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The saproxylic beetle assemblage associated with different host trees in Southwest China

Insect Science 2008年第3期15卷 251-261页

作者： jie wu xiao-dong yu hong-zhang zhou Institute of Zoology Chinese Academy of Sciences Beijing China

Dead wood is a habitat for many insects and other small animals, some of which may be rare or endangered and in need of effective protection. In this paper, saproxylic beetle assemblages associated with different host trees in the subtropical forests in southwestern China were investigated. A total of 277 species （1 439 specimens） in 36 beetle families were collected from 117 dead wood samples, of which 101 samples were identified and respectively belonged to 12 tree genera. The number of saproxylic beetle species varied greatly among logs of different tree genera, with the highest diversity on logs of Juglans. Generally, broad-leaved trees had a higher richness and abundance of saproxylic species than coniferous trees. Cluster analysis revealed that assemblages from broad-leaved tree genera were generally similar （except for Betula） and assemblages from coniferous trees formed another distinct cluster. The subsequent indicator analysis proposed that there are different characteristic species for different cluster groups of host tree genera. In our study, log diameter has no positive influence on beetle species density. Conversely, comparisons of individual-based rarefaction curves suggested that beetle species richness was highest in the small diameter class both in coniferous and broad-leaved tree genera. With increased wood decay, proportion of habitat specialists （saproxylic beetles living on one tree genus） decreased, whereas proportion of habitat generalists （living on more than three tree genera） increased. The beetle species density was found to be higher in early stages, and decreased in later stages as well. A negative influence of altitude on saproxylic beetle species richness and abundance was detected. It was indicated that different tree genera and altitudes possibly display cross effects in modulating the altitudinal distribution and host preference of the beetles.

关键词： China host trees Saproxylic beetle subtropical forest

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Fabrication of Ni-Zn spinel ferrite with superior magnetic performance from electric arc furnace dust and iron scale

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Journal of Iron and Steel Research International 2025年第1期32卷 105-114页

作者： Yang Li Wei-zhe jie Chang Chen Yi Su wu zhou Hua zhang hong-wei Ni The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina The Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan430081HubeiChina

The Ni-ZnFe_(2)O_(4)(NixZn_(1-x)Fe_(2)O_(4),x=0.4-0.7)spinel was synthesized using Zn2+extracted from electric arc furnace dust(EAFD),nickel chloride hexahydrate,and Fe^(3+)extracted from iron scale as raw *** zinc was selectively extracted from EAFD using CaO roasting followed by NH_(4)Cl solution *** ferric ion was leached from iron scale using HCl solution as acid *** experimental results demonstrate a high level of efficiency in the extraction of zinc,with a rate of 97.5%,and the leaching rate of ferric ion is 96.89%.The composition of the leaching solution is primary zinc and iron with low calcium,which is beneficial to the preparation of spinel *** influence of Ni content(x)and calcination temperature on the synthesis and magnetic properties of NixZn_(1-x)Fe_(2)O_(4)compounds was investigated by X-ray diffraction,scanning electron microscopy,and vibrating sample *** results revealed that both Ni content and calcination temperature significantly affect the synthesis and magnetic properties of spinel NixZn_(1-x)Fe_(2)O_(4).Under the conditions of Ni content set at x=0.6,calcination temperature of 1100℃,and a duration of 2 h,a spinel NixZn_(1-x)Fe_(2)O_(4)with high saturation magnetization(Ms=65.7 A m2 kg-1)and low coercivity(Hc=0.056 A m^(-1))was obtained.

关键词： Electric furnace arc dust Iron scale Spinel ferrite Magnetic performance Calcination temperature

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In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis

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Science Bulletin 2025年第3期70卷 407-418页

