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Assessing the possibility of using large language models in ocular surface diseases

International Journal of Ophthalmology(English edition) 2025年第1期18卷 1-8页

作者： Qian Ling Zi-Song Xu Yan-Mei Zeng Qi Hong Xian-Zhe Qian Jin-Yu Hu Chong-Gang Pei Hong Wei jie zou Cheng Chen Xiao-Yu Wang Xu Chen Zhen-Kai Wu Yi Shao Department of Ophthalmology the First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburgNetherlands Changde Hospital Xiangya School of MedicineCentral South University(the First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To assess the possibility of using different large language models(LLMs)in ocular surface diseases by selecting five different LLMS to test their accuracy in answering specialized questions related to ocular surface diseases:ChatGPT-4,ChatGPT-3.5,Claude 2,PaLM2,and ***:A group of experienced ophthalmology professors were asked to develop a 100-question singlechoice question on ocular surface diseases designed to assess the performance of LLMs and human participants in answering ophthalmology specialty exam *** exam includes questions on the following topics:keratitis disease(20 questions),keratoconus,keratomalaciac,corneal dystrophy,corneal degeneration,erosive corneal ulcers,and corneal lesions associated with systemic diseases(20 questions),conjunctivitis disease(20 questions),trachoma,pterygoid and conjunctival tumor diseases(20 questions),and dry eye disease(20 questions).Then the total score of each LLMs and compared their mean score,mean correlation,variance,and confidence were ***:GPT-4 exhibited the highest performance in terms of *** the average scores of the LLMs group with the four human groups,chief physician,attending physician,regular trainee,and graduate student,it was found that except for ChatGPT-4,the total score of the rest of the LLMs is lower than that of the graduate student group,which had the lowest score in the human *** ChatGPT-4 and PaLM2 were more likely to give exact and correct answers,giving very little chance of an incorrect ***-4 showed higher credibility when answering questions,with a success rate of 59%,but gave the wrong answer to the question 28% of the ***:GPT-4 model exhibits excellent performance in both answer relevance and ***2 shows a positive correlation(up to 0.8)in terms of answer accuracy during the *** terms of answer confidence,PaLM2 is second only to GPT4 and surpasses Claude 2,SenseNova,and *** the fact t

关键词： ChatGPT-4.0 ChatGPT-3.5 large language models ocular surface diseases

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Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry

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International Journal of Ophthalmology(English edition) 2025年第2期18卷 258-267页

作者： Li-Jun Ji Jin-Yu Hu Yan-Mei Zeng Qian Ling jie zou Cheng Chen Liang-Qi He Xiao-Yu Wang Hong Wei Xu Chen Yi-Xin Wang Yi Shao Yao Yu Department of Ophthalmology Dahua HospitalShanghai 200237China Department of Endocrine and Metabolic the First Affiliated Hospital of Nanchang UniversityJiangxi Clinical Research Centre for Endocrine and Metabolic DiseaseJiangxi Branch of National Clinical Research Center for metabolic DiseaseNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg Provinciethe Netherlands School of optometry and vision science Cardiff UniversityCardiffCF244HQWalesUK Department of Ophthalmology Shanghai General HospitalShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Eye DiseasesShanghai 200080China

AIM:To elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage(DVH)and its correlation with clinical ***:Twenty-one individuals with DVH(male/female 12/9;mean age 52.29±11.66y)were selected,alongside 21 appropriately matched controls with diabetes mellitus(DM).Voxel-based morphometry(VBM)techniques were employed to identify aberrant functional regions in the *** operating characteristic(ROC)curves were utilized for classification based on the average VBM values of the two groups,and Pearson correlation analysis was conducted to assess the relationship between average VBM values in distinct brain regions and clinical ***:Relative to the DM controls,DVH patients exhibited reduced VBM values in the right superior temporal pole,the right superior temporal gyrus,the right medial orbital frontal gyrus,and the left superior frontal ***,ROC curve analysis of these four brain regions in DVH patients demonstrated a high degree of accuracy,as indicated by the area under the *** average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale(HADS).CONCLUSION:Pathological alterations in four distinct brain regions are observed in patients with DVH,potentially reflecting neuropathological changes associated with this condition.

