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Current Medical Science 2024年第1期44卷 232-240页

作者： Zhi-bin ZHU Meng-jie LIU Jing WANG Zhou SHU jie cao Department of Stomatology Chengdu Seventh People's HospitalChengdu 610044China Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective Secoemestrin C(SC),an epitetrathiodioxopiperazine isolated from Aspergillus nidulans,has been previously reported to have immunomodulatory and hepatoprotective effects against acute autoimmune ***,the effect of SC on regulating the inflammation and its underlying mechanisms in the pathogenesis of psoriasis remain *** study aimed to evaluate the effects of SC on inflammatory dermatosis both in vitro and in *** In vitro,HaCaT cells were induced with tumor necrosis factor-alpha(TNF-α,10 ng/mL)to establish an inflammatory injury model,and the expression of nuclear transcription factor-κB(NF-κB)pathway components was measured using qRT-PCR and Western *** in vivo mouse model of imiquimod(IMQ)-induced psoriasis-like skin inflammation was used to evaluate the effectiveness of SC in alleviating *** SC significantly blocked the activation of NF-κB signaling in TNF-α-stimulated HaCaT *** addition,systemic and local administration of SC improved psoriatic dermatitis in the IMQ-induced mouse *** reduced skin scale and significantly inhibited the secretion of inflammatory factors in skin *** The protective effect of SC against psoriatic-associated inflammation reveals its potential therapeutic value for treating psoriasis.

关键词： secoemestrin C(SC) psoriasis tumor necrosis factor-alpha(TNF-α) nuclear transcription factor-kB(NF-kB) inflammation

A near-zero quiescent power breeze wake-up anemometer based on a rolling-bearing triboelectric nanogenerator

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Microsystems & Nanoengineering 2024年第2期10卷 241-249页

作者： Xianpeng Fu Zhichao Jiang jie cao Zefang Dong Guoxu Liu Meiling Zhu Chi Zhang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing100049China Center on Nanoenergy Research Guangxi Colleges and Universities Key Laboratory of Blue Energy and Systems IntegrationSchool of Physical Science&TechnologyGuangxi UniversityNanning530004China Institute of Intelligent Flexible Mechatronics Jiangsu UniversityZhenjiang212013China College of Engineering Mathematics and Physical ScienceUniversity of ExeterExeterEX44QFUK

Wind sensors have always played an irreplaceable role in environmental information monitoring and are expected to operate with lower power consumption to extend service ***,we propose a breeze wake-up anemometer(B-WA)based on a rolling-bearing triboelectric nanogenerator(RB-TENG)with extremely low static *** B-WA consists of two RB-TENGs,a self-waking-up module(SWM),a signal processing module(SPM),and a wireless transmission *** two RB-TENGs are employed for system activation and wind-speed *** the ambient wind-speed exceeds 2 m/s,the wake TENG(W-TENG)and the SWM can wake up the system within 0.96 *** the same time,the SPM starts to calculate the signal frequency from the measured TENG(M-TENG)to monitor the wind speed with a sensitivity of 9.45 Hz/(m/s).After the wind stops,the SWM can switch off the B-WA within 0.52 s to decrease the system energy *** quiescent on-duty mode,the operating power of the B-WA is less than 30 nW,which can greatly extend the service lifetime of the *** integrating triboelectric devices and rolling bearings,this work has realized an ultralow quiescent power and self-waked-up wireless wind-speed monitoring system,which has foreseeable applications in remote weather monitoring,IoT nodes,and so on.

关键词： generator power service

Ultra-Robust and High-Performance Rotational Triboelectric Nanogenerator by Bearing Charge Pumping

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Energy & Environmental Materials 2024年第2期7卷 347-353页

作者： Xianpeng Fu Yuhan Qin Zhi Zhang Guoxu Liu jie cao Beibei Fan Zhaozheng Wang Zheng Wang Chi Zhang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micronano Energy and Sensor Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences School of Nanoscience and Technology University of Chinese Academy of Sciences Center on Nanoenergy Research School of Physical Science and Technology Guangxi University

As an emerging technology to convert environmental high-entropy energy into electrical energy, triboelectric nanogenerator(TENG) has great demands for further enhancing the service lifetime and output performance in practical applications. Here, an ultra-robust and high-performance rotational triboelectric nanogenerator(R-TENG) by bearing charge pumping is proposed. The R-TENG composes of a pumping TENG(P-TENG), an output TENG(O-TENG), a voltage-multiplying circuit(VMC), and a buffer *** P-TENG is designed with freestanding mode based on a rolling ball bearing, which can also act as the rotating mechanical energy harvester. The output low charge from the P-TENG is accumulated and pumped to the noncontact O-TENG, which can simultaneously realize ultralow mechanical wear and high output performance. The matched instantaneous power of R-TENG is increased by 32 times under 300 r/min. Furthermore, the transferring charge of R-TENG can remain 95% during 15 days(6.4 × 10～6cycles)continuous operation. This work presents a realizable method to further enhance the durability of TENG, which would facilitate the practical applications of high-performance TENG in harvesting distributed ambient micro mechanical energy.

