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Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian Li jie miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

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A low-boom and low-drag design method for supersonic aircraft and its applications on airfoils

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Advances in Aerodynamics 2021年第1期3卷 428-454页

作者： Liu-qing Ye Zheng-yin Ye Kun Ye jie Wu Sheng-jie miao School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Sonic boom reduction has been an urgent need for the development of future supersonic transport,because of the heavy damage of noise *** paper provides a novel concept for supersonic aircraft to reduce the sonic boom and drag coefficient,wherein a suction slot near the leading edge and an injection slot near the trailing edge on the airfoil suction surface are *** make sure of a zero net mass flux flow control,the mass flow sucked in near the leading edge is equal to the mass flow injected near the trailing *** diamond and NACA0008 airfoils are adopted as the baseline airfoil to verify the capability of the proposed design *** effects of the suction and injection location,the suction and injection slot size,the mass flow rate and the attack angle on the ground boom signature and drag coefficient are studied in *** results show that the optimized airfoils with the suction and injection have benefits in both sonic boom reduction and wave drag *** the reduction of the sonic boom intensity is more sensitive to the injection near the trailing edge than the suction near the leading *** the viewpoint of aerodynamics,opening the suction and injection slots will have no adverse effect on the aerodynamic performances of the supersonic aircraft and even increase the lift-drag ratio under some *** energy saving,the suction and injection slots can be selectively opened,which are opened when the supersonic aircraft flies over the city but are closed when the aircraft flies over the sea.

关键词： Supersonic flow Sonic boom Supersonic aircraft Optimization Wave drag Low-boom low-drag design

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Comparison of Small-Scale Actively and Passively Q-Switched Eye-Safe Intracavity Optical Parametric Oscillators at 1.57 μm

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Chinese Physics Letters 2012年第7期29卷 95-98页

作者： miao jie-Guang PAN Yu-Zhai QU Shi-Liang Department of Optoelectronics Science Harbin Institute of Technology(Weihai Campus)Weihai 264209

The first experimental comparison between the actively and passively Q-switched intracavity optical parametric oscillators (IOPOs) at 1.57μm driven by a small-scale diode-pumped Nd:YVO4 laser are thoroughly *** is found that the performances of the two types of IOPOs are *** actively Q-switched IOPO features a shorter pulse duration,a higher peak power,and a superior power and pulse ***,in terms of compactness,operation threshold and conversion efficiency,passively Q-switched IOPOs are more *** is further indicated that the passively Q-switched IOPO at 1.57 μm is a promising and cost-effective eye-safe laser source,especially at the low and moderate output *** addition,instructional improvement measures for the two types of IOPOs are also summarized.

关键词： switched passive pumped

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Compact and Highly Efficient Passively Q-Switched Intracavity KTA-OPO at 1.53 and 3.47 μm

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Chinese Physics Letters 2011年第12期28卷 149-152页

作者： miao jie-Guang PAN Yu-Zhai QU Shi-Liang Department of Optoelectronics Science Harbin Institute of Technology(Weihai Campus)Weihai 264209

Both the signal(1.53µm)and idler(3.47µm)performances of a KTA−based optical parametric oscillator(OPO)are *** KTA-OPO is intracavity driven by a diode-pumped Nd:YVO_(4)/Cr:YAG passively Q−switched laser with a quite compact *** signal and idler average output powers up to 941 and 583 mW,respectively,have been achieved,corresponding to an improved diode-to-idler conversion efficiency of 6.5%and a diode-to-OPO(signal+idler)conversion efficiency of 16.9%.At different pump levels,the signal pulse duration and repetition rate are detected to be in the range of 1.8–3.2 ns and 13–112 kHz,***,near diffraction limited and Gaussian type beam profiles at 1.53 and 3.47µm are also observed.

