检索结果-南通市图书馆

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-min Lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

关键词：

Global Probabilistic Voltage Sensitivity Analysis of Active Distribution Networks Based on the Compound Gaussian Mixture Model

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Dianwang Jishu/Power System Technology 2025年第1期49卷 295-305页

作者： zhang, Ren Wang, jian Shang, jie Hai, Chen Liu, Haoming School of Electrical and Power Engineering Hohai University Jiangsu Province Nanjing 211100 China College of Artificial Intelligence and Automation Hohai University Jiangsu Province Nanjing 211100 China

The stochasticity of the high penetration of distributed generations (DGs) exacerbates the voltage fluctuation of the active distribution networks (ADNs) and complicates its voltage safety analysis. Therefore, this paper proposes a global probability voltage sensitivity analysis method based on the compound Gaussian mixture model (GMM). Firstly, a shared node path impedance-based global voltage sensitivity analytical model of ADN is derived to quantify the impact of global power fluctuations on node voltage. Considering that the voltage fluctuation has the non-Gaussian characteristic under the superposition influence of power uncertainty injected by multiple nodes, the GMM is used to characterize the probability characteristics of DG and load forecasting errors. Then, based on the affine transformation of the global sensitivity matrix to the GMM of DG and load forecasting error, the probability analytic expression of the voltage fluctuation is constructed, which is caused by the uncertainty of DG and load. Finally, based on the GMM characteristic function, the compound GMM characteristic function of the combined influence of the uncertainty of DG and load on voltage fluctuation is derived, and the global probabilistic voltage sensitivity analysis model based on the compound GMM is established. The case study results show that the proposed method can reflect the probability characteristics of the impact of all node power fluctuations on node voltage, and can quickly and accurately calculate the probability of over-voltage in ADNs. © 2025 Power System Technology Press. All rights reserved.

关键词： Affine transforms

Locally Enhanced Flow and Electric Fields Through a Tip Effect for Efficient Flow‑Electrode Capacitive Deionization

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 1-17页

作者： Ziquan Wang Xiangfeng Chen Yuan zhang jie Ma Zhiqun Lin Amor Abdelkader Maria‑Magdalena Titirici Libo Deng College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518060People’s Republic of China Research Center for Environmental Functional Materials College of Environmental Science and EngineeringTongji University1239 Siping RoadShanghai 200092People’s Republic of China Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore Department of Engineering Faculty of Science and TechnologyBournemouth UniversityTalbot CampusFern BarrowPooleEngland BH125BBUK Institut de Chimie de Nice UniversitéCôte d’AzurUMR CNRS 727228 Av.Valrose06108 NiceFrance Department of Chemical Engineering Imperial College LondonSouth Kensington CampusExhibition RdLondon SW72AZUK

Low-electrode capacitive deionization(FCDI)is an emerging desalination technology with great potential for removal and/or recycling ions from a range of ***,it still suffers from inefficient charge transfer and ion transport kinetics due to weak turbulence and low electric intensity in flow electrodes,both restricted by the current ***,a new tip-array current collector(designated as T-CC)was developed to replace the conventional planar current collectors,which intensifies both the charge transfer and ion transport *** effects of tip arrays on flow and electric fields were studied by both computational simulations and electrochemical impedance spectroscopy,which revealed the reduction of ion transport barrier,charge transport barrier and internal *** the voltage increased from 1.0 to 1.5 and 2.0 V,the T-CC-based FCDI system(T-FCDI)exhibited average salt removal rates(ASRR)of 0.18,0.50,and 0.89μmol cm^(-2) min^(-1),respectively,which are 1.82,2.65,and 2.48 folds higher than that of the conventional serpentine current collectors,and 1.48,1.67,and 1.49 folds higher than that of the planar current ***,with the solid content in flow electrodes increased from 1 to 5 wt%,the ASRR for T-FCDI increased from 0.29 to 0.50μmol cm^(-2) min^(-1),which are 1.70 and 1.67 folds higher than that of the planar current ***,a salt removal efficiency of 99.89%was achieved with T-FCDI and the charge efficiency remained above 95%after 24 h of operation,thus showing its superior long-term stability.