关键词： diabetic vitreous hemorrhage voxel-based morphometry Hospital Anxiety and Depression Scale brain areas

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包覆型MCM-41和Hβ分子筛负载的Pd催化剂双功能催化性能

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石油学报(石油加工) 2025年第1期41卷 14-21页

作者：邹洁李翔盛强尚森森王伟银川能源学院化学与生物工程学院宁夏银川750105 天津科技大学化工与材料学院天津市卤水化工与资源生态化利用重点实验室天津300457

采用水热合成法制备了一种MCM-41分子筛介孔孔道沿Hβ沸石内核向外生长的包覆型MCM-41和Hβ复合分子筛(Mβ)。以PdCl 2的盐酸溶液做浸渍液,用常规等体积浸渍法制备了Pd/Mβ催化剂。另外,还以预先硅烷化的Mβ作载体,以Pd(OAc)_(2)的甲苯... 详细信息

采用水热合成法制备了一种MCM-41分子筛介孔孔道沿Hβ沸石内核向外生长的包覆型MCM-41和Hβ复合分子筛(Mβ)。以PdCl 2的盐酸溶液做浸渍液,用常规等体积浸渍法制备了Pd/Mβ催化剂。另外,还以预先硅烷化的Mβ作载体,以Pd(OAc)_(2)的甲苯溶液作浸渍液,用等体积浸渍法制备了Pd/S-Mβ催化剂。采用X射线衍射、N_(2)物理吸附、透射电镜(TEM)和吡啶吸附红外等手段对催化剂进行了表征,并以十氢萘的开环反应和二苯并噻吩的加氢脱硫反应评价了催化剂的性能,认识了金属中心和酸中心沿颗粒内部径向分布对双功催化剂能性能的影响。TEM结果表明,在Pd/Mβ催化剂中,Pd金属颗粒填充于MCM-41介孔相孔道中;而在Pd/S-Mβ催化剂中,Pd金属颗粒分布于催化剂表面。在十氢萘的开环和二苯并噻吩的加氢脱硫反应中,Pd/Mβ表现出双功能特性,是潜在的性能良好的加氢脱硫催化剂。尽管Pd/Mβ和Pd/S-Mβ酸性质基本一致,但是空间上将表面Pd金属组分与内核Hβ沸石酸组分用不具有酸性的MCM-41介孔相分隔后,会导致Pd/S-Mβ催化剂酸中心不能发挥作用。

关键词：颗粒内分布钯双功能催化剂 Hβ沸石 MCM-41分子筛包覆型分子筛复合分子筛

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Readout electronics for the gamma detector of the HIRFL-CSR external target facility

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Nuclear Science and Techniques 2025年第2期36卷 71-81页

作者： Xian-Qin Li Hai-Bo Yang Xiao-Meng Ma Chao-jie zou Tao Liu Xian-Cai Zhou Duo Yan Yang-Zhou Su Shu-Wen Tang Shi-Tao Wang Yu-Hong Yu Zhi-Yu Sun Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physics and Electronic Engineering Northwest Normal UniversityLanzhou 730070China School of Big Data and Information Engineering Guizhou UniversityGuiyang 550025China

The Cooling Storage Ring of the Heavy Ion Research Facility in Lanzhou(HIRFL-CSR)was constructed to study nuclear physics,atomic physics,interdisciplinary science,and related *** External Target Facility(ETF)is located in the main ring of the *** gamma detector of the ETF is built to measure emitted gamma rays with energies below 5 MeV in the center-of-mass frame and is planned to measure light fragments with energies up to 300 *** readout electronics for the gamma detector were designed and *** readout electronics consist of thirty-two front-end cards,thirty-two readout control units(RCUs),one common readout unit,one synchronization&clock unit,and one sub-trigger *** using the real-time peak-detection algorithm implemented in the RCU,the data volume can be significantly *** addition,trigger logic selection algorithms are implemented to improve the selection of useful events and reduce the data *** test results show that the integral nonlinearity of the readout electronics is less than 1%,and the energy resolution for measuring the 60 Co source is better than 5.5%.This study discusses the design and performance of the readout electronics.

关键词： HIRFL-CSR Gamma detector External target facility Readout electronics Readout control unit Common readout unit Peak-detection algorithm

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Reinforcement Learning Based Data Fusion Method for Multi-Sensors

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IEEE/CAA Journal of Automatica Sinica 2020年第6期7卷 1489-1497页

作者： Tongle Zhou Mou Chen jie zou College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China IEEE Science and Technology on Electron-Optic Control Laboratory Luoyang Institute of Electro-Optical Equipment of AvicLuoyang 471023China

In order to improve detection system robustness and reliability, multi-sensors fusion is used in modern air combat. In this paper, a data fusion method based on reinforcement learning is developed for multi-sensors. Initially, the cubic B-spline interpolation is used to solve time alignment problems of multisource data. Then, the reinforcement learning based data fusion(RLBDF) method is proposed to obtain the fusion results. With the case that the priori knowledge of target is obtained, the fusion accuracy reinforcement is realized by the error between fused value and actual value. Furthermore, the Fisher information is instead used as the reward if the priori knowledge is unable to be obtained. Simulations results verify that the developed method is feasible and effective for the multi-sensors data fusion in air combat.

