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Assessment of the inhibitory effects of sodium nitrite, nisin, potassium sorbate, and sodium lactate on Staphylococcus aureus growth and staphylococcal enterotoxin A production in cooked pork sausage using a predictive growth model

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Food Science and Human Wellness 2018年第1期7卷 83-90页

作者： Lu Lin jie Yun Hu Yi Wu Min Chen jie ou Wei Ling Yan Shanghai Food Research Institute Shanghai 200235China Shanghai Municipal Center for Disease Control and Prevention Shanghai 200336China Shanghai Ocean University Shanghai 201306China

This study was conducted to analyze the effects of sodium nitrite,nisin,potassium sorbate,and sodium lactate against Staphylococcus aureus(***)growth and staphylococcal enterotoxins(SEs)production in cooked pork sausage by inoculating sausage samples containing preservative with an *** strain producing staphylococcal enterotoxin A(SEA)and then storing them at 37℃ for 36 *** were analyzed every 3 h to count the *** colonies and to detect *** modified Gompertz model was used to describe *** growth in the samples under various conditions,and the preservatives with a significant antimicrobial effect were *** addition,the antimicrobial effects of the selected preservatives under various concentrations were *** showed that sodium nitrite,nisin,and potassium sorbate had a weak effect against *** growth and had no effect against SEA production,whereas sodium lactate could significantly inhibit *** growth and SEA ***,the antimicrobial effect of sodium lactate was concentration-dependent,wherein sodium lactate concentrationould effectively inhibit *** growth and SEA production,and at 48 g/kg,sodium lactate had a significant inhibitory effect.

关键词： Staphylococcus aureus Staphylococcal enterotoxin A Cooked pork sausage Preservative Sodium lactate

Potential effects of the nursing work environment on the work-family conflict in operating room nurses

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World Journal of Clinical Cases 2021年第26期9卷 7738-7749页

作者： Chun-Mei Fu jie ou Xiao-Mei Chen Mei-Ye Wang Department of Ophthalmology Hainan West Central HospitalDanzhou 571700Hainan ProvinceChina Department of Critical Care Medicine Hainan General HospitalHaikou 570311Hainan ProvinceChina Operation Room The Second Affiliated Hospital of Hainan Medical CollegeHaikou 570311Hainan ProvinceChina Department of General Practice Hainan West Central HospitalDanzhou 571700Hainan ProvinceChina

BACKGRouND The nursing working environment is an important subsystem in the hospital environment.A good working environment could have a positive impact on ***,the work-family conflict and unsatisfactory working environment could significantly reduce their working enthusiasm,efficacy as well as the overall quality of the nursing,increase their fatigue,and thereby compromise their career *** To explore the possible status quo and to analyze the correlation between work environment perception and the work-family conflict among nurses in the operating *** A total of 312 operating room nurses from two first-class hospitals at Grade 2 and two first-class hospitals at Grade 3 in China from May to September 2017 were included in this research using the cluster sampling *** data,including the general information questionnaire,the practice environment scale of the nursing work index(PES-NWI),and the work-family conflict scale,were systematically *** correlation analysis was applied to analyze the correlation between the two scores,with influencing factors analyzed by hierarchical regression *** A total of 312 questionnaires were issued,and the response rate and effective questionnaire rate were both 96.15%(300/312).The total scores of the PES-NWI scale and the work-family conflict scale were 3.07±0.43(vs maximum up to 4 points)and 52.32±8.79(vs maximum up to 90 points),*** scores of the PES-NWI scale were negatively correlated with that of work-family conflict scale(all Pound at a medium level with a negative correlation between the two.

关键词： Operating room nurses Perception of nursing work environment Workfamily conflict Correlation Influencing factors

Gasdermin D Inhibitor Necrosulfonamide Alleviates Lipopolysaccharide/D-galactosamine-induced Acute Liver Failure in Mice

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1148-1154页

作者： Yi-Long Wu Wei-jie ou Ming Zhong Su Lin Yue-Yong Zhu Endoscopy Center the First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Department of Hepatol-ogy Hepatology Research Institutethe First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Endocri-nology Department Metabolic Diseases Research Institutethe First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Fujian Diabetes Research Institute the First Affiliated HospitalFujian Medical UniversityFuzhouFujianChina Clinical Research Center for Liver and Intestinal Diseases of Fujian Province FuzhouFujianChina

Background and Aims:Acute liver failure(ALF)is as-sociated with high *** D(GSDMD)is the executioner of pyroptosis and is involved in the patho-physiology of immune dysregulation This study investi-gated the role of the GSDMD inhibitor necrosulfonamide(NSA)in ***:An ALF model was established by lipopolysaccharide/D-galactosamine challenge in C57BL/6J *** were divided into four groups:normal controls(control group),ALF group(ALF group),dimethyl sulfoxide group(DMSO group),and NSA intervention group(NSA group).Survival was monitored,liver damage was de-termined by hematoxylin and eosin staining,and serum alanine aminotransferase(ALT).Underlying mechanisms were explored by quantitative real-time PCR,western blot-ting,and enzyme-linked immunosorbent ***:Pyroptosis was activated in ALF model *** treat-ed with GSDMD inhibitor NSA developed less severe liver *** reduced the expression of GSDMD,NLRP3,cleaved caspase-1,cleaved caspase-11,and secretion of interleukin-1 beta in ALF mice ***:Py-roptosis was activated in *** alleviated ALF via the pyroptosis pathway.