作者： Da-Yong Hou Ni-yuan zhang Peng zhang Xiang-Peng Li Jiong-Cheng wu Mei-yu Lv Zhi-Jia Wang Xing-jie Hu Jian-xiao Liang hong-Lei Wang yue-Ze Wang Hui-Hui You hong-Wei An Hao Wang Wanhai Xu NHC Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in UrologyHarbin Medical UniversityHarbin 150001China Department of PET-CT/MRI Harbin Medical University Cancer HospitalHarbin 150001China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Tumor metastasis accounts for over 90%of tumor-related deaths,prompting the development of fluorescently labeled tumor-specific molecular imaging agents for differentiating tumors from normal ***,early detection of metastasis lesions by tracking tumor markers alone has proven to be ***,we reported a glycopeptide-based bispecific fluorescence probe(bsProbe)for earlier detection of bladder cancer and *** simultaneously recognition(tumor&tumor microenvironment)and in vivo self-assembly,the tumor accumulation of bsProbe(12.3%ID/g)was obviously increased by∼6 fold compared with that in CXCR4 specific fluorescence probe(sProbe),indicating the obvious advantages of bsProbe over existing tumor metastasis detection ***,bsProbe substantially broadens the tumor diagnosis window and enhances the detection signal to noise ratio(SNR:approximately 9.5),permitting early diagnosis of lung micro-metastasis(∼1 mm),precise identifying of tumor boundaries and micro-tumors in orthotopic tumor *** importantly,bsProbe was demonstrated to distinguish malignant from benign specimen with a specificity of 90.48%and sensitivity of 92.22%in 195 clinical specimens of bladder cancer *** together,this novel synergetic targeting(CD206×CXCR4)strategy provides an attractive method for earlier detection of bladder cancer and metastasis,which might be further extended to the imaging-guided surgery of clinical invisible tumors.

关键词： Self-assembly Peptide Nanomaterial Fluorescence imaging Bladder cancer

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Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期68卷 46-95页

作者： Zhong-Liang Gong hong-jie zhang Yan Cheng Jianxun Liu yuhan Ai Yaqin Li Zhihui Feng Qiong zhang Shaolong Gong Yong Chen Chang-Jiang Yao yuan-yuan Zhu Liang-Jin Xu yu-wu Zhong CAS Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of SciencesBeijing 100190China State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of TechnologyHefei 230009China State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic MaterialsWuhan UniversityWuhan 430072China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China Key Laboratory of Photochemical Conversion and Optoelectronic Materials&CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Photoactive complexes of nonprecious transition metals,mainly including those in the first-row and partially the second-row of the Periodic table of elements,have received increasing attention in view of their low cost and long-term *** are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices,artificial photosynthesis,photocatalysis,biodiagnostics,and therapeutics,*** review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes,including photoactive Zr,V,Cr,Mo,and W complexes,Mn complexes and hybrids,Fe,Co,Ni,and Cu complexes,and Zn and Cd complexes and hybrids.A particular focus is given on the molecular design,modulation of photophysical and photochemical properties,and applications of the representative and lately-developed nonprecious metal *** addition,a perspective on the future development in this field is provided at the end of this review.

关键词： photoactive metal complexes earth-abundant metals nonprecious metal complexes luminescence photochemistry

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RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China(Life Sciences) 2025年第2期68卷 441-453页

作者： Xue Pang Lin Gu Qiu-Ying Han Jia-Qing Xing Ming Zhao Shao-Yi Huang Jun-Xi Yi jie Pan Hao hong Wen Xue Xue-Qing zhou Zhi-Hui Su Xin-Ran zhang Li-Ming Sun Shao-Zhen Jiang Dan Luo Ling Chen Zheng-jie Wang yu yu Tian Xia Xue-Min zhang Ai-Ling Li Tao zhou hong Cai Tao Li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

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Bioinspired Ultrasensitive Flexible Strain Sensors for Real‑Time Wireless Detection of Liquid Leakage

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Nano-Micro Letters 2025年第3期17卷 310-327页

作者： Weilong zhou yu Du Yingying Chen Congyuan zhang xiaowei Ning Heng Xie Ting wu Jinlian Hu Jinping Qu Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationHubei Key Laboratory of Material Chemistry and Service Failure and Hubei Engineering Research Center for Biomaterials and Medical Protective MaterialsSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan 430205People’s Republic of China Department of Biomedical Engineering City University of Hong KongHong KongSAR 999077People’s Republic of China