关键词： Flow-electrode Capacitive deionization Current collector Tip effect Desalination

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De zhang jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Recent progress in metal-organic frameworks(Part II—material application)

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： jiandong Pang Wentao jiang Xue-Wen zhang Hao-Long zhou Yuxiu Sun Wei Gong Bin Wang Fuyin Ma Linwei He Long Chen Qiang Chen He-Qi Zheng Yuanjing Cui Wen-jie Shi Chao zhang Mei Wang Yue-Biao zhang jie-Peng zhang Chongli Zhong Yong Cui Shuao Wang jian-Rong Li Guodong Qian Tong-Bu Lu Huan Pang Xian-He Bu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

关键词：

New insights from a plant immune receptor may help design of disease resistant crops

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2023年第1期66卷 194-196页

作者： jie zhang jian-min zhou State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China

Receptor-like proteins(RLPs)are a class of cell surface immune receptors highly important for plant defense against numerous *** these receptors detect pathogen molecules to activate immune signaling has remained poorly understood.A recent study published in Nature uncovers how an RLP protein called Response to XEG1(RXEG1)is activated by a pathogen protein called XEG1.

关键词： insight crops immune

Plant Immune Mechanisms:From Reductionistic to Holistic Points of View

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2020年第10期13卷 1358-1378页

作者： jie zhang Gitta Coaker jian-min zhou Xinnian Dong State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions College of Advanced Agricutural SciencesUniversity of Chinese Academy of SciencesBeijing 100049China Department of Plant Pathology University of CaliforniaOne Shields AvenueDavisCA 95616USA State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Howard Hughes Medical Institute Duke UniversityDurhamNC 27708USA Department of Biology Duke UniversityPO Box 90338DurhamNC 27708USA

After three decades of the amazing progress made on molecular studies of plant-microbe interactions(MPMI),we have begun to ask ourselves"what are the major questions still remaining?"as if the puzzle has only a few pieces *** an exercise has ultimately led to the realization that we still have many more questions than ***,it would be an impossible task for us to project a coherent"big picture"of the MPMI field in a single ***,we provide our opinions on where we would like to go in our research as an invitation to the community to join us in this exploration of new MPMI frontiers.

关键词： extracellular immunity pattern-triggered immunity (PTI) effector-triggered immunity (ETI) heterogeneity in immune responses translational regulation circadian clock

Non-differentiability of Alpha Function at the Boundary of Flat

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2014年第8期30卷 1341-1352页

作者： jian Lu zhang min zhou Department of Mathematics Nanjing University School of Information Management Nanjing University

With the variational method introduced by Mather,we construct a mechanical Hamiltonian system whose α function has a flat F and is non-differentiable at the boundary *** the case of two degrees of freedom,we prove ... 详细信息

关键词： Mather theory α function mechanical systems

A cross-layer design approach on spectrum allocation and resource scheduling in cognitive PMP networks

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第4期9卷 435-444页

作者： jie CHEN min-jian ZHAO Qiao zhou Shi-ju LI Department of Information Science and Electronic Engineering Zhejiang University Hangzhou 310027 China

We propose the spectrum allocation and resource scheduling algorithms in cognitive point to multipoint (PMP) networks with rapid changes of spectrum opportunities and present a media access control (MAC) protocol based on these algorithms. The objective of spectrum allocation is to make efficient use of the spectrum while maintaining the transceiver synchronization on frequency and time in the network. The objective of resource scheduling is to guarantee the quality of service (QoS) requirements of different kinds of connections and to minimize the total energy consumption in the network as well. By sensing only a small set of possible channels in each slot based on the state transition probability of each channel, our spectrum allocation algorithm achieves high spectrum efficiency in the network. The resource scheduling problem is divided into three sub problems and we derive optimal solutions to these problems by greedy algorithm and convex optimization. The simulation results show that our algorithm can make efficient use of the spectrum and the network resources at a cost of low computational complexity.

关键词： Cognitive point to multipoint (PMP) networks Markov process Cross-layer design Convex optimization