关键词： Liver failure Acute Pyroptosis GSDMD GSDMD-NT Necrosul-fonamide

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减压汇流式PRB污染物迁移阻控性能研究

中国环境科学 2025年第2期45卷 829-840页

作者：郑凯旋李义豪李富丽陈平区杰泳雷蕾陈岩贽王炜丁洁彭香琴刘娜温勇刘晓文王洪涛生态环境部华南环境科学研究所国家环境保护环境污染健康风险评价重点实验室广东广州510655 暨南大学生命科学技术学院广东广州510632 广东工业大学环境科学与工程学院广东广州510006 清华大学环境学院北京100084

减压汇流式渗透性反应墙(PC-PRB)是一种绿色可持续的地下水原位修复技术.本研究基于地下水运动和污染物迁移数学模型,创新性地提出网格自适应细化算法,并开发了基于此算法的污染物对流-弥散数值模拟软件PRB-Trans;利用PRB-Trans解析了... 详细信息

减压汇流式渗透性反应墙(PC-PRB)是一种绿色可持续的地下水原位修复技术.本研究基于地下水运动和污染物迁移数学模型,创新性地提出网格自适应细化算法,并开发了基于此算法的污染物对流-弥散数值模拟软件PRB-Trans;利用PRB-Trans解析了减压汇流过程对PC-PRB污染物捕集性能的影响规律;在给定模拟污染源条件下,与连续式PRB(C-PRB)相比,PC-PRB所需的PRB长度L_(PRB)和PRB高度H_(PRB)分别减少40.0%和70.0%;PC-PRB平面和剖面污染物处理效率分别增加102.9%和348.3%.影响因素探究结果表明,随着导水管长度L_(p)的增加,PC-PRB所需的L_(PRB)和H_(PRB)减少,但减少幅度逐渐降低,同时,PRB厚度H_(PRB)显著增加,导致PRB填料体积增大.为避免此情况出现,建议L_(p)/L_(PRB)比值小于2.此外,由于减压汇流井的混合调配功能和缓冲层的均匀布水功能,PC-PRB可有效解决C-PRB填料利用率低和局部击穿等问题,显示出其在地下水修复领域的应用潜力.

关键词：渗透性反应墙减压汇流污染物迁移阻控数值模拟影响因素分析

A novel small-animal locomotor activity recording device for biological clock research

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Animal Models and Experimental Medicine 2024年第1期7卷 71-76页

作者： Yi-Long Wu Ming Zhong Jun Yin Wei-jie ou Yu-Bin Zhuang Nan-Wen Zhang Su Lin Yue-Yong Zhu Endoscopy Center The First Affiliated HospitalFujian Medical UniversityFuzhouChina Department of Endocrinology The First Affiliated HospitalFujian Medical UniversityFuzhouChina Chuangke Workshop Technology Co. LtdShenzhenChina Department of Digestive Nutrition Fujian Children's HospitalFuzhouChina Experimental Animal Center Fujian Medical UniversityFuzhouChina Department of Pharmacology Fujian Medical UniversityFuzhouChina Department of Hepatology Hepatology Research InstituteClinical Research Center for Liver and Intestinal Diseases of Fujian ProvinceThe First Affiliated HospitalFujian Medical UniversityFuzhouChina

The rodent running-wheel recording apparatus is a reliable approach for studying cir-cadian *** study demonstrated how to construct a simple and intelligent running-wheel recording *** running wheel was attached to the cage's base,whereas the Hall sensor was attached to the cage's ***,the RJ25 adaptor relayed the running signal to the main control ***,the main control board was connected to the USB port of the computer with the USB *** were collected using the online-accessible,self-created software *** Magturning,generated data were saved and exported in real ***,the device was validated by collecting data on the locomotor activities of mice under dif-ferent light *** conclusion,this new device can record circadian activity of *** device is appropriate for interdisciplinary investigations related to biological clock research.

关键词： biological clock circadian rhythm intelligent equipment locomotor activity running wheel

非对称有限电场作用下2-甲基环己酮分子的光谱特性

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吉林大学学报（理学版） 2017年第4期55卷 979-984页

作者：鲍捷欧仁侠吉林医药学院生物医学工程学院吉林吉林132013

采用密度泛函及含时密度泛函理论(TD-DFT)的B3P86方法,在6-311++g(2df)基组水平上计算2-甲基环己酮(CH_3—C_6H_9O)分子从基态到第1~第8个激发态的激发能、波长和振子强度,并考察非对称有限电场对CH_3—C_6H_9O分子激发态的影响规律.结... 详细信息

采用密度泛函及含时密度泛函理论(TD-DFT)的B3P86方法,在6-311++g(2df)基组水平上计算2-甲基环己酮(CH_3—C_6H_9O)分子从基态到第1~第8个激发态的激发能、波长和振子强度,并考察非对称有限电场对CH_3—C_6H_9O分子激发态的影响规律.结果表明:CH_3—C_6H_9O分子的S2,S3,S4,S5,S8等激发态激发能随电场强度的增大呈急剧减小趋势,即外电场作用下CH_3—C_6H_9O分子易于激发和离解.

