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Transcriptomic and machine learning analyses identify hub genes of metabolism and host immune response that are associated with the progression of breast capsular contracture

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Genes & Diseases 2024年第3期11卷 427-437页

作者： Yukun Mao Xueying Hou Su Fu jie luan Breast Plastic and Reconstructive Surgery Center Plastic Surgery HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100144China

Capsular contracture is a prevalent and severe complication that affects the post-operative outcomes of patients who receive silicone breast *** present,prosthesis replacement is the major treatment for capsular contracture after both breast augmentation procedures and breast reconstruction following breast cancer ***,the mecha-nism(s)underlying breast capsular contracture remains *** study aimed to identify the biological features of breast capsular contracture and reveal the potential underlying mechanism using RNA *** tissues from 12 female patients(15 breast capsules)were divided into low capsular contracture(LCC)and high capsular contracture(HCC)groups based on the Baker ***,41 lipid metabolism-related genes were identified through enrichment analysis,and three of these genes were identified as candidate genes by SVM-RFE and LASSO *** then compared the proportions of the 22 types of im-mune cells between the LCC and HCC groups using a CIBERSORT analysis and explored the Cor-relation between the candidate hub features and immune ***,PRKAR2B was positively correlated with the differentially clustered immune cells,which were M1 macro-phages and follicular helper T cells(area under the ROC=0.786).In addition,the expression of PRKAR2B at the mRNA or protein level was lower in the HCC group than in the LCC *** molecular mechanisms were identified based on the expression levels in the high and low PRKAR2B *** findings indicate that PRKAR2B is a novel diagnostic biomarker for breast capsular contracture and might also influence the grade and progression of capsularcontracture.

关键词： Biomarker Breastcapsular contracture Immune infiltration Machinelearning algorithms PRKAR2B

Dexamethasone implant in naive versus refractory patients with diabetic macular edema:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1898-1904页

作者： Qian Xu Chao Yang jie luan Department of Ophthalmology Zhongda HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina School of Medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina

AIM:To evaluate the efficacy and safety of the intravitreal dexamethasone implant in naive and refractory patients with diabetic macular edema(DME).METHODS:PubMed,Embase,Web of Science,and Medline databases were *** main outcomes were best-corrected visual acuity(BCVA)and central retinal thickness(CRT).The secondary outcomes included mean number of injections,intraoperative or postoperative complications including intraocular pressure(IOP)elevation and ***:Ten comparative studies involving a total of 1000 DME eyes including 402 naive eyes and 598 refractory eyes were *** postoperative BCVA in the naive group was significantly better than in the refractory group[mean difference(MD)-0.11,95% confidence interval(CI)-0.17 to-0.05,P=0.0003;MD 8.69,95%CI 5.08 to 12.30,P<0.00001].Additionally,the naive group got greater improvement of BCVA change as well as more gains of BCVA letters than the refractory group[MD 7.71,95%CI 2.02 to 13.40,P=0.008;odds ratio(OR)2.99,95%CI 2.05 to 4.37,P<0.00001].The subgroup analysis revealed that the naive group had significantly higher BCVA gains of≥5,≥10,and≥15 letters compared to the refractory group(P=0.002,0.0001,0.003,respectively).No significant difference was detected between the two groups in either postoperative CRT(MD-22.36,95%CI-46.39 to 1.66,P=0.07)or the overall mean number of injections(MD-0.08,95%CI-0.38 to 0.22,P=0.61).Intraoperative and postoperative complications including the elevation of IOP(OR 0.47,95%CI 0.20 to 1.13,P=0.09)and cataract(OR 1.78,95%CI 0.97 to 3.24,P=0.06)showed no significant differences between the two groups during the follow-up ***:Intravitreal dexamethasone implants for DME can improve anatomical and functional outcomes in both naive and refractory eyes and have a well-acceptable safety ***,naive eyes maintain better visual outcomes than refractory *** provides further evidence of better visual response when used for naive eyes as firstline

关键词： diabetic macular edema dexamethasone implant refractory eyes systemic review

Effectiveness of intravitreal ranibizumab for diabetic macular edema in vitrectomized versus non-vitrectomized eyes:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 729-735页

作者： Yi-Heng Wang Qian Xu jie luan Department of Ophthalmology Zhongda HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina School of Medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina

AIM:To evaluate the effectiveness and safety of intravitreal ranibizumab(IVR)for diabetic macular edema(DME)in vitrectomized versus non-vitrectomized ***:The PubMed,EMBASE,Web of Science,Cochrane,EBSCO were comprehensively searched for studies comparing vitrectomized and non-vitrectomized eyes with *** outcomes of best-corrected visual acuity(BCVA),central macular thickness(CMT),the mean number of intravitreal injection and adverse events were extracted and ***:Six studies involving 641 eyes were *** visual gain significantly improved and CMT significantly reduced in vitrectomized eyes at 6mo and 12mo visits(P<0.05).Although the mean reduction in CMT among non-vitrectomized eyes was significantly greater than in vitrectomized eyes at the 6mo[mean difference(MD)=53.57,95%confidence interval(CI):28.03 to 78.72,P<0.0001]and 12mo(MD=49.65,95%CI:19.58 to 79.72,P=0.01),no significant difference was detected in improvement in BCVA at either 6mo(MD=0.05,95%CI:-0.02 to 0.13,P=0.14)or 12mo(MD=0.03,95%CI:-0.04 to 0.09,P=0.43).Injection number of ranibizumab in non-vitrectomized eyes was significantly less than that in vitrectomized eyes during 6-month period(MD=0.60,95%CI:0.16 to 1.04,P=0.008),while there was no statistically significant difference between the two groups during 12mo of ***:Evidence from current study suggests that IVR was useful for both vitrectomized group and nonvitrectomized group with *** less reduction in macular thickness is found in vitrectomized group,visual improvement between two groups is similar.

