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Carbene-catalyzed activation of cyclopropylcarbaldehydes for mannich reaction andδ-lactam formation:remote enantioselecitvity control and dynamic kinetic asymmetric transformation

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Science China Chemistry 2021年第6期64卷 985-990页

作者： jie lv Jun Xu Xuling Pan Zhichao Jin Yonggui Robin Chi State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityGuiyang 550025China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Division of Chemistry&Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

An N-heterocyclic carbene(NHC)-catalyzed enantioselective Mannich reaction of the remoteγ-carbon of cyclopropylcarbaldehydes is disclosed for the first ***-and enantiomerically enriched multicyclicδ-lactam compound is afforded as the main product from 8 possible stereo-specific isomers through dynamic kinetic asymmetric transformation(DYKAT)*** chiral functional molecules can be afforded from the lactam products through simple protocols with retentions of the optical purities.

关键词： N-heterocyclic carbene organocatalysis dynamic kinetic asymmetric transformation 1-cyclopropylcarbaldehydes asymmetric reactions

Direct transformation of dinitrogen: synthesis of N-containing organic compounds via N-C bond formation

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National Science Review 2020年第10期7卷 1564-1583页

作者： Ze-jie lv Junnian Wei Wen-Xiong Zhang Ping Chen Dehui Deng Zhang-jie Shi Zhenfeng Xi Beijing National Laboratory for Molecular Sciences (BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking University Dalian Institute of Chemical Physics Chinese Academy of Sciences Department of Chemistry Fudan University

N-containing organic compounds are of vital importance to lives. Practical synthesis of valuable N-containing organic compounds directly from dinitrogen(N2), not through ammonia(NH3), is a holy-grail in chemistry and chemical industry. An essential step for this transformation is the functionalization of the activated N2units/ligands to generate N-C bonds. Pioneering works of transition metal-mediated direct conversion of N2into organic compounds via N-C bond formation at metal-dinitrogen [N2-M] complexes have generated diversified coordination modes and laid the foundation of understanding for the N-C bond formation mechanism. This review summarizes those major achievements and is organized by the coordination modes of the [N2-M] complexes(end-on,side-on, end-on-side-on, etc.) that are involved in the N-C bond formation steps, and each part is arranged in terms of reaction types(N-alkylation, N-acylation, cycloaddition, insertion, etc.) between [N2-M]complexes and carbon-based substrates. Additionally, earlier works on one-pot synthesis of organic compounds from N2via ill-defined intermediates are also briefed. Although almost all of the syntheses of N-containing organic compounds via direct transformation of N2so far in the literature are realized in homogeneous stoichiometric thermochemical reaction systems and are discussed here in detail, the sporadically reported syntheses involving photochemical, electrochemical, heterogeneous thermo-catalytic reactions, if any, are also mentioned. This review aims to provide readers with an in-depth understanding of the state-of-the-art and perspectives of future research particularly in direct catalytic and efficient conversion of N2into N-containing organic compounds under mild conditions, and to stimulate more research efforts to tackle this long-standing and grand scientific challenge.

关键词： dinitrogen transformation metal-dinitrogen complex N−C bond formation N-containing organic compounds

Veno-venous-extracorporeal membrane oxygenation treatment for severe capillary leakage syndrome: A case report

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World Journal of Clinical Cases 2021年第33期9卷 10273-10278页

作者： Wei-Xin Nong Qing-jie lv Ye-Sheng Lu Department of EICU Guangxi Guigang People’s HospitalGuigang 537100Guangxi Zhuang Autonomous RegionChina