关键词： Air combat cubic B-spline interpolation data fusion reinforcement learning

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Changes in retinal capillary density in female with type 2 diabetes and gestational diabetes——an analysis based on OCTA technology

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International Journal of Ophthalmology(English edition) 2025年第3期18卷 435-448页

作者： Jing Zhang Yao Yu Xian-Mei Zhou Xuan Liao Jin-Yu Hu Qian Ling jie zou Cheng Chen Liang-Qi He Hong Wei Xu Chen Yi-Xin Wang Yi Shao Rui-Man Li Department of Obstetrics and Gynecology the First Affiliated Hospital of Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Obstetrics and Gynecology Changde HospitalXiangya School of MedicineCentral South University(the First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Endocrine and Metabolic the First Affiliated Hospital of Nanchang UniversityJiangxi Clinical Research Centre FOR Endocrine and Metabolic DiseaseJiangxi Branch of National Clinical Research Center for Metabolic DiseaseNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology of Affiliated Hospital and Ophthalmology&Optometry of Medical School North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg Provinciethe Netherlands School of Optometry and Vision Science Cardiff UniversityCardiffCF244HQWalesUK

AIM:To evaluate alterations in conjunctival vascular density(CVD)and macular capillary density(MCD)in female patients with type 2 diabetes mellitus(T2DM)and gestational diabetes mellitus(GDM)using optical coherence tomography angiography(OCTA).METHODS:A total of 60 female participants were recruited,comprising 20 patients with T2DM,20 patients with GDM,and 20 healthy age-matched controls(HCs).OCTA was used to assess superficial and deep retinal and conjunctival capillary ***,changes in MCD were analyzed using a circular segmentation method(C1-C6),a hemispheric quadrant segmentation method[superior right(SR),superior left(SL),inferior left(IL),and inferior right(IR)],and the early treatment diabetic retinopathy study(ETDRS)segmentation method(S,I,R,L).RESULTS:OCTA unequivocally demonstrated that the variations in CVD among HCs,T2DM,and GDM groups were statistically significant(P<0.001).In the superficial retinal capillary plexus(sRCP),significant differences were observed in the densities of total microvascular(TMI),microvasculature(MIR),and macrovascular(MAR)between patients with T2DM and HCs(P<0.05).Furthermore,the GDM group exhibited a more substantial reduction in MIR density compared to the T2DM group(P<0.01).In the deep retinal capillary plexus(dRCP),significant differences in the densities of TMI and MIR were identified between the T2DM group and HCs(P<0.05),with a notable difference in TMI density also observed between the GDM and T2DM groups(P<0.01).In the receiver operating characteristic(ROC)curve analysis,the area under the ROC curve(AUC)for TMI in sRCP between the T2DM group and HCs was 0.975,with a 95%confidence interval(CI)of 0.941–*** AUC for MIR was highest in dRCP,with an AUC value of 0.914 and a 95%CI ranging from 0.847 to *** comparing the GDM and T2DM groups,the AUC for I region was maximized in sRCP,achieving a value of 0.978 with a 95%CI of 0.953–***,the AUC for R region was maximized in dRCP,reaching a value

关键词： diabetes optical coherence tomography angiography superficial retinal capillary plexus deep retinal capillary plexus retinal region segmentation method

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Effect of particle size on high-pressure methane adsorption of coal

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Petroleum Research 2016年第1期1卷 53-58页

作者： jie zou Reza Rezaee Department of Petroleum Engineering Curtin UniversityWestern AustraliaAustralia

Adsorbed gas cannot be neglected in the evaluation of coalbed methane and shale gas since a significant proportion of gas is stored in the form of adsorbed *** methane of coal and shale has been widely studied by high-pressure methane adsorption *** sample treatment of the experiment,the sample is crushed and sieved to a particular particle size ***,how particle size influence high-pressure methane adsorption is still *** this study,low-pressure nitrogen(N_(2))and high-pressure methane adsorption have been measured on coal samples with different particle *** to N2 sorption analysis,pore volume and surface area increase with particle size *** size distribution of small pores(10nm)decreases with decreasing particle *** particle size by crushing sample introduces new connectivity for closed pores to the particle *** responses of isotherms of high-pressure methane adsorption are different with different particle *** adsorption at initial pressure(145psi)increases with decreasing particle *** increase rate at high pressure(435-870psi)decreases with particle size *** can be explained that fine sample has more pore volume and higher pore volume proportion of small pores(<10nm).Sample with particle size of 150-250μm has the highest Langmuir volume.