Liquid leakage of pipeline networks not only results in considerableresource wastage but also leads to environmental pollution and ecological *** response to this global issue, a bioinspired superhydrophobic thermoplastic polyurethane/carbon nanotubes/graphene nanosheets flexible strain sensor (TCGS) hasbeen developed using a combination of micro-extrusion compression molding andsurface modification for real-time wireless detection of liquid leakage. The TCGSutilizes the synergistic effects of Archimedean spiral crack arrays and micropores,which are inspired by the remarkable sensory capabilities of scorpions. This designachieves a sensitivity of 218.13 at a strain of 2%, which is an increase of 4300%. Additionally, it demonstrates exceptional durability bywithstanding over 5000 usage cycles. The robust superhydrophobicity of the TCGS significantly enhances sensitivity and stability indetecting small-scale liquid leakage, enabling precise monitoring of liquid leakage across a wide range of sizes, velocities, and compositionswhile issuing prompt alerts. This provides critical early warnings for both industrial pipelines and potential liquid leakage scenariosin everyday life. The development and utilization of bioinspired ultrasensitive flexible strain sensors offer an innovative and effectivesolution for the early wireless detection of liquid leakage.

关键词： Thermoplastic polyurethane Bioinspired Cracks Liquid leakage Flexible strain sensor

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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer‑like social memory loss

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Military Medical Research 2025年第1期12卷 48-71页

作者： Hui-Yang Lei Gui-Lin Pi Ting He Rui Xiong Jing-Ru Lv Jia-Le Liu dong-Qin wu Meng-Zhu Li Kun Shi Shi-hong Li Na-Na yu Yang Gao Hui-Ling yu Lin-yu Wei Xin Wang Qiu-Zhi zhou Pei-Lin Zou Jia-Yang zhou Ying-zhou Liu Nai-Ting Shen jie Yang Dan Ke Qun Wang Gong-Ping Liu Xi-Fei Yang Jian-Zhi Wang Ying Yang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Traditional Chinese Medicine the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Key Laboratory of Modern Toxicology of Shenzhen Shenzhen Center for Disease Control and PreventionShenzhen 518055GuangdongChina Co‑Innovation Center of Neuroregeneration Nantong UniversityNantong 226000JiangsuChina

Background:Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease(AD),which is closely related to tau pathology and hippocampal *** to the heterogeneity of brain neurons,the specific roles of different brain neurons in terms of their sensitivity to tau accumulation and their contribution to AD-like social memory loss remain ***,further investigation is ***:We investigated the effects of AD-like tau pathology by Tandem mass tag proteomic and phosphoproteomic analysis,social behavioural tests,hippocampal electrophysiology,immunofluorescence staining and in vivo optical fibre recording of GCaMP6f and ***,we utilized optogenetics and administered ursolic acid(UA)via oral gavage to examine the effects of these agents on social memory in ***:The results of proteomic and phosphoproteomic analyses revealed the characteristics of ventral hippocampal CA1(vCA1)under both physiological conditions and AD-like tau *** tau progressively accumulated,vCA1,especially its excitatory and parvalbumin(PV)neurons,were fully filled with mislocated and phosphorylated tau(p-Tau).This finding was not observed for dorsal hippocampal CA1(dCA1).The overexpression of human tau(hTau)in excitatory and PV neurons mimicked AD-like tau accumulation,significantly inhibited neuronal excitability and suppressed distinct discrimination-associated firings of these neurons within *** excitatory and PV neurons in vCA1 at specific rhythms and time windows efficiently ameliorated tau-impaired social ***,1 month of UA administration efficiently decreased tau accumulation via autophagy in a transcription factor EB(TFEB)-dependent manner and restored the vCA1 microcircuit to ameliorate tau-impaired social ***:This study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau

关键词： Alzheimer’s disease Tau protein Ventral hippocampus Social memory Ursolic acid Transcription factor EB(TFEB)

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Important role of lymphovascular and perineural invasion in prognosis of colorectal cancer patients with N1c disease

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World Journal of Gastroenterology 2025年第5期31卷 57-67页