关键词： OPO pumped switched

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Research on Electronic Document Management System Based on Cloud Computing

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Computers, Materials & Continua 2021年第3期66卷 2645-2654页

作者： Jin Han Cheng Wang jie miao Mingxin Lu Yingchun Wang Jin Shi Nanjing University of Information Science&Technology Nanjing210044 China 2Research Institute of State Grid Hunan Electric Power Company LimitedChangsha410007 China 3Nanjing UniversityNanjing210093 China 4Waterford Institute of TechnologyWaterford CityX91 K0EKIreland

With the development of information technology,cloud computing technology has brought many conveniences to all aspects of work and *** the continuous promotion,popularization and vigorous development of e-government and e-commerce,the number of documents in electronic form is getting larger and *** document is an indispensable main tool and real record of e-government and business *** to scientifically and effectively manage electronic documents?This is an important issue faced by governments and enterprises in improving management efficiency,protecting state secrets or business secrets,and reducing management *** paper discusses the application of cloud computing technology in the construction of electronic file management system,proposes an architecture of electronic file management system based on cloud computing,and makes a more detailed discussion on key technologies and *** electronic file management system is built on the cloud architecture to enable users to upload,download,share,set security roles,audit,and retrieve files based on multiple *** electronic file management system based on cloud computing can make full use of cloud storage,cloud security,and cloud computing technologies to achieve unified,reliable,and secure management of electronic files.

关键词： Cloud computing technology electronic file management system cloud security

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用户签约数据一键查询方案研究及应用

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邮电设计技术 2025年第1期 83-86页

作者：苗杰林朝辉王勇唐斌李蓉中国联合网络通信集团有限公司北京100033 中讯邮电咨询设计院有限公司郑州分公司河南郑州450007

为解决人工处理用户投诉工作量大、手段缺失等问题,基于数字化运营“平台+数据+专家”理念,设计了用户签约数据一键查询的解决方案。面向一线客服及维护人员的难点问题设计了用户签约数据查询算法及流程,同时兼顾核心网信令安全等需求,... 详细信息

为解决人工处理用户投诉工作量大、手段缺失等问题,基于数字化运营“平台+数据+专家”理念,设计了用户签约数据一键查询的解决方案。面向一线客服及维护人员的难点问题设计了用户签约数据查询算法及流程,同时兼顾核心网信令安全等需求,运用专家规则实现用户签约数据统一呈现,提升投诉的自动化、智能化处理效率,进一步增强核心网的自智水平。

关键词：用户投诉用户签约数据一键查询数字化运营

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Trace determination of cobalt ion by using malic acid-malonic acid double substrate oscillating chemical system

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Chinese Chemical Letters 2008年第9期19卷 1103-1107页

作者： jie Wang Wu Yang jie Ren miao Guo Xiao Dong Chen Wen Bin Wang Jin Zhang Gao College of Chemistry ＆ Chemical Engineering Northwest Normal University Lanzhou 730070 China

A novel kinetic method for determination of trace amounts of cobalt ion was proposed and validated. The method is based on adding malic acid into classical Belousov-Zhabotinskii （B-Z） oscillating chemical system to form a double substrate one. The results showed that when the concentration of cobalt ion was in the range of 5.27× 10^-8 to 5.37 × 10^-12 mol L^-1, the change of the oscillating period was directly proportional to the negative logarithm of cobalt ion concentration. The sensitivity and precision of the developed method were quite satisfactory. The limit of detection was down to 5.20 × 10^-13 mol L^-1 which was a highest sensitivity found for determination of metal ions using oscillating chemical reaction so far. Some factors influencing the determination were also examined. The method has been successfully used to determine cobalt ion in vitamin B12 injection.

关键词： Two substrate oscillating chemical system Malic acid Cobalt Determination

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Early warning of core network capacity in space-terrestrial integrated networks

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Journal of Systems Engineering and Electronics 2024年第4期35卷 855-864页

作者： HAN Sai LI Ao ZHANG Dongyue ZHU Bin WANG Zelin WANG Guangquan miao jie MA Hongbing China Unicom Research Institute Beijing 100044China China United Network Communications Group Company Limited Beijing 100033China

With the rapid development of low-orbit satellite com-munication networks both domestically and internationally,space-terrestrial integrated networks will become the future development *** space and terrestrial networks with limi-ted resources,the utilization efficiency of the entire space-terres-trial integrated networks resources can be affected by the core network *** order to improve the response efficiency of core networks expansion construction,early warning of the core network elements capacity is *** on the inte-grated architecture of space and terrestrial network,multidimen-sional factors are considered in this paper,including the number of terminals,login users,and the rules of users’migration during *** artifical intelligence(AI)technologies,the regis-tered users of the access and mobility management function(AMF),authorization users of the unified data management(UDM),protocol data unit(PDU)sessions of session manage-ment function(SMF)are predicted in combination with the num-ber of login users,the number of ***,the core network elements capacity can be predicted in *** proposed method is proven to be effective based on the data from real network.

