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Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu jie gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

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Fixed-Time Synchronization of Complex Networks via Intermittent Control Without Sign Function

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Journal of Systems Science & Complexity 2022年第5期35卷 1748-1760页

作者： gao jie ZHAO Junchan School of Science Southwest Petroleum UniversityChengdu 610500China School of Science Hunan University of Technology and BusinessChangsha 410205China Key Laboratory of Hunan Province for Statistical Learning and Intelligent Computation Changsha 410205China

This paper investigates the fixed-time synchronization problem of complex networks.A novel switching controller is proposed to solve the *** designed controller in this paper only needs intermittently to pin a few of nodes,which could reduce the control time and save the system’s ***,compared with the existing control methods for the fixed-time synchronization,the novel controller does not use the sign function,which could avoid the chattering *** constructing a Lyapunov function and designing a comparison system,some sufficient conditions are obtained to achieve the fixed-time ***,the numerical simulations could verify the effectiveness and feasibility of the proposed control approaches.

关键词： Chattering behaviors complex networks fixed-time synchronization intermittent control

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A Comprehensive Review of Isogeometric Topology Optimization:Methods,Applications and Prospects

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Chinese Journal of Mechanical Engineering 2020年第6期33卷 24-37页

作者： jie gao Mi Xiao Yan Zhang Liang gao Department of Engineering Mechanics School of Aerospace EngineeringHuazhong University of Science and TechnologyWuhan430074China Hubei Key Laboratory for Engineering Structural Analysis and Safety Assessment Huazhong University of Science and TechnologyWuhan430074China The State Key Lab of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan430074China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan430081China

Topology Optimization(TO)is a powerful numerical technique to determine the optimal material layout in a design domain,which has accepted considerable developments in recent *** classic Finite Element Method(FEM)is applied to compute the unknown structural responses in ***,several numerical deficiencies of the FEM significantly influence the effectiveness and efficiency of *** order to eliminate the negative influence of the FEM on TO,IsoGeometric Analysis(IGA)has become a promising alternative due to its unique feature that the Computer-Aided Design(CAD)model and Computer-Aided Engineering(CAE)model can be unified into a same mathematical *** the paper,the main intention is to provide a comprehensive overview for the developments of Isogeometric Topology Optimization(ITO)in methods and ***,some prospects for the developments of ITO in the future are also presented.

关键词： Topology optimization Isogeometric analysis CAD CAE

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Toward nanoscopic cellular imaging by X-ray

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National Science Review 2021年第3期8卷 7-8页

作者： jie gao Zhen Gu Department of Bioengineering University of California State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences Nankai University Jonsson Comprehensive Cancer Center and California Nano Systems Institute University of California

X-ray spectroscopy has nanometer spatial resolution, long penetration depth and excellent elemental specificity. The power of synchrotron-based X-ray microscopy （XRM） has been demonstrated in assessing the structure...

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Effect of Honeycomb Seals on Loss Characteristics in Shroud Cavities of an Axial Turbine

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Chinese Journal of Mechanical Engineering 2013年第1期26卷 69-77页

作者： gao jie ZHENG Qun WANG Zheng College of Power and Energy Engineering Harbin Engineering University

The loss in efficiency due to shroud leakage or tip clearance flow accounts for a substantial part of the overall losses in turbomachinery. It is important to identify the leakage loss characteristics in order to optimize turbomachinery. At present, little information is available in the open literature concerning the effect of honeycomb seals on the loss characteristics in shroud cavities of an axial turbine, despite of the widespread use of the honeycomb seals. Therefore, interaction between rotor labyrinth seal leakage flow with and without honeycomb facings and main flow is investigated to provide the loss characteristics of the mixing process of the re-entering leakage flow into the main flow. The effects of honeycomb seals on the flow in shroud cavities and interaction with the main flow are analyzed. An additional study on the impact of subtle shroud cavity exit geometry is also presented. The investigation results indicate that the honeycomb seal affects the over tip leakage flow and reduces mixing losses when compared to the solid labyrinth seal. The leakage flow interactions with the main flow have considerably changed the flow fields in the endwall regions. The proposed research reveals the effects of honeycomb seals on the loss characteristics in shroud cavities and the impact of subtle shroud cavity exit geometry, and it is helpful for the design optimization of turbomachinery.

