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Chinese Chemical Letters 2024年第5期35卷 290-295页

作者： Jiajia Lv jie gao Hongyu Li Zeli Yuan Nan Dong School of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China School of Pharmacy Zunyi Medical UniversityZunyi 563003China Guizhou International Scientific and Technological Cooperation Base for Medical Photo-Theranostics Technology and Innovative Drug Development Zunyi 563003China

As key biomarkers,amyloid-β(Aβ)plaques are frequently used to diagnose Alzheimer’s disease(AD).Although fluorescence imaging has proven to be effective in detecting these plaques,the gold standard probe thioflavin T(ThT),used for Aβaggregates,cannot be applied in vivo owing to its invasive nature.Therefore,the development of novel fluorescent probes capable of identifying Aβplaques in situ is necessary.Based on the ThT structure,twoπ-conjugated heterocyclic D-π-A probes were designed bearing the hydroxytricyanopyrrole acceptor and N,N-dimethylaminophenyl donor.These probes exhibited red to near-infrared fluorescence emission(λ_(max)=732 nm),large Stokes shifts(>100 nm),exceptional signal-to-noise ratio,rapid response(<30 s),and high binding affinity(NT-HTCP=33.32 nmol/L;NF-HTCP=53.35 nmol/L)for Aβaggregates.As the best candidate,NT-HTCP was used for in situ imaging of Aβplaques in AD mouse models.Furthermore,in vivo research demonstrated that NT-HTCP could cross the blood-brain barrier and continue imaging the Aβplaques with a good signal-to-noise ratio.Additionally,the outcomes of the docking computations helped guide the development of the Aβprobes.This study expands the family of N,N-dimethylaminophenyl-based Aβ-sensitive fluorophores,with NTHTCP emerging as a highly promising imaging agent.

关键词： Amyloid-β Fluorescent probe Hydroxytricyanopyrrole Fluorescence imaging Alzheimer’s disease

Förster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect

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Chinese Chemical Letters 2024年第5期35卷 207-212页

作者： Xiaoyao Ma Jinling Zhang Ge Fang He gao jie gao Li Fu Yuanyuan Hou Gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300000China College of Life Health Dalian UniversityDalian 116622China Dalian Fusheng Pharmaceutical Co. Ltd.Dalian 116000China

The clinical benefit of combination therapy is significant,but it is not easy to define the mechanism of complexity and diversity.Previous studies illustrate that phillygenin(Phi)binds in the allosteric inhibit pocket of protein kinase B(AKT),and swertiamarin(Swe)acts on the pleckstrin homology(PH)domain of AKT.However,the combined synergistic effect of relieving the inflammatory response has yet to be elucidated.Based on high sensitivity,specificity and fast-responsibility fluorescent sensors,the Förster resonance energy transfer(FRET)technique offers a route to provide clear insights into physiological and pathological processes.In the study,molecular docking,the fluorescent probes of Phi and Swe for FRET were designed and synthesized.FRET analysis shown that Swe and Phi concurrently acted on the PH domain and allosterically inhibited pocket of AKT,respectively.The combination of Swe and Phi significantly increased the heat stability of AKT and decreased protease-induced degeneration.In lipopolysaccharides(LPS)-induced mice and cells,the combination arrested AKT activation,nuclear factor kappa-B(NF-κB)phosphorylation,and the expression of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-8.In conclusion,FRET revealed Phi and Swe concurrently targeted AKT on different domains and the combination of Phi and Swe enhanced the anti-inflammatory effect.

关键词： FRET Swertiamarin Phillygenin AKT Anti-inflammation Combinatorial drug

New indices to balanceα-diversity against tree size inequality

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Journal of Forestry Research 2024年第1期35卷 229-237页

作者： Li Zhang Brady K.Quinn Cang Hui Meng Lian Johan Gielis jie gao Peijian Shi College of Ecology and Environment Bamboo Research InstituteNanjing Forestry University159 Longpan RoadNanjing 210037People’s Republic of China Fisheries and Oceans Canada Andrews Biological Station125 Marine Science DriveSt.AndrewsNB E5B 0E4Canada Department of Mathematical Sciences Centre for Invasion BiologyStellenbosch UniversityMatieland 7602South Africa Mathematical and Physical Biosciences African Institute for Mathematical SciencesCape Town 7945South Africa Department of Biosciences Engineering University of AntwerpB-2020 AntwerpBelgium College of Life Science Xinjiang Normal University102 Xinyi RoadUrumqi 830054People’s Republic of China