BACKGROUND Capillary leak syndrome(CLS)is characterized by the leakage of large amounts of fluid and plasma proteins into the interstitial space,resulting in hypoalbuminemia,hypovolemic shock,elevated blood concentration,systemic progressive edema,and multiple serosal cavity *** syndromes such as cavity effusion pose a grave threat to the life and health of the *** SUMMARY A 58-year-old female patient was admitted to the hospital after being in a coma for 6 h following accidental ingestion of a *** was treated with phencyclidine hydrochloride and pralidoxime iodide for detoxification,mechanical ventilation to maintain oxygen supply,continuous renal replacement therapy to maintain the internal environment,and hemoperfusion to promote the excretion of *** also received a transfusion of red blood cells and massive fluid ***,her blood pressure was not *** patient was diagnosed with CLS due to pesticide *** was difficult to maintain under full ventilator support;therefore,veno-venous-extracorporeal membrane oxygenation(VV-ECMO)treatment was given 13 h after *** oxygenation level improved,but a large amount of ascites and pleural effusion soon became *** continued drainage with an indwelling drainage tube,and the ECMO flow *** leakage gradually decreased,and ECMO was discontinued 3 d *** the 6th day,the patient recovered from unconsciousness,but on gastroscopic evaluation,severe erosions were found in her entire *** the family’s consent,treatment was stopped,and the patient was discharged from the hospital on the 7th *** ECMO,liquid resuscitation and management,and improvement in plasma colloidal osmotic pressure,circulation,and tissue oxygen supply are crucial in treating CLS.

关键词： Capillary leakage syndrome Pesticide poisoning Liquid resuscitation Hypoxia index Extracorporeal membrane oxidation Case report

Fluorescence Turn-On/Off Responses of In(Ⅲ)-MOF to Short-Chain Perfluorocarboxylic Acids

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Transactions of Tianjin University 2023年第3期29卷 216-224页

作者： jie lv Yabo Xie Lin-Hua Xie Jian-Rong Li Beijing Key Laboratory for Green Catalysis and Separation Department of Chemical EngineeringBeijing University of TechnologyBeijing 100124China

Short-chain perfluorocarboxylic acids(PFCAs) are a class of persistent organic pollutants that are widely used as substitutes for long-chain PFCAs. However, they also pose a non-negligible risk to ecosystems. In this study, we demonstrated that a fluorescent metal–organic framework(MOF)(named V-101) constructed from In^(3+)and an aromatic-rich tetratopic carboxylate ligand 5-[2,6-bis(4-carboxyphenyl) pyridin-4-yl] isophthalic acid(H4BCPIA) exhibited highly efficient turn-off and turn-on fluorescence responses toward five short-chain PFCAs in water and methanol, respectively. The limits of detection of V-101 toward five short-chain PFCAs are down to μg/L level, and it showed good anti-interference abilities toward short-chain PFCAs in the presence of common metal ions. The major mechanisms associated with fluorescence responses were molecular collisions and interactions between V-101 and short-chain PFCAs. This work demonstrates that the structure variety of MOFs imparts them with the potential of MOFs in the detection of short-chain PFCAs for pollution control.

关键词： Perfl uorocarboxylic acids Fluorescent detection Metal–organic framework(MOF)

MicroRNA-145-3p suppresses the malignant behaviors of T-cell acute lymphoblastic leukemia Jurkat cells via inhibiting the NF-kappaB signaling pathway

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BIOCELL 2020年第1期44卷 101-110页

作者： Xin YANG Liqun LU Li HUANG Jing HE jie lv Department of Pediatrics The First Affiliated Hospital of Chengdu Medical CollegeChengduChina

T-cell acute lymphoblastic leukemia(T-ALL)is a hematological tumor caused by the malignant transformation of immature T-cell progenitor *** studies have stated that microRNAs(miRNAs)may play key roles in T-ALL *** study aimed to investigate the roles of miR-145-3p in T-ALL cell proliferation,invasion,and apoptosis with the involvement of the nuclear factor-kappaB(NF-κB)signaling pathway.T-ALL Jurkat cells were harvested,and the expression of miR-145-3p and NF-κB-p65 was ***-and loss-of-functions of miR-145-3p and NF-κB-p65 were performed to identify their roles in the biological behaviors of Jurkat cells,including proliferation,apoptosis,and ***,the current study demonstrated that miR-145-3p was down-regulated while NF-κB-p65 was up-regulated in Jurkat ***-145-3p directly bound to the 3’untranslated region of NF-κ***-expression of miR-145-3p inhibited Jurkat cell proliferation,invasion,and resistance to apoptosis,while over-expression of NF-κB-p65 presented opposite ***-transfection of miR-145-3p and NF-κB-p65 promoted the malignant behaviors of Jurkat cells compared to miR-145-3p transfection alone,while it reduced these behaviors of Jurkat cells compared to NF-κB-p65 transfection *** together,this study provided evidence that miR-145-3p could suppress proliferation,invasion,and resistance to the death of T-ALL cells via inactivating the NF-κB signaling pathway.