关键词： particle size high-pressure methane adsorption coal shale gas

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A mask R-CNN based method for inspecting cable brackets in aircraft

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Chinese Journal of Aeronautics 2021年第12期34卷 214-226页

作者： Gang ZHAO Jingyu HU Wenlei XIAO jie zou School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China MIIT Key Laboratory oj Aeronautics Intelligent Manufacturing Beihang UniversityBeijing 100191China

In the aviation industry,cable bracket is one of the most common *** traditional assembly state inspection method of cable bracket is to manually compare by viewing 3 D *** purpose of this paper is to address the problem of inefficiency of traditional inspection *** order to solve the problem that machine learning algorithm requires large dataset and manually labeling of dataset is a laborious and time-consuming task,a simulation platform is developed to automatically generate synthetic realistic brackets images with pixel-level annotations based on 3 D digital *** order to obtain accurate shapes of brackets from 2 D image,a brackets recognizer based on Mask R-CNN is *** addition,a semi-automatic cable bracket inspection method is *** this method,the inspector can easily obtain the inspection result only by taking a picture with a portable device,such as augmented reality(AR)*** inspection task will be automatically executed via bracket recognition and *** experimental result shows that the proposed method for automatically labeling dataset is valid and the proposed cable bracket inspection method can effectively inspect cable bracket in the ***,a prototype system based on client-server framework has been developed for validation purpose.

关键词： Aircraft assembly Augmented reality Cable bracket Mask R-CNN Synthetic dataset Template matching Visual inspection

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环索奈德与布地奈德治疗轻中度支气管哮喘的成本-效用分析

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中国药房 2025年第2期36卷 203-207页

作者：邹杰黄洁莹王丽娜杜雯雯徐伟中国药科大学国际医药商学院南京211198

目的评价环索奈德(CIC)与布地奈德(BUD)用于我国轻中度支气管哮喘患者维持治疗的经济性。方法从中国卫生体系角度出发,以我国一项临床试验数据为基础并参考相关文献构建Markov模型,模型循环周期为1周,研究时限为60年,年贴现率为5%,以3... 详细信息

目的评价环索奈德(CIC)与布地奈德(BUD)用于我国轻中度支气管哮喘患者维持治疗的经济性。方法从中国卫生体系角度出发,以我国一项临床试验数据为基础并参考相关文献构建Markov模型,模型循环周期为1周,研究时限为60年,年贴现率为5%,以3倍2023年我国人均国内生产总值(GDP)为意愿支付(WTP)阈值,对CIC和BUD用药方案进行成本-效用分析,并进行单因素敏感性分析、概率敏感性分析及情境分析。结果与BUD方案相比,CIC方案的增量成本为9 401.67元,患者可多获得0.001 3质量调整生命年(QALYs),增量成本-效果比(ICER)为6 928 868.26元/QALY,远超本研究设定的WTP阈值(268 074元/QALY)。单因素敏感性分析显示,CIC、BUD的用法用量及单价是对ICER影响较大的参数;概率敏感性分析证实,基础分析结果较为稳健;情境分析结果显示,当CIC价格降价至159.95元/瓶时,CIC方案具有经济性的概率与BUD方案相当。结论以3倍我国人均GDP为WTP阈值,与BUD相比,CIC在当前价格下用于我国轻中度哮喘患者维持治疗不具有经济性。

关键词：环索奈德布地奈德支气管哮喘维持治疗成本-效用分析

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健康行为过程取向模型对缺血性脑卒中病人出院准备度的提升效果研究

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循证护理 2025年第3期11卷 526-531页

作者：夏莲李秀秀邹洁江南大学附属医院江苏214000

目的:观察健康行为过程取向模型对缺血性脑卒中病人出院准备度的提升效果。方法:选取2021年2月—2024年1月江南大学附属医院神经内科收治的缺血性脑卒中病人152例作为研究对象,采用随机数字表法将病人分为研究组和常规组,各76例。常规... 详细信息

目的:观察健康行为过程取向模型对缺血性脑卒中病人出院准备度的提升效果。方法:选取2021年2月—2024年1月江南大学附属医院神经内科收治的缺血性脑卒中病人152例作为研究对象,采用随机数字表法将病人分为研究组和常规组,各76例。常规组实施常规护理,研究组在常规组基础上实施健康行为过程取向模型下的护理干预,干预4周。比较两组干预前后出院指导质量、出院准备度、急诊就诊率、1个月非计划性再入院率等情况。结果:干预后,研究组出院准备度各维度评分均高于常规组,出院指导质量总分高于常规组,研究组急诊就诊率、1个月非计划性再入院率低于常规组,差异均有统计学意义(P<0.05)。结论:实施健康行为过程取向模型干预护理后,能帮助病人提升出院准备度,改善出院指导质量,减少病人非计划性再入院率等。

关键词：缺血性脑卒中健康行为过程取向模型出院准备度非计划性再入院率出院指导质量

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