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Acute suppurative terminal cholangitis:Clinical characteristics of a new subtype of acute cholangitis

Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 293-299页

作者： Rong-tao Zhu Ye Li Chi-Xian Zhang Wei-jie Wang Ruo-Peng Liang Jian Li Kai Bai Yu-Ling Sun Department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Zhengzhou Key Laboratory of Hepatobiliary and Pancreatic Diseases Zhengzhou 450052China Institute of Hepatobiliary and Pancreatic Diseases Zhengzhou UniversityZhengzhou 450052China Department of Pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Background:Acute suppurative terminal cholangitis(ASTC)is rarer than acute obstructive cholangitis and is not well *** explore this subtype of acute cholangitis,we described our clinical experience with ***:We performed a retrospective review of patients with ASTC admitted to our center from September 2014 to August *** analyzed their clinical characteristics,including etiology,clinical manifestations,imaging features,treatment and ***:A total of 32 ASTC patients were included in the *** majority of the patients had a history of biliary operations,and clinical manifestations were occult and *** positive rate of bacterial culture was 46.9%.All the patients had typical imaging features on computed tomography and magnetic resonance *** with effective antibiotics was provided as soon as diagnosis was *** treatment,most patients had a good *** levels of total bilirubin,aspartate aminotransferase,procalcitonin and gamma-glutamyltransferase were the characteristics of critically ill patients and were associated with relatively poor ***:Our results demonstrated that ASTC should be recognized as a new subtype of acute cholangitis,and that earlier diagnosis and more personalized treatments are needed.

关键词： Acute suppurative terminal cholangitis Acute cholangitis Gram-negative bacterial infections Diagnosis Treatment

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New Results on Equivalence of Multivariate Polynomial Matrices

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Journal of Systems Science & Complexity 2024年

作者： GUAN Jiancheng LIU Jinwang ZHENG Licui WU tao LIU jie School of Mathematics and Computing Science Hunan University of Science and Technology

This paper investigates equivalence of square multivariate polynomial matrices with the determinant being some power of a univariate irreducible *** authors give a necessary and sufficient condition for this *** the authors present an algorithm to reduce a class of multivariate polynomial matrices to their Smith forms.

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Influence of input acoustic power on regenerator's performance

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第9期8卷 1452-1456页

作者： TANG Ke HUANG Zhong-jie JIN tao BAO Rui CHEN Guo-bang Institute of Refrigeration and Co ogenics Zhejiang Universiiy Hangzhou 310027 China

Performance of a pulse tube cooler significantly depends on the efficient operation of its regenerator. Influence of input acoustic power on regenerator's performance is simulated and analyzed with simple harmonic analysis method. Given regenera-tor's dimensions and pressure ratio,there is an optimal input acoustic power for achieving a highest coefficient of performance,due to a compromise between relative time-averaged total energy flux in regenerator and relative acoustic power at regenerator's cold end. Additionally,optimal dimensions of regenerator are also estimated and presented for different input acoustic powers. The computed optimal diameter obviously increases with increase of input acoustic power,while the optimal length decreases slightly,and as a result,a larger input acoustic power requires a smaller aspect ratio (length over diameter).

关键词：交流换热器脉冲冷却管谐波分析声功率

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Green Synthesis of Mechanical Robust Superhydrophobic CNT@PU Coatings with High Flexibility for Extensive Applications

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Journal of Bionic Engineering 2021年第1期18卷 40-54页

作者： Zhengwei Wu Yizhou Shen jie tao Zhenfeng Jia Haifeng Chen Jiawei Jiang Zhen Wang College of Materials Science and Technology Nanjing University of Aeronauics and AstronauticsNanjing 210016China School of Engineering Huzhou UniversityHuzhou Centre HospitalHuzhou 313000China

Superhydrophobic coatings with high flexibility and mechanical durability can well address many practical application *** this end,we proposed and fabricated a kind of bio-based superhydrophobic(multi-walled carbon nanotubes)CNT@PU(polyurethane)*** was demonstrated that the CNT@PU coatings with 64%soft segment content possessed the preferable bonding strength(5B)with metal *** multi-walled carbon nanotubes,as additive materials,were used to construct the microscopic structures of the coating surfaces,which made polyurethane surface superhydrophobic(water contact angle being 156.9°,and water sliding angle being 4.3°).Furthermore,the high bonding strength between CNT and coating matrix led to robust mechanical durability of supertiydrophobic CNT@PU coatings,and the coatings remained superhydrophobicity after 10 cycles of abrasion under 100 g load ***,the superhydrophobic coatings could well resist 5 cycles of tape-peeling action,and presented outstanding *** supernydrophobic CNT@PU coatings with high flexibility and mechanical durability could be applied to various substrates suggesting their big potential in future real-world application.