关键词： bearing charge pumping triboelectric nanogenerators ultralow mechanical wear ultra-robust voltage-multiplying circuit

Effects ofβ-1,3-glucan and ascorbic acid on the nutritional-immune response and antioxidant signaling pathways of live tiger grouper during simulated transport

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Aquaculture and Fisheries 2024年第2期9卷 265-272页

作者： Bo Wu Zhenkun Xu jie cao Qi Wang Jun Mei Jing Xie College of Food Science and Technology Shanghai Ocean UniversityShanghai201306China National Experimental Teaching Demonstration Center for Food Science and Engineering Shanghai Ocean UniversityShanghai201306China Shanghai Engineering Research Center of Aquatic Product Processing and Preservation Shanghai201306China Shanghai Professional Technology Service Platform on Cold Chain Equipment Performance and Energy Saving Evaluation Shanghai201306China

Transport in water is the most common method for transporting live fish in China,however,transport is a strong *** stress could lead to a reduced immune and antioxidant system function of tiger grouper,resulting in sickness and ***,tiger grouper were continuously stressed during transport,which resulted in quality *** is necessary that find a way to relieve the stress of transportation of tiger *** acid is not only a good anti-stress agent,but it is also an effective immunostimulant.β-1,3-glucan is a feed additive that can enhance the immune response of ***,this study evaluated the effects ofβ-1,3-glucan and ascorbic acid on the nutritional-immune response and antioxidant signaling pathways of live tiger grouper during simulated *** indicated that addingβ-1,3-glucan and ascorbic acid in transport-water muted the increase of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)*** addition,β-1,3-glucan and ascorbic acid activated Nrf2 and mediated TOR expression and then up-regulate related mRNA expression of antioxidant and immune *** concluded that the application ofβ-1,3-glucan and ascorbic acid inhibit the increase of metabolism enzymes and inflammatory factors and activate immune and antioxidant signaling pathways to relieve oxidant stress,immune response,and *** the loss of amino acids provided nutrients to relieve oxidative stress and immune response,which demonstrated immune-nutritional response in live tiger grouper during simulated *** results may provide a new solution for alleviating the decline of immune and antioxidant function of tiger grouper caused by transportation stress.

关键词： Tiger grouper β-1,3-Glucan Ascorbic acid Immune response Antioxidant signaling pathway

Reform and Development of English Teaching in Colleges and Universities with the Integration of ChatGPT Technology

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Journal of Contemporary Educational Research 2024年第6期8卷 71-76页

作者： jie cao Jing cao Yuan Tao College of Foreign Studies Hubei Normal UniversityHuangshi435002Hubei ProvinceChina Boda College of Jilin Normal University Siping 136000Jilin ProvinceChina School of Mathematics and Computer Science Jilin Normal UniversitySiping 136000Jilin ProvinceChina

As an artificial intelligence-powered language generation model based on natural language processing,ChatGPT,like other artificial intelligence technologies,possesses super real-time dialogue capabilities and is considered an innovative and intelligent auxiliary teaching tool in the field of language *** article first analyzes the current state of development of artificial intelligence technologies such as ***,it examines the challenges encountered in the reform and development of English teaching in colleges and universities in ***,it summarizes the applications and recommendations for using ChatGPT technology in college-level English teaching.

关键词： ChatGPT Artificial intelligence technologies College English Reform and development

Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators

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World Journal of Stem Cells 2024年第6期16卷 670-689页

作者： Ying Gao Mei-Fang Liu Yang Li Xi Liu Yu-jie cao Qian-Fa Long Jun Yu Jian-Ying Li Department of Respiratory and Critical Care Medicine Shaanxi Provincial Rehabilitation HospitalXi’an 710000Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Second Affiliated Hospital of Ningxia Medical University(The First People’s Hospital of Yinchuan)Yinchuan 750001Ningxia Hui Autonomous RegionChina School of Clinical Medicine Xi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Respiratory and Critical Care Medicine Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Neurosurgery Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina Department of Emergency Xi’an Central HospitalXi’an 710000Shaanxi ProvinceChina