关键词： space-terrestrial integrated networks core network element capacity artificial intelligent(AI)

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An Intelligent Identification Approach of Assembly Interface for CAD Models

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Computer Modeling in Engineering & Sciences 2023年第10期137卷 859-878页

作者： Yigang Wang Hong Li Wanbin Pan Weijuan Cao jie miao Xiaofei Ai Enya Shen School of Media and Design Hangzhou Dianzi UniversityHangzhou310001China School of Software Tsinghua UniversityBeijing100084China

Kinematic semantics is often an important content of a CAD model(it refers to a single part/solid model in this work)in many applications,but it is usually not the belonging of the model,especially for the one retrieved from a common ***,the effective and automatic method to reconstruct the above information for a CAD model is still *** address this issue,this paper proposes a smart approach to identify each assembly interface on every CAD model since the assembly interface is the fundamental but key element of reconstructing kinematic ***,as the geometry of an assembly interface is formed by one or more adjacent faces on each model,a face-attributed adjacency graph integrated with face structure fingerprint is *** can describe each CAD model as well as its assembly interfaces *** that,aided by the above descriptor,an improved graph attention network is developed based on a new dual-level anti-interference filtering mechanism,which makes it have the great potential to identify all representative kinds of assembly interface faces with high accuracy that have various geometric shapes but consistent kinematic ***,based on the abovementioned graph and face-adjacent relationships,each assembly interface on a model can be ***,experiments on representative CAD models are implemented to verify the effectiveness and characteristics of the proposed *** results show that the average assembly-interface-face-identification accuracy of the proposed approach can reach 91.75%,which is about 2%–5%higher than those of the recent-representative graph neural ***,compared with the state-of-the-art methods,our approach is more suitable to identify the assembly interfaces(with various shapes)for each individual CAD model that has typical kinematic pairs.

关键词： Assembly interface identification kinematic semantics reconstruction attributed adjacency graph graph neural network

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受压过程对长龄期自密实棱柱体混凝土抗压强度影响研究

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混凝土 2025年第1期 65-68页

作者：王飞朋苗杰乔文正运城职业技术大学建筑工程学院山西运城044000 吕梁学院建筑与土木工程系山西吕梁033000

采用155 mm×155 mm×305 mm的棱柱体试件,将其在标准养护室中放入,就受压过程对长龄期自密实棱柱体混凝土的抗压强度影响进行了研究。结果表明:在保持水泥、砂率、膨润土、黏土用量以及水胶比等核心参数恒定不变的基础上,可以确定的是... 详细信息

采用155 mm×155 mm×305 mm的棱柱体试件,将其在标准养护室中放入,就受压过程对长龄期自密实棱柱体混凝土的抗压强度影响进行了研究。结果表明:在保持水泥、砂率、膨润土、黏土用量以及水胶比等核心参数恒定不变的基础上,可以确定的是,随着龄期的逐步增加,随着龄期的逐步推进,自密实混凝土的轴心抗压强度或其所能承受的最大应力体现出显著的下降趋势。这一变化趋势与普通混凝土的情况较为相似,其随龄期增长,抗压强度递增,至1年龄期,无粉煤灰混凝土的抗压强度趋于稳定。在龄期逐渐增加以及粉煤灰掺量不断增大的情况下,掺入粉煤灰的混凝土抗压强度呈现出稳步增长的态势。受到龄期的延长的影响,自密实混凝土强度增长系数随之增加,从28 d时的1.00增加到7年时的1.62。自密实混凝土抗压强度与龄期自然对数的关系被证明为正比,且这种正比关系的相关性极强。

关键词：长龄期混凝土抗压强度自密实受压过程

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