关键词： diabetic macular edema ranibizumab vitrectomized eye

A review on vasohibin and ocular neovascularization

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 1004-1008页

作者： Xiao-Nan Hu Yan Ni jie luan Yu-Zhi Ding Department of Ophthalmology Zhongda Hospital Southeast UniversityNanjing 210000Jiangsu ProvinceChina Medical School of Southeast University Nanjing 210000Jiangsu ProvinceChina

Ischemic and neovascular disease is one of the most difficult ocular diseases to deal with ***,poor visual acuity and decreased life quality are bothering patients and ophthalmologists for *** vascular endothelial growth factor(VEGF)was found to be a primary factor in promoting retinal angiogenesis,intravitreal injection of anti-VEGF drugs has been the firstline ***,some patients are refractory to this therapy and problems of economic burden,local complications and adverse effects promote researches into other possible *** vasohibin(VASH)family is a newly-investigated factor in modulating ocular *** family includes VASH1 and VASH2,which show opposite effects of inhibiting and accelerating angiogenesis *** results have been reported in cellular and animal *** further researches,it can be a promising future target of treating ocular neovascular diseases.

关键词： vasohibin ocular neovascularization retinal neovascularization

Efficacy and safety of vitrectomy with internal limiting membrane peeling for diabetic macular edema: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1848-1855页

作者： Xin-Ying Hu Huan Liu Li-Na Wang Yu-Zhi Ding jie luan Department of Ophthalmology Zhongda Hospital Southeast University Department of Epidemiology & Biostatistics School of Public Health Southeast University

AIM： To evaluate the efficacy and safety of vitrectomy with internal limiting membrane（ILM） peeling for diabetic macular edema（DME）. METHODS： The PubMed, Embase, Web of Science, Cochrane, SionMed, ***, CNKI databases and Wanfang databases, published until Oct. 2017, were searched to identify studies comparing the clinical outcomes following vitrectomy with and without ILM peeling, for treating DME. Pooled results were expressed as odds ratios（ORs） with corresponding 95% confidence intervals（CI） for vitrectomy with and without ILM peeling with regard to best corrected visual acuity（BCVA）, central macular thickness（CMT）, and complication incidents. RESULTS： A total of 14 studies involving 857 eyes were included of which three studies were Chinese and the rests were English literatures. Meta-analysis indicated that compared with vitrectomy alone, vitrectomy with ILM peeling could improve BCVA more obviously（OR=1.66, 95%CI： 1.12-2.46, P=0.01） and had higher rate of CMT reduction（OR=3.89, 95%CI： 1.37-11.11, P=0.01）. There were significant statistical differences between the two surgical methods for both BCVA and CMT（P〈0.05）. For the incidence of intraoperative and postoperative complications, the incidence of epiretinal membrane（ERM） was slightly lower in the ILM peeling group than the group without ILM peeling（OR=0.38, 95%CI： 0.07-2.00, P=0.25）, although insignificant statistically. Other incidences of overall complications, iatrogenic peripheral retinal break and increased intraocular pressure indicated no significant difference between two groups（OR=1.19, 95%CI： 0.82-1.73, P=0.36; OR=1.21, 95%CI： 0.66-2.21, P=0.53; OR=1.34, 95%CI： 0.75-2.40, P=0.32）. CONCLUSION： Vitrectomy is effective for DME and the effect can be improved by additional ILM peeling, especially for anatomical efficacy, without increasing the incidence of intraoperative and postoperative complications. However, it is imperative to gain more evaluation in the future due to the paucity of

关键词： internal limiting membrane vitrectomy diabetic macular edema Meta-analysis

2021-2022 monitoring,early warning,and forecasting of global infectious diseases

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Journal of Biosafety and Biosecurity 2022年第2期4卷 98-104页

作者： jie luan Jianbo Ba Bin Liu Xiongli Xu Dong Shu Naval Medical Center of PLA 880 Xiangyin RoadYangpu DistrictShanghaiChina

Background:COVID-19 has had a considerable impact on society since 2019,and the disease has high mortality and infection *** has been a particular focus on how to best manage COVID-19 and how to analyze and predict the epidemic status of infectious diseases in *** The present study analyzed the COVID-19 epidemic patterns and made predictions of future trends based on the statistics obtained from a global infectious disease network data monitoring and early warning system(OBN,http://27.***.41.130:8888/OBN/).The development trends of other major infectious diseases were also *** The global COVID-19 pandemic showed periodic increases throughout *** present,there is a high incidence in European countries,especially in Eastern Europe,followed by in *** risk of contracting COVID-19 was divided into high,medium–high,medium,medium–low,and low grades depending on the stage of the epidemic in each examined region over the current *** occurrence and prevalence of major infectious diseases throughout the world did not significantly change in *** The COVID-19 pandemic has strongly impacted people’s lives and the *** effects of global infectious diseases can be ameliorated by strengthening monitoring and early warning systems and by facilitating the international exchange of information.