关键词： tip leakage flow honeycomb seal mixing losses exit cavity geometry

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3D Janus plasmonic helical nanoapertures for polarization-encrypted data storage

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Light(Science & Applications) 2019年第1期8卷 788-796页

作者： Yang Chen Xiaodong Yang jie gao Department of Mechanical and Aerospace Engineering Missouri University of Science and TechnologyRollaMO 65409USA

Helical structures have attracted considerable attention due to their inherent optical ***,we report a unique type of 3D Janus plasmonic helical nanoaperture with direction-controlled polarization sensitivity,which is simply fabricated via the one-step grayscale focused ion beam milling *** dichroism in transmission of as large as 0.72 is experimentally realized in the forward direction due to the spin-dependent mode coupling process inside the helical ***,in the backward direction,the nanoaperture acquires giant linear dichroism in transmission of up to *** encoding the Janus metasurface with the two nanoaperture enantiomers having specified rotation angles,direction-controlled polarization-encrypted data storage is demonstrated for the first time,where a binary quick-response code image is displayed in the forward direction under the circularly polarized incidence of a specified handedness,while a distinct grayscale image is revealed in the backward direction under linearly polarized illumination with a specified azimuthal *** envision that the proposed Janus helical nanoapertures will provide an appealing platform for a variety of applications,which will range from multifunctional polarization control,enantiomer sensing,data encryption and decryption to optical information processing.

关键词： helical specified backward

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CONVERGENCE RATE OF A GENERALIZED ADDITIVE SCHWARZ ALGORITHM

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Journal of Computational Mathematics 2006年第5期24卷 635-646页

作者： Jin-ping Zeng gao-jie Chen College of Mathematics and Econometrics Hunan University Changsha 410082 China

The convergence rate of a generalized additive Schwarz algorithm for solving boundary value problems of elliptic partial differential equations is studied. A quantitative analysis of the convergence rate is given for the model Dirichlet problem. It will be shown that a greater acceleration of the algorithm can be obtained by choosing the parameter suitably. Some numerical tests are also presented in this paper.

关键词： Schwarz additive algorithm Convergence rate Dirichlet problem.

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Towards designing efficient catalyst for hydrogen oxidation reaction

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Rare Metals 2020年第10期39卷 1107-1109页

作者： Rui-jie gao Ji-Jun Zou Key Laboratory for Green Chemical Technology of the Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Collaborative Innovative Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China

Anion exchange membrane fuel cells(AEMFCs)have attracted increasing research efforts in the past decade due to the advantageous nature of using Pt-free catalysts and cheap components that bring its cost closer to the ... 详细信息

关键词： catalyst closer designing

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Genome-wide analysis of WRKY gene family in Arabidopsis lyrata and comparison with Arabidopsis thaliana and Populus trichocarpa

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Chinese Science Bulletin 2014年第8期59卷 754-765页

作者： Yu Song jie gao Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Mengla Graduate School of the Chinese Academy of Sciences

WRKY transcription factors are important molecules in regulating plant development and ***,the sequenced Arabidopsis lyrata genome allows us to characterize the number and structure of WRKY genes in this species.A total of 71 AlWRKY factors were classified into the previously defined polyphyletic WRKY groups I to *** exon/intron structure and motif compositions of WRKYs were highly conserved in each group,but tended to be different between groups and *** WRKY family has a set of genes similar to that in ***,but in Populus trichocarpa this family has expanded significantly,except for the subgroup III *** duplication and gene conversion events have played important roles during the evolution of the WRKY gene family in the three ***,the gene expansion events differentiated in WRKY subgroups during the evolution,and we have detected positive selection in several sites of the group III *** addition,this subgroup was the most structurally diversified in the WRKY *** study demonstrated that the group III members of WRKY gene families in ***,***,and *** have experienced different selection pressure during the process of evolution and this may have played a vital role in plant adaptation.

关键词：基因家族 WRKY 基因组分析拟南芥植物生长发育和毛子结构转录因子

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Progress in fabricating arrays of soft spherical vessels on mesoscale with spatial control

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Chinese Science Bulletin 2008年第22期53卷 3477-3490页

作者： YANG jie gao ChangYou Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

Microarrays of spherical vessel-like colloids such as liposomes, polymerized vesicles and polyelec-trolyte capsules may find diverse applications in bioanalysis, biosensing, and combinatorial chemistry, for their capabilities in encapsulating chemical species such as drugs, biomolecules, probes, polymers and nanoparticles. This review reports the advances on methods for fabricating microarrays of the various hollow colloids. Related strategies are described in detail, including patterning techniques, surface modification methods, and tethering approaches such as oligonucleotide hybridization, receptor-ligand binding, covalent coupling and electrostatic interaction. The preliminary developments of functionalities of these arrays serving as sensor chips, microcarriers and microreactors are summarized as well.

关键词：泡状体脂质体微胶囊空间控制

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