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Precise nano-programmed ferroptosis with enhanced tumor chemotherapy

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Science China Materials 2020年第10期63卷 2086-2088页

作者： Xing-jie liang College of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Laboratory of Controllable Nanopharmaceuticals CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology of ChinaChinese Academy of Sciences(CAS)Beijing 100190China CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing 100190China

Cancer treatment is one of the greatest challenges in biomedical research,and the development of novel tumor-inhibition mechanisms has long been a topic of interest for researchers in this *** is one such candidate that holds promise for clinical *** is a recently discovered non-apoptotic model of regulated cell death that shows high iron-dependence.

关键词： Cancer clinical chemotherapy

Nanomaterial-based delivery vehicles for therapeutic cancer vaccine development

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Cancer Biology & Medicine 2021年第2期18卷 352-371页

作者： jie liang Xiao Zhao CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety&CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of ChinaBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Nanomaterial-based delivery vehicles such as lipid-based,polymer-based,inorganics-based,and bio-inspired vehicles often carry distinct and attractive advantages in the development of therapeutic cancer *** on various delivery vehicles,specifically designed nanomaterials-based vaccines are highly advantageous in boosting therapeutic and prophylactic antitumor ***,therapeutic vaccines featuring unique properties have made major contributions to the enhancement of antigen immunogenicity,encapsulation efficiency,biocompatibility,and stability,as well as promoting antigen cross-presentation and specific CD8^(+)T cell ***,for clinical applications,tumor-associated antigen-derived vaccines could be an obstacle,involving immune tolerance and deficiency of tumor specificities,in achieving maximum therapeutic ***,when using bioinformatics predictions with emerging innovations of in silico tools,neoantigen-based therapeutic vaccines might become potent personalized vaccines for tumor *** this review,we summarize the development of preclinical therapeutic cancer vaccines and the advancements of nanomaterial-based delivery vehicles for cancer immunotherapies,which provide the basis for a personalized vaccine delivery ***,we review the existing challenges and future perspectives of nanomaterial-based personalized vaccines for novel tumor immunotherapies.

关键词： Nanomaterial-based delivery vehicles bioinformatic prediction neoantigen personalized vaccines tumor immunotherapy

Leaching process of germanium oxide dust

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Rare Metals 2008年第6期27卷 555-559页

作者： liang jie WANG Hua Department of Materials and Metallurgical Engineering Kunming University of Science and Technology Kunming 650093 China Chemistry Department Bo＇ie University Bijie 5511700 China

A thermodynamic analysis on the acid leaching process of germanium oxide dust and discussion on the behaviors of main substances of the dust in the leaching process were carried out. The effects of temperature, acid concentration, leaching time and stirring speed on the leaching rate of germanium were investigated. Based on the characteristic of the dust, the kinetics and reactive mechanism of acid leaching were studied. The results show that the leaching of the dust by acid belonged to ＂the unreacted core shrinking model＂ of producing solid outgrowth layer. The chemical reaction was controlled by inner diffusion process. The apparent activation energy of leaching process was 12.60 kJ/mol. The leaching reaction of germanium was determined to be mainly second order reaction. The optimum conditions were the reaction temperature of 363 K, the leaching time of 2.5 h, the stirring speed of 120 r/min, the solid-to-liquid ratio of 1/8 and the acid concentration of 120 g/L. Under these conditions, the leaching rate of germanium can come up to more than 87%.

关键词： non-ferrous metallurgy leaching process kinetics metallurgical principle germanium oxide dust thermodynamics

Promising Organic Materials Screened out by Computational Strategy Towards Electrically Pumped Lasers

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Chemical Research in Chinese Universities 2020年第6期36卷 1149-1150页

作者： liang jie ZHAO Yongsheng Key Laboratory of Photochemistry Institute of ChemistryChinese Academy of SciencesBeijing 100190P.R.China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China

Although many efforts have been attempted by scientists worldwide,electrically pumped organic lasing emission still remains as one of the greatest challenges in the field of ***,Shuai and coworkers proposed a computational strategy based on time-dependent density ftinctional theory(TDDFT),offering a new avenue to the molecule design and materials selection towards electrically pumped organic *** material property prediction package(MOMAP)previously developed by this group was utilized to obtain photophysical parameters of various organic lasing molecules,and to estimate whether they can fulfill the criteria for electrical *** systematic calculation and evaluation,three compounds,BP3T,CzPVSBF,and BSBCz were screened out as promising candidates,revealing the reliability and universality of the proposed computational *** work has been published online in the Nature Communications in September 8,2020.