关键词： bio-based PU superhydrophobic coatings high flexibility mechanical durability

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Target tracking methods based on a signal-to-noise ratio model

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Frontiers of Information Technology & Electronic Engineering 2020年第12期21卷 1804-1814页

作者： Dai LIU Yong-bo ZHAO Zi-qiao YUAN jie-tao LI Guo-ji CHEN National Lab of Radar Signal Processing Xidian UniversityXi'an 710071China Xi’an Electronic Engineering Research Institute Xi'an 710100China

In traditional target tracking methods,the angle error and range error are often measured by the empirical value,while observation noise is a *** this paper,the angle error and range error are *** are influenced by the signalto-noise ratio(SNR).Therefore,a model related to SNR has been established,in which the SNR information is applied for target *** with an advanced nonlinear filter method,the extended Kalman filter method based on the SNR model(SNR-EKF)and the unscented Kalman filter method based on the SNR model(SNR-UKF)are *** is little difference between the SNR-EKF and SNR-UKF methods in position precision,but the SNR-EKF method has advantages in computation time and the SNR-UKF method has advantages in velocity *** results show that target tracking methods based on the SNR model can greatly improve the tracking performance compared with traditional tracking *** target tracking accuracy and convergence speed of the proposed methods have significant improvements.

关键词： Signal-to-noise ratio(SNR)model Target tracking Angle error Range error Nonlinear filter

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Finite element modelling and experimental investigation of the impact of filling different materials in copper tubes during 3D free bending process

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Chinese Journal of Aeronautics 2020年第2期33卷 721-729页

作者： Xunzhong GUO Xuan CHENG Yong XU jie tao Ali ABD EL-ATY Hai LIU College of Material Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 211100China Jiangsu Key Laboratory of Nuclear Energy Equipment Materials Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211100China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Department of Precision Manufacturing Engineering Suzhou Vocational Institute of Industrial TechnologySuzhou 215104China

3D free bending process,an advanced metal forming technology,has attracted much attention due to its unique geometrical flexibility and *** tubes with materials may effectively reduce the distortion in the cross-section area and restrain wrinkling and collapse of tube *** the present study,the impacts of filling different materials on the copper tubes during 3D free bending process were *** have found that copper tubes filled with low melting point alloys could induce the most uniform stress distribution,which result in better formability and moderate thickness changing rates when compared to SS304 steel balls and PU *** lowest ellipticity reached to 1.467%.

关键词： 3D free bending Ellipticity Filling bending Finite element modelling Force model Thickness

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听见博物馆——现代博物馆的听觉设计

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中国博物馆 2022年第4期 48-52页

作者：陶捷南京师范大学音乐学院南京210097

博物馆内的听觉感受和声音设计可以增加整体呈现的维度、增强观展体验、建立展品和参观者之间特殊的纽带,从而达到理想的教育效果及观看体验。认识声音的本质、作用机制,处理好听觉设计中的基本关系才能够在展陈设计中充分使用听觉元素... 详细信息

博物馆内的听觉感受和声音设计可以增加整体呈现的维度、增强观展体验、建立展品和参观者之间特殊的纽带,从而达到理想的教育效果及观看体验。认识声音的本质、作用机制,处理好听觉设计中的基本关系才能够在展陈设计中充分使用听觉元素,与视觉表达相得益彰。

关键词：博物馆听觉设计声音

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Dammarane-type triterpenoids from Gynostemma longipes and their protective activities on hypoxia-induced injury in PC12 cells

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Chinese Journal of Natural Medicines 2024年第5期22卷 466-480页

作者： LIANG Haizhen CHEN Xiaojuan LI Qi ZHANG Mengmeng LU Pengxin ZHANG jie SONG Juan ZHANG tao GUO Baolin MA Baiping Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China AnKang Chia Tai Pharmaceutical Co. Ltd.Shaanxi 725000China

Sixteen new dammarane-type triterpenoid saponins(1-16)featuring diverse structural variations in the side chain at C-17,along with twenty-one known analogues(17-37),have been isolated from the rhizomes of Gynostemma longipes ***,a plant renowned for its medicinal and edible *** structural elucidation of these compounds was accomplished through comprehensive analyses of 1D and 2D NMR and HRMS spectroscopic data,supplemented by comparison with previously reported *** assays on the isolates for their protective effects against hypoxia-induced damage in pheochromocytoma cells(PC12 cells)revealed that nine saponins exhibited significant anti-hypoxic *** investigation into the anti-hypoxia mechanisms of the representative saponins demonstrated that compounds 22 and 36 markedly reduced the levels of hypoxia-induced ***,these compounds were found to decrease the release of lactate dehydrogenase(LDH)and malondialdehyde(MDA),while increasing the activity of superoxide dismutase(SOD),thereby indicating that the saponins could mitigate hypoxia-induced injuries by ameliorating apoptosis and oxidative *** findings offer substantial evidence for the future utilization and development of ***,identifying dammarane-type triterpenoid saponins as its active anti-hypoxic constituents.