关键词： T-cell acute lymphoblastic leukemia Proliferation Invasion Resistance to apoptosis

Specific sensing of antibiotics with metal-organic frameworks based dual sensor system

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Nano Research 2022年第7期15卷 6430-6437页

作者： Yan-Long Zhao Qiang Chen jie lv Ming-Ming Xu Xin Zhang Jian-Rong Li Beijing Key Laboratory for Green Catalysis and Separation and Department of Environmental Chemical Engineering Faculty of Environment and LifeBeijing University of TechnologyBeijing 100124China

The illegal usage of antibiotics as veterinary drugs is an increasing threat for human *** specific sensing of antibiotics with different toxicity levels is of high challenge,and mainly relies on expensive,time-consuming,and complex *** realize specific sensing by rapid and handy optical sensors,a metal-organic framework(MOF)based dual sensor system is herein developed using two MOF materials BUT-128 and BUT-129 with high sensing selectivity and ***-128 and BUT-129 exhibit the lowest limit of detection(LOD)towards chloramphenicol and furazolidone among reported MOF *** corresponding dual sensor system with enriched signal readouts realized specific sensing of the strictly forbidden antibiotics(chloramphenicol and nitrofurans)from other regulated veterinary drugs including thiamphenicol,a structural analog of ***,the strategy of this work is expected to flourish the development of optical sensors with high specificity for environment and food safety purposes.

关键词： antibiotics specific sensing metal-organic frameworks dual sensor fluorescence quenching

Evolutionary game dynamics of combining the Moran and imitation processes

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Chinese Physics B 2019年第2期28卷 94-105页

作者： Xian-Jia Wang Cui-Ling Gu Shao-jie lv Ji Quan Economics and Management School Wuhan University Institute of Systems Engineering Wuhan University School of Management Wuhan University of Technology

One of the assumptions of previous research in evolutionary game dynamics is that individuals use only one rule to update their strategy. In reality, an individual's strategy update rules may change with the environment, and it is possible for an individual to use two or more rules to update their strategy. We consider the case where an individual updates strategies based on the Moran and imitation processes, and establish mixed stochastic evolutionary game dynamics by combining both processes. Our aim is to study how individuals change strategies based on two update rules and how this affects evolutionary game dynamics. We obtain an analytic expression and properties of the fixation probability and fixation times(the unconditional fixation time or conditional average fixation time) associated with our proposed process. We find unexpected results. The fixation probability within the proposed model is independent of the probabilities that the individual adopts the imitation rule update strategy. This implies that the fixation probability within the proposed model is equal to that from the Moran and imitation processes. The one-third rule holds in the proposed mixed model. However, under weak selection, the fixation times are different from those of the Moran and imitation processes because it is connected with the probability that individuals adopt an imitation update rule. Numerical examples are presented to illustrate the relationships between fixation times and the probability that an individual adopts the imitation update rule, as well as between fixation times and selection intensity. From the simulated analysis, we find that the fixation time for a mixed process is greater than that of the Moran process, but is less than that of the imitation process. Moreover, the fixation times for a cooperator in the proposed process increase as the probability of adopting an imitation update increases; however, the relationship becomes more complex than a linear relationshi

关键词： evolutionary game dynamics Moran process imitation process fixation probability fixation time

Total knee arthroplasty in Ranawat Ⅱ valgus deformity with enlarged femoral valgus cut angle:A new technique to achieve balanced gap

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World Journal of Clinical Cases 2022年第19期10卷 6406-6416页

