detection kit was provided by Promega, USA; type AEG-220G electron microscope was purchased from Hitachi, Japan. METHODS： A total of 48 healthy, adult, female, Sprague Dawley rats were randomly assigned to three groups： normal （n = 6）, sham-surgery （n = 6）, and compression （n = 36）. The compression group was randomly assigned to six subsets at 1,3, 5, 7, 14, and 28 days, respectively, with 6 rats in each subset. A cylindrical silica gel stick was implanted into the rats to compress 75% of the vertebral canal in the compression group; in the sham-surgery group, only vertebral resection was performed; and no procedures were performed in the normal group. MAIN OUTCOME MEASURES： At 1,3, 5, 7, 14, and 28 days following compression, L2-3 spinal cord segments were processed for immunohistochemistry, in situ cell apoptosis detection, and transmission electron microscopy observation. Nissl staining was used to observe neuronal survival in the L2 spinal cord segment. Immunohistochemistry was applied to detect expressions of pro-NGF, p75NTR, and JNK in the L2 s

关键词： cauda equina syndrome p75 neurotrophin receptor spinal cord neurons apoptosis anterior horn

Cyano migration-mediated radical-polar crossover cyclopropanation

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Science China Chemistry 2025年第1期68卷 241-248页

作者： Ziqiang Wang Yasu chen jie li chen Zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials ScienceSoochow University Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.

关键词： cyclopropanation cyano migration radical-polar crossover radical reactions

Decreased numbers of circulating endothelial progenitor cells are associated with hyperglycemia in patients with traumatic brain injury

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Neural Regeneration Research 2019年第6期14卷 984-990页

作者： Hui-jie Wei li liu Fang-lian chen Dong Wang liang Wang Zeng-Guang Wang Rong-Cai Jiang Jing-Fei Dong jie-li chen Jian-Ning Zhang Department of Neurosurgery Tianjin Medical University General HospitalTianjin Neurological InstituteKey Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous SystemMinistry of EducationTianjin Key Laboratory of InjuriesVariations and Regeneration of Nervous System Department of Neurosurgery Peking University International Hospital Thrombosis Research Section Department of MedicineBaylor College of Medicine Department of Neurology Henry Ford Health System

Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their ***, the relationship between blood glucose levels and endothelial progenitor cells in peripheral blood of patients with traumatic brain injury is unclear. In this study, 101 traumatic brain injury patients admitted to the Department of Neurosurgery, Tianjin Medical University General Hospital or the Department of Neurosurgery, Tianjin Huanhu Hospital, China, were enrolled from April 2005 to March 2007. The number of circulating endothelial progenitor cells and blood glucose levels were measured at 1, 4, 7, 14 and 21 days after traumatic brain injury by flow cytometry and automatic biochemical analysis, respectively. The number of circulating endothelial progenitor cells and blood sugar levels in 37 healthy control subjects were also examined. Compared with controls, the number of circulating endothelial progenitor cells in traumatic brain injury patients was decreased at 1 day after injury, and then increased at 4 days after injury,and reached a peak at 7 days after injury. Compared with controls, blood glucose levels in traumatic brain injury patients peaked at 1 day and then decreased until 7 days and then remained stable. At 1, 4, and 7 days after injury, the number of circulating endothelial progenitor cells was negatively correlated with blood sugar levels(r =-0.147, P lial progenitor cells. This study was approved by the Ethical Committee of Tianjin Medical University General Hospital, China(approval No. 200501) in January 2015.

关键词： nerve regeneration endothelial progenitor cells vascular repair vascular remodeling angiogenesis neovascularization blood glucose hyperglycemia traumatic brain injury mobilization suppression senescence alternative therapy brain damage neural regeneration

PROPERTIES OF NATURAL CAVITATION FLOWS AROUND A 2-D WEDGE IN SHALLOW WATER

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Journal of Hydrodynamics 2011年第6期23卷 730-736页

作者： chen Xin LU Chuan-jing li jie chen Ying Department of Engineering Mechanics Shanghai Jiao Tong University Shanghai 200240 China Department of Engineering Mechanics and State Key Laboratory of Ocean Engineering Shanghai Jiao Tong University Shanghai 200240 China

When a body navigates with cavity in shallow water, both flexible free surface and rigid bottom wall will produce great influences on the cavity shape and hydrodynamic performances, and further affect the motion attitude and stability of the body. In the present work, characteristics of the natural cavitating flow around a 2-D symmetrical wedge in shallow water were investigated and the influences of two type boundaries on the flow pattern were analyzed. The Volume Of Fluid （VOF） multiphase flow method which is suitable for free surface problems was utilized, coupled with a natural cavitation model to deal with the mass-transfer process between liquid and vapor phases. Within the range of the cavitation number for computation （0.07-1.81）, the cavity configurations would be divided into three types, viz., stable type, transition type and wake-vortex type. In this article, the shapes of the free surface and the cavity surface, and the hydrodynamic performance of the wedge were discussed under the conditions of relatively small cavitation number （〈0.256）. The present numerical cavity lengths generally accord with experimental data. When the cavitation number was decreased, the cavity was found to become longer and thicker, and the scope of the deformation of the free surface also gradually extends. The free surface and the upper cavity surface correspond fairly to their shapes. However, the lower side of the cavity surface was rather leveled due to the influence of wall boundary. The lift and drag coefficients of this 2-D wedge basically keep linear relations with the natural cavitation number smaller than 0.157, whereas direct proportion for drag and inverse proportion for lift.