作者： Zhi-Gang Sun Shao-Xuan Chen Bai-Long Sun Da-Kui zhang hong-Liang Sun Huang Chen yu-Wan Hu Tong-Yin zhang Zi-Han Han Wen-xiao wu Zhi-Yong Hou Li Yao Jian-Zheng jie Department of General Surgery China-Japan Friendship HospitalBeijing 100029China Department of Radiology China-Japan Friendship HospitalBeijing 100029China Department of Pathology China-Japan Friendship HospitalBeijing 100029China Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730China Institute of Clinical Medical Sciences China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Lymphovascular invasion(LVI)and perineural invasion(PNI)are associated with decreased survival in colorectal cancer(CRC),but its significance in N1c stage remains to be clearly *** We retrospectively identified 107 consecutive patients who had CRC with N1c disease radically resected at our *** were reviewed for LVI and PNI by one pathologist blinded to the patients’***-free survival(DFS),overall survival(OS)and cancer-specific survival(CSS)were determined using the Kaplan-Meier method,with LVI and PNI prognosis differences determined by multivariate analysis using the Cox multiple hazards *** were compared using log-rank *** receiver operating characteristic(ROC)curve was used to evaluate the prognostic predictive *** The median follow-up time was 63.17(45.33-81.37)months for DFS,with 33.64%(36/107)of patients experiencing recurrence;21.5%of tumors were found to be LVI positive and 44.9%PNI *** 5-year DFS rate was greater for patients with LVI-negative tumors compared with LVI-positive tumors(74.0%vs 35.6%),and PNI was similar(82.5%vs 45.1%).On multivariate analysis,LVI[hazard ratio(HR)=3.368,95%confidence interval(CI):1.628-6.966,P=0.001]and PNI(HR=3.055,95%CI:1.478-6.313,P=0.002)were independent prognostic factors for *** patients could be divided into three groups of patients with different prognosis according to LVI and *** 5-year ROC curve for LVI,PNI and their combination prediction of DFS was 0.646,0.709 and 0.759,*** results were seen for OS and *** LVI and PNI could serve as independent prognostic factors of outcomes in N1c CRC *** with LVI or PNI should be given more attention during treatment.

关键词： Colorectal cancer N1c Lymphovascular invasion Perineural invasion Prognosis

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PandaX-xT——A deep underground multi-ten-tonne liquid xenon observatory

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 105-120页

作者： Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Chen Cheng Zhaokan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Lisheng Geng Karl Giboni Linhui Gu Xunan Guo Xuyuan Guo Zhichao Guo Chencheng Han Ke Han Changda He Jinrong He Di Huang Junting Huang zhou Huang Ruquan Hou yu Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shuaijie Li Tao Li Qing Lin Jianglai Liu Congcong Lu xiaoying Lu Lingyin Luo yunyang Luo Wenbo Ma yugang Ma Yajun Mao yue Meng Xuyang Ning Binyu Pang Ningchun Qi Zhicheng Qian Xiangxiang Ren Nasir Shaheed xiaofeng Shang Xiyuan Shao Guofang Shen Lin Si Wenliang Sun Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Xu Wang zhou Wang yuehuan Wei Mengmeng wu Weihao wu yuan wu Mengjiao xiao Xiang xiao Binbin Yan Xiyu Yan Yong Yang Chunxu yu Ying yuan Zhe yuan Youhui yun Xinning Zeng Minzhen zhang Peng zhang Shibo zhang Shu zhang Tao zhang Wei zhang Yang zhang Yingxin zhang yuanyuan zhang Li Zhao Jifang zhou Ning zhou xiaopeng zhou Yong zhou yubo zhou Zhizhen zhou New Cornerstone Science Laboratory Tsung-Dao Lee InstituteShanghai Jiao Tong UniversityShanghai 200240China School of Physics and Astronomy Shanghai Jiao Tong UniversityKey Laboratory for Particle Astrophysics and Cosmology(MoE)Shanghai Key Laboratory for Particle Physics and CosmologyShanghai 200240China Shanghai Jiao Tong University Sichuan Research Institute Chengdu 610213China School of Physics Sun Yat-sen UniversityGuangzhou 510275China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Department of Physics Yantai UniversityYantai 264005China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Physics Beihang UniversityBeijing 102206China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Beijing Key Laboratory of Advanced Nuclear Materials and Physics Beihang UniversityBeijing 102206China Southern Center for Nuclear-Science Theory(SCNT) Institute of Modern PhysicsChinesen Academy of SciencesHuizhou 516000China Yalong River Hydropower Development Company Ltd.Chengdu 610051China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Physics University of MarylandCollege ParkMaryland 20742USA State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Key Laboratory of Particle Physics and Particle Irradiation of Ministry of Education Shandong UniversityQingdao 266237China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China School of Physics Nankai UniversityTianjin 300071China SJTU Paris Elite I