作者： Shuai-jie lv Xiao-Jian Wang jie-Feng Huang Qiang Mao Bang-Jian He Pei-Jian Tong Department of Orthopedics and Traumatology The First Affiliated Hospital and First Clinical College of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina The First Clinical Medical School Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Nearly 10%of patients undergoing primary total knee arthroplasty(TKA)have valgus deformity(VD)of the *** severe VD of the knee,a more lateral structural release is needed to achieve balance between medial and lateral space and neutral femorotibial mechanical axis(FTMA),which is challenging and *** To introduce a new surgical technique of resection,soft tissue release,and FTMA for Ranawat type-Ⅱ VD with a 5-year *** A retrospective study was conducted on patients who underwent TKA from December 2011 to December ***-knee-ankle(HKA),range of motion(ROM),Oxford knee score(OKS),and knee society score(KSS)were used to assess the joint activity of patients in the new theory TKA group(NT-TKA)and were compared with those of the conventional TKA group(C-TKA).RESULTS A total of 103 people(103 knees)were included in this study,including 42 patients with an average follow-up period of 83 mo in the C-TKA group and 61 patients with an average follow-up period of 76 mo in the NT-TKA *** patients had constrained prosthesis,one had common peroneal nerve injury,and two had joint instability in the C-TKA group,but none of these occurred in the NT-TKA *** were significant statistical differences in constrained prosthesis usage and complications between the groups(P=0.002 and P=0.034,respectively).The KSS at 1 mo post-operation for the C-TKA and NT-TKA groups were 11.2±3.8 and 13.3±2.9,respectively,with a significant difference(P=0.007).However,the data of HKA,ROM,OKS KSS,and prosthesis survival rate were insignificant(P>0.05)in both the preoperative and follow-up *** Adopting 5°-7°valgus cut angle for VD and sacrificing 2°neutral FTMA for severe VD which cannot be completely corrected during TKA can reduce the need for soft tissue release,maintain early joint stability,reduce the use of constrained prostheses,and minimize postoperative complications.

关键词： Valgus,knee Arthroplasty Osteotomy Mechanical axis Bone and soft-tissue balance

Tumor microenvironment-responsive artesunate loaded Z-scheme heterostructures for synergistic photo-chemodynamic therapy of hypoxic tumor

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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 37-48页

作者： jie lv Xiaoyu Wang Xue Zhang Runpei Xu Shuyang Hu Shuangling Wang Meng Li College of Pharmacy Key Laboratory of Innovative Drug Development and EvaluationHebei Medical UniversityShijiazhuang 050017China Postdoctoral Mobile Station of Basic Medicine Hebei Medical UniversityShijiazhuang 050017China

Tumor microenvironment(TME)with the particular features of severe hypoxia,insufficient endogenous H2O2,and overexpression of glutathione(GSH)markedly reduced the antitumor efficacy of ***,a TME-responsive multifunctional nanoplatform(Bi2S3@Bi@PDA-HA/Art NRs)was presented for synergistic photothermal therapy(PTT),chemodynamic therapy(CDT),and photodynamic therapy(PDT)to achieve better therapeutic *** Z-scheme heterostructured bismuth sulfide@bismuth nanorods(Bi2S3@Bi NRs)guaranteed excellent photothermal performance of the ***,its ability to produce O2 and reactive oxygen species(ROS)synchronously could relieve tumor hypoxia and improve PDT *** densely coated polydopamine/ammonium bicarbonate(PDA/ABC)and hyaluronic acid(HA)layers on the surface of the nanoplatform enhanced the cancer-targeting capacity and induced the acidic TME-triggered in situ“bomb-like”release of *** CDT treatment was achieved by activating the released Art through intracellular Fe2+ions in an H2O2-independent ***,decreasing the glutathione peroxidase 4(GPX4)levels by Art could also increase the PDT efficiency of Bi2S3@Bi *** to the synergistic effect,this nanoplatform displayed improved antitumor efficacy with minimal toxicity both in vitro and in *** design sheds light on the application of phototherapy combined with the traditional Chinese medicine monomer-artesunate in treating the hypoxic tumor.

关键词： Hypoxia Z-scheme heterostructure Artesunate Tumor microenvironment Glutathione peroxidase 4 Synergistic therapy