The number and composition of species in a community can be quantified withα-diversity indices,including species richness(R),Simpson’s index(D),and the Shannon-Wiener index(H΄).In forest communities,there are large variations in tree size among species and individu-als of the same species,which result in differences in eco-logical processes and ecosystem functions.However,tree size inequality(TSI)has been largely neglected in studies using the available diversity indices.The TSI in the diameter at breast height(DBH)data for each of 99920 m×20 m forest census quadrats was quantified using the Gini index(GI),a measure of the inequality of size distribution.The generalized performance equation was used to describe the rotated and right-shifted Lorenz curve of the cumulative proportion of DBH and the cumulative proportion of number of trees per quadrat.We also examined the relationships ofα-diversity indices with the GI using correlation tests.The generalized performance equation effectively described the rotated and right-shifted Lorenz curve of DBH distributions,with most root-mean-square errors(990 out of 999 quadrats)being<0.0030.There were significant positive correlations between each of threeα-diversity indices(i.e.,R,D,and H’)and the GI.Nevertheless,the total abundance of trees in each quadrat did not significantly influence the GI.This means that the TSI increased with increasing spe-cies diversity.Thus,two new indices are proposed that can balanceα-diversity against the extent of TSI in the com-munity:(1−GI)×D,and(1−GI)×H’.These new indices were significantly correlated with the original D and H΄,and did not increase the extent of variation within each group of indices.This study presents a useful tool for quantifying both species diversity and the variation in tree sizes in forest communities,especially in the face of cumulative species loss under global climate change.

关键词： Diameter at breast height(DBH) Gini index Shannon-Wiener index Simpson’s index Quadrat Tree size

Biomaterials-based anti-inflammatory treatment strategies for Alzheimer's disease

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Neural Regeneration Research 2024年第1期19卷 100-115页

作者： Jianjian Chu Weicong Zhang Yan Liu Baofeng Gong Wenbo Ji Tong Yin Chao gao Danqi Liangwen Mengqi Hao Cuimin Chen Jianhua Zhuang jie gao You Yin Department of Neurology Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical UniversityShanghaiChina School of Pharmacy University College LondonLondonUK Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineClinical Pharmacy Innovation InstituteShanghai Jiao Tong University School of MedicineShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina

The current therapeutic drugs for Alzheimer's disease only improve symptoms,they do not delay disease progression.Therefo re,there is an urgent need for new effective drugs.The underlying pathogenic factors of Alzheimer's disease are not clear,but neuroinflammation can link various hypotheses of Alzheimer's disease;hence,targeting neuroinflammation may be a new hope for Alzheimer's disease treatment.Inhibiting inflammation can restore neuronal function,promote neuro regeneration,reduce the pathological burden of Alzheimer's disease,and improve or even reverse symptoms of Alzheimer's disease.This review focuses on the relationship between inflammation and various pathological hypotheses of Alzheimer's disease;reports the mechanisms and characteristics of small-molecule drugs(e.g.,nonsteroidal anti-inflammatory drugs,neurosteroids,and plant extracts);macromolecule drugs(e.g.,peptides,proteins,and gene therapeutics);and nanocarriers(e.g.,lipid-based nanoparticles,polymeric nanoparticles,nanoemulsions,and inorganic nanoparticles)in the treatment of Alzheimer's disease.The review also makes recommendations for the prospective development of anti-inflammatory strategies based on nanocarriers for the treatment of Alzheimer's disease.

关键词： Alzheimer's disease anti-inflammation blood-brain barrier drug delivery microglia nanoparticles neuroinflammation plant extracts

Dynamic emission characteristics and control strategies of air pollutants from motor vehicles in downtown Beijing,China

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Journal of Environmental Sciences 2024年第2期136卷 637-646页

作者： Yan Shen Tongran Wu Aiping Lian jie gao Fei Peng Guohua Song Xuefang Wu Yangyang Cui Xinyu Liu Yunfei Wan Jing Yan Yifeng Xue National Engineering Research Center of Urban Environmental Pollution Control Beijing Municipal Research Institute of Eco-Environmental ProtectionBeijing 100037China Beijing Municipal Ecology and Environment Bureau Beijing 100048China Beijing Jiaotong University Beijing 100091China