BACKGROUND Pulmonary fibrosis(PF)is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation,causing structural damage and lung *** cell therapy and mesenchymal stem cells-extracellular vesicles(MSC-EVs)offer new hope for PF *** To investigate the therapeutic potential of MSC-EVs in alleviating fibrosis,oxidative stress,and immune inflammation in A549 cells and bleomycin(BLM)-induced mouse *** The effect of MSC-EVs on A549 cells was assessed by fibrosis markers[collagen I andα-smooth muscle actin(α-SMA),oxidative stress regulators[nuclear factor E2-related factor 2(Nrf2)and heme oxygenase-1(HO-1),and inflammatory regu-lators[nuclear factor-kappaB(NF-κB)p65,interleukin(IL)-1β,and IL-2].Similarly,they were assessed in the lungs of mice where PF was induced by BLM after MSC-EV ***-EVs ion PF mice were detected by pathological staining and western ***-cell RNA sequencing was performed to investigate the effects of the MSC-EVs on gene expression profiles of macrophages after modeling in *** Transforming growth factor(TGF)-β1 enhanced fibrosis in A549 cells,significantly increasing collagen I andα-SMA ***,treatment with MSC-EVs demonstrated a remarkable alleviation of these ***,the expression of oxidative stress regulators,such as Nrf2 and HO-1,along with inflammatory regulators,including NF-κB p65 and IL-1β,were mitigated by MSC-EV ***,in a parallel manner,MSC-EVs exhibited a downregulatory impact on collagen deposition,oxidative stress injuries,and inflammatory-related cytokines in the lungs of mice with ***,the mRNA sequencing results suggested that BLM may induce PF in mice by upregulating pulmonary collagen fiber deposition and triggering an immune inflammatory *** findings collectively highlight the potential therapeutic efficacy of MSC-EVs in ameliorating fibrotic processes,oxidative stres

关键词： Mesenchymal stem cells Extracellular vesicles Pulmonary fibrosis Oxidative stress response Epithelial-mesenchymal transition

Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease:A dietary salt-intervention trial

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Science China(Life Sciences) 2024年第8期67卷 1666-1675页

作者： Zhennan Lin Jianxin Li Fangchao Liu jie cao Shufeng Chen Jichun Chen Keyong Huang Yaqin Wang Hongfan Li Yan Wang Jianfeng Huang Dongfeng Gu Xiangfeng Lu Key Laboratory of Cardiovascular Epidemiology Department of EpidemiologyFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical College/National Center for Cardiovascular DiseasesBeijing 100037China Medical School Southern University of Science and TechnologyShenzhen 518055China

Individuals with a high degree of salt sensitivity(SS)have a greater risk of cardiovascular disease(CVD),but whether SS fosters CVD by influencing metabolomics homeostasis remains *** study aimed to reveal the role of the SS-related metabolomics signature in the development of CVDs,based on the MetaSalt study,which was a dietary salt-intervention trial conducted at four centers in China in 2019.A total of 528 participants were recruited and underwent 3 days of baseline observations,a 10-day low-salt intervention,and a 10-day highsalt *** untargeted metabolomics,lipidomics,and BP measurements were scheduled at each *** were grouped into extreme SS,moderate SS,and salt-resistant(SR)individuals according to their BP responses to *** mixed models were used to identify SS-related metabolites and determine the relationship between the SS-related metabolomics signature and arterial *** randomization(MR)analyses were applied to establish the causal pathways among the SS-related metabolites,BP,and *** the 713 metabolites,467 were significantly changed after the high-salt *** them,the changes in 30 metabolites from the low-salt to the high-salt intervention differed among the SS *** the remaining nonsalt-related metabolites,the baseline levels of 11 metabolites were related to *** 41 metabolites explained 23%of the variance in ***,SS and its metabolomics signature were positively correlated with arterial *** analyses demonstrated that the SS-related metabolites may affect CVD risk by altering BP,indicating that the increase in BP was the consequence of the changes in SS-related metabolites rather than the *** study revealed that the metabolomics signature of SS individuals differs from that of SR individuals and that the changes in SS-related metabolites may increase arterial stiffness and foster *** study provides insight into understanding the biolog

关键词： salt sensitivity dietary salt intake metabolomics Mendelian randomization cardiovascular disease

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重大突发公共卫生事件防控策略计算实验分析

系统工程理论与实践 2024年第6期44卷 1950-1964页

作者：刘明开吉曹杰南京理工大学经济管理学院南京210094 徐州工程学院管理工程学院徐州221018

本文借鉴外来物种入侵管理思想,构建一类重大突发公共卫生事件防控策略计算实验分析模型.该模型综合考虑了病毒传播扩散过程中的多重异质性,不仅为重大突发公共卫生事件的当前和未来演变构建演化情景,分析不同非医疗干预措施对事件发展... 详细信息