关键词： pumped pumping lasing

A visual modeling method for spatiotemporal and multidimensional features in epidemiological analysis:Applied COVID-19 aggregated datasets

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Computational Visual Media 2024年第1期10卷 161-186页

作者： Yu Dong Christy jie liang Yi Chen jie Hua School of Computer Science University of Technology SydneySydneyNSW2007Australia Beijing Key Laboratory of Big Data Technology for Food Safety Beijing Technology and Business UniversityBeijing100048China

The visual modeling method enables flexible interactions with rich graphical depictions of data and supports the exploration of the complexities of epidemiological ***,most epidemiology visualizations do not support the combined analysis of objective factors that might influence the transmission situation,resulting in a lack of quantitative and qualitative *** address this issue,we developed a portrait-based visual modeling method called+*** method considers the spatiotemporal features of virus transmission patterns and multidimensional features of objective risk factors in communities,enabling portrait-based exploration and comparison in epidemiological *** applied+msRNAer to aggregate COVID-19-related datasets in New South Wales,Australia,combining COVID-19 case number trends,geo-information,intervention events,and expert-supervised risk factors extracted from local government area-based *** perfected the+msRNAer workflow with collaborative views and evaluated its feasibility,effectiveness,and usefulness through one user study and three subject-driven case *** feedback from experts indicates that+msRNAer provides a general understanding for analyzing comprehension that not only compares relationships between cases in time-varying and risk factors through portraits but also supports navigation in fundamental geographical,timeline,and other factor *** adopting interactions,experts discovered functional and practical implications for potential patterns of long-standing community factors regarding the vulnerability faced by the *** confirmed that+msRNAer is expected to deliver visual modeling benefits with spatiotemporal and multidimensional features in other epidemiological analysis scenarios.

关键词： visual modeling epidemiological analysis spatiotemporal multidimensional COVID-19

The Unconventional Influence of a Nearby Molecule onto Transport of Single C60 Molecule Transistor

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Chinese Physics Letters 2019年第12期36卷 62-66页

作者： Xiao Guo Wen-jie liang Beijing National Center for Condensed Matter Physics Bejjing Key Laboratory for Nanomaterials and NanodevicesInstitute of PhysicsChinese Academy of SciencesBeijing 100190 CAS Center of Excellence in Topological Quantum Computation and School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190 Songshan Lake Materials Laboratory Dongguan 523808

We study the transport property of single C60 molecular transistors with special focus on the situation that other molecules are in *** devices are prepared using electromigration and thermal deposition *** single C60 molecule transistors show typical coulomb blockade behavior at low *** we increase the coverage of molecules slightly by extending the deposition time,the transport spectrum of devices displays a switching behavior in the general coulomb blockade *** attribute this unconventional phenomenon to the influence from a nearby C60 *** analyzing this transport behavior quantitatively based on the parallel-double-quantum-dot model,the interaction from the nearby molecule is proved to be of capacity and tunneling *** stimulation is also applied to the device to investigate the effect of local charging environment variation on intermolecular interaction.