We propose a major upgrade to the existing PandaX-4T experiment at the China Jinping Underground *** new experiment,PandaX-xT,will be a multi-ten-tonne liquid xenon,ultra-low background,and general-purpose *** full-scaled PandaX-xT contains a 43-t liquid xenon active *** an experiment will significantly advance our fundamental understanding of particle physics and *** sensitivity of dark matter direct detection will be improved by nearly two orders of magnitude compared to the current best limits,approaching the so-called“neutrino floor”for a dark matter mass above 10 GeV/c^(2),providing a key test to the Weakly Interacting Massive Particle *** searching for the neutrinoless double beta decay of^(136)Xe isotope in the detector,the effective Majorana neutrino mass can be measured to a 10-41 meV/c^(2) sensitivity,providing a key test to the Dirac/Majorana nature of *** neutrinos and other ultra-rare interactions can also be measured and searched for with an unprecedented background level,opening up new windows of *** on the findings,PandaX-xT will seek the next stage upgrade utilizing isotopic separation of natural xenon.

关键词： dark matter neutrino less double beta decay astrophysical neutrinos liquid xenon

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Lactococcus garvieae aggravates cholestatic liver disease by increasing intestinal permeability and enhancing bile acid reabsorption

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World Journal of Gastroenterology 2025年第10期31卷 103-117页

作者： Man Liu Ying-Lan Ji yu-jie Hu Ying-Xi Su jie Yang xiao-Yi Wang hong-yu Chu Xue zhang Shi-Jing dong Hui Yang yu-Hang Liu Si-Min zhou Li-Ping Guo Ying Ran Yan-Ni Li Jing-Wen Zhao Zhi-Guang zhang Mei-yu Piao Lu zhou Department of Gastroenterology and Hepatology General HospitalTianjin Medical UniversityTianjin 300070China Department of Gastroenterology The Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Gastroenterology Tianjin Medical University General Hospital Airport HospitalTianjin 300308China Department of Gastroenterology and Hepatology Tianjin Third Central HospitalTianjin 300170China

BACKGROUND Although an association between gut microbiota and cholestatic liver disease(CLD)has been reported,the precise functional roles of these microbes in CLD pathogenesis remain largely *** To explore the function of gut microbes in CLD pathogenesis and the effects of gut microbiota on intestinal barrier and bile acid(BA)metabolism in *** Male C57BL/6J mice were fed a 0.05%3,5-diethoxycarbonyl-1,4-dihydrocollidine diet for 2 weeks to induce *** sterile liver tissues of mice were then meticulously harvested,and bacteria in homogenates were identified through culture ***,16S ribosomal DNA sequencing was employed to analyze sterile liver samples collected from eight patients with primary biliary cholangitis(PBC)and three control individuals with hepatic *** functional roles of the identified bacteria in CLD pathogenesis were assessed through microbiota transfer experiments,involving the evaluation of changes in intestinal permeability and BA *** Ligilactobacillus murinus(***)and Lactococcus garvieae(***)were isolated from the bacterial culture of livers from CLD *** was prevalently detected in PBC patients and controls,whereas *** was detected only in patients with PBC but not in *** inoculated with *** exhibited increased susceptibility to experimental CLD,with both in vitro and in vivo indicating that *** disrupted the intestinal barrier function by down-regulating the expression of occludin and zonula ***,*** administration significantly upregulated the expression of the apical sodium-dependent BA transporter in the terminal ileum and increased serum BA *** *** contributes to excessive BA-induced hepatobiliary injury and liver fibrosis by increasing intestinal permeability and enhancing BA reabsorption.

关键词： Cholestasis Microbiota Lactococcus garvieae Intestinal permeability Bile acid

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