关键词： COVID-19 Epidemic Status and development trend Predict

The curvature of cucumber fruits is associated with spatial variation in auxin accumulation and expression of a YUCCA biosynthesis gene

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Horticulture Research 2020年第1期7卷 919-930页

作者： Shengnan Li Chunhua Wang Xiuyan Zhou Dong Liu Chunhong Liu jie luan Zhiwei Qin Ming Xin College of Horticulture and Landscape Architecture Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(Northeast Region)Northeast Agricultural UniversityHarbin 150030China College of Horticulture Fujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyFujian Agriculture and Forestry UniversityFuzhou 350002China

Fruit curving lowers the commercial value of cucumber and leads to significant economic *** mechanism driving the abnormal curving of cucumber is largely *** our previous work,we discovered that 2 days post-anthesis(DPA)was the key time point at which various phenotypic and genotypic characteristics of cucumber fruits are ***,we analyzed the transcriptome of the concave(C1)and convex(C2)sides of curved fruits at 2 DPA by Gene Ontology(GO)enrichment and functional pathway enrichment analyses and identified auxin as a putative factor influencing fruit *** in the curve angle in the fruits and exogenous auxin treatment analyses showed that asymmetric auxin distribution induces fruit *** of differentially expressed genes(DEGs)related to auxin and qPCR validation showed that CsYUC10b had the most significant differential expression when both sides of the curved fruits were *** functional analysis showed that the transcript levels of CsYUC10b and the auxin concentration were even on both sides of the fruit in CsYUC10b-overexpressing plants,which in turn contributed to an equal rate of growth of both sides of cucumber fruits and resulted in a straight shape of the ***,we conclude that CsYUC10b promotes the formation of straight cucumber fruits,with possible applications in the production and breeding of cucumber.

关键词： straight curved curvature

An uncommon case of ectopic breast and its reconstruction

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Chinese Medical Journal 2014年第20期127卷 3674-3675页

作者： Wang Keming luan jie Ma Jiguang 17th Department of Plastic SurgeryPlastic Surgery Hospital ofPeking Union Medical College Beljing 100144 China Department of Plastic Surgery Plastic Surgery Hospital orPeking Union Medical College Beijing 100144 China

Ectopic breasts are described as supernumerary and taberrant breast tissue in multiple studies.1.2 The occurrence is reported generally in a range of 0.2%-5.6% depending on various factors including sex, race, ethnic group, and geographical regions. The classification of ectopic breast was first described by Kajava in 1915 as follows：（1） complete breast with nipple, areola, and glandular tissue; （2） supernumerary breast without areola but with nipple and glandular tissue; （3） supernumerary breast without nipple but with areola and glandular tissue; （4） aberrant glandular tissue only; （5） nipple and areola with gland replaced by fat; （6） nipple only; （7） areola only; and （8） patch of hair only.1 In this study we report an interesting case which belongs to item 1 of Kajava Classification.

关键词： ectopic breast reconstruction

Treatment Options of Macular Edema Secondary to Retinal Vein Occlusion (RVO): A Review

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Open Journal of Ophthalmology 2019年第2期9卷 70-83页

作者： Aradhana Pokharel jie luan Department of Ophthalmology Zhongda Hospital Southeast University Nanjing China

Retinal Vein Occlusion (RVO) is a common retinal vascular disease secondary to diabetic retinopathy resulting in permanent loss of vision despite available treatment options. Main vision impending complication of retinal vein occlusion is macular edema. Laser photocoagulation has been an established method for treating macular edema for many years but nowadays intravitreal injection of Anti-Vascular endothelial growth factors (Ranibizumab, Aflibercept Bevacizumab and Pegaptanib sodium) is the treatment of choice for macular edema from retinal vein occlusion. Intra-vitreal corticosteroids Triamcinolone Acetonide and Dexamethasone implant, are also being used to treat in some macular edema cases but with higher rates of side effects. Numerous surgical methods have been attempted for treating RVO and preventing macular edema;they include pars plana vitrectomy, radial optic neurotomy, laser induced chorioretinal anastomosis, and arteriovenous sheathotomy. Surgical methods supposedly relieve compression of the central retinal vein, altering the pathophysiology of vein occlusion at the level of the lamina cribrosa thus improving blood flow and oxygenation. But limitations result from its complications.

关键词： Retinal Vein Occlusion Macular Edema Branch Retinal Vein Occlusion Central Retinal Vein Occlusion Vascular Endothelial Growth Factor