关键词： 2-甲基环己酮电场激发态含时密度泛函理论

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气相丙酮分子与带电离子的低激发态特性

吉林大学学报（理学版） 2017年第5期55卷 1297-1301页

作者：鲍捷欧仁侠吉林医药学院生物医学工程学院吉林吉林132013

采用密度泛函理论中的B3P86方法,在6-311++G(d,p)基组水平上,优化气相丙酮分子及带电离子的基态稳定几何构型,并用含时密度泛函理论(TD-DFT)方法,研究气相丙酮分子和离子的低激发态特性.结果表明:随着分子获得电子数目的增加,体系能量... 详细信息

采用密度泛函理论中的B3P86方法,在6-311++G(d,p)基组水平上,优化气相丙酮分子及带电离子的基态稳定几何构型,并用含时密度泛函理论(TD-DFT)方法,研究气相丙酮分子和离子的低激发态特性.结果表明:随着分子获得电子数目的增加,体系能量逐渐增加;S1激发态能量与基态能量差值ΔE减小;分子荧光波长急剧增加;电子跃迁轨道数减少.

关键词：丙酮分子离子低激发态轨道跃迁

植物源天然产物对黄曲霉和黄曲霉毒素B_1的抑制作用研究进展

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食品与发酵工业 2021年第1期47卷 317-326页

作者：谢佳雨张雯欧杰上海海洋大学食品学院上海201306 上海水产品加工及贮藏工程技术研究中心上海201306 农业农村部水产品贮藏保鲜质量安全风险评估实验室(上海) 上海201306

黄曲霉毒素B1(aflatoxin B1,AFB1)是化学物质中致癌性最强的一种,对人和动物的健康具有极大的威胁,尤其是对肝脏的损害。AFB1是谷物和粮油中最为多见的真菌毒素,危害性也最强,长期低剂量的摄入AFB1除了会导致肝脏损伤和诱发肝癌之外,也... 详细信息

黄曲霉毒素B1(aflatoxin B1,AFB1)是化学物质中致癌性最强的一种,对人和动物的健康具有极大的威胁,尤其是对肝脏的损害。AFB1是谷物和粮油中最为多见的真菌毒素,危害性也最强,长期低剂量的摄入AFB1除了会导致肝脏损伤和诱发肝癌之外,也会损害人体的其他器官。因此,能够有效防护人体免遭AFB1损伤的功能食品和新型保健药物已成为研究重点。近年来,天然产物因其具有生物活性显著、副作用小、多靶点等优点而备受关注,多种植物源天然产物已被报道能够抑制黄曲霉的生长产毒和AFB1的毒性作用。该文主要综述了植物源天然产物对黄曲霉生长产毒和AFB1毒性作用的抑制作用以及其相关抑制机制,为进一步开展AFB1毒性损伤的防护研究工作,开发能降低AFB1对人和动物的毒性损伤的新型保健药物和功能食品提供参考。

关键词：天然产物黄曲霉黄曲霉毒素B_1 生物活性抑制机制

Fabrication of hierarchical ZnIn2S4@CNO nanosheets for photocatalytic hydrogen production and CO2 photoreduction

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Chinese Journal of Catalysis 2020年第3期41卷 454-463页

作者： Kai Zhu jie ou-Yang Qian Zeng Sugang Meng Wei Teng Yanhua Song Sheng Tang Yanjuan Cui School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003JiangsuChina College of Chemistry and Materials Science Huaibei Normal UniversityHuaibei 235000AnhuiChina

Photocatalytic H2 production and CO2 reduction have attracted considerable attention for clean energy *** this work,we designed an efficient photocatalyst by integrating lamellar oxygen-doped carbon nitride(CNO)nanosheets into ZnIn2S4(ZIS)microflowers by a one-step hydrothermal method.A well-fitted 2D hierarchical hybrid heterostructure was *** visible light irradiation,the ZIS@CNO composite with 40 wt%CNO(ZC 40%)showed the highest hydrogen evolution rate from water(188.4μmol·h-1),which was approximately 2.1 times higher than those of CNO and ZIS(88.6 and 90.2μmol·h-1,respectively).Furthermore,the selective CO production rates of ZC 40%(12.69μmol·h-1)were 2.2 and 14.0 times higher than those of ZIS(5.85μmol·h-1)and CNO(0.91μmol·h-1),respectively,and the CH4 production rate of ZC 40%was 1.18μmol·*** enhanced photocatalytic activity of CNO@ZIS is due mainly to the formation of a heterostructure that can promote the transfer of photoinduced electrons and holes between CNO and ZIS,thereby efficiently avoiding recombination of electron-hole pairs.

关键词： ZnIn2S4 Oxygen doped carbon nitride Photocatalysis H2 production CO2 reduction