本文借鉴外来物种入侵管理思想,构建一类重大突发公共卫生事件防控策略计算实验分析模型.该模型综合考虑了病毒传播扩散过程中的多重异质性,不仅为重大突发公共卫生事件的当前和未来演变构建演化情景,分析不同非医疗干预措施对事件发展的影响,提供升级防控措施的最优时空节点和最小化总感染人数的策略,而且通过病毒检测约束设计,将常见的几种疫情防控策略进行了有机统一刻画.计算实验结果表明,在重大突发公共卫生事件应急响应初期,采取动态清零策略具有其独特的价值,在感染者人数、重症率、危重症率等方面都显著优于其它策略;研究同时发现病毒检测效率、接触系数等均存在明显的边际递减效应,而强软社交距离政策联合使用效果更优.

关键词：重大突发公共卫生事件防控策略计算实验入侵物种管理资源配置

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近10年我国煤与瓦斯突出事故统计规律与动力效应特征分析

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矿业安全与环保 2024年第3期51卷 36-42,49页

作者：曹偈煤矿灾害防控全国重点实验室重庆400037 中煤科工集团重庆研究院有限公司重庆400037

挖掘历史事故案例特征可为准确认识煤与瓦斯突出机理及灾害防控预警提供更多支撑。分析近10年发生的煤与瓦斯突出事故统计数据尤其是较大及以上事故案例,探究突出发生规律及动力效应特征。结果表明:近年来重大以上突出事故基本杜绝,但... 详细信息

挖掘历史事故案例特征可为准确认识煤与瓦斯突出机理及灾害防控预警提供更多支撑。分析近10年发生的煤与瓦斯突出事故统计数据尤其是较大及以上事故案例,探究突出发生规律及动力效应特征。结果表明:近年来重大以上突出事故基本杜绝,但事故死亡人数占煤矿事故总死亡人数的比例仍较高,其平均死亡人数为煤矿事故的2.9倍;事故发生地点以煤层平巷为主,占比为43.2%;综掘机割煤作业时诱导突出事故比例显著上升,近5年占比为57.0%;与其他地质构造相比,断层、煤层厚度变化易导致突出发生,褶曲构造附近的平均突出强度最大,其中38起事故平均突出强度与瓦斯涌出量分别为521.34 t、3.55万m^(3),重大及以上事故突出强度与吨煤瓦斯涌出量均呈波动减小趋势;钻孔喷孔是最为常见的突出预兆,合理利用钻孔信息进行灾害探测及预警是重要的发展方向。证实了突出动力效应在巷道空间发展演化的3个阶段,瓦斯逆流不仅会通过防突风门进入进风巷,也可能会沿回风路线进入其他采掘作业面。

关键词：煤与瓦斯突出事故统计发生规律动力效应事故案例

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Spatial-and spin-resolution ARPES and magnetism beamline at SSRF

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Nuclear Science and Techniques 2024年第8期35卷 23-37页

作者： Fang‑Yuan Zhu jie‑Feng cao Xiang‑Yu Meng Jun‑Qin Li Rui Yu Ya‑Mei Wang Shan Qiao Bo Zhao Ming‑Zhu Zhang Zhong‑Kai Liu Mei‑Xiao Wang Yong Wang Ren‑Zhong Tai Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China ShanghaiTech Laboratory for Topological Physics School of Physical Science and TechnologyShanghai Tech UniversityShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China

The BL07U beamline is a new extreme ultraviolet and soft X-ray beamline housed in the Shanghai Synchrotron Radiation Facility. Beamlines are used in nano-resolved angle-resolved photoemission spectroscopy(nano-ARPES), spin-resolved angle-resolved photoemission spectroscopy(spin-ARPES), X-ray magnetic circular dichroism spectroscopy, and X-ray magnetic linear dichroism spectroscopy for certain scientific research. The BL07U beamline, which is based on a pair of elliptical polarized undulators and a variable-included-angle plane-grating monochromator, delivers circularly or linear polarized X-rays within the energy range of 50–2000 eV. The beamline features two branches: One dedicated to nano-ARPES,which has a minimum spot size of only ~ 200 nm, and another branch comprising spin-ARPES, a vector magnetic field, and superconductive magnetic end-station.

关键词： Soft X-ray beamline Nano-ARPES Spin-ARPES XMCD/XMLD