This study combined the real-time monitoring and investigation of traffic flows to comprehensively analyze the road traffic flow and vehicle structure in downtown Beijing.A dynamic emission inventory of motor vehicle air pollutants in downtown Beijing in 2021 was established,and the impact of these emissions on air quality was simulated and quantified,and different emission reduction control scenarios were proposed to evaluate their environmental improvement effects and explore measures to mitigate the impact of pollution emissions.The results show that the high traffic flow and the structure of the motor vehicle emissions in downtown Beijing are the main causes of severe motor vehicle pollution.Monitoring data shows that traffic flow in central Beijing is dominated by small passenger vehicles,while the vehicle mix is better than in other regions,with 72.0%of vehicles meeting"National V"or higher emission standards.However,to achieve higher air quality goals,further reducing vehicle emissions is necessary.Based on dynamic traffic flow,the average daily emissions of nitrogen oxides(NOX),particulate matters(PM_(2.5))and volatile organic compounds(VOC)from motor vehicles in central Beijing are 17.7 tons,0.6 tons and 14.0 tons,respectively,accounting for 23.0%of the city’s average daily motor vehicle emissions.If a zero-emission zone for motor vehicles were implemented in central Beijing,the annual average emission level of pollutants will be reduced by 10.4%to 21.0%.The designation of ultra-low emission zones for motor vehicles could be effective in improving the air quality in the center of Beijing.

关键词： Motor vehicle Air pollutant Emission characteristics Control strategy Beijing

F?rster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect

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Chinese Chemical Letters 2024年第5期 233-238页

作者： Xiaoyao Ma Jinling Zhang Ge Fang He gao jie gao Li Fu Yuanyuan Hou Gang Bai State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University College of Life Health Dalian University Dalian Fusheng Pharmaceutical Co. Ltd.

The clinical benefit of combination therapy is significant, but it is not easy to define the mechanism of complexity and diversity. Previous studies illustrate that phillygenin(Phi) binds in the allosteric inhibit pocket of protein kinase B(AKT), and swertiamarin(Swe) acts on the pleckstrin homology(PH) domain of AKT. However, the combined synergistic effect of relieving the inflammatory response has yet to be elucidated. Based on high sensitivity, specificity and fast-responsibility fluorescent sensors, the F?rster resonance energy transfer(FRET) technique offers a route to provide clear insights into physiological and pathological processes. In the study, molecular docking, the fluorescent probes of Phi and Swe for FRET were designed and synthesized. FRET analysis shown that Swe and Phi concurrently acted on the PH domain and allosterically inhibited pocket of AKT, respectively. The combination of Swe and Phi significantly increased the heat stability of AKT and decreased protease-induced degeneration. In lipopolysaccharides(LPS)-induced mice and cells, the combination arrested AKT activation, nuclear factor kappa-B(NF-κB)phosphorylation, and the expression of tumor necrosis factor-α(TNF-α), interleukin(IL)-6 and IL-8. In conclusion, FRET revealed Phi and Swe concurrently targeted AKT on different domains and the combination of Phi and Swe enhanced the anti-inflammatory effect.

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Economic Evaluation for 5G Planning of a Distribution Network Considering Network Coupling and Important Node Identification

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Protection and Control of Modern Power Systems 2024年第3期9卷 126-141页

作者： Xiaowei Wang Qiankun Kang Liang Guo Fan Zhang Zhenfeng Liang jie gao Xue Wang Weibo Liu IEEE the School of Electrical Engineering Xi’an University of TechnologyXi’an 710054China Xi’an University of Technology China Zhejiang University HangzhouChina the School of Electrical Engineering Xi’an Jiaotong UniversityXi’anChina the Xi’an Jiaotong University China

The rapid development of communication services in the power distribution network poses challenges for existing wireless communications,and the deployment of a fiber optic network is costly and difficult.The emerging 5G technology has been piloted in power distribution networks,though the cost-effectiveness of its large-scale deployment remains unclear.This paper proposes an economic evaluation method for 5G planning in power distribution networks,considering the coupling relationship between power distribution and communication networks and the identification of important network nodes.First,the objective function to solve the planned number of 5G base stations is established.This is solved using the adaptive particle swarm algorithm and K-means algorithm.Second,the coupling relationship between the distribution and communication networks is discussed and quantified.The node importance of the coupling network is analyzed to identify the important nodes,and micro base stations or optical fibers are added to improve the reliability of the distribution network at the communication level.Finally,an economic evaluation index of 5G planning of the distribution network is established.The paper compares the economic solutions of 5G and 4G communications in city and town scenarios using the IEEE 123-node network as an example,and concludes that the economics of 5G are better than those of 4G.