关键词： Gynostemma longipes Dammarane-type saponins Anti-hypoxia effect Apoptosis

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HSP110 aggravates ischemia-reperfusion injury after liver transplantation by promoting NF-κB pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 344-352页

作者： Qing-Zhi Hu Zhen-Rui Cao Wei-Xiong Zheng Min-jie Zhao Jun-Hua Gong Cong Chen Zhong-Jun Wu Rui tao Department of Hepatobiliary Surgery Bishan Hospital of Chongqing Medical UniversityChongqing 402760China Department of Cardiothoracic Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China c Department of Hepatobiliary Surgery the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Hepatobiliary Surgery the Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

Background:Ischemia-reperfusion injury(IRI)poses a significant challenge to liver transplantation(LT).The underlying mechanism primarily involves overactivation of the immune *** shock protein 110(HSP110)functions as a molecular chaperone that helps stabilize protein ***:An IRI model was established by performing LT on Sprague-Dawley rats,and HSP110 was silenced using ***-eosin staining,TUNEL,immunohistochemistry,ELISA and liver enzyme analysis were performed to assess IRI following *** blotting and quantitative reverse transcription-polymerase chain reaction were conducted to investigate the pertinent molecular ***:Our findings revealed a significant increase in the expression of HSP110 at both the mRNA and protein levels in the rat liver following LT(P<0.05).However,when rats were injected with siRNAHSP110,IRI subsequent to LT was notably reduced(P<0.05).Additionally,the levels of liver enzymes and inflammatory chemokines in rat serum were significantly reduced(P<0.05).Silencing HSP110 with siRNA resulted in a marked decrease in M1-type polarization of Kupffer cells in the liver and downregulated the NF-κB pathway in the liver(P<0.05).Conclusions:HSP110 in the liver promotes IRI after LT in rats by activating the NF-κB pathway and inducing M1-type polarization of Kupffer *** HSP110 to prevent IRI after LT may represent a promising new approach for the treatment of LT-associated IRI.

关键词： Ischemia-reperfusion injury Liver transplantation Inflammation HSP110 Heat shock proteins NF-κB

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Elimination of methicillin‑resistant Staphylococcus aureus biofilms on titanium implants via photothermally‑triggered nitric oxide and immunotherapy for enhanced osseointegration

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Military Medical Research 2024年第2期11卷 157-179页

作者： Yong‑Lin Yu Jun‑jie Wu Chuan‑Chuan Lin Xian Qin Franklin R.Tay Li Miao Bai‑Long tao Yang Jiao Department of Pathology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003GuizhouChina Laboratory Research Center the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Blood Transfusion Laboratory of Radiation Biologythe Second Affiliated HospitalArmy Military Medical UniversityChongqing 400037China Department of Reproductive Endocrinology Chongqing Health Center for Women and ChildrenChongqing 401147China The Graduate School Augusta UniversityAugustaGA 30912USA Department of Stomatology the Seventh Medical Center of PLA General HospitalBeijing 100700China

Background:Treatment of methicillin-resistant Staphylococcus aureus(MRSA)biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium(Ti)*** is a need to explore more effective approaches for the treatment of MRSA biofilm ***:Herein,an interfacial functionalization strategy is proposed by the integration of mesoporous polydopamine nanoparticles(PDA),nitric oxide(NO)release donor sodium nitroprusside(SNP)and osteogenic growth peptide(OGP)onto Ti implants,denoted as Ti-PDA@*** physical and chemical properties of Ti-PDA@SNP-OGP were assessed by scanning electron microscopy,X-ray photoelectron spectroscope,water contact angle,photothermal property and NO release *** synergistic antibacterial effect and elimination of the MRSA biofilms were evaluated by 2′,7′-dichlorofluorescein diacetate probe,1-N-phenylnaphthylamine assay,adenosine triphosphate intensity,O-nitrophenyl-β-D-galactopyranoside hydrolysis activity,bicinchoninic acid *** staining,assays for alkaline phosphatase activity,collagen secretion and extracellular matrix mineralization,quantitative real‑time reverse transcription‑polymerase chain reaction,and enzyme-linked immunosorbent assay(ELISA)were used to evaluate the inflammatory response and osteogenic ability in bone marrow stromal cells(MSCs),RAW264.7 cells and their co-culture *** staining,ELISA,micro-CT,hematoxylin and eosin,Masson's trichrome and immunohistochemistry staining were used to evaluate the eradication of MRSA biofilms,inhibition of inflammatory response,and promotion of osseointegration of Ti-PDA@SNP-OGP in ***:Ti-PDA@SNP-OGP displayed a synergistic photothermal and NO-dependent antibacterial effect against MRSA following near-infrared light(NIR)irradiation,and effectively eliminated the formed MRSA biofilms by inducing reactive oxygen species(ROS)-mediated oxidative stress,destroying bacterial membrane integrity and

关键词： Polydopamine nanoparticles Methicillin-resistant Staphylococcus aureus Nitric oxide Osseointegration Osteo-immunomodulation Photothermal effect Titanium implants

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