关键词： shallow water natural cavitation boundary effect multiphase flow

Influence of Isotope Substitution Helium Atom on Partial Cross Sections in He-HF Collisions

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Communications in Theoretical Physics 2009年第11期52卷 924-928页

作者： YU Chun-Ri ZHANG jie chen li JIANG Gui-Sheng HUANG Guo-Dong School of Physics ＆ Electric Engineering Anqing Teachers College Anqing 246133 China

Close-coupling equation and anisotropic potential developed in our previous research are applied to HE-SHe （4He, 6He, 8He,10He） collision system, and partial cross sections （PCSs） at the incident energy of 40 me V are calculated. By analyzing the differences of these PCSs, change rules of PCSs with the increase of partial wave number, and with the change of the mass of isotope substitution helium atom are obtained. The results show that excitation PCSs converge faster than elastic PCSs for collision energy and each of systems considered here. Also excitation PCSs converge more rapidly for high-excited states. Tail effect is present only in elastic scattering and low-excited states but not in high- excited states. With the increase of the mass of isotope substitution helium atom, converging speed of elastic, total inelastic, and state-to-state excitation PCS slows down, and the maxima of these PCSs undergoes a regular change.

关键词： isotope substitution partial cross section close-coupling equation He-HF collision

Cold water swimming pretreatment reduces cognitive deficits in a rat model of traumatic brain injury

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Neural Regeneration Research 2017年第8期12卷 1322-1328页

作者： Zi-wei Zhou Ya-dan li Wei-wei Gao jie-li chen Shu-yuan Yue Jian-ning Zhang Department of Neurosurgery Tianjin Medical University General Hospital Tianjin China Tianjin Neurological Institute Tianjin China Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System Ministry of Education Tianjin China Tianjin Key Laboratory of Injuries Variations and Regeneration of Nervous System Tianjin China Intensive Care Units Tianjin Huanhu Hospital Tianjin China Department of Neurology Henry Ford Hospital Detroit MI USA

A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and explored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats（cold water swimming for 3 minutes at 4℃） spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34~＋ stem cells and new blood vessels in the injured hippocampus tissue increased significantly in pre-conditioned rats. These data suggest that pretreatment with cold water swimming could promote the proliferation of endothelial progenitor cells and angiogenesis in the peripheral blood and hippocampus. It also ameliorated cognitive deficits caused by experimental traumatic brain injury.

关键词： nerve regeneration cold water swimming cognitive deficits endothelial progenitor cells angiogenesis neural repair stress Morriswater maze fluid percussion injury model CD34 Von Willebrand factor neural regeneration

Expression of PIN Genes in Rice （Oryza sativa L.）： Tissue Specificity and Regulation by Hormones

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Molecular Plant 2009年第4期2卷 823-831页

作者： Ji-Rong Wang Han Hu Gao-Hang Wang Jing li jie-Yu chen Ping Wu State Key Laboratory of Plant Physiology and Biochemistry College of Life Sciences Zi Jin Gang Campus Zhejiang University Hangzhou 310058 People's Republic of China

Twelve genes of the PIN family in rice were analyzed for gene and protein structures and an evolutionary relationship with reported AtPINs in Arabidopsis. Four members of PIN1 （designated as OsPINla-d）, one gene paired with AtPIN2 （OsPIN2）, three members of PIN5 （OsPIN5a-c）, one gene paired with AtPIN8 （OsPIN8）, and three monocot-specific PINs （OsPIN9, OsPINIOa, and b） were identified from the phylogenetic analysis. Tissue-specific expression patterns of nine PIN genes among them were investigated using RT-PCR and GUS reporter. The wide variations in the expression domain in different tissues of the PIN genes were observed. In general, PIN genes are up-regulated by exogenous auxin, while different responses of different PIN genes to other hormones were found.

关键词： Oryza sativa L. PIN family expression pattern.

Descriptions of two new record species of Scutellonema (Nematoda:Tylenchida) from China

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Zoological Research 2014年第1期35卷 72-74页

作者： Hong-Yu TIAN Xiao-Feng ZHU Yu-Xi DUAN li-jie chen Nematology Institute of Northern China College of Plant ProtectionShenyang Agricultural University

From 2011 to 2012, we collected Scutellonema commune from the rhizosphere soil of coconut （cocos nucifera L.） and Scutellonema magniphasma from the rhizosphere soil of Rosa chinensis in Shenyang, China. S. commune was characterized by rounded scutella, which was varied from two annules anterior to the anus and five annules posterior. The lateral field was not areolated at the level of scutella. S. magniphasma was characterized by varying scutellum, about 7.0 μm in diameter, in position from four annules posterior to four annules anterior to the anus, and areolated at the level of the scutellum.

关键词： Hoplolaimidae new record species Scutellonema commune Scutellonema magniphasma

Description of a new Pratylenchus species from China(Tylenchida,Pratylenchidae)

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Zoological Research 2013年第5期34卷 140-142页

作者： Ning liU Xiao-Song ZHOU li-jie chen Yu-Xi DUAN Nematology Institute of Northern China Shenyang Agricultural UniversityShenyang 110866China

Pratylenchus ekrami from maize(Zea mays)roots in Shenyang and luffa(Luffa cylindrica)roots in Dalian,China,are described in this *** from the two areas were identified consistently,and were characterized by a heavy cephalic sclerotization,extending posteriorly up to two body annuli,stylet 11−13μm long,elongating conoid tail,and becoming thinner from *** were not *** ekrami is close to Pratylenchus vulnus,but the most critical characteristics between the two species were the number of lip annuli,stylet size,and shape of stylet *** species is the first reported in China.

关键词： Pratylenchidae Pratylenchus new record species Pratylenchus ekrami