关键词： transport behavior tunneling

Optimal operation of multi-storage tank multi-source system based on storage policy

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第8期11卷 571-579页

作者： Hai-en FANG jie ZHANG Jin-liang GAO School of Municipal and Environment Engineering Harbin Institute of Technology Harbin 150090 China

A two-stage method is developed to solve a new class of multi-storage tank multi-source (MTMS) systems. In the first stage, the optimal storage policy of each tank is determined according to the electricity tariff, and the ground-level storage tank is modeled as a node. In the second stage, the genetic algorithm, combined with a repairing scheme, is applied to solve the pump scheduling problem. The objective of the pump scheduling problem is to ensure that the required volume is adequately provided by the pumps while minimizing the operation cost (energy cost and treatment cost). The decision variables are the settings of the pumps and speed ratio of variable-speed pumps at time steps of the total operational time horizon. A mixed coding methodology is developed according to the characteristics of the decision variables. Daily operation cost savings of approximately 11% are obtained by application of the proposed method to a pressure zone of S. Y. water distribution system (WDS), China.

关键词： Multi-storage tank system Storage policy Genetic algorithm Repairing scheme Pump scheduling

Kinetics of recrystallization for twin-roll casting AZ31 magnesium alloy during homogenization

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International Journal of Minerals,Metallurgy and Materials 2011年第5期18卷 570-575页

作者： Hu Zhao Pei-jie Li liang-ju He National Center of Novel Materials for International Research Tsinghua University Beijing 100084 China

The kinetics of recrystallization for twin-roll casting AZ31 magnesium alloy with different thicknesses during homogenization was *** is shown that fine grains are first formed at the boundaries of deformed bands in the twin-roll casting *** recrystallized grains with no strain are gradually substituted for the deformed microstructure of twin-roll casting AZ31 magnesium *** incubation temperature and time for the recrystallization of a twin-roll casting AZ31 magnesium alloy strip with a thickness of 3 mm are lower and shorter than those of the 6-mm thick strip,*** 3-mm thick twin-roll casting magnesium alloy has finer grains than the 6-mm thick *** activation energies of recrystallization for twin-roll casting AZ31 magnesium alloy slabs with the thickness of 3 and 6 mm are 88 and 69 kJ/mol,*** kinetics curves of recrystallization for twin-roll casting AZ31 magnesium alloy were obtained.

关键词： magnesium alloys twin-roll casting homogenization kinetics grain size

Assessment and mapping of environmental quality in agricultural soils of Zhejiang Province, China

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Journal of Environmental Sciences 2007年第1期19卷 50-54页

作者： CHENG jie-liang SHI Zhou ZHU You-wei Institute of Agricultural Remote Sensing and Information System Zhejiang University Hangzhou 310029 China Protection and Monitoring Station of Agricultural Environment Bureau of Agriculture Zhejiang Province Hangzhou 310020 China

Heavy metal concentrations in agricultural soils of Zhejiang Province were monitored to indicate the status of heavy metal contamination and assess environmental quality of agricultural soils. A total of 908 soil samples were collected from 38 counties in Zbejiang Province and eight heavy metal （Cd, Cr, Pb, Hg, Cu, Zn, Ni and As） concentrations had been evaluated in agricultural soil. It was found 775 samples were unpolluted and 133 samples were slightly polluted and more respectively, that is approximately 14.65% agricultural soil samples had the heavy metal concentration above the threshold level in this province by means of Nemerow＇s synthetical pollution index method according to the second grade of Standards for Soil Environmental Quality of China （GB15618- 1995）. Contamination of Cd was the highest, followed by Ni, As and Zn were lower correspondingly. Moreover, Inverse Distance Weighted （IDW） interpolation method was used to make an assessment map of soil environmental quality based on the Nemerow＇s pollution index and the soil environmental quality was categorized into five grades. Moreover, ten indices were calculated as input parameters for principal component analysis （PCA） and the principal components （PCs） were created to compare environmental quality of different soils and regions. The results revealed that environmental quality of tea soils was better than that of paddy soils, vegetable soils and fruit soils. This study indicated that GIS combined with multivariate statistical approaches proved to be effective and powerful tool in the mapping of soil contamination distribution and the assessment of soil environmental quality on provincial scale, which is beneficial to environmental protection and management decision-making by local government.

关键词： agricultural soil heavy metals soil environmental quality Nemerow's synthetical pollution index multivariate analysis