关键词： 5G coupling relationship node im-portance economic evaluation adaptive particle swarm K-means

Bird’s-eye view of recycled solid wastes in road engineering

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Journal of Road Engineering 2024年第2期4卷 93-150页

作者： Zhuangzhuang Liu Tengteng Feng Xingyi Zhu jie gao Kui Hu Meng Guo Fan Gu Feng Li School of Highway Chang'an UniversityXi'an 710064China Key Laboratory for Special Area Highway Engineering of Ministry of Education Chang'an UniversityXi'an 710064China Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 200092China School of Civil Engineering and Architecture East China Jiaotong UniversityNanchang 330013China College of Civil Engineering and Architecture Henan University of TechnologyZhengzhou 450001China State Key Laboratory of Bridge Engineering Safety and Resilience Beijing University of TechnologyBeijing 100124China Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China School of Traffic&Transportation Engineering Changsha University of Science and TechnologyChangsha 410114China School of Transportation Science and Engineering Beihang UniversityBeijing 102206China

Recent trends in road engineering have explored the potential of incorporating recycled solid wastes into infrastructures that including pavements,bridges,tunnels,and accessory structures.The utilization of solid wastes is expected to offer sustainable solutions to waste recycling while enhancing the performance of roads.This review provides an extensive analysis of the recycling of three main types of solid wastes for road engineering purposes:industrial solid waste,infrastructure solid waste,and municipal life solid waste.Industrial solid wastes suitable for road engineering generally include coal gangue,fly ash,blast furnace slag,silica fume,and steel slag,etc.Infrastructure solid wastes recycled in road engineering primarily consist of construction&demolition waste,reclaimed asphalt pavements,and recycled cement concrete.Furthermore,recent exploration has extended to the utilization of municipal life solid wastes,such as incinerated bottom ash,glass waste,electronics waste,plastic waste,and rubber waste in road engineering applications.These recycled solid wastes are categorized into solid waste aggregates,solid waste cements,and solid waste fillers,each playing distinct roles in road infrastructure.Roles of solid waste acting aggregates,cements,and fillers in road infrastructures were fully investigated,including their pozzolanic properties,integration effects to virgin materials,modification or enhancement solutions,engineering performances.Utilization of these materials not only addresses the challenge of waste management but also offers environmental benefits aiming carbon neutral and contributes to sustainable infrastructure development.However,challenges such as variability in material properties,environmental impact mitigation,secondary pollution to environment by leaching,and concerns regarding long-term performance need to be further addressed.Despite these challenges,the recycled solid wastes hold immense potential in revolutionizing road construction practices and fostering environmental stewardshi

关键词： Road engineering Industrial solid waste Infrastructure solid waste Municipal life waste Recycled materials

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu jie gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the brain.Lysosomes,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular homeostasis.Some studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s disease.Restoring the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s disease.Currently,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and targeting.Recently,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical properties.This review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s disease.This review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal function.In conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s disease.The application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Clinical guidelines for indications,techniques,and complications of autogenous bone grafting

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Chinese Medical Journal 2024年第1期137卷 5-7页

作者： Jianzheng Zhang Shaoguang Li Hongying He Li Han Simeng Zhang Lin Yang Wenxing Han Xiaowei Wang jie gao Jianwen Zhao Weidong Shi Zhuo Wu Hao Wang Zhicheng Zhang Licheng Zhang Wei Chen Qingtang Zhu Tiansheng Sun Peifu Tang Yingze Zhang Senior Department of Orthopedics PLA General HospitalBeijing 100048China The National Clinical Research Center for Orthopedics Sports Medicine&RehabilitationBeijing 100048China The Trauma Orthopedic Branch of Chinese Orthopedic Association ShijiazhuangHebei 050051China Department of Orthopedic Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei 050051China Department of Microsurgical Trauma The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China

Autogenous bone grafts have long been considered the“gold standard”and most effective material in bone regeneration procedures.[1]Autogenous bone grafts are used to repair bone defects caused by nonunion,infection,tumor resection,and spinal and joint fusion.[2]It has been reported that more than 200,000 autologous bone grafts are performed in the United States each year.[3]Although there are no specific statistics on the annual number of bone grafts performed in China,autologous bone grafting is the most common surgical technique in orthopedics.The iliac crest remains the most common donor site,along with the fibula,ribs,tibial metaphysis,proximal humerus,distal radius,and greater trochanter.[4,5]Various bone-graft options provide different amounts and qualities of cortical,cancellous,and corticocancellous bone.[6,7]Autogenous bone graft is osteogenic,histocompatible,provides structural support.

关键词： grafting graft union